Up-regulation of hERG K⁺ channels by B-RAF. by Tatsiana Pakladok, Zohreh Hosseinzadeh, Ahmad Almilaji, Aleksandra Lebedeva, Ekaterina Shumilina, Ioana Alesutan, Florian Lang

“…HERG channel activity is up-regulated by growth factors. …”
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Construction of an integrated database for hERG blocking small molecules. by Tomohiro Sato, Hitomi Yuki, Keiji Ogura, Teruki Honma

“…The recent increase in SAR information about hERG inhibitors in public databases has led to many successful applications of machine learning techniques to predict hERG inhibition. …”
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Molecular Determinants of hERG Channel Block by Terfenadine and Cisapride by Kaichiro Kamiya, Ryoko Niwa, Mikio Morishima, Haruo Honjo, Michael C. Sanguinetti

“…Bioorg Med Chem. 2006;14:3160–3173), our findings suggest that different drugs can adopt distinct modes of binding to the central cavity of hERG. Keywords:: hERG, long QT syndrome, oocyte, voltage clamp…”
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The molecular determinants of R-roscovitine block of hERG channels. by Bryan Cernuda, Christopher Thomas Fernandes, Salma Mohamed Allam, Matthew Orzillo, Gabrielle Suppa, Zuleen Chia Chang, Demosthenes Athanasopoulos, Zafir Buraei

“…In contrast, S624A hERG was inhibited more potently than WT hERG, with a ~ 34% stronger inhibition. …”
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Data on the construction of a recombinant HEK293 cell line overexpressing hERG potassium channel and examining the presence of hERG mRNA and protein expression by Yi Fan Teah, Muhammad Asyraf Abduraman, Azimah Amanah, Mohd Ilham Adenan, Shaida Fariza Sulaiman, Mei Lan Tan

Subjects: “…hERG…”
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Data on the construction of a recombinant HEK293 cell line overexpressing hERG potassium channel and examining the presence of hERG mRNA and protein expression by Yi, Fan Teah, Abduraman, Muhammad Asyraf, Amanah, Azimah, Adenan, Mohd Ilham, Sulaiman, Shaida Fariza, Mei, Lan Tan

“…Tan) [1], which the possible hERG blocking properties of deoxyelephantopin were investigated. …”
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A Book Review: The Comics of Hergé – When The Lines Are Not So Clear by Reijo Valta

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A molecular switch driving inactivation in the cardiac K+ channel HERG. by David A Köpfer, Ulrike Hahn, Iris Ohmert, Gert Vriend, Olaf Pongs, Bert L de Groot, Ulrich Zachariae

“…Mutations impairing hERG inactivation cause life-threatening cardiac arrhythmia, which also occur as undesired side effects of drugs. …”
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Modulation of hERG K+ Channel Deactivation by Voltage Sensor Relaxation by Yu Patrick Shi, Samrat Thouta, Thomas W. Claydon

Subjects: “…hERG…”
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Hysteretic hERG channel gating current recorded at physiological temperature by David K. Jones

“…Abstract Cardiac hERG channels comprise at least two subunits, hERG 1a and hERG 1b, and drive cardiac action potential repolarization. hERG 1a subunits contain a cytoplasmic PAS domain that is absent in hERG 1b. …”
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Structural modeling of the hERG potassium channel and associated drug interactions by Jan Maly, Jan Maly, Aiyana M. Emigh, Aiyana M. Emigh, Kevin R. DeMarco, Kevin R. DeMarco, Kazuharu Furutani, Jon T. Sack, Colleen E. Clancy, Colleen E. Clancy, Igor Vorobyov, Igor Vorobyov, Vladimir Yarov-Yarovoy

Subjects: “…hERG channel…”
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Noncanonical electromechanical coupling paths in cardiac hERG potassium channel by Carlos A. Z. Bassetto, Flavio Costa, Carlo Guardiani, Francisco Bezanilla, Alberto Giacomello

“…Here, authors reveal the existence of a noncanonical kinematic chain of residues involving the S4/S1 and S1/S5 subunit interfaces that controls the gating of the hERG cardiac channel.…”
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Global analysis reveals families of chemical motifs enriched for HERG inhibitors. by Fang Du, Joseph J Babcock, Haibo Yu, Beiyan Zou, Min Li

“…Promiscuous inhibition of the human ether-à-go-go-related gene (hERG) potassium channel by drugs poses a major risk for life threatening arrhythmia and costly drug withdrawals. …”
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hERG K+ Channels Promote Survival of Irradiated Leukemia Cells by Daniela Palme, Milan Misovic, Katrin Ganser, Lukas Klumpp, Helmut R. Salih, Daniel Zips, Daniel Zips, Daniel Zips, Stephan M. Huber

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A Receptor-Independent Effect of Estrone Sulfate on the hERG Channel by Shoko Kakusaka, Mahoko Asayama, Asami Kaihara, Tetsuo Sasano, Takeshi Suzuki, Junko Kurokawa, Tetsushi Furukawa

“…Keywords:: estrogen, K+ channel (hERG), heart…”
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Aggregation-Induced Emission: Lighting Up hERG Potassium Channel by Xiaomeng Zhang, Tingting Liu, Qi Li, Minyong Li, Lupei Du

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The Study on the hERG Blocker Prediction Using Chemical Fingerprint Analysis by Kwang-Eun Choi, Anand Balupuri, Nam Sook Kang

Subjects: “…hERG toxicity…”
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Berberine Induces hERG Channel Deficiency through Trafficking Inhibition by Kaiping Zhang, Duo Zhi, Ting Huang, Yan Gong, Meng Yan, Chen Liu, Ting Wei, Zengxiang Dong, Baoxin Li, Baofeng Yang

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New Insights into Ion Channels: Predicting hERG-Drug Interactions by Michael Fitzpatrick Wempe

Subjects: “…human ether-à-gogo-related gene (hERG)…”
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Structural modeling of hERG channel–drug interactions using Rosetta by Aiyana M. Emigh Cortez, Aiyana M. Emigh Cortez, Kevin R. DeMarco, Kevin R. DeMarco, Kazuharu Furutani, Kazuharu Furutani, Slava Bekker, Slava Bekker, Jon T. Sack, Jon T. Sack, Heike Wulff, Colleen E. Clancy, Colleen E. Clancy, Colleen E. Clancy, Igor Vorobyov, Igor Vorobyov, Vladimir Yarov-Yarovoy, Vladimir Yarov-Yarovoy

Subjects: “…hERG channel…”
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