A Newly Assigned Role of CTCF in Cellular Response to Broken DNAs by Mi Ae Kang, Jong-Soo Lee

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Applications of Programmable Endonucleases in Sequence- and Ligation-Independent Seamless DNA Assembly by Xingchen Xiong, Zhiwen Lu, Lixin Ma, Chao Zhai

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Mammalian Genome Recombineering: Yeast, Still a Helper Microorganism of Choice? by Mila Vrančić, Sandra Gregorić, Andrea Paravić Radičević, Krešimir Gjuračić

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An efficient CRISPR-based strategy to insert small and large fragments of DNA using short homology arms by Oguz Kanca, Jonathan Zirin, Jorge Garcia-Marques, Shannon Marie Knight, Donghui Yang-Zhou, Gabriel Amador, Hyunglok Chung, Zhongyuan Zuo, Liwen Ma, Yuchun He, Wen-Wen Lin, Ying Fang, Ming Ge, Shinya Yamamoto, Karen L Schulze, Yanhui Hu, Allan C Spradling, Stephanie E Mohr, Norbert Perrimon, Hugo J Bellen

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Germline RAD51B variants confer susceptibility to breast and ovarian cancers deficient in homologous recombination by Jeremy Setton, Pier Selenica, Semanti Mukherjee, Rachna Shah, Isabella Pecorari, Biko McMillan, Isaac X. Pei, Yelena Kemel, Ozge Ceyhan-Birsoy, Margaret Sheehan, Kaitlyn Tkachuk, David N. Brown, Liying Zhang, Karen Cadoo, Simon Powell, Britta Weigelt, Mark Robson, Nadeem Riaz, Kenneth Offit, Jorge S. Reis-Filho, Diana Mandelker

“…Furthermore, we demonstrate that tumors harboring biallelic RAD51B alteration are deficient in homologous recombination DNA repair deficiency (HRD), as evidenced by analysis of sequencing data and in vitro functional assays. …”
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Thioparib inhibits homologous recombination repair, activates the type I IFN response, and overcomes olaparib resistance by Li‐Min Wang, Pingyuan Wang, Xiao‐Min Chen, Hui Yang, Shan‐Shan Song, Zilan Song, Li Jia, Hua‐Dong Chen, Xu‐Bin Bao, Ne Guo, Xia‐Juan Huan, Yong Xi, Yan‐Yan Shen, Xin‐Ying Yang, Yi Su, Yi‐Ming Sun, Ying‐Lei Gao, Yi Chen, Jian Ding, Jing‐Yu Lang, Ze‐Hong Miao, Ao Zhang, Jin‐Xue He

Subjects: “…homologous recombination repair…”
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Mutational signatures reveal mutual exclusivity of homologous recombination and mismatch repair deficiencies in colorectal and stomach tumors by Amir Farmanbar, Robert Kneller, Sanaz Firouzi

“…However, little is known about microsatellite (in)stability and its interactions with other DNA repair mechanisms such as homologous recombination (HR) in different cancer types. Based on whole-genome/exome mutational signature analysis, we showed HR deficiency (HRd) and mismatch repair deficiency (MMRd) occur in a significantly mutually exclusive manner in stomach and colorectal adenocarcinomas. …”
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Signatures associated with homologous recombination deficiency and immune regulation to improve clinical outcomes in patients with lung adenocarcinoma by Xueqian Shang, Kang Qi, Xiangzheng Liu, Qinghao Liu, Xining Zhang, Dongliang Wang, Weiming Huang

“…Homologous recombination deficiency (HRD) was used to induce particular DNA aberration profiles and related transcriptome alterations. …”
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Potential value of the homologous recombination deficiency signature we developed in the prognosis and drug sensitivity of gastric cancer by Xin Wu, Qiong Wang, Peifa Liu, Linde Sun, Yu Wang

Subjects: “…homologous recombination deficiency…”
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Rationale for the Use of Homologous Recombination Proficient Molecular Profile as a Biomarker for Therapeutic Targeting in Ovarian Cancer by John Nemunaitis, Laura Stanbery, Adam Walter, Adam Walter, Rodney Rocconi, Philip Stephens, Philip Stephens

Subjects: “…homologous recombination…”
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Functional analyses of rare germline BRCA1 variants by transcriptional activation and homologous recombination repair assays by Nicola Bassi, Henrikke Nilsen Hovland, Kashif Rasheed, Elisabeth Jarhelle, Nikara Pedersen, Eunice Kabanyana Mchaina, Sara Marie Engelsvold Bakkan, Nina Iversen, Hildegunn Høberg-Vetti, Bjørn Ivar Haukanes, Per Morten Knappskog, Ingvild Aukrust, Elisabet Ognedal, Marijke Van Ghelue

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How BRCA and homologous recombination deficiency change therapeutic strategies in ovarian cancer: a review of literature by Martina Arcieri, Martina Arcieri, Veronica Tius, Claudia Andreetta, Stefano Restaino, Anna Biasioli, Elena Poletto, Giuseppe Damante, Giuseppe Damante, Alfredo Ercoli, Lorenza Driul, Lorenza Driul, Anna Fagotti, Domenica Lorusso, Giovanni Scambia, Giuseppe Vizzielli, Giuseppe Vizzielli

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Homologous Recombination DNA Repair Genes Play a Critical Role in Reprogramming to a Pluripotent State by Federico González, Daniela Georgieva, Fabio Vanoli, Zhong-Dong Shi, Matthias Stadtfeld, Thomas Ludwig, Maria Jasin, Danwei Huangfu

“…Additional mechanistic studies uncover a direct role of the homologous recombination (HR) pathway, a pathway essential for error-free repair of DNA DSBs, in reprogramming. …”
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Evaluating homologous recombination activity in tissues to predict the risk of hereditary breast and ovarian cancer and olaparib sensitivity by Tokiwa Motonari, Yuki Yoshino, Moe Haruta, Shino Endo, Shota Sasaki, Minoru Miyashita, Hiroshi Tada, Gou Watanabe, Toshiro Kaneko, Takanori Ishida, Natsuko Chiba

“…Abstract Homologous recombination (HR) repairs DNA damage including DNA double-stranded breaks and alterations in HR-related genes results in HR deficiency. …”
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Mutational pattern off homologous recombination repair (HRR)‐related genes in upper tract urothelial carcinoma by Kaiwei Yang, Wei Yu, Huanhuan Liu, Feng Lou, Shanbo Cao, Huina Wang, Zhisong He

Subjects: “…homologous recombination repair (HRR)…”
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Toward More Comprehensive Homologous Recombination Deficiency Assays in Ovarian Cancer, Part 1: Technical Considerations by Stanislas Quesada, Michel Fabbro, Jérôme Solassol

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Oncogenic Impact of TONSL, a Homologous Recombination Repair Protein at the Replication Fork, in Cancer Stem Cells by Hani Lee, Sojung Ha, SeokGyeong Choi, Soomin Do, Sukjoon Yoon, Yong Kee Kim, Woo-Young Kim

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The Prognostic and Therapeutic Potential of DNA Damage Repair Pathway Alterations and Homologous Recombination Deficiency in Lung Cancer by Karam Khaddour, Manuel Felipe Fernandez, Marsel Khabibov, Airat Garifullin, Danielle Dressler, Iuliia Topchu, Jyoti D. Patel, Frank Weinberg, Yanis Boumber

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Toward More Comprehensive Homologous Recombination Deficiency Assays in Ovarian Cancer Part 2: Medical Perspectives by Stanislas Quesada, Michel Fabbro, Jérôme Solassol

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Relationship between homologous recombination deficiency and clinical features of breast cancer based on genomic scar score by Cong Feng, Yinbin Zhang, Fei Wu, Jia Li, Mengjie Liu, Wei Lv, Chaofan Li, Weiwei Wang, Qinghua Tan, Xiaoyu Xue, Xingcong Ma, Shuqun Zhang

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