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An Insight into the Potassium Currents of hERG and Their Simulation
Published 2023-04-01Subjects: “…hERG potassium channel…”
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The Interaction between hERG1 and β1 Integrins Modulates hERG1 Current in Different Pathological Cell Models
Published 2022-11-01Subjects: “…hERG1…”
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Compte rendu d’Hergé Reporter. Tintin en contexte
Published 2011-08-01Subjects: Get full text
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Data on the construction of a recombinant HEK293 cell line overexpressing hERG potassium channel and examining the presence of hERG mRNA and protein expression
Published 2017“…Tan) [1], which the possible hERG blocking properties of deoxyelephantopin were investigated. …”
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Structural modeling of the hERG potassium channel and associated drug interactions
Published 2022-09-01Subjects: “…hERG channel…”
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Noncanonical electromechanical coupling paths in cardiac hERG potassium channel
Published 2023-02-01“…Here, authors reveal the existence of a noncanonical kinematic chain of residues involving the S4/S1 and S1/S5 subunit interfaces that controls the gating of the hERG cardiac channel.…”
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The Study on the hERG Blocker Prediction Using Chemical Fingerprint Analysis
Published 2020-06-01Subjects: “…hERG toxicity…”
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New Insights into Ion Channels: Predicting hERG-Drug Interactions
Published 2022-09-01Subjects: “…human ether-à-gogo-related gene (hERG)…”
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Structural modeling of hERG channel–drug interactions using Rosetta
Published 2023-11-01Subjects: “…hERG channel…”
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Hydroxychloroquine induces long QT syndrome by blocking hERG channel
Published 2023-05-01Subjects: Get full text
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Rapid characterisation of hERG channel kinetics II: temperature dependence
Published 2019“…In this Part II, we use this protocol to study the temperature dependence of hERG kinetics using Chinese hamster ovary cells overexpressing hERG1a on the Nanion SyncroPatch 384PE, a 384-well automated patch-clamp platform, with temperature control. …”
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Contributions of HERG K+ current to repolarization of the human ventricular action potential.
Published 2008“…For these reasons we and others have attempted to define the functional role for HERG-mediated K+ currents in repolarization of the action potential in the human ventricle. …”
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The Effect of a Synthetic Estrogen, Ethinylestradiol, on the hERG Block by E-4031
Published 2021-09-01Subjects: Get full text
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Representaciones de latinoamérica en “Las aventuras de Tintín” de Hergé
Published 2022-11-01Subjects: Get full text
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Characterization of amiodarone action on currents in hERG-T618 gain-of-function mutations
Published 2023-11-01Subjects: Get full text
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Ensemble of structure and ligand-based classification models for hERG liability profiling
Published 2023-03-01Subjects: “…hERG…”
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Purification and structural characterization of the voltage-sensor domain of the hERG potassium channel
Published 2013“…The hERG protein contains a voltage-sensor domain (VSD) that is important for sensing voltage changes across the membrane. …”
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Mathematical modelling of hERG channel kinetics using sinusoidal voltage protocols
Published 2017“…Drug block of the hERG channel is a primary focus of existing cardiac proarrhythmic safety assessment strategies. hERG plays a fundamental role in repolarization of the cardiac action potential and block of this channel can lead to prolongation of, and morphological changes to, the cardiac action potential, which are implicated in increasing proarrhythmic risk. …”
Conference item