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161
Sterile activation of invariant natural killer T cells by ER-stressed antigen presenting cells
Published 2019“…<p>Invariant NKT (iNKT) cells are a subset of innate-like lymphocytes that recognize lipid antigen presented on monomorphic CD1d molecules. …”
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162
Invariant Valpha14 chain NKT cells promote Plasmodium berghei circumsporozoite protein-specific gamma interferon- and tumor necrosis factor alpha-producing CD8+ T cells in the live...
Published 2005“…Greater numbers of hepatic Valpha14iNKT cells secreted interleukin-4 than IFN-gamma. …”
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163
Alteration of circulating unconventional T cells in cerebral ischemia: an observational study
Published 2022-06-01“…Our results demonstrate for the first time the reduction of peripheral blood NKTL, iNKT and γδ T cells in patients with the cerebral ischemia, and particularly reduced iNKT and γδ T cells in the acute phase. …”
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164
The influence of invariant natural killer T cells on myeloid-derived suppressor cell generation and function
Published 2011“…Moreover, iNKT cell adoptive transfer into flu-infected mice has been shown to abolish the expansion and flu-induced suppressive activity of the MDSCs in a CD1d- and CD40-dependent manner. …”
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165
Mechanisms of induction and modulation of the pro-inflammatory cytokine interleukin-1beta
Published 2012“…</p> <p>We hypothesise that this effect of iNKT cells is important in controlling inflammatory responses in vivo, and demonstrate exacerbated IL-1beta production and inflammation during influenza virus infection of iNKT cell-deficient animals. …”
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166
Natural Killer T Cells Are Involved in Atherosclerotic Plaque Instability in Apolipoprotein-E Knockout Mice
Published 2021-11-01“…However, it remained unclear whether iNKT cells are also involved in plaque instability. …”
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167
Invariant natural killer T cells in lung diseases
Published 2023-09-01“…Here, we provide insights into the biology of iNKT cells in health and disease, with a particular focus on the role of pulmonary iNKT cells in airway inflammation and other lung diseases.…”
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168
Activation of invariant NKT cells in early phase of experimental autoimmune encephalomyelitis results in differentiation of Ly6Chi inflammatory monocyte to M2 macrophages and impro...
Published 2012“…Adoptive transfer of M2-enriched cells to iNKT-deficient mice markedly improved neurologic impairment. …”
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169
Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans.
Published 2008“…Adoptive transfer of iNKT cells abolished the suppressive activity of MDSCs, restored IAV-specific immune responses, reduced IAV titer, and increased survival rate. …”
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170
Invariant Natural Killer T Cells Shape the Gut Microbiota and Regulate Neutrophil Recruitment and Function During Intestinal Inflammation
Published 2018-05-01“…Invariant natural killer T (iNKT) cells and neutrophils play an increasingly important part in the pathogenesis of inflammatory diseases, but their precise roles in modulating colitis remain unclear. …”
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171
Utilizing the adjuvant properties of CD1d-dependent NK T cells in T cell-mediated immunotherapy.
Published 2004“…Together these data highlight the therapeutic potential of iNKT cell ligands in vaccination strategies, particularly "heterologous prime-boost" strategies against tumors, and provide evidence that iNKT cell stimulation may be exploited in the development of oral vaccines.…”
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172
Utilizing the adjuvant properties of CD1d-dependent NK T cells in T cell-mediated immunotherapy
Published 2004“…Together these data highlight the therapeutic potential of iNKT cell ligands in vaccination strategies, particularly "heterologous prime-boost" strategies against tumors, and provide evidence that iNKT cell stimulation may be exploited in the development of oral vaccines.…”
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173
Preparation, characterisation and entrapment of a non-glycosidic threitol ceramide into liposomes for presentation to invariant natural killer T cells
Published 2011“…Dendritic cells (DCs) are able to present glycolipids to invariant natural killer T (iNKT) cells in vivo. Very few compounds have been found to stimulate iNKT cells, and of these, the best characterised is the glycolipid α-galactosylceramide, which stimulates the production of large quantities of interferon-gamma (IFN-γ) and interleukin-4 (IL-4). …”
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174
Preparation, characterisation and entrapment of a non-glycosidic threitol ceramide into liposomes for presentation to invariant natural killer T cells.
Published 2011“…Dendritic cells (DCs) are able to present glycolipids to invariant natural killer T (iNKT) cells in vivo. Very few compounds have been found to stimulate iNKT cells, and of these, the best characterised is the glycolipid α-galactosylceramide, which stimulates the production of large quantities of interferon-gamma (IFN-γ) and interleukin-4 (IL-4). …”
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175
Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans.
Published 2008“…Adoptive transfer of iNKT cells abolished the suppressive activity of MDSCs, restored IAV-specific immune responses, reduced IAV titer, and increased survival rate. …”
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176
Peripheral blood invariant natural killer T cells throughout pregnancy and in preeclamptic women.
Published 2010“…Invariant natural killer T (iNKT) cells are implicated in the pathogenesis of several diseases. …”
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177
Activated invariant NKT cells regulate osteoclast development and function.
Published 2011“…Invariant NKT (iNKT) cells modulate innate and adaptive immune responses through activation of myeloid dendritic cells and macrophages and via enhanced clonogenicity, differentiation, and egress of their shared myeloid progenitors. …”
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178
Motility and tumor infiltration are key aspects of invariant natural killer T cell anti-tumor function
Published 2024-02-01“…Abstract Dysfunction of invariant natural killer T (iNKT) cells contributes to immune resistance of tumors. …”
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179
Pivotal Advance: Invariant NKT cells reduce accumulation of inflammatory monocytes in the lungs and decrease immune-pathology during severe influenza A virus infection.
Published 2012“…Activation of iNKT cells correlated with reduction of MCP-1 levels and improved outcome. iNKT cells were able to selectively lyse infected, MCP-1-producing monocytes in vitro, in a CD1d-dependent process. …”
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180
Interaction between invariant NKT cells and myeloid-derived suppressor cells in cancer patients: evidence and therapeutic opportunities.
Published 2012“…Recently, we presented evidence that iNKT cells are able to interact with and decrease the numbers of circulating MDSCs in melanoma patients. …”
Journal article