Showing 1 - 20 results of 289 for search '"Hergé"', query time: 0.10s Refine Results
  1. 1

    An Insight into the Potassium Currents of hERG and Their Simulation by Rolando Guidelli

    Published 2023-04-01
    Subjects: “…hERG potassium channel…”
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    Article
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    Noncanonical electromechanical coupling paths in cardiac hERG potassium channel by Carlos A. Z. Bassetto, Flavio Costa, Carlo Guardiani, Francisco Bezanilla, Alberto Giacomello

    Published 2023-02-01
    “…Here, authors reveal the existence of a noncanonical kinematic chain of residues involving the S4/S1 and S1/S5 subunit interfaces that controls the gating of the hERG cardiac channel.…”
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    Article
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    New Insights into Ion Channels: Predicting hERG-Drug Interactions by Michael Fitzpatrick Wempe

    Published 2022-09-01
    Subjects: “…human ether-à-gogo-related gene (hERG)…”
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    Article
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    Rapid characterisation of hERG channel kinetics II: temperature dependence by Lei, CL, Clerx, M, Beattie, KA, Melgari, D, Hancox, JC, Gavaghan, DJ, Polonchuk, L, Wang, K, Mirams, GR

    Published 2019
    “…In this Part II, we use this protocol to study the temperature dependence of hERG kinetics using Chinese hamster ovary cells overexpressing hERG1a on the Nanion SyncroPatch 384PE, a 384-well automated patch-clamp platform, with temperature control. …”
    Journal article
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    Contributions of HERG K+ current to repolarization of the human ventricular action potential. by Fink, M, Noble, D, Virag, L, Varro, A, Giles, W

    Published 2008
    “…For these reasons we and others have attempted to define the functional role for HERG-mediated K+ currents in repolarization of the action potential in the human ventricle. …”
    Journal article
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    Purification and structural characterization of the voltage-sensor domain of the hERG potassium channel by Ng, Hui Qi, Kim, Young Mee, Huang, Qiwei, Gayen, Shovanlal, Yildiz, Ahu Arslan, Yoon, Ho Sup, Sinner, Eva-Kathrin, Kang, CongBao

    Published 2013
    “…The hERG protein contains a voltage-sensor domain (VSD) that is important for sensing voltage changes across the membrane. …”
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    Journal Article
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    Mathematical modelling of hERG channel kinetics using sinusoidal voltage protocols by Beattie, K, Bardenet, R, Louttit, J, Vandenberg, J, Hill, A, Gavaghan, D, De Boer, T, Mirams, G

    Published 2017
    “…Drug block of the hERG channel is a primary focus of existing cardiac proarrhythmic safety assessment strategies. hERG plays a fundamental role in repolarization of the cardiac action potential and block of this channel can lead to prolongation of, and morphological changes to, the cardiac action potential, which are implicated in increasing proarrhythmic risk. …”
    Conference item