Application of Human Stem Cell−derived Cardiomyocytes in Safety Pharmacology Requires Caution Beyond hERG by Jonsson, M, Vos, M, Mirams, G, Duker, G, Sartipy, P, de Boer, T, van Veen, T

“…The only compound that triggered EADs was hERG blocker Cisapride. Computer simulations and APclamp showed that the immature AP of hESC-CM prevents proper functioning of INa-channels, and result in lower peak/maximal currents of several other channels, compared to the adult situation. …”

Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG by Jonsson, M, Vos, M, Mirams, G, Duker, G, Sartipy, P, De Boer, T, Van Veen, T

“…The only compound that triggered EADs was hERG blocker Cisapride. Computer simulations and AP clamp showed that the immature AP of hESC-CM prevents proper functioning of I Na-channels, and result in lower peak/maximal currents of several other channels, compared to the adult situation. …”

Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG. by Jonsson, M, Vos, M, Mirams, G, Duker, G, Sartipy, P, de Boer, T, van Veen, T

“…The only compound that triggered EADs was hERG blocker Cisapride. Computer simulations and AP clamp showed that the immature AP of hESC-CM prevents proper functioning of I(Na)-channels, and result in lower peak/maximal currents of several other channels, compared to the adult situation. …”

Modelling effects of Sotalol on Action Potential morphology using a novel Markov model of the HERG channel by Brennan, T, Fink, M, Rodriguez, B, Tarassenko, LT

The faint source population at 15.7 GHz - III. A high-frequency study of HERGs and LERGs by Whittam, I, Riley, J, Green, D, Jarvis, M

“…Optical spectra are used to classify 17 of the sources as high-excitation or low-excitation radio galaxies (HERGs and LERGs respectively), for the remaining sources three other methods are used; these are optical compactness, X-ray observations and mid-infrared colour--colour diagrams. 32 sources are HERGs and 35 are LERGs while the remaining 29 sources could not be classified. …”

Florian Moine, Casterman, de Tintin à Tardi (1919-1999) by Christophe Meunier

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Joost Swarte: la "línea clara" como herramienta en la representación arquitectónica by Borja Ramón López Cotelo

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Evolutionary coupling analysis guides identification of mistrafficking-sensitive variants in cardiac K+ channels: Validation with hERG by Yihong Zhang, Amy L. Grimwood, Jules C. Hancox, Stephen C. Harmer, Christopher E. Dempsey

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Chaperone Rer1 involves in transport of hERG potassium channel protein in cell line HEK293T by CHEN Bang-sheng, YU Xiao-ling, MAO Fei-yan, LIAN Jiang-fang, YU Xu-yun

Subjects: “…chaperone|rer1|herg|lqts…”
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Multiple mechanisms underlie reduced potassium conductance in the p.T1019PfsX38 variant of hERG by Majid K. Al Salmani, Rezvan Tavakoli, Wajid Zaman, Ahmed Al Harrasi

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hERG1 Potassium Channel Expression in Colorectal Adenomas: Comparison with Other Preneoplastic Lesions of the Gastrointestinal Tract by Elena Lastraioli, Jessica Iorio, Federica Petrelli, Anna Tomezzoli, Serena Battista, Maria Raffaella Ambrosio, Mariella Chiudinelli, Federica De Salvatore, Luca Messerini, Vincenzo Villanacci, Luca Saragoni, Annarosa Arcangeli

Subjects: “…hERG1 potassium channels…”
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Importance of modelling hERG binding in predicting drug-induced action potential prolongations for drug safety assessment by Hui Jia Farm, Michael Clerx, Fergus Cooper, Liudmila Polonchuk, Ken Wang, David J. Gavaghan, David J. Gavaghan, Chon Lok Lei, Chon Lok Lei

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Insight into the molecular interaction between the cyclic nucleotide-binding homology domain and the eag domain of the hERG channel by Li, Qingxin, Ng, Hui Qi, Yoon, Ho Sup, Kang, CongBao

Subjects: “…hERG…”
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HERG determines alternating behavior at fast pacing by modulating action potential morphology and sarcolemmal Ca2+ balance by Bueno−Orovio, A, Orini, M, Hanson, B, Hayward, M, Taggart, P, Lambiase, P, Burrage, K, Rodriguez, B

Importance of modelling hERG binding in predicting drug-induced action potential prolongations for drug safety assessment by Farm, HJ, Clerx, M, Cooper, F, Polonchuk, L, Wang, K, Gavaghan, DJ, Lei, CL

“…Here, we study the impact of including state-dependent drug binding in a mathematical model of hERG when translating hERG inhibition to action potential changes. …”

Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells. by Damodara Reddy Vaddi, Lin Piao, Shakil A Khan, Ning Wang, Nanduri R Prabhakar, Jayasri Nanduri

“…The alpha subunit of the voltage gated human ether-a-go-go-related (hERG) potassium channel regulates cell excitability in a broad range of cell lines. …”
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Correction: Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells

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Correction: Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells. by Damodara Reddy Vaddi, Lin Piao, Shakil A Khan, Ning Wang, Nanduri R Prabhakar, Jayasri Nanduri

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Transfer RNA-mediated restoration of potassium current and electrical correction in premature termination long-QT syndrome hERG mutants by Viggo G. Blomquist, Jacqueline Niu, Papiya Choudhury, Ahmad Al Saneh, Henry M. Colecraft, Christopher A. Ahern

“…Adenoviral-mediated expression of mutant hERG channels in cultured adult guinea pig cardiomyocytes prolonged action potential durations, and this deleterious effect was corrected upon adenoviral delivery of a human ArgUGA tRNA to restore full-length hERG protein. …”
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Toward Quantitative Models in Safety Assessment: A Case Study to Show Impact of Dose–Response Inference on hERG Inhibition Models by Fjodor Melnikov, Lennart T. Anger, Catrin Hasselgren

Subjects: “…hERG…”
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