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Hox genes are not always Colinear
Published 2006-01-01“…Considering both the prototypical and derived deuterostome Hox clusters leads us to hypothesize that Temporal Colinearity is the main constraining force on Hox cluster organisation, but until we have a much deeper understanding of the mechanistic basis for this phenomenon, and know how widespread across the Bilateria the mechanism(s) is/are, then we cannot know how the Hox cluster of the last common bilaterian operated and what have been the major evolutionary forces operating upon the Hox gene cluster.</p>…”
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Seeking Sense in the Hox Gene Cluster
Published 2022-11-01“…The Hox gene cluster, responsible for patterning of the head–tail axis, is an ancestral feature of all bilaterally symmetrical animals (the Bilateria) that remains intact in a wide range of species. …”
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Octopod Hox genes and cephalopod plesiomorphies
Published 2023-09-01“…Here, we study developmental Hox and ParaHox gene expression in Octopus vulgaris. Hox genes are expressed in a near-to-staggered fashion, among others in homologous organs of cephalopods such as the stellate ganglia, the arms, or funnel. …”
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Anterior Hox Genes and the Process of Cephalization
Published 2021-08-01Subjects: “…Hox genes…”
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Duplicated Hox genes in the spider <it>Cupiennius salei</it>
Published 2007-03-01“…<p>Abstract</p> <p>Background</p> <p>Hox genes are expressed in specific domains along the anterior posterior body axis and define the regional identity. …”
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SNPs and Hox gene mapping in <it>Ciona intestinalis</it>
Published 2008-01-01“…This latter result represents an important platform for future studies on Hox genes showing deviations from the archetypal topology.…”
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An Overview of Hox Genes in Lophotrochozoa: Evolution and Functionality
Published 2016-03-01“…Hox genes are regulators of animal embryonic development. …”
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HOX Genes in High Grade Ovarian Cancer
Published 2019-08-01“…HOX genes are highly conserved members of the homeobox superfamily that have a crucial role in determining cellular identity. …”
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Hox gene evolution in nematodes: novelty conserved.
Published 2003“…The conserved homeobox (Hox) gene cluster is neither conserved nor clustered in the nematode Caenorhabditis elegans. …”
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Deciphering The Potential Role of Hox Genes in Pancreatic Cancer
Published 2019-05-01Subjects: “…Hox genes…”
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Hox gene regulation in the central nervous system of Drosophila
Published 2014-04-01Subjects: Get full text
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Physical Laws Shape Up HOX Gene Collinearity
Published 2021-05-01Subjects: “…hox gene collinearity…”
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Special Issue “Hox Genes in Development: New Paradigms”
Published 2022-08-01“…In this Special Issue on “Hox genes in development: new paradigms”, we present a compilation of articles and reviews tackling various aspects of the Hox biology field [...]…”
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HOX gene complement and expression in the planarian Schmidtea mediterranea
Published 2016-03-01“…Less well known is how planarians maintain spatial patterning in long-lived adult animals or how they re-pattern tissues during regeneration. HOX genes are good candidates to regulate planarian spatial patterning, yet the full complement or genomic clustering of planarian HOX genes has not yet been described, primarily because only a few have been detectable by in situ hybridization, and none have given morphological phenotypes when knocked down by RNAi. …”
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Uncoupling time and space in the collinear regulation of Hox genes.
Published 2009-03-01“…During development of the vertebrate body axis, Hox genes are transcribed sequentially, in both time and space, following their relative positions within their genomic clusters. …”
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Butterfly eyespot serial homology: enter the Hox genes
Published 2011-04-01“…<p>Abstract</p> <p>Hox genes modify serial homology patterns in many organisms, exemplified in vertebrates by modification of the axial skeleton and in arthropods by diversification of the body segments. …”
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The Enigmatic HOX Genes: Can We Crack Their Code?
Published 2019-03-01“…There are 39 genes in the subgroup of homeobox genes that constitute the human HOX gene family. Correct embryonic development of flies and vertebrates is, in part, mediated by the unique and highly regulated expression pattern of the HOX genes. …”
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Hox genes maintain critical roles in the adult skeleton
Published 2020“…Hox genes are indispensable for the proper patterning of the skeletal morphology of the axial and appendicular skeleton during embryonic development. …”
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