Preservation of cortical histamine H3 receptors in ischemic vascular and mixed dementias by Sheng, Y, Lee, J, Medhurst, A, Wilcock, G, Esiri, M, Wong, P, Chen, C, Lai, M

“…Aim: Histamine H3 receptor antagonists have been proposed as a novel therapeutic approach for the symptomatic treatment of Alzheimer's disease (AD). …”

Preservation of cortical histamine H3 receptors in ischemic vascular and mixed dementias. by Sheng, Y, Lee, J, Medhurst, A, Wilcock, G, Esiri, M, Wong, P, Chen, C, Lai, M

“… AIM: Histamine H(3) receptor antagonists have been proposed as a novel therapeutic approach for the symptomatic treatment of Alzheimer's disease (AD). …”

Calyx and dimorphic neurons of mouse Scarpa's ganglion express histamine H3 receptors by Zucca Gianpiero, Zampini Valeria, Botta Laura, Tritto Simona, Valli Paolo, Masetto Sergio

“…Recent works on amphibians showed that histamine H3 receptor antagonists, e.g. betahistine, inhibit the afferent discharge recorded from the vestibular nerve. …”
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Histamine H3 receptors inhibit serotonin release in substantia nigra pars reticulata. by Threlfell, S, Cragg, S, Kalló, I, Turi, G, Coen, C, Greenfield, S

Novel chalcone-based fluorescent human histamine H3 receptor ligands as pharmacological tools by Holger eStark

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Role of histamine H3 receptor in glucagon‐secreting αTC1.6 cells by Tadaho Nakamura, Takeo Yoshikawa, Fumito Naganuma, Attayeb Mohsen, Tomomitsu Iida, Yamato Miura, Akira Sugawara, Kazuhiko Yanai

Subjects: “…Histamine H3 receptor…”
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Correction: Identification and Characterization of ZEL-H16 as a Novel Agonist of the Histamine H3 Receptor

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QSAR study on the histamine (H3) receptor antagonists using the genetic algorithm: Multi parameter linear regression by Adimi Maryam, Salimi Mahmoud, Nekoei Mehdi

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Postsynaptic histamine H3 receptors in ventral basal forebrain cholinergic neurons modulate contextual fear memory by Yanrong Zheng, Lishi Fan, Zhuowen Fang, Zonghan Liu, Jiahui Chen, Xiangnan Zhang, Yi Wang, Yan Zhang, Lei Jiang, Zhong Chen, Weiwei Hu

“…Summary: Overly strong fear memories can cause pathological conditions. Histamine H3 receptor (H3R) has been viewed as an optimal drug target for CNS disorders, but its role in fear memory remains elusive. …”
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Loss of Melanopsin Photoreception and Antagonism of the Histamine H3 Receptor by Ciproxifan Inhibit Light-Induced Sleep in Mice. by Fanuel Muindi, Damien Colas, Jesse Ikeme, Norman F Ruby, H Craig Heller

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Loss of Melanopsin Photoreception and Antagonism of the Histamine H3 Receptor by Ciproxifan Inhibit Light-Induced Sleep in Mice by Muindi, Fanuel, Colas, Damien, Ikeme, Jesse, Ruby, Norman F., Heller, H. Craig

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Recovery of the histamine H3 receptor activity lost in yeast cells through error-prone PCR and in vivo selection by Ayami Watanabe, Ami Nakajima, Mitsunori Shiroishi

“…In this study, we performed random mutagenesis using error-prone PCR and then an in vivo screening to obtain mutants that recovered the activity of the human histamine H3 receptor (H3R), which loses its signaling function when expressed in yeast. …”
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Therapeutic potential of LINS01 histamine H3 receptor antagonists as antineoplastic agents for triple negative breast cancer by Ignacio A. Ospital, Mónica A. Táquez Delgado, Melisa B. Nicoud, Michelle F. Corrêa, Gustavo A. Borges Fernandes, Isabela W. Andrade, Paolo Lauretta, Rocío Martínez Vivot, María Betina Comba, María Marta Zanardi, Daniela Speisky, Juan L. Uriburu, João P.S. Fernandes, Vanina A. Medina

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Modulation of dopamine D1 receptors via histamine H3 receptors is a novel therapeutic target for Huntington's disease by David Moreno-Delgado, Mar Puigdellívol, Estefanía Moreno, Mar Rodríguez-Ruiz, Joaquín Botta, Paola Gasperini, Anna Chiarlone, Lesley A Howell, Marco Scarselli, Vicent Casadó, Antoni Cortés, Sergi Ferré, Manuel Guzmán, Carmen Lluís, Jordi Alberch, Enric I Canela, Silvia Ginés, Peter J McCormick

“…To reduce D1R over-activation, we present a strategy based on targeting complexes of D1R and histamine H3 receptors (H3R). Using an HD mouse striatal cell model and HD mouse organotypic brain slices we found that D1R-induced cell death signaling and neuronal degeneration, are mitigated by an H3R antagonist. …”
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Ciproxifan, a Histamine h3 receptor antagonist as a potential therapeutic agent in Alzheimer's disease / Siti Murnirah Jaafar by Jaafar, Siti Murnirah

“…A Histamine H3 receptor antagonist, ciproxifan has been shown to enhance the release of neurotransmitters which play an important role in cognitive process. …”
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Effect of moderate prenatal ethanol exposure on the differential expression of two histamine H3 receptor isoforms in different brain regions of adult rat offspring by Suzy Davies, Kiana S. Lujan, Ella J. Rappaport, Carlos F. Valenzuela, Daniel D. Savage

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Revisiting Preclinical Observations of Several Histamine H3 Receptor Antagonists/Inverse Agonists in Cognitive Impairment, Anxiety, Depression, and Sleep–Wake Cycle Disorder by Mera Alhusaini, Mera Alhusaini, Nermin Eissa, Nermin Eissa, Nermin Eissa, Ali K. Saad, Ali K. Saad, Rami Beiram, Rami Beiram, Bassem Sadek, Bassem Sadek

“…The possible involvement of brain HA in neuropathology has gained attention recently, and its role in many (patho)physiological brain functions including memory, cognition, and sleep–wake cycle paved the way for further research on the etiology of several brain disorders. Histamine H3 receptor (H3R) evidenced in the brains of rodents and humans remains of special interest, given its unique position as a pre- and postsynaptic receptor, controlling the synthesis and release of HA as well as different other neurotransmitters in different brain regions, respectively. …”
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Recent Advances in Molecular Pharmacology of the Histamine Systems: Physiology and Pharmacology of Histamine H3 Receptor: Roles in Feeding Regulation and Therapeutic Potential for Metabolic Disorders by Tokita Shigeru, Takahashi Kazuhiko, Kotani Hidehito

“…Keywords:: histamine, histamine H3 receptor, obesity, central nervous system disorder, inverse agonist…”
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Antagonism of Histamine H3 receptors Alleviates Pentylenetetrazole-Induced Kindling and Associated Memory Deficits by Mitigating Oxidative Stress, Central Neurotransmitters, and c-Fos Protein Expression in Rats by Alaa Alachkar, Sheikh Azimullah, Mohamed Lotfy, Ernest Adeghate, Shreesh K. Ojha, Rami Beiram, Dorota Łażewska, Katarzyna Kieć-Kononowicz, Bassem Sadek

Subjects: “…histamine H3 receptor…”
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Histamine H3 receptor activation reduces the impairment in prepulse inhibition (PPI) of the acoustic startle response and Akt phosphorylation induced by MK-801 (dizocilpine), antagonist at N-Methyl-d-Aspartate (NMDA) receptors by Aquino-Miranda, G, Rivera-Ramírez, N, Márquez-Gómez, R, Escamilla-Sánchez, J, González-Pantoja, R, Ramos-Languren, L-E, Perez-Neri, I, Bueno-Nava, A, Ríos, C, Arias-Montaño, J-A