Association between arterial hypertension and liver outcomes using polygenic risk scores: a population-based study by Fredrik Åberg, Katri Kantojärvi, Ville Männistö, Anna But, Veikko Salomaa, Teemu Niiranen, Martti Färkkilä, Panu Luukkonen, Satu Männistö, Annamari Lundqvist, Markus Perola, Antti Jula

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The effects of baroreflex activation therapy on blood pressure and sympathetic function in patients with refractory hypertension: the rationale and design of the Nordic BAT study* by Daniel Gordin, Fadl Elmula M. Fadl Elmula, Bert Andersson, Anders Gottsäter, Johan Elf, Thomas Kahan, Kent Lodberg Christensen, Pirkka Vikatmaa, Leena Vikatmaa, Thomas Bastholm Olesen, Per-Henrik Groop, Michael Hecht Olsen, Ilkka Tikkanen

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Effects of angiotensin II blockade on cardiomyocyte regeneration after myocardial infarction in rats by Heli Segersvärd, Päivi Lakkisto, Hanna Forsten, Katariina Immonen, Riikka Kosonen, Eeva Palojoki, Esko Kankuri, Ari Harjula, Mika Laine, Ilkka Tikkanen

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Implementing a New Electronic Health Record System in a University Hospital: The Effect on Reported Medication Errors by Carita Lindén-Lahti, Sanna-Maria Kivivuori, Lasse Lehtonen, Lotta Schepel

“…The aim of this paper was to describe the changes in reported MEs in Helsinki University Hospital (HUS) during and after implementing an EPIC-based electronic health record system (APOTTI), with the first features of a closed-loop EMMS. …”
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Early clinical features of new-onset refractory status epilepticus (NORSE) in adults by Anna Haanpää, Sini M. Laakso, Antti Kinnunen, Leena Kämppi, Nina Forss

“…Methods A retrospective cohort study of adult NORSE patients treated in the intensive care units of Helsinki University Hospital 2007-2018. Results We found 19 adult NORSE patients who divided into three subgroups on the basis of their clinical features: viral encephalitis (n = 5, 26%), febrile infection-related epilepsy syndrome (FIRES) (n = 6, 32%) and afebrile NORSE (n = 8, 42%). …”
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Laboratory Assessment of Unfractionated Heparin (UFH) with Activated Clotting Time (ACT) and Anti-Xa Activity during Peripheral Arterial Angiographic Procedure by Tuukka Helin, Tomi Tirri, Heidi Korkala, Kimmo Lappalainen, Lotta Joutsi-Korhonen

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Can Chromoendoscopy Improve the Early Diagnosis of Gastric Carcinoma in Dogs? by Marcus Vinicius Candido, Pernilla Syrjä, Susanne Kilpinen, Søren Meisner, Mohsen Hanifeh, Thomas Spillmann

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Frontal Sinus Balloon Sinuplasty—Patient Satisfaction and Factors Predicting Reoperation by Sara Sainio, Karin Blomgren, Anni Koskinen, Marie Lundberg

“…Setting Department of Otorhinolaryngology–Head and Neck Surgery, Helsinki University Hospital and University of Helsinki, Finland. …”
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SLC-0111, an inhibitor of carbonic anhydrase IX, attenuates hepatoblastoma cell viability and migration by Katja Eloranta, Marjut Pihlajoki, Emmi Liljeström, Ruth Nousiainen, Tea Soini, Jouko Lohi, Stefano Cairo, Stefano Cairo, Stefano Cairo, David B. Wilson, David B. Wilson, Seppo Parkkila, Seppo Parkkila, Seppo Parkkila, Markku Heikinheimo, Markku Heikinheimo, Markku Heikinheimo

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Socioeconomic disparities in use of rhythm control therapies in patients with incident atrial fibrillation: A Finnish nationwide cohort study by Konsta Teppo, Jussi Jaakkola, Fausto Biancari, Olli Halminen, Miika Linna, Jari Haukka, Jukka Putaala, Pirjo Mustonen, Janne Kinnunen, Alex Luojus, Saga Itäinen-Strömberg, Juha Hartikainen, Aapo L. Aro, K.E. Juhani Airaksinen, Mika Lehto

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Shorter birth length and decreased T-cell production and function predict severe infections in children with non–severe combined immunodeficiency cartilage–hair hypoplasia by Eetu Pello, MD, Leena Kainulainen, MD, PhD, Mikko Vakkilainen, MSc, Paula Klemetti, MD, PhD, Mervi Taskinen, MD, PhD, Outi Mäkitie, MD, PhD, Svetlana Vakkilainen, MD, PhD

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Low nuclear expression of HIF‐hydroxylases PHD2/EGLN1 and PHD3/EGLN3 are associated with poor recurrence‐free survival in clear cell renal cell carcinoma by Lassi Luomala, Kalle Mattila, Paula Vainio, Harry Nisén, Teijo Pellinen, Jouni Lohi, Teemu D. Laajala, Petrus Järvinen, Anna‐Riina Koskenniemi, Panu Jaakkola, Tuomas Mirtti

“…Patients and Methods In this study, we analyzed the associations of PHD2 and PHD3 with histopathological tumor features and recurrence‐free survival (RFS) in a retrospective cohort of 173 patients who had undergone surgery for localized ccRCC at Helsinki University Hospital (HUH), Finland. An external validation cohort of 191 patients was obtained from Turku University Hospital (TUH), Finland. …”
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<i>STAT3</i> Mutation Is Associated with STAT3 Activation in CD30⁺ ALK⁻ ALCL by Emma I. Andersson, Oscar Brück, Till Braun, Susanna Mannisto, Leena Saikko, Sonja Lagström, Pekka Ellonen, Sirpa Leppä, Marco Herling, Panu E. Kovanen, Satu Mustjoki

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Self-Reported Physician Diagnosed Asthma with COPD is Associated with Higher Mortality than Self-Reported Asthma or COPD Alone – A Prospective 24-Year Study in the Population of He... by Juuso Jalasto, Paula Kauppi, Ritva Luukkonen, Ari Lindqvist, Arnulf Langhammer, Hannu Kankaanranta, Helena Backman, Eva Rönmark, Anssi Sovijärvi, Päivi Piirilä

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An aMMP-8 Point-of-Care and Questionnaire Based Real-Time Diagnostic Toolkit for Medical Practitioners by Ismo T. Räisänen, Hanna Lähteenmäki, Shipra Gupta, Andreas Grigoriadis, Vaibhav Sahni, Juho Suojanen, Hanna Seppänen, Taina Tervahartiala, Dimitra Sakellari, Timo Sorsa

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Higher Soong grade predicts flexor tendon issues after volar plating of distal radius fractures – a retrospective cohort study by Henri Vasara, Petra Tarkiainen, Antti Stenroos, Jussi Kosola, Turkka Anttila, Anni Aavikko, Panu H Nordback, Samuli Aspinen

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Factors influencing patient and health care delays in Oropharyngeal Cancer by Markus Nieminen, Timo Atula, Leif Bäck, Antti Mäkitie, Lauri Jouhi, Katri Aro

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High-volume evacuation mitigates viral aerosol spread in dental procedures by Rasmus Malmgren, Hanna Välimaa, Lotta Oksanen, Enni Sanmark, Petra Nikuri, Paavo Heikkilä, Jani Hakala, Aleksi Ahola, Simeoni Yli-Urpo, Ville Palomäki, Eija Asmi, Svetlana Sofieva, Antti Rostedt, Sirpa Laitinen, Martin Romantschuk, Tarja Sironen, Nina Atanasova, Susanna Paju, Laura Lahdentausta-Suomalainen

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CRISPR/Cas9-mediated activation of NR5A1 steers female human embryonic stem cell-derived bipotential gonadal-like cells towards a steroidogenic cell fate by Laura Danti, Karolina Lundin, Kirsi Sepponen, Dawit A. Yohannes, Juha Kere, Timo Tuuri, Juha S. Tapanainen

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Synthetic computed tomography based dose calculation in prostate cancer patients with hip prostheses for magnetic resonance imaging-only radiotherapy by Lauri Koivula, Tiina Seppälä, Juhani Collan, Harri Visapää, Mikko Tenhunen, Arthur Korhonen

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