Effects of the Antitussive Drug Cloperastine on Ventricular Repolarization in Halothane-Anesthetized Guinea Pigs by Akira Takahara, Kaori Fujiwara, Atsushi Ohtsuki, Takayuki Oka, Iyuki Namekata, Hikaru Tanaka

“…Keywords:: cloperastine, antitussive drug, hERG K+ channel, QT interval, monophasic action potential…”
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Early afterdepolarisation tendency as a simulated pro-arrhythmic risk indicator by McMillan, B, Gavaghan, D, Mirams, G

“…Drugs which cause TdP block the hERG cardiac potassium channel. However, not all drugs that block hERG cause TdP. …”

The Stripe 82 1-2 GHz Very Large Array Snapshot Survey: multiwavelength counterparts by Prescott, M, Whittam, I, Jarvis, M, McAlpine, K, Richter, L, Fine, S, Mauch, T, Heywood, I, Vaccari, M

“…For the objects with spectroscopy, we separate radio-loud active galactic nuclei (AGN) and star-forming galaxies (SFGs) using three diagnostics and then further divide our radio-loud AGN into the high and low excitation radio galaxy (HERG and LERG) populations. A control-matched sample of HERGs and LERGs, matched on stellar mass, redshift, and radio luminosity, reveals that the host galaxies of LERGs are redder and more concentrated than HERGs. …”

Mathematical modelling of drug-ion channel interactions for cardiac safety assessment by Beattie, K

“…</p> <p>We demonstrate how existing mathematical models of hERG channel kinetics can behave very differently when used to simulate the same voltage protocol. …”

Computational assessment of drug−induced effects on the electrocardiogram: from ion channel block to body surface potentials by Zemzemi, N, Bernabeu, M, Saiz, J, Cooper, J, Pathmanathan, P, Mirams, G, Pitt−Francis, J, Rodriguez, B

“…<strong>Key results</strong> Introducing a 50% hERG block results in 7.8% prolongation of the APD90 and 5.7% QT interval prolongation, whereas the hERG block does not affect the QRS interval. …”

Quantitative Comparison of Effects of Dofetilide, Sotalol, Quinidine, and Verapamil between Human Ex vivo Trabeculae and In silico Ventricular Models Incorporating Inter-Individual... by Britton, O, Abi-Gerges, N, Page, G, Ghetti, A, Miller, P, Rodriguez, B

“…To assess the impact of variability in IC50 measurements, and the effects of including state-dependent drug binding dynamics, each drug simulation was repeated with two different IC50 datasets, and with both the original O'Hara-Rudy hERG model and a recently published state-dependent model of hERG and hERG block. …”

LOFAR-Boötes: Properties of high- and low-excitation radio galaxies at $0.5 &lt; z &lt; 2.0$ by Williams, W, Rivera, G, Best, P, Hardcastle, M, Röttgering, H, Duncan, K, Gasperin, F, Jarvis, M, Miley, G, Mahony, E, Morabito, L, Nisbet, D, Prandoni, I, Smith, D, Tasse, C, White, G

“…The fraction of HERGs increases with redshift, as does the fraction of sources in galaxies with lower stellar masses. …”

A microtranslatome coordinately regulates sodium and potassium currents in the human heart by Catherine A Eichel, Erick B Ríos-Pérez, Fang Liu, Margaret B Jameson, David K Jones, Jennifer J Knickelbine, Gail A Robertson

“…Here, we show that mRNA transcripts encoding INa and IKr channels (SCN5A and hERG, respectively) are associated in defined complexes during protein translation. …”
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Solid-phase synthesis and biological evaluation of piperazine-based novel bacterial topoisomerase inhibitors by Flagstad, Thomas, Pedersen, Mette T., Jakobsen, Tim H., Felding, Jakob, Tolker-Nielsen, Tim, Givskov, Michael, Qvortrup, Katrine, Nielsen, Thomas E.

“…A proof-of-concept library was synthesized with the ability to modulate both hERG affinity and antibacterial activity through scaffold substitutions.…”
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Exercise and quality of life in cancer by Carmen Fiuza-Luces, Pedro L. Valenzuela, Alejandro Santos-Lozano, Ana Ruiz-Casado, Alejandro Lucia

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Galaxy And Mass Assembly (GAMA): The environments of high- and low-excitation radio galaxies by Ching, J, Croom, S, Sadler, E, Robotham, A, Brough, S, Baldry, I, Bland-Hawthorn, J, Colless, M, Driver, S, Holwerda, B, Hopkins, A, Jarvis, M, Johnston, H, Kelvin, L, Liske, J, Loveday, J, Norberg, P, Pracy, M, Steele, O, Thomas, D, Wang, L

“…We find that LERGs and HERGs exist in different environments and that this difference is dependent on radio luminosity. …”

Effect of Postdismissal Pharmacist Visits for Patients Using High-Risk Medications by Joseph R. Herges, PharmD, BCPS, Lori B. Herges, PharmD, BCPS, Ross A. Dierkhising, MS, Kristin C. Mara, MS, Amanda Z. Davis, PharmD, BCACP, Kurt B. Angstman, MD

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Prediction of Thorough QT study results using action potential simulations based on ion channel screens by Mirams, G, Davies, M, Brough, S, Bridgland−Taylor, M, Cui, Y, Gavaghan, D, Abi−Gerges, N

“…Methods: Ion current reduction was measured, in the presence of marketed drugs which have had a TQT study, for channels encoded by hERG, CaV1.2, NaV1.5, KCNQ1/MinK, and Kv4.3/KChIP2.2. …”

Insight into the mechanism of inactivation and pH sensitivity in potassium channels from molecular dynamics simulations. by Stansfeld, P, Grottesi, A, Sands, Z, Sansom, MS, Gedeck, P, Gosling, M, Cox, B, Stanfield, P, Mitcheson, J, Sutcliffe, M

“…This process is rapid in the hERG K (+) channel and is fundamental to its physiological role. …”

Ion channels: structure of a molecular brake by Sansom, M

“…<p>A combination of crystallographic and mutagenesis studies on the HERG K⁺ channel, a key determinant of cardiac excitability, has suggested how the protein's extramembraneous amino-terminal domain might act as a ‘molecular brake’ that slows down channel deactivation.…”

Physical Exercise and the Hallmarks of Breast Cancer: A Narrative Review by Celia García-Chico, Susana López-Ortiz, Saúl Peñín-Grandes, José Pinto-Fraga, Pedro L. Valenzuela, Enzo Emanuele, Claudia Ceci, Grazia Graziani, Carmen Fiuza-Luces, Simone Lista, Alejandro Lucia, Alejandro Santos-Lozano

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Metformin Reduces Potassium Currents and Prolongs Repolarization in Non-Diabetic Heart by Layse Malagueta-Vieira, Julieta Fernández-Ruocco, María P. Hortigón-Vinagre, Víctor Zamora, Julián Zayas-Arrabal, Leyre Echeazarra, Godfrey L. Smith, Martín Vila Petroff, Emiliano Medei, Óscar Casis, Mónica Gallego

“…Metformin incubation also reduced I_hERG in HEK293 cells. Finally, metformin incubation prolonged action potential duration at 30% and 90% of repolarization in hIPS-CMs, which is compatible with the reduction of I_to and I_hERG. …”
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The ion channel basis of pharmacological effects of amiodarone on myocardial electrophysiological properties, a comprehensive review by Illia Gelman, Neelakshi Sharma, Olivia Mckeeman, Peter Lee, Noah Campagna, Nicole Tomei, Adrian Baranchuk, Shetuan Zhang, Mohammad El-Diasty

“…The primary target of class III antiarrhythmic drugs is the cardiac human ether-a-go-go-related gene (hERG) encoded channel, KCNH2, commonly known as HERG, that conducts the rapidly activating delayed rectifier potassium current (IKr). …”
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Acute osimertinib exposure induces electrocardiac changes by synchronously inhibiting the currents of cardiac ion channels by Peiwen Li, Xiaohui Tian, Gongxin Wang, Enshe Jiang, Yanming Li, Guoliang Hao

“…Osimertinib inhibited the hERG channel in a concentration-dependent manner, with an IC50 of 2.21 ± 1.29 μM. …”
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Electrophysiological Characterization of Spontaneously Contracting Cell Aggregates Obtained from Rainbow Trout Larvae with Multielectrode Arrays by Julia M. Mehnert, Matthias Brandenburger, Bianka Grunow

“…Many drugs interact with hERG potassium channels and consequently cause life threatening ventricular arrhythmias, further highlighting the importance of suitable model systems. …”
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