PALB2 or BARD1 loss confers homologous recombination deficiency and PARP inhibitor sensitivity in prostate cancer by Kasia M. Dillon, Raie T. Bekele, Zsofia Sztupinszki, Timothy Hanlon, Shahrzad Rafiei, Zoltan Szallasi, Atish D. Choudhury, Kent W. Mouw

“…We used functional approaches to directly test the impact of PALB2 and BARD1 loss on homologous recombination (HR) function and PARP inhibitor sensitivity in prostate cancer cell lines. …”
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Concordance between Three Homologous Recombination Deficiency (HRD) Assays in Patients with High-Grade Epithelial Ovarian Cancer by Elena Fountzilas, Kyriaki Papadopoulou, Thomas Chatzikonstantinou, Georgios Karakatsoulis, Pantelis Constantoulakis, Aikaterini Tsantikidi, Georgios Tsaousis, Sofia Karageorgopoulou, Anna Koumarianou, Davide Mauri, Anastasios Ntavatzikos, Zacharenia Saridaki, Georgios Petrakis, Florentia Fostira, George Fountzilas, Michalis Liontos

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CBL0137 impairs homologous recombination repair and sensitizes high-grade serous ovarian carcinoma to PARP inhibitors by Xue Lu, Yaowu He, Rebecca L. Johnston, Devathri Nanayakarra, Sivanandhini Sankarasubramanian, J. Alejandro Lopez, Michael Friedlander, Murugan Kalimutho, John D. Hooper, Prahlad V. Raninga, Kum Kum Khanna

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p53 null Fluorescent Yellow Direct Repeat (FYDR) mice have normal levels of homologous recombination by Wiktor-Brown, Dominika M., Sukup-Jackson, Michelle R., Fakhraldeen, Saja A., Hendricks, Carrie A., Engelward, Bevin P.

“…In addition, p53 interacts with repair proteins involved in homologous recombination. Mitotic homologous recombination (HR) plays an essential role in the repair of double-strand breaks (DSBs) and broken replication forks. …”
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Redundancy between nucleases required for homologous recombination promotes PARP inhibitor resistance in the eukaryotic model organism Dictyostelium by Kolb, A, Gunn, A, Lakin, N

“…<p>ADP-ribosyltransferases (ARTs) promote repair of DNA single strand breaks (SSBs) and disruption of this pathway by Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPi) is toxic to cells with defects in homologous recombination (HR). Here we show that this relationship is conserved in the simple eukaryote <em>Dictyostelium</em> and exploit this organism to define mechanisms that drive resistance of HR-deficient cells to PARPi. …”

Saccharomyces cerevisiae C1D is implicated in both non-homologous DNA end joining and homologous recombination. by Erdemir, T, Bilican, B, Cagatay, T, Goding, C, Yavuzer, U

“…In addition, using a novel plasmid-based in vivo recombination assay, we show that yc1d mutant strains are also defective in homologous recombination. These results indicate that YC1D is implicated in both homologous recombination and NHEJ pathways for the repair of DNA double-strand breaks.…”

DNA ADP-ribosylation stalls replication and is reversed by RecF-mediated homologous recombination and nucleotide excision repair by Lawarée, E, Jankevicius, G, Cooper, C, Ahel, I, Uphoff, S, Tang, CM

“…Removal of ADPr from DNA requires the sequential activity of two DNA repair pathways, with RecF-mediated homologous recombination likely to transfer ADP-ribosylation from single- to double-stranded DNA (dsDNA) and subsequent nucleotide excision repair eliminating the lesion. …”

A bimodal pattern of relatedness between the Salmonella Paratyphi A and Typhi genomes: convergence or divergence by homologous recombination? by Didelot, X, Achtman, M, Parkhill, J, Thomson, N, Falush, D

“…We developed a Bayesian changepoint model that uses variation in the degree of nucleotide divergence along two genomes to detect homologous recombination between these strains, and with other lineages of Salmonella enterica. …”

Selections that isolate recombinant mitochondrial genomes in animals by Hansong Ma, Patrick H O'Farrell

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A deep-learning-based genomic status estimating framework for homologous recombination deficiency detection from low-pass whole genome sequencing by Yang Liu, Xiang Bi, Yang Leng, Dan Chen, Juan Wang, Youjia Ma, Min-Zhe Zhang, Bo-Wei Han, Yalun Li

Subjects: “…Homologous recombination deficiency…”
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RecA filament sliding on DNA facilitates homology search by Kaushik Ragunathan, Cheng Liu, Taekjip Ha

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From DNA Sequences to Chemical Structures – Methods for Mining Microbial Genomic and Metagenomic Data Sets for New Natural Products by Jurica Zucko, Antonio Starcevic, Janko Diminic, Mouhsine Elbekali, Mohamed Lisfi, Paul F. Long, John Cullum, Daslav Hranueli

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Somatic mutations in four novel genes contribute to homologous recombination deficiency in breast cancer: a real‐world clinical tumor sequencing study by Yongsheng Huang, Yuntan Qiu, Linxiaoxiao Ding, Shuwei Ren, Yuanling Jiang, Jiahuan Luo, Jinghua Huang, Xinke Yin, Sha Fu, Jianli Zhao, Kaishun Hu, Jianwei Liao

Subjects: “…homologous recombination…”
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Next-generation sequencing of homologous recombination genes could predict efficacy of platinum-based chemotherapy in non-small cell lung cancer by Linlin Zhang, Shasha Guan, Fanlu Meng, Lin Teng, Diansheng Zhong

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PARP inhibitor era in ovarian cancer treatment: a systematic review and meta-analysis of randomized controlled trials by István Baradács, Brigitta Teutsch, Alex Váradi, Alexandra Bilá, Ádám Vincze, Péter Hegyi, Tamás Fazekas, Balázs Komoróczy, Péter Nyirády, Nándor Ács, Ferenc Bánhidy, Balázs Lintner

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Stable overexpression and targeted gene deletion of the causative agent of ash dieback Hymenoscyphus fraxineus by Tobias Lutz, Birgit Hadeler, Mareike Jaeckel, Barbara Schulz, Cornelia Heinze

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Correction: RecA filament sliding on DNA facilitates homology search by Kaushik Ragunathan, Cheng Liu, Taekjip Ha

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An asymmetric PCR-based, reliable and rapid single-tube native DNA engineering strategy by Bi Yanzhen, Qiao Xianfeng, Hua Zaidong, Zhang Liping, Liu Ximei, Li Li, Hua Wenjun, Xiao Hongwei, Zhou Jingrong, Wei Qingxin, Zheng Xinmin

Subjects: “…Intramolecular homologous recombination…”
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Analyzing Plant Gene Targeting Outcomes and Conversion Tracts with Nanopore Sequencing by Paul A. P. Atkins, Maria Elena S. Gamo, Daniel F. Voytas

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High Expression of MRE11A Is Associated with Shorter Survival and a Higher Risk of Death in CRC Patients by Daniel de Barcellos Azambuja, Helena de Castro e Gloria, Gabriel e Silva Montenegro, Antonio Nocchi Kalil, Jean-Sébastien Hoffmann, Natalia Motta Leguisamo, Jenifer Saffi

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