Protocol of a first-in-human clinical trial to evaluate the safety, tolerability, and preliminary efficacy of the bispecific CD276xCD3 antibody CC-3 in patients with colorectal can... by Susanne Jung, Susanne Jung, Susanne Jung, Richard F. Schlenk, Richard F. Schlenk, Christopher Hackenbruch, Christopher Hackenbruch, Christopher Hackenbruch, Sandra S.L. Roldan Pinzon, Michael Bitzer, Martin Pflügler, Juliane S. Walz, Juliane S. Walz, Juliane S. Walz, Gundram Jung, Jonas S. Heitmann, Jonas S. Heitmann, Jonas S. Heitmann, Helmut R. Salih, Helmut R. Salih

“…Secondary endpoints include overall safety, efficacy, survival, quality of life, and pharmacokinetic investigations.Ethics and disseminationThe CD276xCD3 study was approved by the Ethics Committee of the Medical Faculty of the Heinrich Heine University Düsseldorf and the Paul-Ehrlich-Institut (P00702). …”
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Evaluation of Myocardial Gene Expression Profiling for Superior Diagnosis of Idiopathic Giant-Cell Myocarditis and Clinical Feasibility in a Large Cohort of Patients with Acute Car... by Felicitas Escher, Heiko Pietsch, Ganna Aleshcheva, Philip Wenzel, Friedrich Fruhwald, Christian Stumpf, Dirk Westermann, Johann Bauersachs, Frank Enseleit, Frank Ruschitzka, Herbert Nägele, Karl-Ludwig Laugwitz, Hendrik Haake, Norbert Frey, Johannes Brachmann, Kurt Huber, Rüdiger Christian Braun-Dullaeus, Martin W. Bergmann, Jörg Strotmann, Gerian Grönefeld, Jürgen Krülls-Münch, Ralf Westenfeld, Carsten Skurk, Ulf Landmesser, Burkert Pieske, Ulrich M. Gross, Lars Morawietz, Heinz-Peter Schultheiss

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Association of glycated hemoglobin A1c levels with cardiovascular outcomes in the general population: results from the BiomarCaRE (Biomarker for Cardiovascular Risk Assessment in E... by Christoph Sinning, Nataliya Makarova, Henry Völzke, Renate B. Schnabel, Francisco Ojeda, Marcus Dörr, Stephan B. Felix, Wolfgang Koenig, Annette Peters, Wolfgang Rathmann, Ben Schöttker, Hermann Brenner, Giovanni Veronesi, Giancarlo Cesana, Paolo Brambilla, Tarja Palosaari, Kari Kuulasmaa, Inger Njølstad, Ellisiv Bøgeberg Mathiesen, Tom Wilsgaard, Stefan Blankenberg, Stefan Söderberg, Marco M. Ferrario, Barbara Thorand

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Chemotherapy-related hyperbilirubinemia in pediatric acute lymphoblastic leukemia: a genome-wide association study from the AIEOP-BFM ALL study group by Stefanie V. Junk, Elke Schaeffeler, Martin Zimmermann, Anja Möricke, Rita Beier, Peter Schütte, Birthe Fedders, Julia Alten, Laura Hinze, Norman Klein, Andreas Kulozik, Martina U. Muckenthaler, Rolf Koehler, Arndt Borkhardt, Jayaram Vijayakrishnan, David Ellinghaus, Michael Forster, Andre Franke, Astrid Wintering, Christian P. Kratz, Martin Schrappe, Matthias Schwab, Richard S. Houlston, Gunnar Cario, Martin Stanulla

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Fine mapping and sequence analysis reveal a promising candidate gene encoding a novel NB-ARC domain derived from wild rice (Oryza officinalis) that confers bacterial blight resista... by Pragya Sinha, Dilip Kumar T., Hajira Sk, Manish Solanki, C. G. Gokulan, Ayyappa Das, Anila Miriyala, Rekha Gonuguntala, Punniakoti Elumalai, Kousik M. B. V. N, Masthani S. K., Chaitra Kumboju, Yugander Arra, Yugander Arra, Laha G. S., N. Neerja Chirravuri, Hitendra Kumar Patel, Irfan Ahmad Ghazi, Sung-Ryul Kim, Kshirod K. Jena, Surekha Rani Hanumanth, Ricardo Oliva, Satendra K. Mangrauthia, Raman Menakshi Sundaram

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Towards a European health research and innovation cloud (HRIC) by F. M. Aarestrup, A. Albeyatti, W. J. Armitage, C. Auffray, L. Augello, R. Balling, N. Benhabiles, G. Bertolini, J. G. Bjaalie, M. Black, N. Blomberg, P. Bogaert, M. Bubak, B. Claerhout, L. Clarke, B. De Meulder, G. D’Errico, A. Di Meglio, N. Forgo, C. Gans-Combe, A. E. Gray, I. Gut, A. Gyllenberg, G. Hemmrich-Stanisak, L. Hjorth, Y. Ioannidis, S. Jarmalaite, A. Kel, F. Kherif, J. O. Korbel, C. Larue, M. Laszlo, A. Maas, L. Magalhaes, I. Manneh-Vangramberen, E. Morley-Fletcher, C. Ohmann, P. Oksvold, N. P. Oxtoby, I. Perseil, V. Pezoulas, O. Riess, H. Riper, J. Roca, P. Rosenstiel, P. Sabatier, F. Sanz, M. Tayeb, G. Thomassen, J. Van Bussel, M. Van den Bulcke, H. Van Oyen

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Post-COVID exercise intolerance is associated with capillary alterations and immune dysregulations in skeletal muscles by Tom Aschman, Emanuel Wyler, Oliver Baum, Andreas Hentschel, Rebekka Rust, Franziska Legler, Corinna Preusse, Lil Meyer-Arndt, Ivana Büttnerova, Alexandra Förster, Derya Cengiz, Luiz Gustavo Teixeira Alves, Julia Schneider, Claudia Kedor, Judith Bellmann-Strobl, Aminaa Sanchin, Hans-Hilmar Goebel, Markus Landthaler, Victor Corman, Andreas Roos, Frank L. Heppner, Helena Radbruch, Friedemann Paul, Carmen Scheibenbogen, Nora F. Dengler, Werner Stenzel

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Associations of endogenous androgens and sex hormone-binding globulin with kidney function and chronic kidney disease by Lina Hui Ying Lau, Lina Hui Ying Lau, Lina Hui Ying Lau, Jana Nano, Jana Nano, Cornelia Prehn, Alexander Cecil, Wolfgang Rathmann, Wolfgang Rathmann, Tanja Zeller, Tanja Zeller, Andreas Lechner, Jerzy Adamski, Jerzy Adamski, Jerzy Adamski, Annette Peters, Annette Peters, Annette Peters, Annette Peters, Barbara Thorand, Barbara Thorand

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Comparative Analysis of Microfluidics Thrombus Formation in Multiple Genetically Modified Mice: Link to Thrombosis and Hemostasis by Magdolna Nagy, Johanna P. van Geffen, David Stegner, David J. Adams, Attila Braun, Susanne M. de Witt, Margitta Elvers, Mitchell J. Geer, Marijke J. E. Kuijpers, Karl Kunzelmann, Jun Mori, Cécile Oury, Joachim Pircher, Irina Pleines, Alastair W. Poole, Yotis A. Senis, Remco Verdoold, Christian Weber, Christian Weber, Bernhard Nieswandt, Johan W. M. Heemskerk, Constance C. F. M. J. Baaten, Constance C. F. M. J. Baaten

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Comparison of individualized behavioral predictions across anatomical, diffusion and functional connectivity MRI by Leon Qi Rong Ooi, Jianzhong Chen, Shaoshi Zhang, Ru Kong, Angela Tam, Jingwei Li, Elvisha Dhamala, Juan Helen Zhou, Avram J Holmes, B. T. Thomas Yeo

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Multimodal Treatment of Nasopharyngeal Carcinoma in Children, Adolescents and Young Adults-Extended Follow-Up of the NPC-2003-GPOH Study Cohort and Patients of the Interim Cohort by Tristan Römer, Sabrina Franzen, Hanna Kravets, Ahmed Farrag, Anna Makowska, Hans Christiansen, Michael J. Eble, Beate Timmermann, Gundula Staatz, Felix M. Mottaghy, Martina Bührlen, Ulrich Hagenah, Alexander Puzik, Pablo Hernáiz Driever, Jeanette Greiner, Norbert Jorch, Stephan Tippelt, Dominik T. Schneider, Gabriele Kropshofer, Tobias R. Overbeck, Holger Christiansen, Triantafyllia Brozou, Gabriele Escherich, Martina Becker, Waltraud Friesenbichler, Tobias Feuchtinger, Wolfram Puppe, Nicole Heussen, Ralf D. Hilgers, Udo Kontny

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The associations of Positive and Negative Valence Systems, Cognitive Systems and Social Processes on disease severity in anxiety and depressive disorders by Bernd R. Förstner, Sarah Jane Böttger, Alexander Moldavski, Malek Bajbouj, Andrea Pfennig, André Manook, Marcus Ising, Andre Pittig, Andre Pittig, Ingmar Heinig, Andreas Heinz, Klaus Mathiak, Klaus Mathiak, Thomas G. Schulze, Thomas G. Schulze, Thomas G. Schulze, Frank Schneider, Frank Schneider, Inge Kamp-Becker, Andreas Meyer-Lindenberg, Frank Padberg, Tobias Banaschewski, Michael Bauer, Rainer Rupprecht, Hans-Ulrich Wittchen, Hans-Ulrich Wittchen, Michael A. Rapp, Mira Tschorn

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Polygenic risk scores indicate extreme ages at onset of breast cancer in female BRCA1/2 pathogenic variant carriers by Julika Borde, Yael Laitman, Britta Blümcke, Dieter Niederacher, Konstantin Weber-Lassalle, Christian Sutter, Andreas Rump, Norbert Arnold, Shan Wang-Gohrke, Judit Horváth, Andrea Gehrig, Gunnar Schmidt, Véronique Dutrannoy, Juliane Ramser, Julia Hentschel, Alfons Meindl, Christopher Schroeder, Barbara Wappenschmidt, Christoph Engel, Karoline Kuchenbaecker, Rita K. Schmutzler, Eitan Friedman, Eric Hahnen, Corinna Ernst

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Characterisation of divertor detachment onset in JET-ILW hydrogen, deuterium, tritium and deuterium–tritium low-confinement mode plasmas by M. Groth, V. Solokha, S. Aleiferis, S. Brezinsek, M. Brix, I.S. Carvalho, P. Carvalho, G. Corrigan, D. Harting, N. Horsten, I. Jepu, J. Karhunen, K. Kirov, B. Lomanowski, K.D. Lawson, C. Lowry, A.G. Meigs, S. Menmuir, E. Pawelec, T. Pereira, A. Shaw, S. Silburn, B. Thomas, S. Wiesen, P. Börner, D. Borodin, S. Jachmich, D. Reiter, G. Sergienko, Z. Stancar, B. Viola, P. Beaumont, J. Bernardo, I. Coffey, N.J. Conway, E. de la Luna, D. Douai, C. Giroud, J. Hillesheim, L. Horvath, A. Huber, P. Lomas, C.F. Maggi, M. Maslov, C. Perez von Thun, S. Scully, N. Vianello, M. Wischmeier

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Integrated Proteo-Transcriptomic Analyses Reveal Insights into Regulation of Pollen Development Stages and Dynamics of Cellular Response to Apple Fruit Crinkle Viroid (AFCVd)-Infec... by Ankita Shrestha, Ajay Kumar Mishra, Jaroslav Matoušek, Lenka Steinbachová, David Potěšil, Vishnu Sukumari Nath, Praveen Awasthi, Tomáš Kocábek, Jernej Jakse, Lenka Záveská Drábková, Zbyněk Zdráhal, David Honys, Gerhard Steger

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Combining PSA and PET features to select candidates for salvage lymph node dissection in recurrent prostate cancer by Carlo A. Bravi, Axel Heidenreich, Nicola Fossati, Giorgio Gandaglia, Nazareno Suardi, Elio Mazzone, Armando Stabile, Vito Cucchiara, Daniar Osmonov, Klaus‐Peter Juenemann, R. Jeffrey Karnes, Alexander Kretschmer, Alexander Buchner, Christian Stief, Andreas Hiester, Peter Albers, Gaëtan Devos, Steven Joniau, Hendrik Van Poppel, Bernhard Grubmüller, Shahrokh Shariat, Derya Tilki, Markus Graefen, Inderbir S. Gill, Alexander Mottrie, Pierre I. Karakiewicz, Francesco Montorsi, Alberto Briganti, David Pfister

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L-DOPA increases slow-wave sleep duration and selectively modulates memory persistence in older adults by Hanna K. Isotalus, Hanna K. Isotalus, Will J. Carr, Jonathan Blackman, Jonathan Blackman, George G. Averill, Oliver Radtke, James Selwood, James Selwood, Rachel Williams, Elizabeth Ford, Liz McCullagh, James McErlane, Cian O’Donnell, Claire Durant, Ullrich Bartsch, Matt W. Jones, Carlos Muñoz-Neira, Alfie R. Wearn, John P. Grogan, John P. Grogan, John P. Grogan, Elizabeth J. Coulthard, Elizabeth J. Coulthard

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The effect of exposure to long working hours on ischaemic heart disease: A systematic review and meta-analysis from the WHO/ILO Joint Estimates of the Work-related Burden of Diseas... by Jian Li, Frank Pega, Yuka Ujita, Chantal Brisson, Els Clays, Alexis Descatha, Marco M. Ferrario, Lode Godderis, Sergio Iavicoli, Paul A. Landsbergis, Maria-Inti Metzendorf, Rebecca L. Morgan, Daniela V. Pachito, Hynek Pikhart, Bernd Richter, Mattia Roncaioli, Reiner Rugulies, Peter L. Schnall, Grace Sembajwe, Xavier Trudel, Akizumi Tsutsumi, Tracey J. Woodruff, Johannes Siegrist

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Acridones as promising drug candidates against Oropouche virus by Marielena Vogel Saivish, Gabriela de Lima Menezes, Roosevelt Alves da Silva, Leticia Ribeiro de Assis, Igor da Silva Teixeira, Umberto Laino Fulco, Clarita Maria Secco Avilla, Raphael Josef Eberle, Igor de Andrade Santos, Karolina Korostov, Mayara Lucia Webber, Gislaine Celestino Dutra da Silva, Maurício Lacerda Nogueira, Ana Carolina Gomes Jardim, Luis Octavio Regasin, Mônika Aparecida Coronado, Carolina Colombelli Pacca

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The Global Brain Health Survey: Development of a Multi-Language Survey of Public Views on Brain Health by Isabelle Budin-Ljøsne, Barbara Bodorkos Friedman, Sana Suri, Cristina Solé-Padullés, Sandra Düzel, Christian A. Drevon, Christian A. Drevon, William F. C. Baaré, Athanasia Monika Mowinckel, Enikő Zsoldos, Kathrine Skak Madsen, Rebecca Bruu Carver, Paolo Ghisletta, Paolo Ghisletta, Paolo Ghisletta, Mari R. Arnesen, David Bartrés Faz, Andreas M. Brandmaier, Anders Martin Fjell, Aud Kvalbein, Richard N. Henson, Rogier A. Kievit, Laura Nawijn, Roland Pochet, Alfons Schnitzler, Kristine B. Walhovd, Larysa Zasiekina

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