Design, Synthesis, and Neuroprotective Effects of Novel Cinnamamide-Piperidine and Piperazine Derivatives by Jia-Yi Li, Xin-Yan Peng, Yi-Lei Huang, Ling Jiang, Jian-Qi Li, Xue-Zhi Yang, Qing-Wei Zhang

Subjects: Get full text

Computational determination of toxicity risks associated with a selection of approved drugs having demonstrated activity against COVID-19 by Maral Aminpour, Williams Ernesto Miranda Delgado, Soren Wacker, Sergey Noskov, Michael Houghton, D. Lorne J. Tyrrell, Jack A. Tuszynski

Subjects: Get full text

Novel Bacterial Topoisomerase inhibitors (NBTIs) – A comprehensive review by Jigar Desai, Sachchidanand S, Sanjay Kumar, Rajiv Sharma

Subjects: Get full text

Characterization of the novel mutant A78T-HERG from a long QT syndrome type 2 patient: Instability of the mutant protein and stabilization by heat shock factor 1 by Takehito Kondo, Ichiro Hisatome, Shouichi Yoshimura, Endang Mahati, Tomomi Notsu, Peili Li, Kazuhiko Iitsuka, Masaru Kato, Kazuyoshi Ogura, Junichiro Miake, Takeshi Aiba, Wataru Shimizu, Yasutaka Kurata, Shinji Sakata, Naoe Nakasone, Haruaki Ninomiya, Akira Nakai, Katsumi Higaki, Yasushi Kawata, Yasuaki Shirayoshi, Akio Yoshida, Kazuhiro Yamamoto

“…WT-HERG, but not A78T-HERG, was expressed on the plasma membrane. …”
Get full text

Long QT Syndrome Type 2: Emerging Strategies for Correcting Class 2 <i>KCNH2</i> (<i>hERG</i>) Mutations and Identifying New Patients by Makoto Ono, Don E. Burgess, Elizabeth A. Schroder, Claude S. Elayi, Corey L. Anderson, Craig T. January, Bin Sun, Kalyan Immadisetty, Peter M. Kekenes-Huskey, Brian P. Delisle

Subjects: Get full text

A new hERG allosteric modulator rescues genetic and drug‐induced long‐QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells by Luca Sala, Zhiyi Yu, Dorien Ward‐van Oostwaard, Jacobus PD vanVeldhoven, Alessandra Moretti, Karl‐Ludwig Laugwitz, Christine L Mummery, Adriaan P IJzerman, Milena Bellin

Subjects: Get full text

Regulation of Kv11.1 Isoform Expression by Polyadenylate Binding Protein Nuclear 1 by Matthew R. Stump, Rachel T. Nguyen, Rachel H. Drgastin, Delaney Search, Qiuming Gong, Zhengfeng Zhou

Subjects: Get full text

Cardiac safety assessment of a novel recombinant bispecific antibody targeting the ether-à-go-go related gene 1 (hERG1)-β1 integrin macromolecular complex by Lorenzo Santini, Claudia Duranti, Chiara Palandri, Lucrezia Giammarino, Monica Musumeci, Lucia Carlucci, Chiara Capitani, Chiara Capitani, Rossella Colasurdo, Rossella Colasurdo, Fabio Recchia, Elisabetta Cerbai, Raffaele Coppini, Annarosa Arcangeli

“…Cardiac cells were incubated in vitro with i) the scDb-hERG1-β1, ii) the full length anti-hERG1 monoclonal antibody (mAb-hERG1) and iii) its single chain Fragment variable derivative (scFv-hERG1), from which the scDb-hERG1-β1 was assembled. …”
Get full text

The 5-HT4 Agonists Cisapride, Mosapride, and CJ-033466, a Novel Potent Compound, Exhibit Different Human Ether-a-go-go-Related Gene (hERG)-Blocking Activities by Tetsuo Toga, Yumi Kohmura, Ryoichi Kawatsu

“…Cisapride was found to be the most potent of the hERG blockers. CJ-033466 had the widest safety margin between its hERG blocking activity and 5-HT4 agonism among the tested compounds. …”
Get full text

Dual Mechanisms of Cardiac Action Potential Prolongation by 4-Oxo-Nonenal Increasing the Risk of Arrhythmia; Late Na⁺ Current Induction and hERG K⁺ Channel Inhibition by Seong-Woo Choi, Ming-Zhe Yin, Na-Kyeong Park, Joo-Han Woo, Sung-Joon Kim

“…We previously reported the arrhythmic potential of 4-HNE by suppression of cardiac human Ether-a-go-go Related Gene (hERG) K⁺ channels with prolonged action potential duration (APD) in cardiomyocytes. …”
Get full text

Histamine-3 Receptor Inverse Agonists for the Treatment of Obesity: Validation of the Target and Identification of Novel Series by Pascale David Pierson, Christoph Ullmer, Sven Taylor, Tadakatsu Takahashi, Franz Schuler, Monique Schmitt, Rosa María Rodríguez Sarmiento, Olivier Roche, Hans Richter, Susanne Raab, Jean-Marc Plancher, Matthias Nettekoven, Toshito Nakagawa, Peter Mohr, Jörg Huwyler, Cornelia Hertel, Silvia Gatti-Mac Arthur, Christian Freichel, Ruby Wiegand

Subjects: “…Herg…”
Get full text

Effect of vinpocetine on embryonic heart rate in vitro by Helen Elizabeth Ritchie, Jaimie W. Polson, Andrea Xia, William Webster

Subjects: Get full text

Are financial stocks driven by substantive factors or virtual factors? Comparing Taiwan and China markets by Ho Chi Ming

Subjects: Get full text

Two four-marker haplotypes on 7q36.1 region indicate that the potassium channel gene <it>HERG1 </it>(<it>KCNH2</it>, <it>Kv11.1</it>) is related to schizophrenia: a case control study by Ozbek Ugur, Yesilbursa Dogan, Oncu Fatih, Cine Naci, Acuner Tufan, Atalar Fatmahan, Turkcan Solmaz

“…The HERG1 channel is encoded by <it>HERG1 </it>(<it>KCNH2</it>, <it>Kv11.1</it>) gene and is most highly expressed in heart and brain. …”
Get full text

Toward in vivo-relevant hERG safety assessment and mitigation strategies based on relationships between non-equilibrium blocker binding, three-dimensional channel-blocker interactions, dynamic occupancy, dynamic exposure, and cellular arrhythmia. by Hongbin Wan, Gianluca Selvaggio, Robert A Pearlstein

“…The human ether-a-go-go-related voltage-gated cardiac ion channel (commonly known as hERG) conducts the rapid outward repolarizing potassium current in cardiomyocytes (IKr). …”
Get full text

Antioxidant potential of flavonoid glycosides from Manniophyton fulvum Müll. (Euphorbiaceae): Identification and molecular modeling by Smith B. Babiaka, Rene Nia, Kennedy O. Abuga, James A. Mbah, Vincent de Paul N. Nziko, Dietrich H. Paper, Fidele Ntie-Kang

Subjects: Get full text

Sphingosine 1-Phosphate and Cancer: Lessons from Thyroid Cancer Cells by Kid Törnquist

Subjects: Get full text

Cardiovascular and Respiratory Toxicity of Protamine Sulfate in Zebrafish and Rodent Models by Joanna Miklosz, Bartlomiej Kalaska, Piotr Podlasz, Małgorzata Chmielewska-Krzesińska, Miłosz Zajączkowski, Adam Kosiński, Dariusz Pawlak, Andrzej Mogielnicki

Subjects: Get full text

Huffing and twist: Fatal Torsade de pointes associated with Tetrafluoroethane Inhalation and amphetamine use by Joseph Burke, Mark C. P. Haigney, Morteza Farasat, Philip S. Mehler, Mori J. Krantz

Subjects: “…hERG…”
Get full text

Calculations of the binding free energies of the Comprehensive in vitro Proarrhythmia Assay (CiPA) reference drugs to cardiac ion channels by Tatsuki Negami, Tohru Terada

Subjects: “…herg…”
Get full text