Targeting adrenergic receptors to mitigate invariant natural killer T cells-induced acute liver injury by Michelangelo Bauwelz Gonzatti, Beatriz Marton Freire, Maísa Mota Antunes, Gustavo Batista de Menezes, Jhimmy Talbot, Jean Pierre Schatzmann Peron, Alexandre Salgado Basso, Alexandre Castro Keller

“…Summary: Invariant Natural Killer T (iNKT) cell activation by α-galactosylceramide (αGC) potentiates cytotoxic immune responses against tumors. …”
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B cell receptor-mediated uptake of CD1d-restricted antigen augments antibody responses by recruiting invariant NKT cell help in vivo. by Barral, P, Eckl-Dorna, J, Harwood, N, De Santo, C, Salio, M, Illarionov, P, Besra, G, Cerundolo, V, Batista, F

“…Subsequently, iNKT cells provide the help required for stimulating B cell proliferation and differentiation. iNKT-stimulated B cells develop within extrafollicular foci and mediate the production of high titers of specific IgM and early class-switched antibodies. …”

Characterisation of expression and function of respiratory epithelial CD1d by Hajipouran Benam, K

“…I hypothesized that CD1d is expressed on REC and that it contributes to activation of iNKT cells in the lungs via presentation of endogenous or pathogenic glycolipids. …”

Activation of Invariant Natural Killer T Cells Redirects the Inflammatory Response in Neonatal Sepsis by Alexandra C. Bolognese, Alexandra C. Bolognese, Weng-Lang Yang, Weng-Lang Yang, Weng-Lang Yang, Laura W. Hansen, Archna Sharma, Jeffrey M. Nicastro, Gene F. Coppa, Ping Wang, Ping Wang, Ping Wang

“…We hypothesized that iNKT cells would play an important role in mediating the neonatal immune response to sepsis. …”
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Lipoproteins act as vehicles for lipid antigen delivery and activation of invariant natural killer T cells by Suzanne E. Engelen, Francesca A. Ververs, Angela Markovska, B. Christoffer Lagerholm, Jordan M. Kraaijenhof, Laura I.E. Yousif, Yasemin-Xiomara Zurke, Can M.C. Gulersonmez, Sander Kooijman, Michael Goddard, Robert J. van Eijkeren, Peter J. Jervis, Gurdyal S. Besra, Saskia Haitjema, Folkert W. Asselbergs, Eric Kalkhoven, Hidde L. Ploegh, Marianne Boes, Vincenzo Cerundolo, G.K. Hovingh, Mariolina Salio, Edwin C.A. Stigter, Patrick C.N. Rensen, Claudia Monaco, Henk S. Schipper

“…Invariant natural killer T (iNKT) cells act at the interface between lipid metabolism and immunity because of their restriction to lipid antigens presented on CD1d by antigen-presenting cells (APCs). …”
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Lipoproteins act as vehicles for lipid antigen delivery and activation of invariant natural killer T cells by Engelen, SE, Ververs, FA, Markovska, A, Lagerholm, BC, Kraaijenhof, JM, Yousif, LI, Zurke, Y-X, Gulersonmez, CM, Kooijman, S, Goddard, M, van Eijkeren, RJ, Jervis, PJ, Besra, GS, Haitjema, S, Asselbergs, FW, Kalkhoven, E, Ploegh, HL, Boes, M, Cerundolo, V, Hovingh, GK, Salio, M, Stigter, EC, Rensen, PC, Monaco, C, Schipper, HS

“…Invariant natural killer T (iNKT) cells act at the interface between lipid metabolism and immunity because of their restriction to lipid antigens presented on CD1d by antigen-presenting cells (APCs). …”

Saposins modulate human invariant Natural Killer T cells self-reactivity and facilitate lipid exchange with CD1d molecules during antigen presentation. by Salio, M, Ghadbane, H, Dushek, O, Shepherd, D, Cypen, J, Gileadi, U, Aichinger, M, Napolitani, G, Qi, X, Van Der Merwe, P, Wojno, J, Veerapen, N, Cox, L, Besra, G, Yuan, W, Cresswell, P, Cerundolo, V

“…Although it has been shown that prosaposin-deficient mice fail to positively select invariant natural killer T (iNKT) cells, it remains unclear whether saposins can facilitate loading of endogenous iNKT cell agonists in the periphery during inflammatory responses. …”

A phase 1/2 clinical trial of invariant natural killer T cell therapy in moderate-severe acute respiratory distress syndrome by Terese C. Hammond, Marco A. Purbhoo, Sapana Kadel, Jerome Ritz, Sarah Nikiforow, Heather Daley, Kit Shaw, Koen van Besien, Alexandra Gomez-Arteaga, Don Stevens, Waldo Ortuzar, Xavier Michelet, Rachel Smith, Darrian Moskowitz, Reed Masakayan, Burcu Yigit, Shannon Boi, Kah Teong Soh, John Chamberland, Xin Song, Yu Qin, Ilya Mishchenko, Maurice Kirby, Valeriia Nasonenko, Alexa Buffa, Jennifer S. Buell, Dhan Chand, Marc van Dijk, Justin Stebbing, Mark A. Exley

“…Abstract Invariant natural killer T (iNKT) cells, a unique T cell population, lend themselves for use as adoptive therapy due to diverse roles in orchestrating immune responses. …”
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The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation. by McCarthy, C, Shepherd, D, Fleire, S, Stronge, V, Koch, M, Illarionov, P, Bossi, G, Salio, M, Denkberg, G, Reddington, F, Tarlton, A, Reddy, BG, Schmidt, R, Reiter, Y, Griffiths, G, Van Der Merwe, P, Besra, G, Jones, E, Batista, F, Cerundolo, V

“…We extended this analysis by studying iNKT cell synapse formation and iNKT cell activation by the same panel of alpha-GalCer analogues. …”

Structure and binding kinetics of three different human CD1d-alpha-galactosylceramide-specific T cell receptors. by Gadola, S, Koch, M, Marles-Wright, J, Lissin, N, Shepherd, D, Matulis, G, Harlos, K, Villiger, P, Stuart, D, Jakobsen, B, Cerundolo, V, Jones, E

“…Invariant human TCR Valpha24-Jalpha18+/Vbeta11+ NKT cells (iNKT) are restricted by CD1d-alpha-glycosylceramides. …”

Nonglycosidic agonists of invariant NKT cells for use as vaccine adjuvants. by Reddy, BG, Silk, J, Salio, M, Balamurugan, R, Shepherd, D, Ritter, G, Cerundolo, V, Schmidt, R

“…Based on the crystal structures of human alpha-GalCer-CD1d and iNKT-alpha-GalCer-CD1d complexes, nonglycosidic analogues of alpha-GalCer were synthesized. …”

Deep immunophenotyping of natural killer T(NKT) cells in tumor microenviroment of heptatocellular carcinoma(HCC) by Subramaniam, Shaalini

“…Secondly, when compared to the NT compartment, CD4+iNKT cells were particularly enriched in tumor. Thirdly, the expression of IL22 by tumor-enriched iNKT cells when activated ex vivo may indicate a potential role for tumor progression. …”
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The Framework for Human Host Immune Responses to Four Types of Parasitic Infections and Relevant Key JAK/STAT Signaling by Tsung-Han Wen, Kuo-Wang Tsai, Yan-Jun Wu, Min-Tser Liao, Kuo-Cheng Lu, Wan-Chung Hu

“…For free-living extracellular protozoa, the eradicable host immunological pathway is TH22 immunity involving neutrophils (N1), interleukin-22 CD4 T cells, innate lymphoid cells 3 (NCR+ ILC3), iNKT17 cells, and IgG2 B cells. For free-living extracellular protozoa, the tolerable host immunological pathway is TH17 immunity involving neutrophils (N2), interleukin-17 CD4 T cells, innate lymphoid cells 3 (NCR- ILC3), iNKT17 cells, and IgA2 B cells. …”
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A potent adjuvant effect of a CD1d-binding NKT cell ligand in human immune system mice by Xiangming Li, Jing Huang, Izumi Kaneko, Min Zhang, Shiroh Iwanaga, Masao Yuda, Moriya Tsuji

“…Objectives: A CD1d-binding invariant natural killer T (iNKT)-cell stimulatory glycolipid, namely 7DW8-5, is shown to enhance the efficacy of radiation-attenuated sporozoites (RAS)-based malaria vaccine in mice. …”
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Harnessing invariant NKT cells in vaccination strategies. by Cerundolo, V, Silk, J, Masri, S, Salio, M

“…In addition, we describe structural and kinetic analyses that assist in the design of optimal iNKT-cell agonists that could be used in the clinical setting as vaccine adjuvants.…”

Nanomapping of CD1d-glycolipid complexes on THP1 cells by using simultaneous topography and recognition imaging. by Duman, M, Chtcheglova, L, Zhu, R, Bozna, B, Polzella, P, Cerundolo, V, Hinterdorfer, P

“…TREC was conducted using magnetically coated atomic force microscopy tips functionalized with a biotinylated iNKT cell receptor (TCR). The recognition map revealed binding sites visible as dark spots, resulting from oscillation amplitude reduction during specific binding between iNKT TCR and the CD1d-glycolipid complex. …”

Type 1 invariant natural killer T cells in chronic inflammation and tissue fibrosis by Vipin Kumar, Vipin Kumar, Marc Hertz, Albert Agro, Adam J. Byrne, Adam J. Byrne

“…Thus, targeting a pathway upstream of these immune mechanisms, such as the inhibition of iNKT activation, may be important in modulating various fibrotic conditions.…”
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Diversity-Oriented Synthesis of a Molecular Library of Immunomodulatory α-Galactosylceramides with Fluorous-Tag-Assisted Purification and Evaluation of Their Bioactivities in Regar... by Yeng-Nan Chen, Jung-Tung Hung, Fan-Dan Jan, Yung-Yu Su, Jih-Ru Hwu, Alice L. Yu, Avijit K. Adak, Chun-Cheng Lin

“…Structural variants of α-galactosylceramide (α-GalCer) that stimulate invariant natural killer T (iNKT) cells constitute an emerging class of immunomodulatory agents in development for numerous biological applications. …”
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Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A. by De Santo, C, Arscott, R, Booth, S, Karydis, I, Jones, M, Asher, R, Salio, M, Middleton, M, Cerundolo, V

“…Because SAA-1-producing melanomas promoted differentiation of IL-10-secreting neutrophils, harnessing iNKT cells could be useful therapeutically by decreasing the frequency of immunosuppressive neutrophils and restoring tumor-specific immune responses.…”

Biology of CD1- and MR1-restricted T cells. by Salio, M, Silk, J, Jones, E, Cerundolo, V

“…In this review, we describe the most recent events in the field, with particular emphasis on (a) structural and functional aspects of lipid presentation by CD1 molecules, (b) the development of CD1d-restricted invariant natural killer T (iNKT) cells and transcription factors required for their differentiation, (c) the ability of iNKT cells to modulate innate and adaptive immune responses through their cross talk with lymphoid and myeloid cells, and (d) MR1-restricted and group I (CD1a, CD1b, and CD1c)-restricted T cells.…”