Early innate cell interactions with Mycobacterium tuberculosis in protection and pathology of tuberculosis by Poornima Sankar, Bibhuti Bhusan Mishra

“…This review underscores the interactions between Mtb and various innate immune cells, such as macrophages, dendritic cells, granulocytes, NK cells, innate lymphocytes-iNKT and ILCs. In addition, the contribution of alveolar epithelial cell and endothelial cells that constitutes the mucosal barrier in TB immunity will be discussed. …”
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Activation and in vivo evolution of the MAIT cell transcriptome in mice and humans reveals tissue repair functionality by Hinks, T, Marchi, E, Jabeen, M, Olshanksy, M, Kurioka, A, Pediongco, T, Meehan, B, Kostenko, L, Turner, S, Corbett, A, Chen, Z, Klenerman, P, McCluskey, J

“…Transcriptomes of MAIT cells and H2-M3-specific CD8+ T cells displayed the most similarities to invariant natural killer T (iNKT) cells when activated, but to γδ T cells after the resolution of infection. …”

Alpha-galactosylceramide (αGalCer) enhances vaccine-induced protection in a model of ricin intoxication by Jennifer L. Yates, Elizabeth Leadbetter, Nicholas J. Mantis

“…Alpha-galactosylceramide (αGalCer) is a glycolipid derived from a marine sponge that is a potent activator of both mouse and human invariant natural killer T (iNKT) cells. For that reason, αGalCer is a promising vaccine adjuvant that has been shown to improve both humoral and cellular immunity when co-administered with various vaccines, including candidate vaccines for biodefense. …”
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Key Factors for Thymic Function and Development by Valentin P. Shichkin, Mariastefania Antica

“…These include the MHC restricted single positive CD4+ CD8- and CD4- CD8+ cells, regulatory T lymphocytes (Foxp3+), innate natural killer T cells (iNKT), and γδT cells. Several physiological causes comprising stress and aging and medical treatments such as thymectomy and chemo/radiotherapy can harm the thymus function. …”
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Myelin Recovery in Multiple Sclerosis: The Challenge of Remyelination by Edward L. Hogan, Ewa Kurowska, Naren L. Banik, Maria Podbielska

“…The crucial question of why remyelination fails is approached is several ways by examining the role in remyelination of available MS medications and avenues being actively pursued to promote remyelination including: (i) cytokine-based immune-intervention (targeting calpain inhibition), (ii) antigen-based immunomodulation (targeting glycolipid-reactive iNKT cells and sphingoid mediated inflammation) and (iii) recombinant monoclonal antibodies-induced remyelination.…”
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Tissue-Resident Lymphocytes: Implications in Immunotherapy for Hepatocellular Carcinoma by Ji Won Han, Seung Kew Yoon

“…In addition, the role of other tissue-resident populations such as tissue resident regulatory T (Treg) cells, mucosal associated invariant T (MAIT) cells, γδ T cells, and invariant natural killer T (iNKT) cells in anti-tumor immunity is also actively being investigated. …”
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Recent Development in NKT-Based Immunotherapy of Glioblastoma: From Bench to Bedside by Yutao Li, Amit Sharma, Jarek Maciaczyk, Ingo G. H. Schmidt-Wolf

“…Among cancer immunotherapeutic approaches, we propose that adjuvant NKT immunotherapy with invariant NKT (iNKT) and cytokine-induced killer (CIK) cells may improve the clinical scenario of this devastating disease. …”
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The VITAL assay: a versatile fluorometric technique for assessing CTL- and NKT-mediated cytotoxicity against multiple targets in vitro and in vivo. by Hermans, I, Silk, J, Yang, J, Palmowski, M, Gileadi, U, McCarthy, C, Salio, M, Ronchese, F, Cerundolo, V

“…We show that this assay, referred to as the VITAL assay, can be used to assess cytotoxic activity of CTL and iNKT cells in vivo and in vitro. CTL responses measured in vivo could be correlated with antigen doses used in immunization strategies, and also with the size of specific CTL populations enumerated in the blood with fluorescent MHC/peptide tetramers. …”

Protocol to isolate mature thymic T cell subsets using fluorescence-activated cell sorting for assessing gene expression by RNA-seq and transcription factor binding across the geno... by Dimitris Theofilatos, Tarmo Äijö, Ageliki Tsagaratou

“…Summary: Here, we describe steps to isolate mature thymic T cell subsets, namely CD4 single positive (SP), CD8 SP, and invariant natural killer T (iNKT) cells starting from murine total thymocytes using fluorescence-activated cell sorting. …”
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PLZF controls the expression of a limited number of genes essential for NKT cell function by Michael eGleimer, Harald eVon Boehmer, Taras eKreslavsky

“…Expression of the transcriptional regulators Id2, previously shown to be required for iNKT cell survival in the liver and c-Maf, which shapes the NKT cytokine profile, was compromised in PLZF-deficient cells. …”
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The immune modulating properties of mucosal-associated invariant T cells by Ioannidis, M, Cerundolo, V, Salio, M

“…MAIT cells belong to the innate like T family of cells with a memory phenotype, which allows them to rapidly release Interferon (IFN)-γ, tumor necrosis factor (TNF)-α, and in some circumstances Interleukin (IL)-17 and IL-10, exerting an immunomodulatory role on the ensuing immune response, akin to iNKT cells and γδ T cells. Recent studies implicate MAIT cells in a variety of inflammatory, autoimmune diseases, and in cancer. …”

Recognition of <i>Candida albicans</i> and Role of Innate Type 17 Immunity in Oral Candidiasis by Anna Pavlova, Irshad Sharafutdinov

“…The study discusses recent advances in research of the interleukin-17 (IL-17) producing innate cells, including natural T helper 17 (nTh17) cells, γδ T cells, invariant natural killer T (iNKT) cells and type 3 innate lymphoid cells (ILC3) that are involved in response to oral <i>C. albicans</i> infections.…”
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Reconstitution of T Cell Subsets Following Allogeneic Hematopoietic Cell Transplantation by Linde Dekker, Coco de Koning, Caroline Lindemans, Stefan Nierkens

“…Here, we review the current knowledge regarding CD4⁺ and CD8⁺ T cells, γδ T cells, iNKT cells, Treg cells, MAIT cells and naive and memory T cell reconstitution, as well as their relations to outcome, considering different cell sources and immunosuppressive therapies. …”
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Mecanismos inmunológicos implicados en la patología del asma alérgica by Fredy Alexander Pazmiño, Myriam Lucía Navarrete Jiménez

“…Las células que, en el momento, están implicadas en la cascada inflamatoria del asma atópica son: células epiteliales de la vía aérea, las diferentes subpoblaciones de células T y B, mastocitos, células dendríticas, eosinófilos, basófilos, macrófagos, células iNKT y plaquetas, además de la red de citoquinas, quimioquinas y señales co-estimulatorias y regulatorias correspondientes a cada una de las subpoblaciones celulares que orquestan este proceso. …”
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Co-delivery of PLGA encapsulated invariant NKT cell agonist with antigenic protein induce strong T cell-mediated antitumor immune responses by Dölen, Y, Kreutz, M, Gileadi, U, Tel, J, Vasaturo, A, van Dinther, E, Hout-Kuijer, v, Cerundolo, V, Figdor, C

“…Here, we compared the efficacy of the invariant NKT (iNKT) cell agonist α-galactosylceramide (α-GalCer) and TLR ligands (R848 and poly I:C) as an adjuvant for the full length ovalbumin (OVA) in PLGA nanoparticles. …”

MAIT Cells Come to the Rescue in Cancer Immunotherapy? by Zuzanna Lukasik, Dirk Elewaut, Koen Venken

“…This is discussed through the prism of knowledge and experiences with invariant natural killer T cells (iNKT)&#8212;another prominent unconventional T cell subset that shares many features with MAIT cells.…”
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Non-Conventional Allogeneic Anti-BCMA Chimeric Antigen Receptor-Based Immune Cell Therapies for Multiple Myeloma Treatment by Zhicheng Du, Sumin Zhu, Xi Zhang, Zhiyuan Gong, Shu Wang

“…In general, anti-BCMA CAR gene-edited αβ T cells and CAR-Natural Killer (NK) cells are at the forefront, with multiple clinical trials ongoing, while CAR-γδ T cells and CAR-invariant Natural Killer T (iNKT) cells are still in pre-clinical studies. Other immune cells such as macrophages, B cells, and dendritic cells have been mainly developed to target other antigens and have the potential to be used to target BCMA. …”
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Fibroblastic reticular cells mitigate acute GvHD via MHCII-dependent maintenance of regulatory T cells by Haroon Shaikh, Joern Pezoldt, Zeinab Mokhtari, Juan Gamboa Vargas, Duc-Dung Le, Josefina Peña Mosca, Estibaliz Arellano Viera, Michael A.G. Kern, Caroline Graf, Niklas Beyersdorf, Manfred B. Lutz, Angela Riedel, Maike Büttner-Herold, Alma Zernecke, Hermann Einsele, Antoine-Emmanuel Saliba, Burkhard Ludewig, Jochen Huehn, Andreas Beilhack

“…Animals lacking MHCII expression on Ccl19-Cre–expressing FRCs (MHCIIΔCcl19) showed aberrant CD4+ T cell activation in the effector phase, resulting in exacerbated aGvHD that was associated with significantly reduced expansion of Foxp3+ Tregs and invariant NK T (iNKT) cells. Skewed Treg maintenance in MHCIIΔCcl19 mice resulted in loss of protection from aGvHD provided by adoptively transferred donor Tregs. …”
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Natural Killer T Cell Diversity and Immunotherapy by Eduardo I. Tognarelli, Cristián Gutiérrez-Vera, Pablo A. Palacios, Ignacio A. Pasten-Ferrada, Fernanda Aguirre-Muñoz, Daniel A. Cornejo, Pablo A. González, Leandro J. Carreño

“…In this review, we summarize key features of iNKTs and current understandings of modulatory α-galactosylceramide (α-GalCer) variants, a model iNKT cell activator that can shift the outcome of adaptive immune responses. …”
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Development of Stem Cell-Derived Immune Cells for Off-the-Shelf Cancer Immunotherapies by Yan-Ruide Li, Zachary Spencer Dunn, Yang Zhou, Derek Lee, Lili Yang

“…In this review, we discuss recent advances in developing stem cell-engineered allogeneic cell therapies that aim to overcome the limitations of current autologous and allogeneic cell therapies, with a special focus on stem cell-engineered conventional αβ T cells, unconventional T (iNKT, MAIT, and γδ T) cells, and natural killer (NK) cells.…”
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