hERG1 Potassium Channel Expression in Colorectal Adenomas: Comparison with Other Preneoplastic Lesions of the Gastrointestinal Tract by Elena Lastraioli, Jessica Iorio, Federica Petrelli, Anna Tomezzoli, Serena Battista, Maria Raffaella Ambrosio, Mariella Chiudinelli, Federica De Salvatore, Luca Messerini, Vincenzo Villanacci, Luca Saragoni, Annarosa Arcangeli

Subjects: “…hERG1 potassium channels…”
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Effects of Tannic Acid, Green Tea and Red Wine on hERG Channels Expressed in HEK293 Cells. by Xi Chu, Yusong Guo, Bingyuan Xu, Wenya Li, Yue Lin, Xiaorun Sun, Chunhua Ding, Xuan Zhang

“…The present study investigated the effects of tannic acid, green teas and red wines on hERG currents. The effects of tannic acid, teas and red wines on hERG currents stably transfected in HEK293 cells were studied with a perforated patch clamp technique. …”
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Importance of modelling hERG binding in predicting drug-induced action potential prolongations for drug safety assessment by Hui Jia Farm, Michael Clerx, Fergus Cooper, Liudmila Polonchuk, Ken Wang, David J. Gavaghan, David J. Gavaghan, Chon Lok Lei, Chon Lok Lei

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Computational Analysis of the Mode of Action of Disopyramide and Quinidine on hERG-Linked Short QT Syndrome in Human Ventricles by Dominic G. Whittaker, Haibo Ni, Alan P. Benson, Alan P. Benson, Jules C. Hancox, Jules C. Hancox, Henggui Zhang, Henggui Zhang, Henggui Zhang

“…Effects of multi-channel block by disopyramide and quinidine, including binding kinetics and altered potency of IKr/hERG channel block in SQT1 and state-dependent block of sodium channels, were simulated on action potential and multicellular tissue models. …”
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Insight into the molecular interaction between the cyclic nucleotide-binding homology domain and the eag domain of the hERG channel by Li, Qingxin, Ng, Hui Qi, Yoon, Ho Sup, Kang, CongBao

Subjects: “…hERG…”
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HERG determines alternating behavior at fast pacing by modulating action potential morphology and sarcolemmal Ca2+ balance by Bueno−Orovio, A, Orini, M, Hanson, B, Hayward, M, Taggart, P, Lambiase, P, Burrage, K, Rodriguez, B

Importance of modelling hERG binding in predicting drug-induced action potential prolongations for drug safety assessment by Farm, HJ, Clerx, M, Cooper, F, Polonchuk, L, Wang, K, Gavaghan, DJ, Lei, CL

“…Here, we study the impact of including state-dependent drug binding in a mathematical model of hERG when translating hERG inhibition to action potential changes. …”

Florian Moine, Casterman, de Tintin à Tardi (1919-1999) by Christophe Meunier

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Joost Swarte: la "línea clara" como herramienta en la representación arquitectónica by Borja Ramón López Cotelo

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Molecular determinants of interactions between the N-terminal domain and the transmembrane core that modulate hERG K+ channel gating. by Jorge Fernández-Trillo, Francisco Barros, Angeles Machín, Luis Carretero, Pedro Domínguez, Pilar de la Peña

“…A conserved eag domain in the cytoplasmic amino terminus of the human ether-a-go-go-related gene (hERG) potassium channel is critical for its slow deactivation gating. …”
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Computational modeling reveals key contributions of KCNQ and hERG currents to the malleability of uterine action potentials underpinning labor. by Wing-Chiu Tong, Rachel M Tribe, Roger Smith, Michael J Taggart

“…Of the delayed rectifying K(+) currents family it is of interest that KCNQ and hERG channels have been reported to be gestationally regulated in the uterus. …”
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hERG1 and HIF-2α Behave as Biomarkers of Positive Response to Bevacizumab in Metastatic Colorectal Cancer Patients by Jessica Iorio, Elena Lastraioli, Lorenzo Tofani, Giulia Petroni, Lorenzo Antonuzzo, Luca Messerini, Giuseppe Perrone, Damiano Caputo, Maria Francesconi, Maria Michelina Amato, Moris Cadei, Giuseppina Arcangeli, Vincenzo Villanacci, Luca Boni, Roberto Coppola, Francesco Di Costanzo, Annarosa Arcangeli

“…Conclusions: hERG1 and aHIF-2α might help to identify patients who would benefit from bevacizumab treatment.…”
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Modulation of HERG K+ Channels by Chronic Exposure to Activators and Inhibitors of PKA and PKC: Actions Independent of PKA and PKC Phosphorylation by Liliang Shu, Wanzhe Zhang, Gang Su, Jingchao Zhang, Chao Liu, Jing Xu

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Eag Domains Regulate LQT Mutant hERG Channels in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. by Qiang-Ni Liu, Matthew C Trudeau

“…We report here that i-eag domains slowed the deactivation kinetics of hERG R56Q channels in hiPSC-CMs. hERG R56Q channels prolonged the AP of hiPSCs, and the AP was shortened by co-expression of i-eag domains and hERG R56Q channels. …”
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Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells. by Damodara Reddy Vaddi, Lin Piao, Shakil A Khan, Ning Wang, Nanduri R Prabhakar, Jayasri Nanduri

“…The alpha subunit of the voltage gated human ether-a-go-go-related (hERG) potassium channel regulates cell excitability in a broad range of cell lines. …”
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Isoform-specific dominant-negative effects associated with hERG1 G628S mutation in long QT syndrome. by Matthew R Stump, Qiuming Gong, Zhengfeng Zhou

“…Mutations in the human ether-a-go-go-related gene 1 (hERG1) cause type 2 long QT syndrome (LQT2). The hERG1 gene encodes a K(+) channel with properties similar to the rapidly activating delayed rectifying K(+) current in the heart. …”
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Action potential clamp and pharmacology of the variant 1 Short QT Syndrome T618I hERG K⁺ channel. by Aziza El Harchi, Dario Melgari, Yi Hong Zhang, Henggui Zhang, Jules C Hancox

“…This study aimed to determine effects of the T618I-hERG mutation on (i) hERG current (I(hERG)) elicited by ventricular action potentials; (ii) the sensitivity of I(hERG) to inhibition by four clinically used antiarrhythmic drugs.Electrophysiological recordings of I(hERG) were made at 37°C from HEK 293 cells expressing wild-type (WT) or T618I hERG. …”
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Sérialité et personnages by Olivier Odaert

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Tintin face à l’actualité : la transposition de l’affaire Lindbergh dans Tintin en Amérique by Jean Rime

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CardioTox net: a robust predictor for hERG channel blockade based on deep learning meta-feature ensembles by Abdul Karim, Matthew Lee, Thomas Balle, Abdul Sattar

“…Abstract Motivation Ether-a-go-go-related gene (hERG) channel blockade by small molecules is a big concern during drug development in the pharmaceutical industry. …”
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