The Hospital Frailty Risk Score (HFRS) applied to primary data: protocol for a systematic review by Simon Conroy, Thomas Gilbert, Bronwen Warner, Abdullah Alshibani, Rhiannon K Owen, Abir Mukherjee

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Generation of two induced pluripotent stem cell lines and the corresponding isogenic controls from Parkinson’s disease patients carrying the heterozygous mutations c.1290A > G (p.T... by Axel Chemla, Giuseppe Arena, Claudia Saraiva, Clara Berenguer-Escuder, Dajana Grossmann, Anne Grünewald, Christine Klein, Philip Seibler, Jens C. Schwamborn, Rejko Krüger

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Expanding Scope of Practice for Ontario Regulated Health Professionals during COVID-19 by Sophia Myles, Kathleen Leslie, Sioban Nelson, Tracey L. Adams

“…Le 21 avril 2021, le gouvernement de l'Ontario a émis une nouvelle ordonnance en vertu de la Loi de 1990 sur la protection civile et la gestion des situations d'urgence, qui autorise les professionnels de la santé réglementés à exercer au-delà de leur champ d'exercice habituel lorsqu'ils travaillent en milieu hospitalier et fournissent des soins liés à une pandémie. …”
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Expanding Scope of Practice for Ontario Regulated Health Professionals during COVID-19 by Sophia Myles, Kathleen Leslie, Sioban Nelson, Tracey L. Adams

“…Le 21 avril 2021, le gouvernement de l'Ontario a émis une nouvelle ordonnance en vertu de la Loi de 1990 sur la protection civile et la gestion des situations d'urgence, qui autorise les professionnels de la santé réglementés à exercer au-delà de leur champ d'exercice habituel lorsqu'ils travaillent en milieu hospitalier et fournissent des soins liés à une pandémie. …”
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Validation des seuils cliniques dans la version remplie par les parents du Questionnaire sur les points forts et les points faibles au sein d’un vaste échantillon d’enfants et de j... by Sarah E. Turner, Raelyne L. Dopko, Gary Goldfield, Paula Cloutier, Kathleen Pajer, Mohcene Abdessemed, Fatima Mougharbel, Michael Ranney, Matt D. Hoffmann, Justin J. Lang

“…MéthodologieCette étude est fondée sur les données d’enfants et de jeunes de 6 à 17 ans provenant de l’Enquête canadienne sur les mesures de la santé (n = 3 435) et de dossiers de consultations externes du Centre hospitalier pour enfants de l’est de l’Ontario (n = 1 075). …”
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A Medicoeconomic Evaluation of a Telehealth Platform for Elective Outpatient Surgeries: Protocol for a Randomized Controlled Trial by Florian Robin, Maxim Roy, Alexandre Kuftedjian, Laurelie Perret, Frédéric Lavoie, Alexandre Castonguay, Marie-Pascale Pomey, Cedrick Zaouter, Guy Pare

“…This study has been approved by the ethics board of Centre hospitalier de l’Université de Montréal (University of Montreal Health Centre). …”
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Older Adult Perspectives on Statin Continuation and Discontinuation in Primary Cardiovascular Disease Prevention: A Mixed-Methods Study by Brunner L, Mooser B, Spinewine A, Rodondi N, Aubert CE

“…Laureline Brunner,1 Blandine Mooser,1,2 Anne Spinewine,3,4 Nicolas Rodondi,1,2 Carole Elodie Aubert1,2 1Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland; 2Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; 3Université catholique de Louvain, Louvain Drug Research Institute, Clinical Pharmacy Research Group, Brussels, Belgium; Department of Pharmacy, Centre Hospitalier Universitaire (CHU) UCL Namur, Yvoir, Belgium; 4Clinical Pharmacy Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, Brussels, BelgiumCorrespondence: Carole Elodie Aubert, Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Anna-von-Krauchthal Weg 7, Bern, CH-3010, Switzerland, Tel +41 31 632 03 98, Email caroleelodie.aubert@insel.chBackground and Purpose: Evidence for statin use for primary cardiovascular disease prevention in older adults is limited. …”
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Polypharmacy and Excessive Polypharmacy Among Persons Living with Chronic Pain: A Cross-Sectional Study on the Prevalence and Associated Factors by Zahlan G, De Clifford-Faugère G, Nguena Nguefack HL, Guénette L, Pagé MG, Blais L, Lacasse A

“…Ghita Zahlan,1 Gwenaelle De Clifford-Faugère,1 Hermine Lore Nguena Nguefack,1 Line Guénette,2,3 M Gabrielle Pagé,4,5 Lucie Blais,6 Anaïs Lacasse1 1Département des sciences de la santé, Université du Québec en Abitibi-Témiscamingue, Rouyn-Noranda, Quebec, Canada; 2Faculté de pharmacie, Université Laval, Quebec, Quebec, Canada; 3Centre de recherche, CHU de Québec - Université Laval, Quebec, Quebec, Canada; 4Centre de recherche, Centre hospitalier de l’Université de Montréal (CRCHUM), Montreal, Quebec, Canada; 5Département d’anesthésiologie et de médecine de la douleur, Faculté de médecine, Université de Montréal, Montreal, Quebec, Canada; 6Faculté de pharmacie, Université de Montréal, Montreal, Quebec, CanadaCorrespondence: Anaïs Lacasse, Département des sciences de la santé, Université du Québec en Abitibi-Témiscamingue, 445, boul. de l’Université, Rouyn-Noranda, Qc, J9X 5E4, Canada, Tel +1 819 762-0971, 2722, Email lacassea@uqat.caPurpose: Polypharmacy can be defined as the concomitant use of ≥ 5 medications and excessive polypharmacy, as the use of ≥ 10 medications. …”
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Smoking, Urban Housing and Work-Aggravated Asthma are Associated with Asthma Severity in a Cross-Sectional Observational Study by Chevereau-Choquet M, Thoreau B, Taillé C, Marchand-Adam S, Morel H, Plantier L, Portel L

“…Marie Chevereau-Choquet,1 Benjamin Thoreau,2,3 Camille Taillé,4,5 Sylvain Marchand-Adam,1,6 Hugues Morel,7 Laurent Plantier,1,6,* Laurent Portel8,* 1Service de Pneumologie et Explorations Fonctionnelles Respiratoires, CHRU de Tours, Tours, France; 2Service de Médecine Interne, National Referral Center for Rare Systemic Autoimmune Diseases, AP-HP, Hôpital Cochin, Paris, France; 3Inserm U1016, CNRS UMR8104, Université Paris Cité, Institut Cochin, Paris, France; 4Service de Pneumologie A, AP-HP Nord, Hôpital Bichat Claude Bernard, Paris, France; 5Inserm U1152, Université Paris Cité, Paris, France; 6CEPR, Inserm UMR1100, Université de Tours, Tours, France; 7Service de Pneumologie, CHR d’Orléans, Orléans, France; 8Service de Pneumologie, Centre Hospitalier Robert Boulin, Libourne, France*These authors contributed equally to this workCorrespondence: Laurent Plantier, Service de Pneumologie et Explorations Fonctionnelles Respiratoires, CHRU de Tours, 2 Bd Tonnellé, Tours, 37044, France, Email laurent.plantier@univ-tours.frPurpose: Severe asthma affects 5 to 10% of asthmatics and accounts for a large part of asthma-related morbidity and costs. …”
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Adapting and Evaluating an AI-Based Chatbot Through Patient and Stakeholder Engagement to Provide Information for Different Health Conditions: Master Protocol for an Adaptive Platf... by Yuanchao Ma, Sofiane Achiche, Marie-Pascale Pomey, Jesseca Paquette, Nesrine Adjtoutah, Serge Vicente, Kim Engler, Moustafa Laymouna, David Lessard, Benoît Lemire, Jamil Asselah, Rachel Therrien, Esli Osmanlliu, Ma'n H Zawati, Yann Joly, Bertrand Lebouché

“…ResultsFrom July 2022 to October 2023, this master protocol led to four substudies conducted at the McGill University Health Centre or the Centre hospitalier de l’Université de Montréal (both in Montreal, Quebec, Canada): (1) MARVIN for HIV (large-scale implementation expected in mid-2024), (2) MARVIN-Pharma for community pharmacists providing HIV care (usability study planned for mid-2024), (3) MARVINA for breast cancer, and (4) MARVIN-CHAMP for pediatric infectious conditions (both in preparation, with development to begin in early 2024). …”
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Impact and cost of a 2-week community-based screening and awareness program for diabetes and cardiovascular risk factors in a Swiss canton by Bovet P, Hirsiger P, Emery F, De Bernardini J, Rossier C, Trebeljahr J, Hagon-Traub I

“…Pascal Bovet1, Philippe Hirsiger2, Frédéric Emery3, Jessica De Bernardini2, Christophe Rossier3, Josefine Trebeljahr2, Isabelle Hagon-Traub21Institute of Social and Preventive Medicine (IUMSP), University of Lausanne and Centre Universitaire Hospitalier Vaudois (CHUV), Lausanne, Switzerland; 2Public Health Service, Department of Health and Social Action, Canton of Vaud, Lausanne, Switzerland; 3Association of Pharmacists, Canton of Vaud, Lausanne, SwitzerlandBackground: Community-based diabetes screening programs can help sensitize the population and identify new cases. …”
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Subfertile patients underestimate their risk factors of reprotoxic exposure by Nadia Nouiakh, Claire Sunyach, Sarah-Lyne Jos, Irène Sari-Minodier, Catherine Metzler-Guillemain, Blandine Courbiere, Florence Bretelle, Jeanne Perrin

“…Resultats Dans notre centre hospitalier universitaire, 390 patients infertiles (185 hommes et 185 femmes) nécessitant un traitement d’AMP ont complété un auto-questionnaire avant la consultation, afin d’évaluer leurs connaissances sur les expositions reprotoxiques, leurs sources d’information sur ce sujet, et leur perception de leurs propres expositions. …”
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Program of Uncontrolled Donation After Circulatory Death as Potential Solution to the Shortage of Organs: A Canadian Single-Center Retrospective Cohort Study by D'Aragon F, Lachance O, Lafleur V, Ortega-Deballon I, Masse MH, Trepanier G, Lamarche D, Battista MC

“…Frederick D’Aragon,1,2 Olivier Lachance,1 Vincent Lafleur,1 Ivan Ortega-Deballon,3,4 Marie-Helene Masse,5 Gabrielle Trepanier,6 Daphnee Lamarche,1 Marie-Claude Battista5 1Department of Anesthesiology, Faculty of Medicine and Health Sciences Université de Sherbrooke, Sherbrooke, Quebec, Canada; 2Centre de recherche du Centre hospitalier universitaire de Sherbrooke, Sherbrooke, Quebec, Canada; 3Nursing Department, Faculty of Medicine and Health Sciences, Universidad de Alcalá, Madrid, Spain; 4Helicopter & Nursing Care Unit, Emergency Medical Service SUMMA 112, Madrid, Spain; 5Department of Medicine, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec, Canada; 6Department of Family Medicine and Emergency, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Quebec, CanadaCorrespondence: Frederick D’Aragon, 3001 12e Avenue N, Sherbrooke, PQ, J1H 5N4, Canada, Tel +1 819 821-8000 ext. 70103, Email Frederick.D’Aragon@USherbrooke.caPurpose: Worldwide, the number of patients waiting for organ transplantation exceeds the number of organs available. …”
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Randomized phase II trial in prostate cancer with hormone-sensitive OligometaSTatic relapse: Combining stereotactic ablative radiotherapy and durvalumab (POSTCARD GETUG P13): Study... by Maximilien Rogé, Yoann Pointreau, Paul Sargos, Emmanuel Meyer, Ulrike Schick, Ali Hasbini, Emmanuel Rio, Guillaume Bera, Amandine Ruffier, Magali Quivrin, Mathieu Chasseray, Igor Latorzeff, Etienne Martin, Valentine Guimas, Pascal Pommier, Thomas Leroy, Philippe Ronchin, Alexis Lepinoy, Audrey Grand, Lysian Cartier, Ossama Didas, Fabrice Denis, Vincent Libois, Audrey Blanc-Lapierre, Stéphane Supiot

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SARS-CoV-2 seroprevalence and living conditions in Bamako (Mali): a cross-sectional multistage household survey after the first epidemic wave, 2020 by Laurent Vidal, Emmanuel Bonnet, Ismaila Thera, Souleymane Sanogo, Luis Sagaon-Teyssier, Abdoulaye A Djimde, Issaka Sagara, Jordi Landier, Hubert Balique, Jean Gaudart, Marc-Karim Bendiane, Mady Cissoko, Bourema Kouriba, Abdoul Karim Sangare, Abdoulaye Katilé, Ibrahima Berthé, Siriman Traore, Maiga Hadiata, Elisabeth Sogodogo, Karyn Coulibaly, Abdoulaye Guindo, Ousmane Dembele, Zoumana Doumbia, Charles Dara, Mathias Altmann

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Occurrences of post-traumatic stress disorder, anxiety, depression, and burnout syndrome in ICU staff workers after two-year of the COVID-19 pandemic: the international PSY-CO in I... by Claire Roger, Lowel Ling, Mélissa Petrier, Loubna Elotmani, Enora Atchade, Bernard Allaouchiche, Frédéric Aubrun, Jean-Michel Constantin, Claire Dahyot-Fizelier, Nathalie Delhaye, Hervé Dupont, Marc-Olivier Fischer, Marc Garnier, Etienne Gayat, Carole Ichai, Samir Jaber, Jérome Morel, Benoit Plaud, Thomas Rimmelé, Sylvaine Robin, Renee Saba, Gavin M. Joynt, Jean-Yves Lefrant, Pascale Fabbro-Peray, Jeffrey Lipman, Ismael Conejero, Kevin Laupland

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Management and Survival of Elderly and Very Elderly Patients with Ovarian Cancer: An Age-Stratified Study of 1123 Women from the FRANCOGYN Group by Yolaine Joueidi, Ludivine Dion, Sofiane Bendifallah, Camille Mimoun, Alexandre Bricou, Krystel Nyangoh Timoh, Pierre Collinet, Cyril Touboul, Lobna Ouldamer, Henri Azaïs, Yohann Dabi, Cherif Akladios, Geoffroy Canlorbe, Pierre-Adrien Bolze, Hélène Costaz, Mathieu Mezzadri, Tristan Gauthier, Frederic Kridelka, Pauline Chauvet, Nicolas Bourdel, Martin Koskas, Xavier Carcopino, Emilie Raimond, Olivier Graesslin, Lise Lecointre, Marcos Ballester, Cyrille Huchon, Jean Levêque, Vincent Lavoué

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Understanding the potential of digital therapies in implementing the standard of care for depression in Europe by Philippe Courtet, Odile Amiot, Enrique Baca-Garcia, Lara Bellardita, Giancarlo Cerveri, Anne-Hélène Clair, Diego De Leo, Dominique Drapier, Eric Fakra, Francis Gheysen, Lucas Giner, Ana Gonzalez-Pinto, Gualberto Gussoni, Emmanuel Haffen, Laurent Lecardeur, Fermin Mayoral-Cleries, Francesco Saverio Mennini, Pilar A Sáiz, Eduard Vieta, Diego Alberto Hidalgo, Umberto Volpe

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Updates on radiotherapy-immunotherapy combinations: Proceedings of 6th annual ImmunoRad conference by Fabiana Gregucci, Sheila Spada, Mary Helen Barcellos-Hoff, Nina Bhardwaj, Charleen Chan Wah Hak, Alba Fiorentino, Chandan Guha, Monica L. Guzman, Kevin Harrington, Fernanda G. Herrera, Jamie Honeychurch, Theodore Hong, Lorea Iturri, Elisabeth Jaffee, Sana D. Karam, Simon R.V. Knott, Constantinos Koumenis, David Lyden, Ariel E. Marciscano, Alan Melcher, Michele Mondini, Anna Mondino, Zachary S. Morris, Sean Pitroda, Sergio A. Quezada, Laura Santambrogio, Stephen Shiao, John Stagg, Irma Telarovic, Robert Timmerman, Marie-Catherine Vozenin, Ralph Weichselbaum, James Welsh, Anna Wilkins, Chris Xu, Roberta Zappasodi, Weiping Zou, Alexandre Bobard, Sandra Demaria, Lorenzo Galluzzi, Eric Deutsch, Silvia C. Formenti

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The increase in cardiac output induced by a decrease in positive end-expiratory pressure reliably detects volume responsiveness: the PEEP-test study by Christopher Lai, Rui Shi, Alexandra Beurton, Francesca Moretto, Soufia Ayed, Nicolas Fage, Francesco Gavelli, Arthur Pavot, Martin Dres, Jean-Louis Teboul, Xavier Monnet

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