Co-regulation and function of FOXM1/RHNO1 bidirectional genes in cancer by Carter J Barger, Linda Chee, Mustafa Albahrani, Catalina Munoz-Trujillo, Lidia Boghean, Connor Branick, Kunle Odunsi, Ronny Drapkin, Lee Zou, Adam R Karpf

“…FOXM1 and RHNO1 each promote oncogenic phenotypes in HGSC cells, including clonogenic growth, DNA homologous recombination repair, and poly-ADP ribosylase inhibitor resistance. …”
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Physapruin A Enhances DNA Damage and Inhibits DNA Repair to Suppress Oral Cancer Cell Proliferation by Tzu-Jung Yu, Ching-Yu Yen, Yuan-Bin Cheng, Chia-Hung Yen, Jiiang-Huei Jeng, Jen-Yang Tang, Hsueh-Wei Chang

“…In contrast, the mRNA expressions for DNA repair signaling, including homologous recombination (HR) and non-homologous end joining (NHEJ)-associated genes, were inhibited by PHA in oral cancer cells. …”
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The <i>brlA</i> Gene Deletion Reveals That Patulin Biosynthesis Is Not Related to Conidiation in <i>Penicillium expansum</i> by Chrystian Zetina-Serrano, Ophélie Rocher, Claire Naylies, Yannick Lippi, Isabelle P. Oswald, Sophie Lorber, Olivier Puel

“…A <i>P. expansum</i> PeΔ<i>brlA</i> deficient strain was generated by homologous recombination. In vivo, suppression of <i>brlA</i> completely blocked the development of conidiophores that takes place after the formation of coremia/synnemata, a required step for the perforation of the apple epicarp. …”
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Transcriptome and Proteome Analyses Reveal Stage-Specific DNA Damage Response in Embryos of Sturgeon (<i>Acipenser ruthenus</i>) by Ievgeniia Gazo, Ravindra Naraine, Ievgen Lebeda, Aleš Tomčala, Mariola Dietrich, Roman Franěk, Martin Pšenička, Radek Šindelka

“…CPT and olaparib downregulated oxidative phosphorylation and metabolic pathways, and upregulated pathways involved in nucleotide excision repair, base excision repair, and homologous recombination. We observed the upregulated expression of zona pellucida sperm-binding proteins in all treatment groups, as well as the upregulation of several glycolytic enzymes. …”
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Prognostic Role of CRS in High Grade Serous Ovarian Tumour Patients Receiving Neoadjuvant Chemotherapy in a Tertiary Care Hospital of Central India by Manal Ashraf Ali, Naila Durrani, Khaneta Parveen, Zeeshanuddin Ahmad, Farah Jalaly Meenai

“…The advent of molecular genetics has allowed us to categorise tumours as per the mutations they possess, the prominent in High Grade Serous Carcinoma (HGSC) being Tumour Protein 53 (TP53), Breast Carcinoma 1/2 (BRCA1/2) and Homologous Recombination Deficiency (HRD). This knowledge is used to cater to the specific therapeutic needs of the patients. …”
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Genetics, Genomics and Emerging Molecular Therapies of Pancreatic Cancer by Jakub Liu, Magdalena Mroczek, Anna Mach, Maria Stępień, Angelika Aplas, Bartosz Pronobis-Szczylik, Szymon Bukowski, Magda Mielczarek, Ewelina Gajewska, Piotr Topolski, Zbigniew J. Król, Joanna Szyda, Paula Dobosz

“…The pathogenesis of pancreatic cancer can in many cases be characterised by homologous recombination deficiency (HRD)—cell inability to effectively repair DNA. …”
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Chromosome Segregation and Cell Division Defects in <i>Escherichia coli</i> Recombination Mutants Exposed to Different DNA-Damaging Treatments by Ksenija Zahradka, Jelena Repar, Damir Đermić, Davor Zahradka

“…Homologous recombination repairs potentially lethal DNA lesions such as double-strand DNA breaks (DSBs) and single-strand DNA gaps (SSGs). …”
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Ovine Herpesvirus 2 Glycoprotein B Complementation Restores Infectivity to a Bovine Herpesvirus 4 gB-Null Mutant by Daniela D. Moré, Katherine N. Baker, Smriti Shringi, Reginaldo G. Bastos, Donal O’Toole, Gaetano Donofrio, Cristina W. Cunha

“…In this study, we used homologous recombination to insert OvHV-2 ORF 8, encoding gB, into the BoHV-4 gB-null mutant genome, creating a chimeric BoHV-4 virus carrying and expressing OvHV-2 gB (BoHV-4∆gB/OvHV-2-gB) that was infectious and able to replicate in vitro. …”
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Revealing Key Genes and Pathways in Potato Scab Disease Resistance through Transcriptome Analysis by Chuang Li, Baoqi Yuan, Chuan Zhang, Qi Yao, Hongxia He, Qingfeng Wang, Jinping Liang, Nan Li, Xu Zhu, Zhongwei Wang

“…GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) enrichment analyses revealed several significant metabolic pathways, such as ADP binding, heme binding, chloroplast thylakoid membrane, photosynthesis, glutathione metabolism, and homologous recombination, among others. Notably, the correlation between chloroplast pathways (GO:0019745) and photosynthesis (map00195) highlights photosynthesis’s role in potato scab response, while the oxygen transport (GO:0031408)-related glutathione metabolism pathway (map00480) emphasizes antioxidant defenses. …”
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Antifungal activity of biosynthesized silver nanoparticles from Candida albicans on the strain lacking the CNP41 gene by Darshan Dhabalia, Shareefraza J Ukkund, Usman Taqui Syed, Wasim Uddin, M Anaul Kabir

“…Furthermore, pioneering work of homologous recombination technique was systematically employed to delete uncharacterized gene orf 19.3120 (CNP 41) in the C86 strain creating the deletion strain C403 of C. albicans . …”
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Multimolecular characteristics and role of BRCA1 interacting protein C-terminal helicase 1 (BRIP1) in human tumors: a pan-cancer analysis by Ruohuang Wang, Jisheng Zhang, Xin Cui, Shun Wang, Ting Chen, Yanfang Niu, Xiaoyun Du, Jingwen Kong, Lin Wang, Yan Jiang

“…“Basal transcription factors,” “homologous recombination,” “nucleotide excision repair,” and DNA metabolism pathways may play a role in the functional mechanisms of BRIP1. …”
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Prime Editing Technology and Its Prospects for Future Applications in Plant Biology Research by Md. Mahmudul Hassan, Guoliang Yuan, Jin-Gui Chen, Gerald A. Tuskan, Xiaohan Yang

“…However, low frequency of homologous recombination in plants and difficulty of delivering the donor DNA molecules make this process extremely inefficient. …”
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Arsenite Impairs BRCA1-Dependent DNA Double-Strand Break Repair, a Mechanism Potentially Contributing to Genomic Instability by Tizia Matthäus, Sandra Stößer, Hatice Yasemin Seren, Vivien M. M. Haberland, Andrea Hartwig

“…Furthermore, in the absence of arsenite, the lack of functional BRCA1 impaired the largely error-free homologous recombination (HR), leading to a shift towards the error-prone non-homologous end-joining (NHEJ). …”
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Germline Variants in 32 Cancer-Related Genes among 700 Chinese Breast Cancer Patients by Next-Generation Sequencing: A Clinic-Based, Observational Study by Liu Yang, Fei Xie, Chang Liu, Jin Zhao, Taobo Hu, Jinbo Wu, Xiaotao Zhao, Shu Wang

“…The variants in panel genes, HRR (homologous recombination repair)-related genes, and <i>BRCA1/2</i> were significantly associated with the following clinicopathological factors: age at the initial diagnosis of BC, family history of any cancer, molecular subtype, Ki-67 index, and hereditary risk. …”
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Characterization of regulatory genes Plhffp and Plpif1 involved in conidiation regulation in Purpureocillium lavendulum by Yu Wei, Feng-Na Qi, Yan-Rui Xu, Ke-Qin Zhang, Jianping Xu, Yan-Ru Cao, Lian-Ming Liang

“…Both genes were knocked out through homologous recombination, and phenotypic analysis revealed a significant difference in conidiation between the knockout strains and the wild-type strain (ku80). …”
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cGAS-STING pathway expression correlates with genomic instability and immune cell infiltration in breast cancer by Mengting Chen, Shibo Yu, Tineke van der Sluis, Mieke C. Zwager, Carolien P. Schröder, Bert van der Vegt, Marcel A. T. M. van Vugt

“…Also, cGAS-STING scores are correlated with genomic instability metrics, such as homologous recombination deficiency (P < 0.001) and tumor mutational burden (P < 0.01). …”
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Current strategies for the targeted treatment of high-grade serous epithelial ovarian cancer and relevance of BRCA mutational status by Angiolo Gadducci, Valentina Guarneri, Fedro Alessandro Peccatori, Graziana Ronzino, Giuseppa Scandurra, Claudio Zamagni, Paolo Zola, Vanda Salutari

“…Germline mutations of the genes BRCA1 and BRCA2, which encode proteins essential for the repair of double-strand DNA breaks through homologous recombination, lead to increased cancer predisposition. …”
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Overlapping gene dependencies for PARP inhibitors and carboplatin response identified by functional CRISPR-Cas9 screening in ovarian cancer by Ricardo Coelho, Alessandra Tozzi, Muriel Disler, Flavio Lombardo, André Fedier, Mónica Núñez López, Florian Freuler, Francis Jacob, Viola Heinzelmann-Schwarz

“…Abstract PARP inhibitors (PARPi) have revolutionized the therapeutic landscape of epithelial ovarian cancer (EOC) treatment with outstanding benefits in regard to progression-free survival, especially in patients either carrying BRCA1/2 mutations or harboring defects in the homologous recombination repair system. Yet, it remains uncertain which PARPi to apply and how to predict responders when platinum sensitivity is unknown. …”
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Characteristics of germline DNA damage response gene mutations in ovarian cancer in Southwest China by Kaiyu Fu, Qingli Li, Jie Wang, Mengpei Zhang, Xinyu Yan, Kemin Li, Liang Song, Lan Zhong, Yu Ma, Jinghong Chen, Jing Zeng, Danqing Wang, Di Shao, Shida Zhu, Rutie Yin

“…Abstract DNA damage response (DDR) pathways are responsible for repairing endogenous or exogenous DNA damage to maintain the stability of the cellular genome, including homologous recombination repair (HRR) pathway, mismatch repair (MMR) pathway, etc. …”
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The Prognostic Value and Potential Mechanism of Tumor-Nutrition-Inflammation Index and Genes in Patients with Advanced Lung Cancer by Huan Wang, Yuting Shi, Yueli Shi, Mengqing Cao, Long Zhang, Yuan Wu, Yun Xu, Kai Wang, Xianwu Weng

“…In addition, tumor-nutrition-inflammation index and genes play an important role in LC development that might affect some pathways related to tumor development including cell cycle, homologous recombination, and P53 signaling pathway from a molecular level. …”
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