Impact of Exacerbation History on Dupilumab Efficacy in Children with Uncontrolled Moderate-to-Severe Asthma: LIBERTY ASTHMA VOYAGE Study by Guilbert TW, Tolcachier A, Fiocchi AG, Katelaris CH, Phipatanakul W, Begin P, de Mir I, Altincatal A, Gall R, Ledanois O, Radwan A, Jacob-Nara JA, Deniz Y, Rowe PJ

“…Theresa W Guilbert,1 Alberto Tolcachier,2 Alessandro G Fiocchi,3 Constance H Katelaris,4,5 Wanda Phipatanakul,6,7 Philippe Begin,8 Inés de Mir,9 Arman Altincatal,10 Rebecca Gall,11 Olivier Ledanois,12 Amr Radwan,11 Juby A Jacob-Nara,13 Yamo Deniz,11 Paul J Rowe13 1Department of Pediatrics, Cincinnati Children’s Hospital and University of Cincinnati, Cincinnati, OH, USA; 2Center for Allergy and Respiratory Diseases, Buenos Aires, Argentina; 3Bambino Gesù Children’s Hospital IRCCS, Rome, Italy; 4Department of Medicine, Campbelltown Hospital, Campbelltown, NSW, Australia; 5Immunology & Allergy Unit, Western Sydney University, Sydney, NSW, Australia; 6Department of Allergy and Immunology, Boston Children’s Hospital, Boston, MA, USA; 7Department of Pediatrics, Harvard Medical School, Boston, MA, USA; 8Centre Hospitalier Universitaire (CHU) Sainte-Justine, Montreal, QC, Canada; 9Pediatric Pulmonary Unit, Hospital Universitari Vall d’Hebron, Barcelona, Spain; 10Sanofi, Cambridge, MA, USA; 11Regeneron Pharmaceuticals Inc., Tarrytown, NY, USA; 12Sanofi, Paris, France; 13Sanofi, Bridgewater, NJ, USACorrespondence: Theresa W Guilbert, Cincinnati Children’s Hospital and University of Cincinnati, 3333 Burnet Ave, Cincinnati, OH, 45229, USA, Tel +1 513-636-6771, Email theresa.guilbert@cchmc.orgPurpose: Dupilumab, a fully human monoclonal antibody, blocks the shared receptor component for interleukins-4/-13, key and central drivers of type 2 inflammation in multiple diseases. …”
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Impact of Cardiovascular and Metabolic Comorbidities on Long-term Outcomes of Home-based Pulmonary Rehabilitation in COPD by Grosbois JM, Détrée A, Pierache A, Bautin N, Pérez T, Wallaert B, Chenivesse C, Le Rouzic O

“…Jean-Marie Grosbois,1 Axelle Détrée,2 Adeline Pierache,3,4 Nathalie Bautin,5,6 Thierry Pérez,5,6 Benoit Wallaert,5,6 Cécile Chenivesse,5,6 Olivier Le Rouzic5,6 1FormAction Santé, Pérenchies, F-59840, France; 2Groupe Hospitalier Loos Haubourdin, Réhabilitation Respiratoire, Loos, F-59120, France; 3Université de Lille, CHU Lille, ULR 2694 - METRICS: Évaluation des technologies de santé et des pratiques médicales, Lille, F-59000, France; 4CHU Lille, Department of Biostatistics, Lille, F-59000, France; 5Université de Lille, CHU Lille, CNRS, Inserm, Institut Pasteur de Lille, U1019 - UMR 9017 - CIIL - Center for Infection and Immunity of Lille, Lille, F-59000, France; 6CHU Lille, Pneumologie et Immuno-Allergologie, Centre de référence constitutif pour les maladies pulmonaires rares, Lille, F-59000, FranceCorrespondence: Olivier Le Rouzic, Pneumologie et Immuno-Allergologie, Institut Cœur Poumon, 1 boulevard Jules Leclercq, CHU de Lille, Lille, 59037, France, Tel +33 3 20 44 59 48, Fax +33 3 20 44 57 68, Email olivier.lerouzic@univ-lille.frBackground: Cardiovascular and metabolic comorbidities in chronic obstructive pulmonary disease (COPD) are associated with higher symptoms burden. …”
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Antibiotic Resistance of <i>Haemophilus influenzae</i> in Nasopharyngeal Carriage of Children with Acute Otitis Media and in Middle Ear Fluid from Otorrhea by Zein Assad, Robert Cohen, Emmanuelle Varon, Corinne Levy, Stéphane Bechet, François Corrard, Andreas Werner, Naïm Ouldali, Stéphane Bonacorsi, Alexis Rybak

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A small protein coded within the mitochondrial canonical gene nd4 regulates mitochondrial bioenergetics by Laura Kienzle, Stefano Bettinazzi, Thierry Choquette, Marie Brunet, Hajar Hosseini Khorami, Jean-François Jacques, Mathilde Moreau, Xavier Roucou, Christian R. Landry, Annie Angers, Sophie Breton

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Evidence for a competitive relationship between executive functions and statistical learning by Felipe Pedraza, Bence C. Farkas, Teodóra Vékony, Frederic Haesebaert, Romane Phelipon, Imola Mihalecz, Karolina Janacsek, Royce Anders, Barbara Tillmann, Gaën Plancher, Dezső Németh

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COVID-19-related mental health difficulties among marginalised populations: A literature review by Chaka Camara, Pamela J. Surkan, Judith Van Der Waerden, Andrea Tortelli, Naomi Downes, Cécile Vuillermoz, Maria Melchior

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Implementing the Point Spread Function Deconvolution for Better Molecular Characterization of Newly Diagnosed Gliomas: A Dynamic ¹⁸F-FDOPA PET Radiomics Study by Shamimeh Ahrari, Timothée Zaragori, Marie Bros, Julien Oster, Laetitia Imbert, Antoine Verger

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Predicting Disease Progression and Mortality in Aortic Stenosis: A Systematic Review of Imaging Biomarkers and Meta-Analysis by Alain Nchimi, Alain Nchimi, John E. Dibato, Laurent Davin, Laurent Schoysman, Cécile Oury, Patrizio Lancellotti, Patrizio Lancellotti

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The Quality of Discharge Summaries After Acute Kidney Injury by Cameron Giles, Milica Novakovic, Wilma Hopman, Erin F. Barreto, William Beaubien-Souligny, Peter Birks, Javier A. Neyra, Ron Wald, Samuel A. Silver

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Outcomes of Antifungal Prophylaxis in High-Risk Haematological Patients (AML under Intensive Chemotherapy): The SAPHIR Prospective Multicentre Study by Jean-Pierre Gangneux, Christophe Padoin, Mauricette Michallet, Emeline Saillio, Alexandra Kumichel, Régis Peffault de La Tour, Patrice Ceballos, Thomas Gastinne, Arnaud Pigneux

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Interrupted CAG expansions in ATXN2 gene expand the genetic spectrum of frontotemporal dementias by Clémence Fournier, Vincent Anquetil, Agnès Camuzat, Sandrine Stirati-Buron, Véronique Sazdovitch, Laura Molina-Porcel, Sabrina Turbant, Daisy Rinaldi, Raquel Sánchez-Valle, Mathieu Barbier, Morwena Latouche, Neuro-CEB Neuropathology Network, Giovanni Stevanin, Danielle Seilhean, Alexis Brice, Charles Duyckaerts, Isabelle Le Ber

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Application of a Novel Algorithm for Expanding Newborn Screening for Inherited Metabolic Disorders across Europe by Simon A. Jones, David Cheillan, Anupam Chakrapani, Heather J. Church, Simon Heales, Teresa H. Y. Wu, Georgina Morton, Patricia Roberts, Erica F. Sluys, Alberto Burlina

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Effectiveness of a Therapeutic Educational Oral Health Program for Persons with Schizophrenia: A Cluster Randomized Controlled Trial and Qualitative Approach by Frederic Denis, Corinne Rat, Lucie Cros, Valerie Bertaud, Wissam El-Hage, Lysiane Jonval, Agnès Soudry-Faure

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Satisfactory outcomes of patellar tendon reconstruction using achilles’ tendon allograft with bone block after infected total knee arthroplasty by Theofylaktos Kyriakidis, Charalampos Pitsilos, Jacques Hernigou, René Verdonk, Michael Hantes

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Suicidal Ideation of Healthcare Workers During COVID-19: An Ecological Momentary Assessment by Christine Genest, Nicolas Bergeron, Émilie Provost-Tremblay, Marie-Michèle Dufour, Stéphane Guay, Steve Geoffrion

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MHC Class II Expression Influences the Composition and Distribution of Immune Cells in the Metastatic Colorectal Cancer Microenvironment by Brian D. Griffith, Simon Turcotte, Jenny Lazarus, Fatima Lima, Samantha Bell, Lawrence Delrosario, Jake McGue, Santhoshi Krishnan, Morgan D. Oneka, Hari Nathan, J. Joshua Smith, Michael I. D’Angelica, Jinru Shia, Marina Pasca Di Magliano, Arvind Rao, Timothy L. Frankel

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Completeness and Mismatch of Patient-Important Outcomes After Trauma by Arthur James, MD, MSc, Philippe Ravaud, MD, PhD, Carolina Riveros, MSc, Mathieu Raux, MD, PhD, Viet-Thi Tran, MD, PhD

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Intrinsic foot joints adapt a stabilized-resistive configuration during the stance phase by Paul-André Deleu, Laurence Chèze, Raphaël Dumas, Jean-Luc Besse, Thibaut Leemrijse, Bernhard Devos Bevernage, Ivan Birch, Alexandre Naaim

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Computed tomography morphometric comparison of the pelvis in children with and without rectal prolapse in Niger by Salifou Seyni Taoueye, Innoussa Daouda Bako, Christel Laleye, Armel Hadonou, Alido Soumana, Habibou Abarchi, Yacouba Harouna Guimba, Sani Rachid, Gervais Hounnou, Augustin Agossou Voyeme, Christine Chappard

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Oligometastatic Disease Detection with ⁶⁸Ga-PSMA-11 PET/CT in Hormone-Sensitive Prostate Cancer Patients (HSPC) with Biochemical Recurrence after Radical Prostatectomy:... by Carlos Artigas, Romain Diamand, Qaid Ahmed Shagera, Nicolas Plouznikoff, Fabrice Fokoue, François-Xavier Otte, Thierry Gil, Alexandre Peltier, Dirk Van Gestel, Patrick Flamen

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