ROGUE AGENT #2 : HARD TO KILL / by Darke, Jack

Why Are Bad Products So Hard to Kill? by Simester, Duncan, Zhang, Juanjuan

“…We argue that bad products are hard to kill because firms face an inherent conflict when designing managers' incentives. …”
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Standing on the shoulders of microbes: How cancer biologists are expanding their view of hard‐to‐kill persister cells by Yaara Oren

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Domain-RIP Analysis: A Technique for Analyzing Mutation Stubbornness by Huan Lin, Yawen Wang, Yunzhan Gong, Dahai Jin

“…One possible solution, as is proposed in this paper, is to measure the difficulty of killing a mutant and choose the stubborn (hard-to-kill) mutants in testing, which can be used to challenge the engineers to design new tests so to enhance the testing effectiveness. …”
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Biomimetic doxorubicin/ginsenoside co-loading nanosystem for chemoimmunotherapy of acute myeloid leukemia by Mo Chen, Yingyu Qiao, Jie Cao, La Ta, Tianyuan Ci, Xue Ke

“…Abstract Background Acute myeloid leukemia (AML) showed limited clinical therapeutic efficiency with chemotherapy for its multi-distributed lesions and hard-to-kill leukemia cells deep in the bone marrow. …”
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Numerical modeling of nanodrug distribution in tumors with heterogeneous vasculature. by Cheng-Ying Chou, Wan-I Chang, Tzyy-Leng Horng, Win-Li Lin

“…This might mean that it is hard to kill tumor stem cells hiding in it. The current model indicated that the effectiveness of the anti-tumor drug delivery was determined by the interplay of the vascular density and nanoparticle size, which governs the drug transport properties. …”
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Emerging Nanopharmaceuticals and Nanonutraceuticals in Cancer Management by Lavinia Salama, Elizabeth R. Pastor, Tyler Stone, Shaker A. Mousa

“…Moreover, low doses can cause cancer cells to acquire resistance, thus making them hard to kill. A solution that could potentially enhance drug targeting and delivery lies in understanding the complexity of nanotechnology. …”
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Multi-Task Optimization-Based Test Data Generation for Mutation Testing via Relevance of Mutant Branch and Input Variable by Xiangying Dang, Xiangjuan Yao, Dunwei Gong, Tian Tian, Baicai Sun

“…However, it is difficult to obtain test data for killing a large number of mutants, especially for hard-to-kill mutants. Mutant branch is formed by an original statement of a program under test and its mutated statement. …”
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CARA MEMATIKAN POHON RASAMALA SEBELUM PENEBANGAN DAN PENGARUHNYA TERHADAP SERANGAN KUMBANG AMBROSIA by Paimin Sukartana, Abdurahim Martawijaya

“…The  experiment  concludes  that : • It  seemed  hard  to kill  rasamala trees  by girdling  even  though  the girdled   section  was singed  with  blowtorch. • Poisoning   with  5% sodium  arsenite  solution was  effective  if  the chemical  was brushed  on  the  girdled  section. …”
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Alternative Options to Glyphosate for Control of Large <i>Echinochloa colona</i> and <i>Chloris virgata</i> Plants in Cropping Fallows by Bill Davidson, Tony Cook, Bhagirath S. Chauhan

“…Therefore, to help growers contain these hard to kill fallow weeds, an alternate approach to glyphosate application is needed. …”
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Biological Suppression of Major Mealybug Species on Horticultural Crops in India by M Mani, A Krishnamoorthy, C Shivaraju

“… Mealybugs, known to be 'hard to kill pests', live in protected areas and most stages in their life cycle are covered in a waxy coating. …”
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Synergistic Microbicidal Effect of Auranofin and Antibiotics Against Planktonic and Biofilm-Encased S. aureus and E. faecalis by Pengfei She, Linying Zhou, Shijia Li, Yiqing Liu, Lanlan Xu, Lihua Chen, Zhen Luo, Yong Wu

“…The single use of conventional antibiotics hardly completely kills the bacterial cells of interest, especially in the form of biofilms. …”
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Fabaceae species: physiological behavior of desiccation tolerance during the germination process by D. M. R. Silva, J. C. C. Santos, R. N. Costa, J. V. Santos, S. A. Santos, L. K. S. Silva, J. M. S. J. Pavão, J. V. Silva

“…Then the seeds were placed in humid chambers and replaced in germination conditions for the resumption of growth analysis thus seeds that germinated and continued its growth were considered tolerant to desiccation, the others were considered hard or killed. The experimental design was completely randomized and the data were submitted to analysis of variance and polynomial regression. …”
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Burden of Antibiotic Resistance in Common Infectious Diseases: Role of Antibiotic Combination Therapy by Kishor C Mehta, Ramesh R Dargad, Dhammraj M Borade, Onkar C Swami

“…Therefore, the best rational approach to fight these infections is to ‘hit early and hit hard’ and kills drug-susceptible bacteria before they become resistant. …”
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