Genomic features of Chinese small cell lung cancer by Jun Liu, Zhuxiang Zhao, Shuquan Wei, Binkai Li, Ziwen Zhao

“…DNA damage repair (DDR) pathway analysis showed that the most frequently enriched DDR pathways were fanconi anaemia (FA, 29.41%) and homology recombination (HR, 21.57%). Notably, 9.33% SCLC patients in our cohort had pathogenic or likely pathogenic germline gene variants. …”
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Structure and mechanics of the spasmoneme, a biological spring within the protozoan Vorticella convallaria by France, Danielle Cook

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Germline mutation landscape of Chinese patients with familial breast/ovarian cancer in a panel of 22 susceptibility genes by Jiayu Wang, Weiwei Li, Yujian Shi, Yan Huang, Tao Sun, Lili Tang, Qing Lu, Qiumo Lei, Ning Liao, Feng Jin, Hui Li, Tao Huang, Jun Qian, Danmei Pang, Shusen Wang, Peizhi Fan, Xinhong Wu, Ying Lin, Haiyan Qin, Binghe Xu

“…All the mutations detected were mainly seen in the homologous recombinant repair pathway. Compared to BRCA2 mutation, BRCA1 mutation is higher in younger female patients (P < 0.01). …”
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Targeting of RRM2 suppresses DNA damage response and activates apoptosis in atypical teratoid rhabdoid tumor by Le Hien Giang, Kuo-Sheng Wu, Wei-Chung Lee, Shing-Shung Chu, Anh Duy Do, Chun A. Changou, Huy Minh Tran, Tsung-Han Hsieh, Hsin-Hung Chen, Chia-Ling Hsieh, Shian-Ying Sung, Alice L. Yu, Yun Yen, Tai-Tong Wong, Che-Chang Chang

“…Moreover, we provide evidence that COH29 treatment led to genomic instability, suppressed homologous recombinant DNA damage repair, and subsequently induced ATRT cell death through apoptosis in ATRT cells. …”
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Baseline Mutations and Up-Regulation of PI3K-AKT Pathway Serve as Potential Indicators of Lack of Response to Neoadjuvant Chemotherapy in Stage II/III Breast Cancer by Menghao Dong, Benjie Shan, Xinghua Han, Xiaotian Zhao, Fufeng Wang, Liuqing Zhu, Qiuxiang Ou, Xiaopeng Ma, Yueyin Pan

“…Mutated phosphatidylinositol-3-kinase-AKT (PI3K-AKT) pathway and homologous recombinational repair pathway were also more frequently observed in patients evaluated as non-pCR. …”
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