Development of off-the-shelf hematopoietic stem cell-engineered invariant natural killer T cells for COVID-19 therapeutic intervention by Yan-Ruide Li, Zachary Spencer Dunn, Gustavo Garcia, Camille Carmona, Yang Zhou, Derek Lee, Jiaji Yu, Jie Huang, Jocelyn T. Kim, Vaithilingaraja Arumugaswami, Pin Wang, Lili Yang

Subjects: “…Invariant natural killer T (iNKT) cell…”
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Involvement of the 4-1BB/4-1BBL pathway in control of monocyte numbers by invariant NKT cells. by Cole, S, Benam, K, Mcmichael, A, Ho, L

“…Blocking 4-1BBL in alpha-galactosylceramide-activated iNKT-monocyte cocultures reduced iNKT proliferation and abrogated monocytic IL-12 production. …”

Direct engagement of TLR4 in invariant NKT cells regulates immune diseases by differential IL-4 and IFN-γ production in mice. by Ji Hyung Kim, Hye Sung Kim, Hye Young Kim, Sae Jin Oh, Doo Hyun Chung

“…However, whether TLR4 directly activates iNKT cells is unknown. Therefore, the expression and function of TLR4 in iNKT cells were investigated. …”
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CD1d presentation of glycolipids. by Speak, A, Cerundolo, V, Platt, F

“…Of these molecules CD1d has been the subject of much interest over the past 10 years following the discovery that this molecule presents antigens to a group of T cells known as invariant natural killer T cells (iNKT). iNKT cells carry an invariant T cell receptor which contains homologous gene segments in mouse and man. iNKT cells are positively selected in the thymus in the same manner as major histocompatibility complex restricted T cells, except iNKT cells require CD1d to be presented by thymocytes rather than epithelial cells. …”

Human invariant NKT cells are required for effective in vitro alloresponses. by Patterson, S, Kotsianidis, I, Almeida, A, Politou, M, Rahemtulla, A, Matthew, B, Schmidt, R, Cerundolo, V, Roberts, I, Karadimitris, A

“…Importantly, adding back fresh iNKT cells restored the reactivity of iNKT cell-depleted MLR to near baseline levels. …”

Immunometabolic factors in adolescent chronic disease are associated with Th1 skewing of invariant Natural Killer T cells by Ververs, FA, Engelen, SE, Nuboer, R, Vastert, B, van der Ent, CK, Van't Land, B, Garssen, J, Monaco, C, Boes, M, Schipper, HS

“…We considered that immunometabolic factors might affect iNKT cell function. To this end, we investigated iNKT cell phenotype and function in a cohort of adolescents with chronic disease and immunometabolic abnormalities. …”

Functions of CD1d-Restricted Invariant Natural Killer T Cells in Antimicrobial Immunity and Potential Applications for Infection Control by Yuki Kinjo, Shogo Takatsuka, Naoki Kitano, Shun Kawakubo, Masahiro Abe, Keigo Ueno, Yoshitsugu Miyazaki

“…CD1d-restricted invariant natural killer T (iNKT) cells are innate-type lymphocytes that express a T-cell receptor (TCR) containing an invariant α chain encoded by the Vα14 gene in mice and Vα24 gene in humans. …”
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Insights into mucosal-associated invariant T cell biology from studies of invariant natural killer T cells by Garner, L, Klenerman, P, Provine, N

“…Mucosal-associated invariant T (MAIT) cells and invariant natural killer T (iNKT) cells are innate-like T cells that function at the interface between innate and adaptive immunity. …”

Cutting Edge: The Ontogeny and Function of Va14Ja18 Natural T Lymphocytes Require Signal Processing by Protein Kinase Cθ and NF-κB by Stanic, AK, Bezbradica, JS, Park, J-J, Van Kaer, L, Boothby, MR, Joyce, S

“…The rapid and robust immunoregulatory cytokine response of Va14Ja18 natural T (iNKT) cells to glycolipid Ags determines their diverse functions. …”

Cutting edge: nonglycosidic CD1d lipid ligands activate human and murine invariant NKT cells. by Silk, J, Salio, M, Reddy, BG, Shepherd, D, Gileadi, U, Brown, J, Masri, S, Polzella, P, Ritter, G, Besra, G, Jones, E, Schmidt, R, Cerundolo, V

“…Invariant NKT cells (iNKT cells) recognize CD1d/glycolipid complexes. …”

The actin cytoskeleton modulates the activation of invariant NKT cells by segregating CD1d nanoclusters on antigen presenting cells by Cerundolo, V, Salio, M, Shepherd, D, Torreno-Pina, J, Manzo, C, Aichinger, M, Oddone, A, Bestra, G, Garcia-Parajo, M

“…Invariant natural killer T (iNKT) cells recognize endogenous and exogenous lipid antigens presented in the context of CD1d molecules. …”

Human invariant NKT cells display alloreactivity instructed by invariant TCR-CD1d interaction and killer Ig receptors by Patterson, S, Chaidos, A, Neville, D, Poggi, A, Butters, T, Roberts, I, Karadimitris, A

“…Invariant NKT (iNKT) cells are a subset of highly conserved immunoregulatory T cells that modify a variety of immune responses, including alloreactivity. …”

Distinct Roles of Dendritic Cells and B Cells in Va14Ja18 Natural T Cell Activation In Vivo by Bezbradica, J, Stanic, A, Matsuki, N, Bour-Jordan, H, Bluestone, J, Thomas, J, Unutmaz, D, Van Kaer, L, Joyce, S

“…Va14Ja18 natural T (iNKT) cells are innate, immunoregulatory lymphocytes that recognize CD1d-restricted lipid Ags such as α-galactosylceramide (αGalCer). …”

Combination of NKT14m and Low Dose IL-12 Promotes Invariant Natural Killer T Cell IFN-γ Production and Tumor Control by Peng Guan, Robert Schaub, Kim E. Nichols, Rupali Das

“…However, many tumors down-regulate CD1d and evade iNKT cell attack. To circumvent this critical barrier to iNKT cell anti-tumor activity, a novel monoclonal antibody (mAb), NKT14 has been recently developed. …”
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Invariant natural killer T-cell dynamics in human immunodeficiency virus–associated tuberculosis by Walker, N, Opondo, C, Meintjes, G, Jhilmeet, N, Friedland, J, Elkington, P, Wilkinson, R, Wilkinson, K

“…</p><br/> <p><strong>Conclusions</strong><br/> Reduced iNKT cell CD4+ subsets as a result of HIV-1 infection may skew iNKT cell functionality toward cytotoxicity. …”

Essential role for autophagy during invariant NKT cell development by Salio, M, Puleston, D, Mathan, T, Shepherd, D, Stranks, A, Adamopoulou, E, Veerapen, N, Besra, G, Hollander, G, Simon, A, Cerundolo, V

“…Although autophagy modulates MHC antigen presentation, it remains unclear whether autophagy defects impact on CD1d lipid loading and presentation to invariant natural killer T (iNKT) cells and on iNKT cell differentiation in the thymus. …”

Harnessing the power of invariant natural killer T cells in cancer immunotherapy by Bedard, M, Salio, M, Cerundolo, V

“…Invariant natural killer T (iNKT) cells are a distinct subset of innate-like lymphocytes bearing an invariant T-cell receptor, through which they recognize lipid antigens presented by monomorphic CD1d molecules. …”

Modulation of human natural killer T cell ligands on TLR-mediated antigen-presenting cell activation. by Salio, M, Speak, A, Shepherd, D, Polzella, P, Illarionov, P, Veerapen, N, Besra, G, Platt, F, Cerundolo, V

“…Invariant natural killer T (iNKT) cells are a subset of nonconventional T cells recognizing endogenous and/or exogenous glycolipid antigens in the context of CD1d molecules. …”

Activation and Regulation of B Cell Responses by Invariant Natural Killer T Cells by Derek G. Doherty, Ashanty M. Melo, Ana Moreno-Olivera, Andreas C. Solomos

“…CD1d-restricted invariant natural killer T (iNKT) cells play central roles in the activation and regulation of innate and adaptive immunity. …”
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Human invariant NKT cells display alloreactivity instructed by invariant TCR-CD1d interaction and killer Ig receptors. by Patterson, S, Chaidos, A, Neville, D, Poggi, A, Butters, T, Roberts, I, Karadimitris, A

“…Invariant NKT (iNKT) cells are a subset of highly conserved immunoregulatory T cells that modify a variety of immune responses, including alloreactivity. …”