Patterns of Chromosomal Variation, Homoeologous Exchange, and Their Relationship with Genomic Features in Early Generations of a Synthetic Rice Segmental Allotetraploid by Guo Li, Ying Wu, Yan Bai, Na Zhao, Yuhui Jiang, Ning Li, Xiuyun Lin, Bao Liu, Chunming Xu

“…Local HE frequencies in the tetraploids and homologous recombination (HR) rates in diploids within 1 Mb sliding windows were significantly correlated with each other and showed similar overall distribution profiles. …”
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Real‐world data of poly (ADP‐ribose) polymerase inhibitor response in Japanese patients with ovarian cancer by Ryosuke Uekusa, Akira Yokoi, Eri Watanabe, Kosuke Yoshida, Masato Yoshihara, Satoshi Tamauchi, Yusuke Shimizu, Yoshiki Ikeda, Nobuhisa Yoshikawa, Kaoru Niimi, Shiro Suzuki, Hiroaki Kajiyama

“…Abstract Background Poly (ADP‐ribose) polymerase (PARP) inhibitors have been increasingly used in the treatment of ovarian cancer, with BRCA positivity and homologous recombination deficiency (HRD) being common biomarkers used for predicting their efficacy. …”
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RMI1 facilitates repair of ionizing radiation–induced DNA damage and maintenance of genomic stability by Lianying Fang, Yuxiao Sun, Mingxin Dong, Mengmeng Yang, Jianxiu Hao, Jiale Li, Huanteng Zhang, Ningning He, Liqing Du, Chang Xu

“…Abstract Ionizing radiation (IR) causes a wide variety of DNA lesions, of which DNA double-stranded breaks (DSBs) are the most deleterious. Homologous recombination (HR) is a crucial route responsible for repairing DSBs. …”
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Two promoters in the esx-3 gene cluster of Mycobacterium smegmatis respond inversely to different iron concentrations in vitro by Zhuo Fang, Mae Newton-Foot, Samantha Leigh Sampson, Nicolaas Claudius Gey van Pittius

“…Results The gene mycP 3 was deleted from wildtype M. smegmatis via homologous recombination. The mycP 3 gene was complemented in the deletion mutant using each of the two intrinsic promoters from the M. smegmatis esx-3 gene cluster. …”
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Development of a Method for Determination of brucella suis Biovars Using Multilocus Real-time PCR by N. A. Osina, D. A. Sitmbetov, I. V. Domanina, O. Yu. Lyashova, S. A. Shcherbakova, I. A. Kas’yan, Zh. A. Kas’yan, E. G. Bulgakova

“…It has been established that in strains of B. suis II, IV biovars and B. canis, the terminal part of the BRA0368 gene, comprising 21 nucleotides (repeated in the BRA0367 gene) and the “TAA” stop codon, as well as almost the entire sequence of the BRA0367 gene were lost, owing to homologous recombination in the IncP genome island. A 21-nucleotide direct repeat and the “TGA” stop codon of the BRA0367 gene replaced the analogous region of the BRA0368 gene which resulted in the deletion the size of 185 bp. …”
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Male sterility and somatic hybridization in plant breeding by Alejandro A. Edera, Laura Evangelina Garcia, Carlos Federico Marfil, M. Virginia Sanchez-Puerta

“…The molecular mechanisms responsible for CMS are highly variable and involve RNA editing, homologous and non-homologous recombination, as well as a variety of gene regulators like non coding RNA. …”
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MOF Phosphorylation by ATM Regulates 53BP1-Mediated Double-Strand Break Repair Pathway Choice by Arun Gupta, Clayton R. Hunt, Muralidhar L. Hegde, Sharmistha Chakraborty, Durga Udayakumar, Nobuo Horikoshi, Mayank Singh, Deepti B. Ramnarain, Walter N. Hittelman, Sarita Namjoshi, Aroumougame Asaithamby, Tapas K. Hazra, Thomas Ludwig, Raj K. Pandita, Jessica K. Tyler, Tej K. Pandita

“…Cell-cycle phase is a critical determinant of the choice between DNA damage repair by nonhomologous end-joining (NHEJ) or homologous recombination (HR). Here, we report that double-strand breaks (DSBs) induce ATM-dependent MOF (a histone H4 acetyl-transferase) phosphorylation (p-T392-MOF) and that phosphorylated MOF colocalizes with γ-H2AX, ATM, and 53BP1 foci. …”
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A Quantitative Chemotherapy Genetic Interaction Map Reveals Factors Associated with PARP Inhibitor Resistance by Hsien-Ming Hu, Xin Zhao, Swati Kaushik, Lilliane Robillard, Antoine Barthelet, Kevin K. Lin, Khyati N. Shah, Andy D. Simmons, Mitch Raponi, Thomas C. Harding, Sourav Bandyopadhyay

“…We identify that ARID1A loss confers resistance to PARP inhibitors in cells and ovarian cancer patients and that loss of GPBP1 causes resistance to cisplatin and PARP inhibitors through the regulation of genes involved in homologous recombination. This map helps navigate patient genomic data and optimize chemotherapeutic regimens by delineating factors involved in the response to specific types of DNA damage. : Hu et al. map the impact of knockdown of 625 cancer and DNA repair genes on the cellular response to every class of chemotherapy. …”
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Integration of tumour sequencing and case–control data to assess pathogenicity of RAD51C missense variants in familial breast cancer by Belle W. X. Lim, Na Li, Simone M. Rowley, Ella R. Thompson, Simone McInerny, Magnus Zethoven, Rodney J. Scott, Lisa Devereux, Erica K. Sloan, Paul A. James, Ian G. Campbell

“…Biallelic loss of the wild-type alleles corresponded strongly with ER- and TN breast tumours, high homologous recombination deficiency scores and mutational signature 3. …”
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Combined PARP and Dual Topoisomerase Inhibition Potentiates Genome Instability and Cell Death in Ovarian Cancer by Inken Flörkemeier, Julia S. Hillmann, Jörg P. Weimer, Jonas Hildebrandt, Nina Hedemann, Christoph Rogmans, Astrid Dempfle, Norbert Arnold, Bernd Clement, Dirk O. Bauerschlag

“…P8-D6 induces DNA damage that can be repaired by base excision repair or homologous recombination in which PARP plays a major role. …”
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Antitumor Activity of the Xanthonoside XGAc in Triple-Negative Breast, Ovarian and Pancreatic Cancer by Inhibiting DNA Repair by Juliana Calheiros, Liliana Raimundo, João Morais, Ana Catarina Matos, Sonia Anna Minuzzo, Stefano Indraccolo, Emília Sousa, Marta Correia da Silva, Lucília Saraiva

“…XGAc also induced genotoxicity, inhibiting the expression of DNA repair proteins particularly involved in homologous recombination, including BRCA1, BRCA2 and RAD51. …”
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How the Analysis of the Pathogenetic Variants of DDR Genes Will Change the Management of Prostate Cancer Patients by Alessandro Sciarra, Marco Frisenda, Giulio Bevilacqua, Alessandro Gentilucci, Susanna Cattarino, Gianna Mariotti, Francesco Del Giudice, Giovanni Battista Di Pierro, Pietro Viscuso, Paolo Casale, Benjamin I. Chung, Riccardo Autorino, Simone Crivellaro, Stefano Salciccia

“…The incidence of PVs in homologous recombination repair (HRR) genes among men with metastatic PC varied between 11% and 33%, which was significantly higher than that in non-metastatic PC, and <i>BRCA2</i> mutations were more frequent when compared to other DDR genes. …”
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The fundamental units, processes and patterns of evolution, and the Tree of Life conundrum by Wolf Yuri I, Koonin Eugene V

“…Recombination within a FUE is common between very closely related sequences where homologous recombination is feasible but becomes negligible for longer evolutionary distances. …”
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A supernumerary synthetic chromosome in Komagataella phaffii as a repository for extraneous genetic material by Dariusz Abramczyk, Maria del Carmen Sanchez Olmos, Adan Andres Ramirez Rojas, Daniel Schindler, Daniel Robertson, Stephen McColm, Adele L. Marston, Paul N. Barlow

“…It contains, within its q arm, a landing zone in which genes of interest alternate with long (approx. 1-kb) non-coding DNA chosen to facilitate homologous recombination and serve as spacers. The landing zone can be extended along the nanochromosome, in an inch-worming mode of sequential gene integrations, accompanied by recycling of just two antibiotic-resistance markers. …”
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REV7 Monomer Is Unable to Participate in Double Strand Break Repair and Translesion Synthesis but Suppresses Mitotic Errors by Faye M. Vassel, Daniel J. Laverty, Ke Bian, Cortt G. Piett, Michael T. Hemann, Graham C. Walker, Zachary D. Nagel

“…The Rev7 dimerization interface is also required for shieldin function, as both Rev7^−/− cells and Rev7^−/− cells expressing Rev7^{K44A/R124A/A135D} exhibit decreased proficiency in rejoining some types of double strand breaks, as well as increased homologous recombination. Interestingly, Rev7^{K44A/R124A/A135D} retains some function in cell cycle regulation, as it maintains an interaction with Ras-related nuclear protein (Ran) and partially rescues the formation of micronuclei. …”
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ATR Inhibition Potentiates PARP Inhibitor Cytotoxicity in High Risk Neuroblastoma Cell Lines by Multiple Mechanisms by Harriet E. D. Southgate, Lindi Chen, Deborah A. Tweddle, Nicola J. Curtin

“…CHK1^S345 and H2AX^S129 phosphorylation was assessed using Western blotting to determine ATR activity and RS, respectively. RS and homologous recombination repair (HRR) activity was also measured by γH2AX and Rad51 foci formation using immunofluorescence. …”
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Tumor Signature Analysis Implicates Hereditary Cancer Genes in Endometrial Cancer Development by Olga Kondrashova, Jannah Shamsani, Tracy A. O’Mara, Felicity Newell, Amy E. McCart Reed, Sunil R. Lakhani, Judy Kirk, John V. Pearson, Nicola Waddell, Amanda B. Spurdle

“…Signature analysis also indicated that germline loss-of-function variants in homologous recombination (<i>BRCA1</i>, <i>PALB2</i>, <i>RAD51C</i>) or base excision (<i>NTHL1</i>, <i>MUTYH</i>) repair genes can contribute to EC development in some individuals with germline variants in these genes. …”
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Estrogen receptor inhibition mediates radiosensitization of ER-positive breast cancer models by Anna R. Michmerhuizen, Lynn M. Lerner, Andrea M. Pesch, Connor Ward, Rachel Schwartz, Kari Wilder-Romans, Meilan Liu, Charles Nino, Kassidy Jungles, Ruth Azaria, Alexa Jelley, Nicole Zambrana Garcia, Alexis Harold, Amanda Zhang, Bryan Wharram, Daniel F. Hayes, James M. Rae, Lori J. Pierce, Corey W. Speers

“…Combination treatment resulted in an increase in double-strand DNA (dsDNA) breaks as a result of inhibition of non-homologous end joining-mediated dsDNA break repair with no effect on homologous recombination. Treatment with tamoxifen or fulvestrant in combination with RT also increased the number of senescent cells but did not affect apoptosis or cell cycle distribution. …”
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Somatic NGS Analysis of DNA Damage Response (DDR) Genes <i>ATM</i>, <i>MRE11A</i>, <i>RAD50</i>, <i>NBN</i>, and <i>ATR</i> in Locally Advanced Rectal Cancer Treated with Neoadjuva... by Andrea Montori, Aldo Germani, Mario Ferri, Annalisa Milano, Teresa Valentina Ranalli, Maria Piane, Emanuela Pilozzi

“…Conclusions: Our data show that the genes involved in the Homologous Recombination (HR) pathway are rarely mutated in LARC; however, given the identification of a missense mutation in RAD 50 in one case of pCR, it could be worth exploring its potential role as a biomarker in larger series.…”
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Outbreak of OXA-232-producing carbapenem-resistant Klebsiella pneumoniae ST15 in a Chinese teaching hospital: a molecular epidemiological study by Xiaoyan Wu, Xiangchen Li, Junjie Yu, Mengli Shen, Chenliang Fan, Yewei Lu, Junshun Gao, Xiaosi Li, Hongsheng Li

“…Comparative genomics showed that the IncFII-type and IncHI1B-type plasmids of cluster 2 had homologous recombination at the insertion sequence sites compared with the same type of plasmids in cluster 1, resulting in the insertion of 4 new drug resistance genes, including TEM-1, APH(6)-Id, APH(3’’)-Ib and sul2.ConclusionsOur study observed the clonal spread of ST15 OXA-232-producing between patients and the hospital environment. …”
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