Showing 381 - 400 results of 651 for search '"Herning"', query time: 0.09s Refine Results
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    Tamoxifen for the treatment of myeloproliferative neoplasms: A Phase II clinical trial and exploratory analysis by Zijian Fang, Giuditta Corbizi Fattori, Thomas McKerrell, Rebecca H. Boucher, Aimee Jackson, Rachel S. Fletcher, Dorian Forte, Jose-Ezequiel Martin, Sonia Fox, James Roberts, Rachel Glover, Erica Harris, Hannah R. Bridges, Luigi Grassi, Alba Rodriguez-Meira, Adam J. Mead, Steven Knapper, Joanne Ewing, Nauman M. Butt, Manish Jain, Sebastian Francis, Fiona J. Clark, Jason Coppell, Mary F. McMullin, Frances Wadelin, Srinivasan Narayanan, Dragana Milojkovic, Mark W. Drummond, Mallika Sekhar, Hesham ElDaly, Judy Hirst, Maike Paramor, E. Joanna Baxter, Anna L. Godfrey, Claire N. Harrison, Simón Méndez-Ferrer

    Published 2023-11-01
    “…TAMARIN Phase-II, multicenter, single-arm clinical trial assessed tamoxifen’s safety and activity in patients with stable MPNs, no prior thrombotic events and mutated JAK2 V617F , CALR ins5 or CALR del52 peripheral blood allele burden ≥20% (EudraCT 2015-005497-38). 38 patients were recruited over 112w and 32 completed 24w-treatment. The study’s A’herns success criteria were met as the primary outcome ( ≥ 50% reduction in mutant allele burden at 24w) was observed in 3/38 patients. …”
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    Monogenic signs of susceptibility to ischemic stroke: literature review by Vitaliy Tsymbaliuk, Iryna Vasileva

    Published 2016-03-01
    “…These syndromes include: cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL, mutation in the NOTCH3 gene); cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL, mutation in the HTRA1 gene); Fabry disease (FD, GLA D313Y mutation); COL4A1-related brain small vessel disease associated with mutation in the gene encoding IVα1 collagen; Ehlers Danlos syndrome (EDS) caused by mutation in the COL3A1 gene; hereditary endotheliopathy with retinopathy, nephropathy and stroke (HERNS, mutation in the TREX1 gene); sickle cell disease (SCD, mutation in the beta-globin gene); homocystinuria - hereditary metabolic disorder associated with mutations in the MTHFR, MTRR, MTR CBS genes of the folate cycle; neurofibromatosis type 1 (NF1, mutation in the gene NF1); hereditary hemorrhagic telangiectasia (HHT, mutations in the ENG, ALK1 or SMAD4 genes); hereditary cerebral amyloid angiopathy (CAA, mutation in the APP gene); cerebral cavernous malformations (CCM, mutations in the CCM1, CCM2 or CCM3 genes); mithochondrial encephalopathy lactic acidosis and strokelike episodes (MELAS, mutations in the MT-ND1, MT-ND5, MT-TH, MT-TL1, MT-TV genes).The study of the genetic profile permits to personify medical tactics in ischemic stroke.…”
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