Updates in the Treatment of Peripheral T-Cell Lymphomas by Saleh K, Michot JM, Ribrag V

“…Khalil Saleh,1 Jean-Marie Michot,1,2 Vincent Ribrag1,2 1Department of Hematology, Gustave Roussy Cancer Campus, Villejuif, 94800, France; 2Département d’Innovation Thérapeutique et d’Essais Précoces (DITEP), Gustave Roussy Cancer Campus, Villejuif, 94800, FranceCorrespondence: Vincent RibragDepartment of Hematology, Gustave Roussy Cancer Campus, 114 rue Edouard Vaillant, Villejuif, 94800, FranceTel +33 1 42 11 59 54Fax +33 1 42 11 52 70Email vincent.ribrag@gustaveroussy.frAbstract: Peripheral T-cell lymphomas (PTCLs) represent a heterogeneous group of rare hematologic malignancies accounting for less than 10% of non-Hodgkin lymphomas. The 2016 classification of World Health Organization recognized 29 different entities of PTCLs. …”
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Cucurbitacin E and I target the JAK/STAT pathway and induce apoptosis in Sézary cells by Isabella J. Brouwer, Jacoba J. Out-Luiting, Maarten H. Vermeer, Cornelis P. Tensen

“…Cutaneous T-cell lymphomas and leukemias (CTCLs) are a heterogeneous group of extranodal non-Hodgkin's lymphomas. These are characterized by an accumulation of malignant CD4+ T-lymphocytes in the skin, lymph nodes, and peripheral blood. …”
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Curious case of bilateral non-resolving vitritis - Unmasking the masquerade on ultra-widefield imaging by Kushal Delhiwala

“…Vitreous sample sent for cytology and immunohistochemistry showed diffuse large B-cell non-Hodgkins lymphoma with CD20 and MUM1-positive cells. OD underwent two IV rituximab injections at monthly interval initially followed by PPV with IV rituximab and methotrexate. …”
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Histopathological Profile of Colorectal Cancer in Yemen - An Eight Years Retrospective Study by Al-Samawi A.S., (M. Phill, MCPS) and Aulaqi S.M.

“…The female cases were 167 (41.3%) whereas the male cases were 237 (58.7%). Non-Hodgkin's lymphomas (NHL) accounted, for 25 (5.7%). The rest of the cases were three carcinoid, two undifferentiated, two leiomyosarcomas, and one gastrointestinal malignant epithelioid tumor. …”
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Genomic Landscape of Primary Mediastinal B-Cell Lymphoma Cell Lines. by Haiping Dai, Stefan Ehrentraut, Stefan Nagel, Sonja Eberth, Claudia Pommerenke, Wilhelm G Dirks, Robert Geffers, Srilaxmi Kalavalapalli, Maren Kaufmann, Corrina Meyer, Silke Faehnrich, Suning Chen, Hans G Drexler, Roderick A F MacLeod

“…Primary mediastinal B-Cell lymphoma (PMBL) is a recently defined entity comprising ~2-10% non-Hodgkin lymphomas (NHL). Unlike most NHL subtypes, PMBL lacks recurrent gene rearrangements to serve as biomarkers or betray target genes. …”
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Primary cutaneous B‐Cell lymphoblastic lymphoma presenting with solitary scalp mass in a female child: A case report and review of the literature by Fatemeh Montazer, Alireza Sanei Motlagh, Ramtin Dastgir

“…Abstract Lymphoblastic lymphoma is a group of non‐Hodgkin lymphomas that account for approximately 2% of all lymphomas. …”
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Immunomodulating effects of antitumor drugs Bruton tyrosine kinase inhibitors and the possibility of their use in allergic and infectious diseases by Yu. S. Torshina, N. B. Serebryanaya, T. V. Glazanova, M. A. Mikhalyova, S. V. Voloshin

“…Bruton's tyrosine kinase (BTK) inhibitors represent a class of drugs that have demonstrated their efficacy and safety in patients with chronic lymphocytic leukemia and non-Hodgkin's lymphomas who were considered refractory to any previously used type of therapy. …”
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Bispecific antibodies and CAR-T cells: dueling immunotherapies for large B-cell lymphomas by Asaad Trabolsi, Artavazd Arumov, Jonathan H. Schatz

“…CD19-directed chimeric antigen receptor T-cell (CAR-19) therapies are increasingly altering the prognostic landscape for rel/ref patients with DLBCL and related aggressive B-cell non-Hodgkin lymphomas. Long-term follow up data show ongoing disease-free outcomes consistent with cure in 30–40% after CAR-19, including high-risk patients primary refractory to or relapsing within 1 year of frontline treatment. …”
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Atypical COVID-19 dynamics in a patient with mantle cell lymphoma exposed to rituximab by Gianpaolo Marcacci, Giuseppe Fiorentino, Francesco Volzone, Umberto Falcone, Roberto Parrella, Daniela Donnarumma, Silvia D’Ovidio, Anna Annunziata, Giovanni Micallo, Giuseppe Portella, Annarosaria De Chiara, Rosaria De Filippi, Stefania Crisci, Antonio Pinto

“…Abstract Patients with non-hodgkin lymphomas (NHL) represent a population of special interest during the current Coronavirus disease-19 (COVID-19) pandemics. …”
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Spectrum of Disease Manifestations in Patients with Selective Immunoglobulin E Deficiency by César Picado, Iñaki Ortiz de Landazuri, Alexandru Vlagea, Irina Bobolea, Ebymar Arismendi, Rosanel Amaro, Jacobo Sellarés, Joan Bartra, Raimon Sanmarti, José Hernandez-Rodriguez, José-Manuel Mascaró, Jordi Colmenero, Eva C. Vaquero, Mariona Pascal

“…Thirty percent of patients developed malignancies, with non-Hodgkin lymphomas (13.4%) being the most prevalent. Conclusions: The clinical manifestations of SIgED encompass a variety of infectious, non-infectious complications, and malignancy. …”
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Genetic Variants of the NKG2C/HLA-E Receptor–Ligand Axis Are Determinants of Progression-Free Survival and Therapy Outcome in Aggressive B-Cell Lymphoma by Bettina Wagner, Ulrich Dührsen, Andreas Hüttmann, Holger Nückel, Rafael Tomoya Michita, Hana Rohn, Sabine Schramm, Peter A. Horn, Vera Rebmann

“…Aggressive B-cell lymphomas account for the majority of non-Hodgkin lymphomas (B-NHL). NK cells govern the responses to anti-CD20 monoclonal antibodies and have emerged as attractive targets for immunotherapy in subtypes of B-NHL. …”
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Effectiveness of Bone Marrow Biopsy for the Diagnosis of Pyrexia of Unknown Cause. by Mehwish Sajjad, Shaheen Kouser, Fatima Arshad, Ambreen Fatima, Mohammad Sohaib Tauheed, Saima Minhas, Mehreen Mehmood, Hira Qadir, Huma Mansoori

“…The most frequent diagnosis in biopsies of PUO patients was Non-Hodgkins Lymphoma in about 25% of patients.Conclusion:Certain laboratory and clinical parameters can detect major hematological diseases like malignancies when bone marrow biopsy is used for the workup of pyrexia of unknown origin. …”
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Primary hematologic malignancies with the onset of involvement of the major salivary glands in rheumatologic practice by V. I. Vasilyev, I. V. Gaiduk, S. G. Palshina, V. R. Gorodetsky, E. V. Sokol, E. B. Rodionova, M. V. Burtseva, N. S. Shornikova, N. A. Probatova, N. V. Kokosadze, A. I. Pavlovskaya, N. A. Kupryshina, T. N. Safonova

“…The prevailing hematologic malignances with MSG involvement were non-Hodgkin lymphomas (NHL), indolent MALT-lymphomas in 12 (23%) patients, follicular lymphomas in 6 (11.5%), and AL-amyloidosis affecting the SMSG in 9 (17.3%). …”
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<i>STAT3</i> Mutation Is Associated with STAT3 Activation in CD30⁺ ALK⁻ ALCL by Emma I. Andersson, Oscar Brück, Till Braun, Susanna Mannisto, Leena Saikko, Sonja Lagström, Pekka Ellonen, Sirpa Leppä, Marco Herling, Panu E. Kovanen, Satu Mustjoki

“…Peripheral T-cell lymphomas (PTCL) are a heterogeneous, and often aggressive group of non-Hodgkin lymphomas. Recent advances in the molecular and genetic characterization of PTCLs have helped to delineate differences and similarities between the various subtypes, and the JAK/STAT pathway has been found to play an important oncogenic role. …”
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Prevalence, Distribution, and Histopathological Features of Malignant Tumors Reported at Tertiary Level in Afghanistan: A 3-Year Study by Malakzai HA, Haidary AM, Gulzar S, Haidari M, Ibrahimkhil AS, Saadaat R, Hakimi A, Sadat Hofiani SM, Rahmani S, Abdul-Ghafar J

“…Small intestine was a frequently involved site affected by extranodal non-Hodgkin lymphomas. Overall, the majority of the cancers were diagnosed in stage-II.Conclusion: Findings in our study were somewhat similar to data presented elsewhere in the world, with some significant differences that could be related to the local factors. …”
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No increased risk of cancer associated with metal-on-metal or ceramic-on-ceramic procedures compared to other bearing surfaces in patients with total hip arthroplasty: A nationwide... by Nicole L Pratt, Flavia M Cicuttini, Yuanyuan Wang, Stephen E Graves

“…Significantly increased risk of melanoma, non-Hodgkins lymphoma, myeloma, leukaemia, prostate, colon, bladder and kidney cancer was found for csTHA and, prostate cancer, melanoma for rsTHA procedures when compared to the Australian population, although risk was not significantly different across bearing surfaces.…”
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Cutaneous T-cell lymphomas with pathogenic somatic mutations and absence of detectable clonal T-cell receptor gene rearrangement: two case reports by Rebecca Rojansky, Sebastian Fernandez-Pol, Erica Wang, Kerri E. Rieger, Roberto A. Novoa, James L. Zehnder, Christian A. Kunder, Youn H. Kim, Michael S. Khodadoust, Ryanne A. Brown

“…Abstract Background Cutaneous T-cell lymphomas (CTCL) are a heterogeneous group of extranodal non-Hodgkin lymphomas for which diagnosis can be challenging given the potential for overlap with inflammatory dermatoses. …”
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Incidence of cancer among residents of high temperature geothermal areas in Iceland: a census based study 1981 to 2010 by Kristbjornsdottir Adalbjorg, Rafnsson Vilhjalmur

“…The HR for pancreatic cancer was 2.85 (95% CI 1.39 to 5.86), breast cancer 1.59 (95% CI 1.10 to 2.31), lymphoid and hematopoietic cancer 1.64 (95% CI 1.00 to 2.66), and non-Hodgkins lymphoma 3.25 (95% CI 1.73 to 6.07). The HR for basal cell carcinoma of the skin was 1.61 (95% CI 1.10 to 2.35). …”
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No increased risk of cancer associated with metal-on-metal or ceramic-on-ceramic procedures compared to other bearing surfaces in patients with total hip arthroplasty: A nationwide... by Nicole L. Pratt, Flavia M. Cicuttini, Yuanyuan Wang, Stephen E. Graves

“…Significantly increased risk of melanoma, non-Hodgkins lymphoma, myeloma, leukaemia, prostate, colon, bladder and kidney cancer was found for csTHA and, prostate cancer, melanoma for rsTHA procedures when compared to the Australian population, although risk was not significantly different across bearing surfaces. …”
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Hypercalcemia as a rare presentation of angioimmunoblastic T cell lymphoma: a case report by Sana Chams, Inaya Hajj Hussein, Skye El Sayegh, Nour Chams, Khalid Zakaria

“…Abstract Background Angioimmunoblastic T cell lymphoma is a rare malignancy, accounting for only 2% of all non-Hodgkin lymphomas, first described in the 1970s and subsequently accepted as a distinct entity in the current World Health Organization classification. …”
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