Nucleoporin 54 contributes to Homologous recombination repair and post-replicative DNA integrity by Rodriguez-Berriguete, G, Granata, G, Puliyadi, R, Tiwana, G, Prevo, R, Wilson, R, Yu, S, Buffa, F, Humphrey, T, McKenna, W, Higgins, G

“…Interestingly, we found that Nup54 is epistatic with the Homologous Recombination (HR) factor Rad51. Moreover, using specific DNA damage repair reporters, we observed a decreased HR repair activity upon Nup54 knockdown. …”

Roles for APRIN (PDS5B) in homologous recombination and in ovarian cancer prediction by Couturier, A, Fleury, H, Patenaude, A, Bentley, V, Rodrigue, A, Coulombe, Y, Niraj, J, Pauty, J, Berman, J, Dellaire, G, Di Noia, J, Mes-Masson, A, Masson, J

“…APRIN is a new homologous recombination (HR) mediator as it counteracts the RPA inhibitory effect on RAD51 loading to ssDNA. …”

The involvement of Srs2 in post-replication repair and homologous recombination in fission yeast. by Doe, C, Whitby, M

“…Homologous recombination is important for the repair of double-strand breaks and daughter strand gaps, and also helps restart stalled and collapsed replication forks. …”

Screening for inhibitors of and novel proteins within the homologous recombination DNA repair pathway by Kingham, G

“…The homologous recombination (HR) pathway of DNA repair is essential for the faithful repair of double-stranded DNA breaks (DSBs) in all organisms and as such helps maintain genomic stability. …”

Determination of BRCAness Phenotype in Breast Tumors for the Appointment of Neoadjuvant Chemotherapy Based on Platinum and Taxanes by Matvey Mihajlovich Tsyganov, Marina K. Ibragimova, Evgeniy Y. Garbukov, Olga D. Bragina, Ariana A. Karchevskaya, Evgeny A. Usynin, Nikolai V. Litvyakov

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Moderate-Risk Genes for Hereditary Ovarian Cancers Involved in the Homologous Recombination Repair Pathway by Akiko Abe, Issei Imoto, Arisa Ueki, Hidetaka Nomura, Hiroyuki Kanao

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Copy number alteration features in pan-cancer homologous recombination deficiency prediction and biology by Huizi Yao, Huimin Li, Jinyu Wang, Tao Wu, Wei Ning, Kaixuan Diao, Chenxu Wu, Guangshuai Wang, Ziyu Tao, Xiangyu Zhao, Jing Chen, Xiaoqin Sun, Xue-Song Liu

“…Abstract Homologous recombination deficiency (HRD) renders cancer cells vulnerable to unrepaired double-strand breaks and is an important therapeutic target as exemplified by the clinical efficacy of poly ADP-ribose polymerase (PARP) inhibitors as well as the platinum chemotherapy drugs applied to HRD patients. …”
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The Homologous Recombination Deficiency Scar in Advanced Cancer: Agnostic Targeting of Damaged DNA Repair by Vilma Pacheco-Barcia, Andrés Muñoz, Elena Castro, Ana Isabel Ballesteros, Gloria Marquina, Iván González-Díaz, Ramon Colomer, Nuria Romero-Laorden

Subjects: “…homologous recombination deficiency…”
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Combination of FACS and homologous recombination for the generation of stable and high-expression engineered cell lines. by Lei Shi, Xuesi Chen, Wenying Tang, Zhenyi Li, Jin Liu, Feng Gao, Jianli Sang

“…Here, we have designed a new strategy for the generation of stable and high-expression cell lines by combining homologous recombination (HR) and fluorescence-activated cell sorting (FACS). …”
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Homologous recombination repair rathway and RAD54L in early-stage lung adenocarcinoma by Shaopeng Zheng, Lintong Yao, Fasheng Li, Luyu Huang, Yunfang Yu, Zenan Lin, Hao Li, Jin Xia, Michael Lanuti, Haiyu Zhou

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Homologous Recombination Repair Gene Alterations Are Associated with Tumor Mutational Burden and Survival of Immunotherapy by Mamoru Ito, Makoto Kubo, Hitomi Kawaji, Yoshiki Otsubo, Kanako Kurata, Hikaru Abutani, Mikita Suyama, Yoshinao Oda, Tomoharu Yoshizumi, Masafumi Nakamura, Eishi Baba

Subjects: “…homologous recombination repair gene…”
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Competitive repair by naturally dispersed repetitive DNA during non-allelic homologous recombination. by Margaret L Hoang, Frederick J Tan, David C Lai, Sue E Celniker, Roger A Hoskins, Maitreya J Dunham, Yixian Zheng, Douglas Koshland

“…Genome rearrangements often result from non-allelic homologous recombination (NAHR) between repetitive DNA elements dispersed throughout the genome. …”
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Essential role of the BRCA2B gene in somatic homologous recombination in Arabidopsis thaliana by Padinhatta Purayil Amritha, Jasmine M. Shah

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Prevalent role of homologous recombination in the repair of specific double-strand breaks in Rhizobium etli by Fares Osam Yáñez-Cuna, Diana Aguilar-Gómez, Araceli Dávalos, David Romero

“…Repair of a DSB may be achieved through homologous recombination (either between adjacent or distant repeats) or NHEJ. …”
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Mutations in Homologous Recombination Genes and Loss of Heterozygosity Status in Advanced-Stage Breast Carcinoma by Brooke B. Bartow, Gene P. Siegal, Ceren Yalniz, Ahmed M. Elkhanany, Lei Huo, Qingqing Ding, Aysegul A. Sahin, Hua Guo, Cristina Magi-Galluzzi, Shuko Harada, Xiao Huang

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Loss of CENP-I Impairs Homologous Recombination and Sensitizes Cells to PARP1 Inhibition by Tuyen T. Dang, Julio C. Morales

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First Isolation and Identification of Homologous Recombination Events of Porcine Adenovirus from Wild Boar by Mami Oba, Sumiya Borjigin, Fuka Kikuchi, Toru Oi, Hitoshi Takemae, Hiroho Ishida, Hironobu Murakami, Naoyuki Aihara, Takanori Shiga, Junichi Kamiie, Tetsuya Mizutani, Makoto Nagai

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Tumors defective in homologous recombination rely on oxidative metabolism: relevance to treatments with PARP inhibitors by Álvaro Lahiguera, Petra Hyroššová, Agnès Figueras, Diana Garzón, Roger Moreno, Vanessa Soto‐Cerrato, Iain McNeish, Violeta Serra, Conxi Lazaro, Pilar Barretina, Joan Brunet, Javier Menéndez, Xavier Matias‐Guiu, August Vidal, Alberto Villanueva, Barbie Taylor‐Harding, Hisashi Tanaka, Sandra Orsulic, Alexandra Junza, Oscar Yanes, Cristina Muñoz‐Pinedo, Luís Palomero, Miquel Àngel Pujana, José Carlos Perales, Francesc Viñals

“…Here, we show that homologous recombination‐defective (HRD) cancers rely on oxidative metabolism to supply NAD+ and ATP for poly(ADP‐ribose) polymerase (PARP)‐dependent DNA repair mechanisms. …”
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Homologous recombination deficiency signatures in gastrointestinal and thoracic cancers correlate with platinum therapy duration by Erica S. Tsang, Veronika Csizmok, Laura M. Williamson, Erin Pleasance, James T. Topham, Joanna M. Karasinska, Emma Titmuss, Intan Schrader, Stephen Yip, Basile Tessier-Cloutier, Karen Mungall, Tony Ng, Sophie Sun, Howard J. Lim, Jonathan M. Loree, Janessa Laskin, Marco A. Marra, Steven J. M. Jones, David F. Schaeffer, Daniel J. Renouf

“…Abstract There is emerging evidence about the predictive role of homologous recombination deficiency (HRD), but this is less defined in gastrointestinal (GI) and thoracic malignancies. …”
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Parental histone distribution and location of the replication obstacle at nascent strands control homologous recombination by Cristina González-Garrido, Félix Prado

“…Therefore, parental histone distribution and location of the replication obstacle at the lagging or leading strand regulate homologous recombination.…”
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