Electrophysiological characterization of a small molecule activator on human ether-a-go-go-related gene (hERG) potassium channel by Xiuming Dong, Yani Liu, Heling Niu, Gongxin Wang, Liying Dong, Anruo Zou, KeWei Wang

“…The human ether-a-go-go-related gene (hERG) encodes the K+ channel that carries the rapid component of the delayed rectifier current in the human heart. …”
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Binding of RPR260243 at the intracellular side of the hERG1 channel pore domain slows closure of the helix bundle crossing gate by Eva-Maria Zangerl-Plessl, Wei Wu, Michael C. Sanguinetti, Anna Stary-Weinzinger

“…By contrast, RPR did not slow deactivation of C-terminal truncated hERG1 channels or D540K hERG1 mutant channels activated by hyperpolarization. …”
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Combination Therapy with a Bispecific Antibody Targeting the hERG1/β1 Integrin Complex and Gemcitabine in Pancreatic Ductal Adenocarcinoma by Tiziano Lottini, Claudia Duranti, Jessica Iorio, Michele Martinelli, Rossella Colasurdo, Franco Nicolás D’Alessandro, Matteo Buonamici, Stefano Coppola, Valentina Devescovi, Vincenzo La Vaccara, Alessandro Coppola, Roberto Coppola, Elena Lastraioli, Annarosa Arcangeli

“…With the aim of improving the treatment outcome of PDAC, we tested the effect of combining Gemcitabine with a novel single chain bispecific antibody (scDb) targeting the cancer-specific hERG1/β1 integrin complex. First, using the scDb (scDb-hERG1-β1) in immunohistochemistry (IHC), Western blot (WB) analysis and immunofluorescence (IF), we confirmed the presence of the hERG1/β1 integrin complex in primary PDAC samples and PDAC cell lines. …”
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Derivation of Highly Predictive 3D-QSAR Models for hERG Channel Blockers Based on the Quantum Artificial Neural Network Algorithm by Taeho Kim, Kee-Choo Chung, Hwangseo Park

Subjects: “…hERG channel blockers…”
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mTOR Modulation of <i>I_Kr</i> through hERG1b-Dependent Mechanisms in Lipotoxic Heart by Kelly A. Aromolaran, Jenny Do, Joyce Bernardi, Ademuyiwa S. Aromolaran

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A population of in silico models to face the variability of human induced pluripotent stem cell-derived cardiomyocytes: the hERG block case study by Paci, M, Passini, E, Severi, S, Hyttinen, J, Rodriguez, B

Pour une poétique de la mer dans Tintin by Samuel Bidaud

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Colombian Scorpion <i>Centruroides margaritatus</i>: Purification and Characterization of a Gamma Potassium Toxin with Full-Block Activity on the hERG1 Channel by José Beltrán-Vidal, Edson Carcamo-Noriega, Nina Pastor, Fernando Zamudio-Zuñiga, Jimmy Alexander Guerrero-Vargas, Santiago Castaño, Lourival Domingos Possani, Rita Restano-Cassulini

“…CmERG1 inhibits hERG1 currents with an IC₅₀ of 3.4 ± 0.2 nM. …”
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Functional Impact of BeKm-1, a High-Affinity hERG Blocker, on Cardiomyocytes Derived from Human-Induced Pluripotent Stem Cells by Stephan De Waard, Jérôme Montnach, Barbara Ribeiro, Sébastien Nicolas, Virginie Forest, Flavien Charpentier, Matteo Elia Mangoni, Nathalie Gaborit, Michel Ronjat, Gildas Loussouarn, Patricia Lemarchand, Michel De Waard

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Utilizing Heteroatom Types and Numbers from Extensive Ligand Libraries to Develop Novel hERG Blocker QSAR Models Using Machine Learning-Based Classifiers by Safa Haddad, Lalehan Oktay, Ismail Erol, Kader Şahin, Serdar Durdagi

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Aborted Cardiac Arrest in LQT2 Related to Novel <i>KCNH2</i> (<i>hERG</i>) Variant Identified in One Lithuanian Family by Neringa Bileišienė, Jūratė Barysienė, Violeta Mikštienė, Eglė Preikšaitienė, Germanas Marinskis, Monika Keževičiūtė, Algirdas Utkus, Audrius Aidietis

“…Mutations in human ether-à-go-go related gene (<i>KCNH2</i> (7q36.1), formerly named <i>hERG</i>) are responsible for Long QT syndrome type 2 (LQT2). …”
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High throughput clone screening on overexpressed hERG1 and Kv1.3 potassium channels using ion channel reader (ICR) label free technology by Alberto Montalbano, Cesare Sala, Ginevra Chioccioli Altadonna, Andrea Becchetti, Annarosa Arcangeli

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Long QT Syndrome Type 2: Emerging Strategies for Correcting Class 2 <i>KCNH2</i> (<i>hERG</i>) Mutations and Identifying New Patients by Makoto Ono, Don E. Burgess, Elizabeth A. Schroder, Claude S. Elayi, Corey L. Anderson, Craig T. January, Bin Sun, Kalyan Immadisetty, Peter M. Kekenes-Huskey, Brian P. Delisle

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Design, Synthesis, and Neuroprotective Effects of Novel Cinnamamide-Piperidine and Piperazine Derivatives by Jia-Yi Li, Xin-Yan Peng, Yi-Lei Huang, Ling Jiang, Jian-Qi Li, Xue-Zhi Yang, Qing-Wei Zhang

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A new hERG allosteric modulator rescues genetic and drug‐induced long‐QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells by Luca Sala, Zhiyi Yu, Dorien Ward‐van Oostwaard, Jacobus PD vanVeldhoven, Alessandra Moretti, Karl‐Ludwig Laugwitz, Christine L Mummery, Adriaan P IJzerman, Milena Bellin

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Cardiac safety assessment of a novel recombinant bispecific antibody targeting the ether-à-go-go related gene 1 (hERG1)-β1 integrin macromolecular complex by Lorenzo Santini, Claudia Duranti, Chiara Palandri, Lucrezia Giammarino, Monica Musumeci, Lucia Carlucci, Chiara Capitani, Chiara Capitani, Rossella Colasurdo, Rossella Colasurdo, Fabio Recchia, Elisabetta Cerbai, Raffaele Coppini, Annarosa Arcangeli

“…Cardiac cells were incubated in vitro with i) the scDb-hERG1-β1, ii) the full length anti-hERG1 monoclonal antibody (mAb-hERG1) and iii) its single chain Fragment variable derivative (scFv-hERG1), from which the scDb-hERG1-β1 was assembled. …”
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Regulation of Kv11.1 Isoform Expression by Polyadenylate Binding Protein Nuclear 1 by Matthew R. Stump, Rachel T. Nguyen, Rachel H. Drgastin, Delaney Search, Qiuming Gong, Zhengfeng Zhou

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Dual Mechanisms of Cardiac Action Potential Prolongation by 4-Oxo-Nonenal Increasing the Risk of Arrhythmia; Late Na⁺ Current Induction and hERG K⁺ Channel Inhibition by Seong-Woo Choi, Ming-Zhe Yin, Na-Kyeong Park, Joo-Han Woo, Sung-Joon Kim

“…We previously reported the arrhythmic potential of 4-HNE by suppression of cardiac human Ether-a-go-go Related Gene (hERG) K⁺ channels with prolonged action potential duration (APD) in cardiomyocytes. …”
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Effect of vinpocetine on embryonic heart rate in vitro by Helen Elizabeth Ritchie, Jaimie W. Polson, Andrea Xia, William Webster

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Are financial stocks driven by substantive factors or virtual factors? Comparing Taiwan and China markets by Ho Chi Ming

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