Non-glycosidic compounds can stimulate both human and mouse iNKT cells. by Jukes, J, Gileadi, U, Ghadbane, H, Yu, T, Shepherd, D, Cox, L, Besra, G, Cerundolo, V

“…Invariant natural killer T (iNKT) cells recognize CD1d/glycolipid complexes and upon activation with synthetic agonists display immunostimulatory properties. …”

Melanoma Cells Inhibit iNKT Cell Functions via PGE2 and IDO1 by Enza Torre, Giulia Pinton, Grazia Lombardi, Silvia Fallarini

Subjects: “…iNKT cells…”
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Towards a better understanding of human iNKT cell subpopulations for improved clinical outcomes by Alex Look, Daniel Burns, Ivo Tews, Ivo Tews, Ali Roghanian, Ali Roghanian, Salah Mansour, Salah Mansour

Subjects: “…iNKT cell…”
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EARLY TREATMENT-NAIVE RHEUMATOID ARTHRITIS IS CHARACTERIZED BY QUALITATIVE CHANGES OF THE INKT REGULATORY CELL REPERTOIRE by Mansour, S, Tocheva, A, Goulston, L, Platten, H, Edwards, C, Cooper, C, Gadola, S

Parallel Session 8: Molecular and clinical interfaces of invariant natural killer T cells (iNKT) by Denney, L, Cole, S, McMichael, A, Ho, L

Lack of PD-L1 expression by iNKT cells improves the course of influenza A infection. by Hadi Maazi, Abinav K Singh, Anneliese O Speak, Vincent Lombardi, Jonathan Lam, Bryant Khoo, Kyung Soo Inn, Arlene H Sharpe, Jae U Jung, Omid Akbari

“…There is evidence indicating that invariant Natural Killer T (iNKT) cells play an important role in defense against influenza A virus (IAV). …”
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Uhrf1 Controls iNKT Cell Survival and Differentiation through the Akt-mTOR Axis by Yu Cui, Xufeng Chen, Jiali Zhang, Xiang Sun, Haifeng Liu, Li Bai, Chenqi Xu, Xiaolong Liu

“…Here, we report that Uhrf1 is essential for invariant natural killer T (iNKT) cell development. We found that Uhrf1 was significantly upregulated in stage 1 iNKT cells. …”
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Tissue-specific metabolic profile drives iNKT cell function during obesity and liver injury by Cristhiane Favero Aguiar, Felipe Corrêa-da-Silva, Michelangelo Bauwelz Gonzatti, Monara Kaelle Angelim, Marco Antonio Pretti, Gustavo Gastão Davanzo, Bianca Gazieri Castelucci, Lauar Brito Monteiro, Gisele Castro, João Victor Virgilio-da-Silva, Guilherme Ribeiro, Vitor Jaccomo, Mirella C. Pereira Andrade, Webster Leonardo Costa, Victor Gambarini, Fernanda Fernandes Terra, José Carlos Alves-Filho, Niels Olsen Saraiva Câmara, Mariana Boroni, Alexandre Castro Keller, Pedro M. Moraes-Vieira

“…Summary: Invariant natural killer T (iNKT) cells are a distinct population of lymphocytes characterized by their reactivity to glycolipids presented by CD1d. iNKT cells are found throughout the body, and little is known about their tissue-specific metabolic regulation. …”
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iNKT cells from patients with secondary progressive multiple sclerosis display pro-inflammatory profiles by Sara De Biasi, Anna Maria Simone, Milena Nasi, Elena Bianchini, Diana Ferraro, Francesca Vitetta, Lara Gibellini, Marcello Pinti, Cinzia Del Giovane, Patrizia Sola, Andrea Cossarizza

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Insights into the heterogeneity of iNKT cells: tissue-resident and circulating subsets shaped by local microenvironmental cues by Guangwei Cui, Shinya Abe, Ryoma Kato, Ryoma Kato, Koichi Ikuta

Subjects: “…iNKT cell…”
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Amide analogues of CD1d agonists modulate iNKT-cell-mediated cytokine production. by Wojno, J, Jukes, J, Ghadbane, H, Shepherd, D, Besra, G, Cerundolo, V, Cox, L

“…The prototypical iNKT cell agonist is α-galactosyl ceramide (α-GalCer). …”

Role for lysosomal phospholipase A2 in iNKT cell-mediated CD1d recognition by Paduraru, C, Bezbradica, J, Kunte, A, Kelly, R, Shayman, J, Veerapen, N, Cox, L, Besra, G, Cresswell, P

“…Invariant natural killer T (iNKT) cells recognize self lipid antigens presented by CD1d molecules. …”

Differential iNKT and T Cells Activation in Non-Alcoholic Fatty Liver Disease and Drug-Induced Liver Injury by Estefanía Caballano-Infantes, Alberto García-García, Carlos Lopez-Gomez, Alejandro Cueto, Mercedes Robles-Diaz, Aida Ortega-Alonso, Flores Martín-Reyes, Ismael Alvarez-Alvarez, Isabel Arranz-Salas, Francisco Ruiz-Cabello, Isabel M. Lucena, Eduardo García-Fuentes, Raúl J. Andrade, Miren García-Cortes

“…Results: There was an increase in iNKT cells in NAFLD patients compared to DILI or control subjects. …”
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RIPK1 deficiency prevents thymic NK1.1 expression and subsequent iNKT cell development by Thomas Hägglöf, Thomas Hägglöf, Raksha Parthasarathy, Nathaniel Liendo, Nathaniel Liendo, Elizabeth A. Dudley, Elizabeth A. Leadbetter

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Vam6 reduces iNKT cell function in tumor via modulating AMPK/mTOR pathways by Shiyu Bai, Shiyu Bai, Qielan Wu, Qielan Wu, Shasha Zhu, Yuwei Zhang, Yuwei Zhang, Xuran Chen, Xuran Chen, Miya Su, Miya Su, Jun Pan, Jun Pan, Shuhang Li, Shuhang Li, Ting Yue, Linfeng Xu, Di Xie, Di Xie, Chenxi Tian, Chenxi Tian, Dan Zhao, Xiang Li, Xiang Li, Junjie Hou, Lu Wang, Sicheng Fu, Sicheng Fu, Yanhong Xue, Amin Jiang, Dong Li, Tao Xu, Zhigang Tian, Zhigang Tian, Zhigang Tian, Rongbin Zhou, Rongbin Zhou, Rongbin Zhou, Huimin Zhang, Huimin Zhang, Li Bai, Li Bai, Li Bai, Li Bai, Li Bai

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CD169(+) macrophages present lipid antigens to mediate early activation of iNKT cells in lymph nodes. by Barral, P, Polzella, P, Bruckbauer, A, van Rooijen, N, Besra, G, Cerundolo, V, Batista, F

“…Invariant natural killer T cells (iNKT cells) are involved in the host defense against microbial infection. …”

Synthesis of truncated analogues of the iNKT cell agonist, α-galactosyl ceramide (KRN7000), and their biological evaluation by Veerapen, N, Reddington, F, Salio, M, Cerundolo, V, Besra, G

“…Stimulation of iNKT cells by α-galactosyl ceramide (α-GalCer), also known as KRN7000, and its truncated analogue OCH induces both Th1- and Th2-cytokines, with OCH inducing a Th2-cytokine bias. …”

Synthesis of truncated analogues of the iNKT cell agonist, α-galactosyl ceramide (KRN7000), and their biological evaluation. by Veerapen, N, Reddington, F, Salio, M, Cerundolo, V, Besra, G

“…Stimulation of iNKT cells by α-galactosyl ceramide (α-GalCer), also known as KRN7000, and its truncated analogue OCH induces both Th1- and Th2-cytokines, with OCH inducing a Th2-cytokine bias. …”

Commitment toward the natural T (iNKT) cell lineage occurs at the CD4+8+ stage of thymic ontogeny by Bezbradica, JS, Hill, T, Stanic, AK, Van Kaer, L, Joyce, S

“…Similarly, introgression of a rearranged Vα14Jα18 transgene into RORγ0/0 mice results in functional iNKT cells. Thus, our data support the “T cell receptor-instructive (mainstream precursor) model” of iNKT cell lineage specification where Vα14-to-Jα18 rearrangement, positive selection, and iNKT cell lineage commitment occur at or after the DP stage of ontogeny.…”

Tnpo3 controls splicing of the pre-mRNA encoding the canonical TCR α chain of iNKT cells by Norimasa Iwanami, Andreas S. Richter, Katarzyna Sikora, Thomas Boehm

“…Abstract Unconventional T cells, such as innate natural killer T cells (iNKT) cells, are an important part of vertebrate immune defences. iNKT recognise glycolipids through a T cell receptor (TCR) that is composed of a semi-invariant TCR α chain, paired with a restricted set of TCR β chains. …”
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