Challenges in next generation sequencing of homology recombination repair genomic variants in prostate cancer: A nationwide survey and calibration project in China by Huanwen Wu, Liqun Zhou, Xiaoyan Zhou, Qiang Wei, Nengtai Ouyang, Jianyong Shao, Jian Huang, Zhiyong Liang

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Homologous Recombination Deficiency and Cyclin E1 Amplification Are Correlated with Immune Cell Infiltration and Survival in High-Grade Serous Ovarian Cancer by Lilian van Wagensveld, Juliette O. A. M. van Baal, Maite Timmermans, Duco Gaillard, Lauri Borghuis, Seth B. Coffelt, Efraim H. Rosenberg, Christianne A. R. Lok, Hans W. Nijman, Loes F. S. Kooreman, Joyce Sanders, Marco de Bruijn, Lodewyk F. A. Wessels, Rianne van der Wiel, Christian Rausch, Annegien Broeks, Roy F. P. M. Kruitwagen, Maaike A. van der Aa, Gabe S. Sonke, Philip C. Schouten, Koen K. Van de Vijver, Hugo M. Horlings

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Deep Sequencing of Early T Stage Colorectal Cancers Reveals Disruption of Homologous Recombination Repair in Microsatellite Stable Tumours with High Mutational Burdens by Jun Li, Pascal Steffen, Benita C. Y. Tse, Mahsa S. Ahadi, Anthony J. Gill, Alexander F. Engel, Mark P. Molloy

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The Development and Testing of a Patient Decision Aid for Individuals with Homologous Recombinant Proficient Ovarian Cancer Who Are Considering Niraparib Maintenance Therapy by Laura Hopkins, Mark Carey, Linda Brown, Sabryna McCrea, Mark Milne, Dawne Tokaryk, Dawn Stacey

“…The aim of this study was to develop a decision aid for patients with homologous recombinant proficient (HRP) tumors, as the benefit–harm ratio of niraparib needs consideration. …”
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Prevention of DNA Replication Stress by CHK1 Leads to Chemoresistance Despite a DNA Repair Defect in Homologous Recombination in Breast Cancer by Felix Meyer, Saskia Becker, Sandra Classen, Ann Christin Parplys, Wael Yassin Mansour, Britta Riepen, Sara Timm, Claudia Ruebe, Maria Jasin, Harriet Wikman, Cordula Petersen, Kai Rothkamm, Kerstin Borgmann

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Germline Mutations in Other Homologous Recombination Repair-Related Genes Than <i>BRCA1/2</i>: Predictive or Prognostic Factors? by Laura Cortesi, Claudia Piombino, Angela Toss

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Prevalence of Homologous Recombination Deficiency in First-Line PARP Inhibitor Maintenance Clinical Trials and Further Implication of Personalized Treatment in Ovarian Cancer by E Sun Paik, Ha Kyun Chang, Sanghoon Lee

“…Among ovarian cancer patients with <i>BRCA</i> mutation or homologous recombination deficiency (HRD), the efficacy of Poly-ADP-ribose polymerase (PARP) inhibitors such as olaparib, niraparib, veliparib, and rucaparib has been proven in a number of clinical trials. …”
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The enrichment of Fanconi anemia/homologous recombination pathway aberrations in ATM/ATR-mutated NSCLC was accompanied by unique molecular features and poor prognosis by Wei Wei, Fangfang Shi, Yang Xu, Yang Jiao, Ying Zhang, Qiuxiang Ou, Xue Wu, Lingyi Yang, Jinhuo Lai

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Rosa26-GFP Direct Repeat (RaDR-GFP) Mice Reveal Tissue- and Age-Dependence of Homologous Recombination in Mammals In Vivo by Sukup-Jackson, Michelle R., Kiraly, Orsolya, Na, Li, Rowland, Elizabeth A., Winther, Kelly E., Chow, Danielle N., Kimoto, Takafumi, Matsuguchi, Tetsuya, Jonnalagadda, Vidya S., Maklakova, Vilena I., Singh, Vijay R., Wadduwage, Dushan N., Rajapakse, Jagath, So, Peter T. C., Collier, Lara S., Engelward, Bevin P., Kay, Jennifer Elizabeth

“…Homologous recombination (HR) is critical for the repair of double strand breaks and broken replication forks. …”
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Mph1 requires mismatch repair-independent and -dependent functions of MutSα to regulate crossover formation during homologous recombination repair by Tay, Y, Sidebotham, J, Wu, L

“…In budding yeast the DNA helicase Mph1 prevents genome rearrangements during ectopic homologous recombination (HR) by suppressing the formation of crossovers (COs). …”

Break-induced loss of heterozygosity in fission yeast: dual roles for homologous recombination in promoting translocations and preventing de novo telomere addition. by Cullen, J, Hussey, S, Walker, C, Prudden, J, Wee, B, Davé, A, Findlay, J, Savory, A, Humphrey, T

“…These events required the homologous recombination (HR) genes rad32(+), rad50(+), nbs1(+), rhp51(+), rad22(+), rhp55(+), rhp54(+), and mus81(+). …”

The DNA damage checkpoint pathway promotes extensive resection and nucleotide synthesis to facilitate homologous recombination repair and genome stability in fission yeast. by Blaikley, E, Tinline-Purvis, H, Kasparek, T, Marguerat, S, Sarkar, S, Hulme, L, Hussey, S, Wee, B, Deegan, R, Walker, C, Pai, C, Bähler, J, Nakagawa, T, Humphrey, T

“…Here we identify roles for the DNA damage checkpoint pathway in facilitating homologous recombination (HR) repair and suppressing extensive LOH and chromosomal rearrangements in response to a DSB. …”

Expression of a homologously recombined erythopoietin-SV40 T antigen fusion gene in mouse liver: evidence for erythropoietin production by Ito cells. by Maxwell, P, Ferguson, D, Osmond, M, Pugh, C, Heryet, A, Doe, BG, Johnson, M, Ratcliffe, P

“…We have obtained transgenic mice in which an erythropoietin-SV40 virus T antigen fusion gene is homologously recombined into the native Epo locus. This gene is expressed in a tissue-specific manner closely resembling that of the native Epo gene. …”

PARP Inhibitors: A Major Therapeutic Option in Endocrine-Receptor Positive Breast Cancers by Laetitia Collet, Julien Péron, Frédérique Penault-Llorca, Pascal Pujol, Jonathan Lopez, Gilles Freyer, Benoît You

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R-Loop Formation in Meiosis: Roles in Meiotic Transcription-Associated DNA Damage by Yasuhiro Fujiwara, Mary Ann Handel, Yuki Okada

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An easy method to generate recombinant pseudorabies virus expressing the capsid protein of Porcine circovirus type 2d by Jingqiang Ren, Jingqiang Ren, Jingqiang Ren, Rachel Madera, Chase Cunningham, Jishu Shi, Lihua Wang

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Construction of an Unmarked Zymomonas mobilis Mutant Using a Site-Specific FLP Recombinase by Shao-Lan Zou, Jie-Fang Hong, Cui Wang, Xin Jing, Min-Hua Zhang

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Genetic and Biochemical Characterizations of aLhr1 Helicase in the Thermophilic Crenarchaeon <i>Sulfolobus acidocaldarius</i> by Shoji Suzuki, Norio Kurosawa, Takeshi Yamagami, Shunsuke Matsumoto, Tomoyuki Numata, Sonoko Ishino, Yoshizumi Ishino

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Effective sequential combined therapy with carboplatin and a CDC7 inhibitor in ovarian cancer by Junping Li, Hong Hu, Jinping He, Yuling Hu, Manting Liu, Bihui Cao, Dongni Chen, Xiaodie Ye, Jian Zhang, Zhiru Zhang, Wen Long, Hui Lian, Deji Chen, Likun Chen, Lili Yang, Zhenfeng Zhang

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The deletion of omp19 gene of brucella abortus 2308 reduces its survival in mouse macrophage and in mice by Yueli WANG, Zhongchen MA, Huan ZHANG, Jihai YI, Yong WANG, Tiansen LI, Chuangfu CHEN

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