CAR-iNKT cells targeting clonal TCRVβ chains as a precise strategy to treat T cell lymphoma by Aileen G. Rowan, Aileen G. Rowan, Kanagaraju Ponnusamy, Hongwei Ren, Graham P. Taylor, Graham P. Taylor, Lucy B. M. Cook, Lucy B. M. Cook, Lucy B. M. Cook, Anastasios Karadimitris, Anastasios Karadimitris

“…Efficacy of the CAR constructs was tested using conventional T cells as effectors (CAR-T). Since invariant NKT (iNKT) cell do not incite acute graft-versus-host disease and are suitable for ‘off-the-shelf’ immunotherapy, we generated anti-TCRVβ CAR-iNKT cells.ResultsWe show that anti-TCRVβ CAR-T cells selectively kill their cognate tumour targets while leaving >90% of the physiological TCR repertoire intact. …”
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IL-21-armored B7H3 CAR-iNKT cells exert potent antitumor effects by Yilin Liu, Yuanyuan Dang, Chuhan Zhang, Liu Liu, Wenhui Cai, Liantao Li, Lin Fang, Meng Wang, Shunzhe Xu, Gang Wang, Junnian Zheng, Huizhong Li

“…Summary: CD1d-restricted invariant NKT (iNKT) cells play a critical role in tumor immunity. …”
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735 Peripheral and tissue persistence of agenT-797, an allogeneic iNKT cell-based cell therapy for the treatment of cancer by Rachel E Sanborn, Trisha M Wise-Draper, Marc Van Dijk, Breelyn Wilky, Anthony El-Khoueiry, John Hamm, Benjamin Garmezy, Benedito Carneiro, Jamie Moon, Sue Ryu, Irene R Ramos, Marco A Purbhoo, Dave SB Hoon

TET proteins regulate T cell and iNKT cell lineage specification in a TET2 catalytic dependent manner by Tarmo Äijö, Dimitris Theofilatos, Meng Cheng, Meng Cheng, Matthew D. Smith, Yue Xiong, Albert S. Baldwin, Ageliki Tsagaratou, Ageliki Tsagaratou, Ageliki Tsagaratou

“…Here, we investigate shared signatures in gene expression of Tet2/3 DKO CD4 single positive (SP) and iNKT cells in the thymus. We discover that TET proteins exert a fundamental role in regulating the expression of the lineage specifying factor Th-POK, which is encoded by Zbtb7b. …”
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[Glycosphingolipids Gb3 and iGb3. In vivo roles in hemolytic-uremic syndrome and iNKT cell function]. by Porubsky, S, Luckow, B, Bonrouhi, M, Speak, A, Cerundolo, V, Platt, F, Gröne, H

“…RESULTS: For 1) Gb3-deficient mice were insensitive to otherwise lethal doses of VT, and 2) iGb3-deficient mice showed normal numbers of iNKT cells. Furthermore the function of iNKT cells evolving in iGb3-deficient mice was unaffected. …”

Abnormalities in iNKT cells are associated with impaired ability of monocytes to produce IL-10 and suppress T-cell proliferation in sarcoidosis. by Crawshaw, A, Kendrick, Y, Mcmichael, A, Ho, L

“…Moreover, iNKT cells enhanced monocytic IL-10 production in vitro. …”

Glycosphingolipids Gb3 and iGb3. In vivo roles in hemolytic-uremic syndrome and iNKT cell function by Porubsky, S, Luckow, B, Bonrouhi, M, Speak, A, Cerundolo, V, Platt, F, Gröne, H

“…For 1) Gb3-deficient mice were insensitive to otherwise lethal doses of VT, and 2) iGb3-deficient mice showed normal numbers of iNKT cells. Furthermore the function of iNKT cells evolving in iGb3-deficient mice was unaffected. …”

Impaired thymic iNKT cell differentiation at early precursor stage in murine haploidentical bone marrow transplantation with GvHD by Weijia Zhao, Yujia Wang, Xinwei Zhang, Jie Hao, Kunshan Zhang, Xiaojun Huang, Yingjun Chang, Hounan Wu, Rong Jin, Qing Ge, Qing Ge

“…IntroductionEarly recovery of donor-derived invariant natural killer T (iNKT) cells are associated with reduced risk of graft-versus-host disease (GvHD) and overall survival. …”
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Oral antibiotics relieve allergic asthma in post-weaning mice via reducing iNKT cells and function of ADRB2 by Na Li, Na Li, Jie Chen, Sitao Xie, Meng Zhang, Tianyun Shi, Yanchao He, Zhijun Jie, Xiao Su

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The role of invariant natural killer T (iNKT) cells in modulating the lung inflammatory response during influenza A virus infection by McEwen-Smith, R, De Santo, C, Salio, M, Napolitani, G, Cerundolo, V

T cell receptor CDR2 beta and CDR3 beta loops collaborate functionally to shape the iNKT cell repertoire. by Mallevaey, T, Scott-Browne, J, Matsuda, J, Young, M, Pellicci, D, Patel, O, Thakur, M, Kjer-Nielsen, L, Richardson, S, Cerundolo, V, Howell, A, McCluskey, J, Godfrey, D, Rossjohn, J, Marrack, P, Gapin, L

“…This restriction of the iNKT TCR repertoire during thymic selection paradoxically ensures that each peripheral iNKT cell recognizes a similar spectrum of antigens.…”

An investigation into the regulatory capacity of invariant natural killer T (iNKT) cells during the innate and adaptive immune response to influenza infection by McEwen-Smith, R

“…Invariant natural killer T (iNKT) cells, a subset of CD1d-restricted T lymphocytes, have been identified as important modulators of immunity, mediating both pro- and anti-inflammatory responses. …”

PD-1 checkpoint inhibition enhances the antilymphoma activity of CD19-CAR-iNKT cells that retain their ability to prevent alloreactivity by Anita Schmitt, Brigitte Neuber, Michael Schmitt, Melanie Märklin, Boris Klimovich, Claudia Lengerke, Emmanuelle Moraes Ribeiro, Kathy-Ann Secker, Ana-Maria Nitulescu, Rebekka Schairer, Hildegard Keppeler, Anton Wesle, Hannes Schmid, Daniela Chmiest, Silvia Podavini, Fulya Korkmaz, Corina Schneidawind, Dominik Schneidawind

“…Preclinical murine models and clinical data suggest that invariant natural killer T (iNKT) cells prevent acute and chronic GVHD. In addition, iNKT cells are crucial for efficient immune responses against malignancies and contribute to reduced relapse rates after transplantation. …”
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Ets1 Promotes the Differentiation of Post-Selected iNKT Cells through Regulation of the Expression of Vα14Jα18 T Cell Receptor and PLZF by Ya-Ting Chuang, Wan-Chu Chuang, Chih-Chun Liu, Chia-Wei Liu, Yu-Wen Huang, Huang-Yu Yang, I-Cheng Ho, Tzong-Shyuan Tai

Subjects: “…iNKT cells…”
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Mettl3-m6A-Creb1 forms an intrinsic regulatory axis in maintaining iNKT cell pool and functional differentiation by Menghao You, Jingjing Liu, Jie Li, Ce Ji, Haochen Ni, Wenhui Guo, Jiarui Zhang, Weiwei Jia, Zhao Wang, Yajiao Zhang, Yingpeng Yao, Guotao Yu, Huanyu Ji, Xiaohu Wang, Dali Han, Xuguang Du, Meng Michelle Xu, Shuyang Yu

“…Here, we show that Mettl3 intrinsically regulates invariant natural killer T (iNKT) cell development and function in an m6A-dependent manner. …”
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Beyond αβ T cells: NK, iNKT, and γδT cell biology in leukemic patients and potential for off-the-shelf adoptive cell therapies for AML by Andrew Kent, Andrew Kent, Andrew Kent, Lyndsey S. Crump, Eduardo Davila, Eduardo Davila, Eduardo Davila, Eduardo Davila

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Identification of a PD-L1+Tim-1+ iNKT subset that protects against fine particulate matter–induced airway inflammation by Christina Li-Ping Thio, Alan Chuan-Ying Lai, Jo-Chiao Wang, Po-Yu Chi, Ya-Lin Chang, Yu-Tse Ting, Shih-Yu Chen, Ya-Jen Chang

“…Unexpectedly, we found that invariant natural killer T (iNKT) cells played a protective role in PM2.5-induced pulmonary inflammation. …”
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Activated iNKT cells enhance the anti-tumor effect of antigen specific CD8 T cells on mesothelin-expressing salivary gland cancer by Yuji Makita, Naoki Kunii, Daiju Sakurai, Fumie Ihara, Shinichiro Motohashi, Akane Suzuki, Toshinori Nakayama, Yoshitaka Okamoto

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Profiling of innate and adaptive immune cells during influenza virus infection reveals sex bias in invariant natural killer T (iNKT) cells by Piotr Humeniuk, Aidan Barrett, Hannes Axelsson, Carmen Corciulo, Christina Drevinge, Alicia Del Carpio Pons, Davide Angeletti, Julia M. Scheffler, Ulrika Islander

Subjects: “…invariant natural killer T (iNKT) cells…”
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SOX chemotherapy with anti-PD-1 and iNKT cell immunotherapies for stage IV gastric adenocarcinoma with liver metastases: A case report by Dezhao Li, Mei Liu, Jinhuan Wang, Jia Guo, Ningzhi Xu, Ningzhi Xu, Jun Lu

“…Pre-clinical studies and clinical trials have demonstrated the antitumor efficacy of invariant natural killer T (iNKT) cells in various malignancies, including GC. …”
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