RAD51 Inhibition Shows Antitumor Activity in Hepatocellular Carcinoma by Mingang Pan, Yu Sha, Jianguo Qiu, Yunmeng Chen, Lele Liu, Muyu Luo, Ailong Huang, Jie Xia

Subjects: Get full text

Preliminary study on efficacy and safety of fluzoparib in patients with metastatic castration-resistant prostate cancer by WEI Yu , ZHANG Tingwei , HE Yi , LI Jun , BI Jianbin , ZENG Yu , WAN Lijun , WU Gaoliang , WANG Huansheng , ZHANG Jun , ZHU Wei , QU Yuanyuan , ZHU Yao , YE Dingwei

Subjects: “…prostate cancer| fluzoparib| homologous recombination repair deficiency| efficacy…”
Get full text

Recent Advances in Enhancing the Therapeutic Index of PARP Inhibitors in Breast Cancer by Camille Franchet, Jean-Sébastien Hoffmann, Florence Dalenc

Subjects: Get full text

Application of Cloning-Free Genome Engineering to <i>Escherichia coli</i> by Lucia Romeo, Antonia Esposito, Alberto Bernacchi, Daniele Colazzo, Alberto Vassallo, Marco Zaccaroni, Renato Fani, Sara Del Duca

Subjects: Get full text

SUMO is a pervasive regulator of meiosis by Nikhil R Bhagwat, Shannon N Owens, Masaru Ito, Jay V Boinapalli, Philip Poa, Alexander Ditzel, Srujan Kopparapu, Meghan Mahalawat, Owen Richard Davies, Sean R Collins, Jeffrey R Johnson, Nevan J Krogan, Neil Hunter

Subjects: Get full text

Targeting DNA damage response deficiency in the treatment of breast cancer by JIN Yizi, LIN Mingxi, ZHANG Jian

Subjects: “…|dna damage response|homologous recombination|breast cancer|treatment…”
Get full text

Targeting the DNA Damage Response Machinery for Lung Cancer Treatment by Katharigatta N. Venugopala

Subjects: Get full text

Expression of EhRAD54, EhRAD51, and EhBLM proteins during DNA repair by homologous recombination in Entamoeba histolytica by del Socorro Charcas-Lopez Ma., Garcia-Morales Lorena, Pezet-Valdez Marisol, Lopez-Camarillo Cesar, Zamorano-Carrillo Absalom, Marchat Laurence A.

Subjects: Get full text

TaRECQ4 contributes to maintain both homologous and homoeologous recombination during wheat meiosis by Jeanne Bazile, Isabelle Nadaud, Pauline Lasserre-Zuber, Jonathan Kitt, Romain De Oliveira, Frédéric Choulet, Pierre Sourdille

Subjects: Get full text

Genetic Manipulation of the Brassicaceae Smut Fungus <i>Thecaphora thlaspeos</i> by Lesley Plücker, Kristin Bösch, Lea Geißl, Philipp Hoffmann, Vera Göhre

Subjects: Get full text

Functional Characterization of New Polyketide Synthase Genes Involved in Ochratoxin A Biosynthesis in Aspergillus Ochraceus fc-1 by Liuqing Wang, Yan Wang, Qi Wang, Fei Liu, Jonathan Nimal Selvaraj, Lingna Liu, Fuguo Xing, Yueju Zhao, Lu Zhou, Yang Liu

Subjects: Get full text

Role of RadA and DNA Polymerases in Recombination-Associated DNA Synthesis in Hyperthermophilic Archaea by Gaëlle Hogrel, Yang Lu, Nicolas Alexandre, Audrey Bossé, Rémi Dulermo, Sonoko Ishino, Yoshizumi Ishino, Didier Flament

Subjects: “…homologous recombination…”
Get full text

Overcoming Platinum and PARP-Inhibitor Resistance in Ovarian Cancer by Michelle McMullen, Katherine Karakasis, Ainhoa Madariaga, Amit M. Oza

Subjects: Get full text

The key role of CYC2 during meiosis in Tetrahymena thermophila by Qianlan Xu, Ruoyu Wang, A. R. Ghanam, Guanxiong Yan, Wei Miao, Xiaoyuan Song

Subjects: Get full text

Corelation of Homologous Recombination Repair System by Studying a Single-nucleotide Polymorphism in Xrcc3 Gene with Initiation and Progression of Colorectal Cancer by Majid Motovali-Bashi, Jafar Maleki, Simin Hemmati, Hassan Korbekandi

Subjects: Get full text

Germline mutations in homologous recombination repair genes among Chinese pancreatic ductal adenocarcinoma patients detected using next‐generation sequencing by Huiqin Jiang, Fei Huang, Xinning Chen, Li Zhang, Minna Shen, Baishen Pan, Beili Wang, Wei Guo

Subjects: Get full text

Society of Gynecologic Oncology Journal Club: Controversial conversations in gynecologic cancer – Navigating maintenance therapy for homologous recombinant proficient ovarian cancer by Whitney N. Goldsberry, Barbara S. Norquist, Rodney P. Rocconi, Susan C. Modesitt, Renata R. Urban

“…On August 3rd, 2022, SGO hosted a Journal Club focused on the role of maintenance therapy for homologous recombinant proficient (HRP) patients with ovarian cancer. …”
Get full text

557 Chronicity of exposure and ensuing resistance to platinum chemotherapy sensitizes homologous recombination-deficient pancreatic ductal adenocarcinoma to immune checkpoint blockade by Jashodeep Datta, Nipun Merchant, Anna Bianchi, Iago De Castro Silva, Ifeanyichukwu Ogobuiro, Samara Singh, Vanessa Garrido, Lucas Caeiro, Haleh Amirian, Luis Alberto Nivelo, Karthik Rajkumar, Andrew Adams, Nagaraj Nagathihalli

Genetic evidence for single-strand lesions initiating Nbs1-dependent homologous recombination in diversification of Ig v in chicken B lymphocytes. by Makoto Nakahara, Eiichiro Sonoda, Kuniharu Nojima, Julian E Sale, Katsuya Takenaka, Koji Kikuchi, Yoshihito Taniguchi, Kyoko Nakamura, Yoshiki Sumitomo, Ronan T Bree, Noel F Lowndes, Shunichi Takeda

“…Homologous recombination (HR) is initiated by DNA double-strand breaks (DSB). …”
Get full text

Toxoplasma gondii infection-induced host cellular DNA damage is strain-dependent and leads to the activation of the ATM-dependent homologous recombination pathway by Lisbeth Rojas-Barón, Carlos Hermosilla, Anja Taubert, Zahady D. Velásquez

“…Focusing on the RH strain, we furthermore demonstrated that T. gondii-infected primary host cells showed a DNA damage response by activating the ATM-dependent homologous recombination (HR) pathway. In contrast, key molecules of the nonhomologous DNA end joining (NHEJ) pathway were either not affected or downregulated in RH-infected host cells, suggesting that this pathway is not activated by infection. …”
Get full text