The role of natural killer T cells in atherosclerosis by Engelen, SE

“…It proposes innovative imaging modalities to study the APC-iNKT axis in the human plaque, and associates NKT plaque-abundance with clinical parameters for the first time. …”

IL-1 and IL-23 mediate early IL-17A production in pulmonary inflammation leading to late fibrosis. by Paméla Gasse, Nicolas Riteau, Rachel Vacher, Marie-Laure Michel, Alain Fautrel, Franco di Padova, Lizette Fick, Sabine Charron, Vincent Lagente, Gérard Eberl, Marc Le Bert, Valérie F J Quesniaux, François Huaux, Maria Leite-de-Moraes, Bernhard Ryffel, Isabelle Couillin

“…Using FACS analysis, we show a very early IL-17A and IL-17F expression by RORγt(+) γδ T cells and to a lesser extent by CD4αβ(+) T cells, but not by iNKT cells, 24 hrs after BLM administration. Moreover, IL-23p19 and IL-17A expressions or IL-17RA signaling are necessary to pulmonary TGF-β1 production, collagen deposition and evolution to fibrosis.…”
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Phage display-derived recombinant antibodies with TCR-like specificity against alpha-galactosylceramide and its analogues in complex with human CD1d molecules. by Denkberg, G, Stronge, V, Zahavi, E, Pittoni, P, Oren, R, Shepherd, D, Salio, M, McCarthy, C, Illarionov, P, van der Merwe, A, Besra, G, Dellabona, P, Casorati, G, Cerundolo, V, Reiter, Y

“…The glycolipid alpha-galactosylceramide (alpha-GalCer) is a potent activator of invariant natural killer T (iNKT) cells and has been shown to be an effective agent against cancer, infections and autoimmune diseases. …”

Thalidomide Exerts Anti-Inflammatory Effects in Cutaneous Lupus by Inhibiting the IRF4/NF-ҡB and AMPK1/mTOR Pathways by Sandra Domingo, Cristina Solé, Teresa Moliné, Berta Ferrer, Josefina Cortés-Hernández

“…Immune cell subset analysis in thalidomide’s CLE responder patients showed a reduction of circulating and tissue cytotoxic T-cells with an increase of iNKT cells and a shift towards a Th2 response. We conducted an RNA-sequencing study using CLE skin biopsies performing a Therapeutic Performance Mapping System (TMPS) analysis in order to generate a predictive model of its mechanism of action and to identify new potential therapeutic targets. …”
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Alterations of Specific Lymphocytic Subsets with Aging and Age-Related Metabolic and Cardiovascular Diseases by Ying Jen Chen, Yi Jen Liao, Van Thi Ngoc Tram, Chung Hao Lin, Kuo Chen Liao, Chao Lien Liu

“…The frequencies of CD3T, CD8T and invariant natural killer T (iNKT) cells were decreased in the EH, E-MD and E-CVD cohorts, indicating a decline in defense function. …”
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Mucosal-associated invariant T cell alterations during the development of human type 1 diabetes by Ahmad Mahfuz, Gazali, Schroderus, Anna-Mari, Salonen, Kirsti Näntö, Rintamäki, Reeta, Pihlajamäki, Jussi, Knip, Mikael, Veijola, Riitta, Toppari, Jorma, Ilonen, Jorma, Kinnunen, Tuure

“…Methods We analysed the frequency, phenotype and functionality of peripheral bloodMAIT cells, as well as γδ T cells, invariant natural killer T (iNKT) cells and natural killer (NK) cells with flow cytometry in a cross-sectional paediatric cohort (aged 2–15) consisting of 51 children with newly diagnosed type 1 diabetes, 27 autoantibody-positive (AAb+) at-risk children, and 113 healthy control children of similar age and HLA class II background. …”
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Immunotherapy and immunomodulation for haematological malignancies by Mussai, F, Dr Francis Mussai

“…Finally, invariant Natural Killer T cells (iNKT) were shown to be cytotoxic to some AML blasts, in the presence of alpha Galactosylceramide, and thus able to restore T cell proliferation.…”

Targeting MYC in combination with epigenetic regulators induces synergistic anti-leukemic effects in MLLr leukemia and simultaneously improves immunity by Rahel Fitzel, Kathy-Ann Secker-Grob, Hildegard Keppeler, Fulya Korkmaz, Rebekka Schairer, Estelle Erkner, Dominik Schneidawind, Claudia Lengerke, Thomas Hentrich, Julia M. Schulze-Hentrich, Corina Schneidawind

“…Moreover, we found activation of T, NK and iNKT cells, release of immunomodulatory cytokines and downregulation of the PD-1/PD-L1 axis upon inhibitor treatment leading to improved cytotoxicity.In summary, the inhibition of MYC and MAT2A or PRMT5 drives robust synergistic anti-leukemic activity in MLLr leukemia. …”
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The role of DOCK8 in the maintenance of CD8+ T cell memory and invariant NKT cells by Crawford, G

“…In addition to the loss of peripheral T cells, rare populations of lymphocytes such as invariant natural killer T cells (iNKT) were also reduced in the liver and thymus. …”

Neuroimmune Responses in a New Experimental Animal Model of Cerebral Aspergillosis by Brianne N. Sullivan, Mia A. Baggett, Christa Guillory, MaryJane Jones, Chad Steele

“…The IN + IV + steroid group demonstrated significant decreases in monocytes, eosinophils, dendritic cells (DCs), and invasive natural killer T (iNKT) cells, but not neutrophils or γδ T cells, in the brain compared to the IN + IV group. …”
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Convergence, plasticity, and tissue residence of regulatory T cell response via TCR repertoire prism by Tatyana O Nakonechnaya, Bruno Moltedo, Ekaterina V Putintseva, Sofya Leyn, Dmitry A Bolotin, Olga V Britanova, Mikhail Shugay, Dmitriy M Chudakov

“…This transition includes a dominant tumor-responding eCD4 CDR3 motif, as well as characteristic iNKT TCRα CDR3. In addition, we examine the homeostatic tissue residency of clonal eTreg populations by excluding the site of challenge from our analysis. …”
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Transmitted Fetal Immune Response in Cases of SARS-CoV-2 Infections during Pregnancy by Ernesto González-Mesa, Eduardo García-Fuentes, Rafael Carvia-Pontiasec, Ana I. Lavado-Fernández, Celia Cuenca-Marín, María Suárez-Arana, Marta Blasco-Alonso, Blanca Benítez-Lara, Laura Mozas-Benítez, Ana González-Cazorla, Herink Egeberg-Neverdal, Jesús S. Jiménez-López

“…Lymphocyte subsets were studied according to CD3, CD8, CD4, CD34, and invariant natural Killer T cells (iNKT) markers. We used in situ hybridization techniques for the detection of viral RNA in placentas. (3) Results: During the study period, 79 pregnant women and their corresponding newborns were recruited. …”
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Activation and In Vivo Evolution of the MAIT Cell Transcriptome in Mice and Humans Reveals Tissue Repair Functionality by Timothy S.C. Hinks, Emanuele Marchi, Maisha Jabeen, Moshe Olshansky, Ayako Kurioka, Troi J. Pediongco, Bronwyn S. Meehan, Lyudmila Kostenko, Stephen J. Turner, Alexandra J. Corbett, Zhenjun Chen, Paul Klenerman, James McCluskey

“…Transcriptomes of MAIT cells and H2-M3-specific CD8+ T cells displayed the most similarities to invariant natural killer T (iNKT) cells when activated, but to γδ T cells after the resolution of infection. …”
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Profiling ovarian cancer tumor and microenvironment during disease progression for cell-based immunotherapy design by Yan-Ruide Li, Christopher J. Ochoa, Yichen Zhu, Adam Kramer, Matthew Wilson, Ying Fang, Yuning Chen, Tanya Singh, Gabriella Di Bernardo, Enbo Zhu, Derek Lee, Neda A. Moatamed, Joanne Bando, Jin J. Zhou, Sanaz Memarzadeh, Lili Yang

“…Notably, we identified CD1d as a biomarker of the OC microenvironment and demonstrated its targeting by invariant natural killer T (iNKT) cells. Overall, our study presents a comprehensive immuno-profiling of OC tumor and microenvironment during disease progression, guiding the development of immunotherapies for OC treatment, especially for recurrent disease.…”
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CD4+ T cell-derived IL-22 enhances liver metastasis by promoting angiogenesis by Tao Zhang, Ramez Wahib, Dimitra E. Zazara, Jöran Lücke, Ahmad Mustafa Shiri, Jan Kempski, Lilan Zhao, Theodora Agalioti, Andres Pablo Machicote, Olympia Giannou, Ioannis Belios, Rongrong Jia, Siwen Zhang, Joseph Tintelnot, Hannes Seese, Julia Kristin Grass, Baris Mercanoglu, Louisa Stern, Pasquale Scognamiglio, Mohammad Fard-Aghaie, Philipp Seeger, Jonas Wakker, Marius Kemper, Benjamin Brunswig, Anna Duprée, Panagis M. Lykoudis, Anastasia Pikouli, Emmanouil Giorgakis, Pablo Stringa, Natalia Lausada, Maria Virginia Gentilini, Gabriel E. Gondolesi, Kai Bachmann, Philipp Busch, Rainer Grotelüschen, Ioannis C. Maroulis, Petra C. Arck, Ryosuke Nakano, Angus W. Thomson, Tarik Ghadban, Michael Tachezy, Nathaniel Melling, Eike-Gert Achilles, Victor G. Puelles, Felix Nickel, Thilo Hackert, Oliver Mann, Jakob R. Izbicki, Jun Li, Nicola Gagliani, Samuel Huber, Anastasios D. Giannou

“…We previously found that IL-22 produced by tissue resident iNKT17 cells promotes cancer cell extravasation, the early step of metastasis. …”
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