Normal development and function of invariant natural killer T cells in mice with isoglobotrihexosylceramide (iGb3) deficiency. by Porubsky, S, Speak, A, Luckow, B, Cerundolo, V, Platt, F, Gröne, H

“…CD1d-restricted natural killer T (NKT) cells, expressing the invariant T cell antigen receptor (TCR) chain encoded by Valpha14-Jalpha18 gene segments in mice and Valpha24-Jalpha18 in humans [invariant NKT (iNKT) cells], contribute to immunoregulatory processes, such as tolerance, host defense, and tumor surveillance. iNKT cells are positively selected in the thymus by CD1d molecules expressed by CD4(+)/CD8(+) cortical thymocytes. …”

Reciprocal Crosstalk between Dendritic Cells and Natural Killer T Cells: Mechanisms and Therapeutic Potential by Christian W. Keller, Stefan Freigang, Jan D. Lünemann, Jan D. Lünemann

“…The bidirectional crosstalk between DCs and iNKT cells determines the functional outcome of iNKT cell-targeted responses and iNKT cell agonists are used and currently being evaluated as adjuvants to enhance the efficacy of antitumor immunotherapy. …”
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Dual modifications of α-galactosylceramide synergize to promote activation of human invariant natural killer t cells and stimulate anti-tumor immunity by Chennamadhavuni, D, Saavedra-Avila, NA, Carreño, LJ, Guberman-Pfeffer, MJ, Arora, P, Yongqing, T, Pryce, R, Koay, H-F, Godfrey, DI, Keshipeddy, S, Richardson, SK, Sundararaj, S, Lo, JH, Wen, X, Gascón, JA, Yuan, W, Rossjohn, J, Le Nours, J, Porcelli, SA, Howell, AR

“…Glycosylceramides that activate CD1d-restricted invariant natural killer T (iNKT) cells have potential therapeutic applications for augmenting immune responses against cancer and infections. …”

Program Cell Death Receptor-1-Mediated Invariant Natural Killer T-Cell Control of Peritoneal Macrophage Modulates Survival in Neonatal Sepsis by Eleanor A. Fallon, Tristen T. Chun, Whitney A. Young, Chyna Gray, Alfred Ayala, Daithi S. Heffernan

“…We have shown that invariant natural killer T (iNKT) cells mediate sepsis-induced end-organ changes and immune responses, including macrophage bacterial phagocytosis, a finding regulated by the check point protein program cell death receptor-1 (PD-1). …”
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De novo fatty-acid synthesis protects invariant NKT cells from cell death, thereby promoting their homeostasis and pathogenic roles in airway hyperresponsiveness by Jaemoon Koh, Yeon Duk Woo, Hyun Jung Yoo, Jun-Pyo Choi, Sae Hoon Kim, Yoon-Seok Chang, Kyeong Cheon Jung, Ji Hyung Kim, Yoon Kyung Jeon, Hye Young Kim, Doo Hyun Chung

“…Invariant natural-killer T (iNKT) cells play pathogenic roles in allergic asthma in murine models and possibly also humans. …”
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TLR9-mediated dendritic cell activation uncovers mammalian ganglioside species with specific ceramide backbones that activate invariant natural killer T cells. by Christophe Paget, Shenglou Deng, Daphnée Soulard, David A Priestman, Silvia Speca, Johanna von Gerichten, Anneliese O Speak, Ashish Saroha, Yael Pewzner-Jung, Anthony H Futerman, Thierry Mallevaey, Christelle Faveeuw, Xiaobo Gu, Frances M Platt, Roger Sandhoff, François Trottein

“…CD1d-restricted invariant natural killer T (iNKT) cells represent a heterogeneous population of lipid-reactive T cells that are involved in many immune responses, mediated through T-cell receptor (TCR)-dependent and/or independent activation. …”
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TLR9-mediated dendritic cell activation uncovers mammalian ganglioside species with specific ceramide backbones that activate invariant natural killer T cells by Paget, C, Deng, S, Soulard, D, Priestman, D, Speca, S, von Gerichten, J, Speak, A, Saroha, A, Pewzner-Jung, Y, Futerman, A, Mallevaey, T, Faveeuw, C, Gu, X, Platt, F, Sandhoff, R, Trottein, F

“…CD1d-restricted invariant natural killer T (iNKT) cells represent a heterogeneous population of lipid-reactive T cells that are involved in many immune responses, mediated through T-cell receptor (TCR)–dependent and/or independent activation. …”

Dendritic cell function can be modulated through cooperative actions of TLR ligands and invariant NKT cells. by Hermans, I, Silk, J, Gileadi, U, Masri, S, Shepherd, D, Farrand, K, Salio, M, Cerundolo, V

“…We show that pathogen-derived signals to DC mediated via TLRs can be modulated by activated invariant NKT (iNKT) cells. DC maturation induced in vivo with any one of a variety of TLR ligands was greatly improved through simultaneous administration of the iNKT cell ligand alpha-galactosylceramide. …”

Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems by Arico Maurizo, Pende Daniela, Cerundolo Vincenzo, Salio Mariolina, Stinchcombe Jane C, Griffiths Gillian M

“…High-resolution electron micrographs of the immunological synapse formed between NK and iNKT cytolytic cells with their targets revealed that in both NK and iNKT cells, the centrioles could be found associated (or 'docked') with the plasma membrane within the immunological synapse. …”
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Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems. by Stinchcombe, J, Salio, M, Cerundolo, V, Pende, D, Arico, M, Griffiths, G

“…High-resolution electron micrographs of the immunological synapse formed between NK and iNKT cytolytic cells with their targets revealed that in both NK and iNKT cells, the centrioles could be found associated (or 'docked') with the plasma membrane within the immunological synapse. …”

Unique adipose tissue invariant natural killer T cell subpopulations control adipocyte turnover in mice by Sang Mun Han, Eun Seo Park, Jeu Park, Hahn Nahmgoong, Yoon Ha Choi, Jiyoung Oh, Kyung Min Yim, Won Taek Lee, Yun Kyung Lee, Yong Geun Jeon, Kyung Cheul Shin, Jin Young Huh, Sung Hee Choi, Jiyoung Park, Jong Kyoung Kim, Jae Bum Kim

“…Abstract Adipose tissue invariant natural killer T (iNKT) cells are a crucial cell type for adipose tissue homeostasis in obese animals. …”
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Zeb2 regulates differentiation of long-lived effector of invariant natural killer T cells by Tomonori Iyoda, Kanako Shimizu, Takaho Endo, Takashi Watanabe, Ichiro Taniuchi, Honoka Aoshima, Mikiko Satoh, Hiroshi Nakazato, Satoru Yamasaki, Shin-ichiro Fujii

“…Abstract After activation, some invariant natural killer T (iNKT) cells are differentiated into Klrg1+ long-lived effector NKT1 cells. …”
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Contribution of monocytes to immunopathology during influenza A virus infection by Cole, S, Suzanne Cole

“…Induction of monocyte apoptosis by activated iNKT cells was investigated in vitro as a possible mechanism by which activated iNKT cells controlled monocyte numbers.…”

Binding strength and dynamics of invariant natural killer cell T cell receptor/CD1d-glycosphingolipid interaction on living cells by single molecule force spectroscopy. by Bozna, B, Polzella, P, Rankl, C, Zhu, R, Salio, M, Shepherd, D, Duman, M, Cerundolo, V, Hinterdorfer, P

“…Invariant natural killer T (iNKT) cells are a population of T lymphocytes that play an important role in regulating immunity to infection and tumors by recognizing endogenous and exogenous CD1d-bound lipid molecules. …”

Granulocyte-Macrophage Colony-Stimulating Factor Regulates Effector Differentiation of Invariant Natural Killer T Cells during Thymic Ontogeny by Bezbradica, J, Gordy, L, Stanic, A, Dragovic, S, Hill, T, Hawiger, J, Unutmaz, D, Van Kaer, L, Joyce, S

“…Invariant natural killer T (iNKT) cell-derived cytokines have important functions in inflammation, host defense, and immunoregulation. …”

Implications for invariant natural killer T cell ligands due to the restricted presence of isoglobotrihexosylceramide in mammals. by Speak, A, Salio, M, Neville, D, Fontaine, J, Priestman, D, Platt, N, Heare, T, Butters, T, Dwek, R, Trottein, F, Exley, M, Cerundolo, V, Platt, F

“…Development of invariant natural killer T (iNKT) cells requires the presentation of lipid ligand(s) by CD1d molecules in the thymus. …”

Cancer Immunotherapeutic Potential of NKTT320, a Novel, Invariant, Natural Killer T Cell-Activating, Humanized Monoclonal Antibody by Nishant P. Patel, Peng Guan, Devika Bahal, Tanwir Hashem, Felix Scheuplein, Robert Schaub, Kim E. Nichols, Rupali Das

“…As such, iNKTs serve as a powerful tool for use in cell-based cancer immunotherapy. iNKT cell activation commonly requires engagement of the invariant T cell receptor (iTCR) by CD1d presenting glycolipid antigens. …”
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Novel lipid antigens for NKT cells in cancer by Michael S. Lee, Michael S. Lee, Tonya J. Webb, Tonya J. Webb

“…Next, we will discuss the cancer lipidome and how it may be exploited by iNKT cells through a window of opportunity. Finally, we will review, in detail, novel lipid antigens for iNKT cells in cancer.…”
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Regulation of hematopoiesis in vitro and in vivo by invariant NKT cells. by Kotsianidis, I, Silk, J, Spanoudakis, E, Patterson, S, Almeida, A, Schmidt, R, Tsatalas, C, Bourikas, G, Cerundolo, V, Roberts, I, Karadimitris, A

“…Invariant natural killer T cells (iNKT cells) are a small subset of immunoregulatory T cells highly conserved in humans and mice. …”

Sterile activation of invariant natural killer T cells by ER-stressed antigen-presenting cells by Bedard, M, Shrestha, D, Priestman, D, Wang, Y, Schneider, F, Matute, J, Iyer, S, Gileadi, U, Prota, G, Kandasamy, M, Veerapen, N, Besra, G, Fritzsche, M, Zeissig, S, Shevchenko, A, Christianson, J, Platt, F, Eggeling, C, Blumberg, R, Salio, M, Cerundolo, V

“…Invariant NKT (iNKT) cells have the unique ability to shape immunity during antitumor immune responses and other forms of sterile and nonsterile inflammation. …”