Sterile activation of invariant natural killer T cells by ER-stressed antigen presenting cells by Bedard, M

“…<p>Invariant NKT (iNKT) cells are a subset of innate-like lymphocytes that recognize lipid antigen presented on monomorphic CD1d molecules. …”

Invariant Valpha14 chain NKT cells promote Plasmodium berghei circumsporozoite protein-specific gamma interferon- and tumor necrosis factor alpha-producing CD8+ T cells in the live... by Korten, S, Anderson, R, Hannan, C, Sheu, E, Sinden, R, Gadola, S, Taniguchi, M, Hill, A

“…Greater numbers of hepatic Valpha14iNKT cells secreted interleukin-4 than IFN-gamma. …”

Alteration of circulating unconventional T cells in cerebral ischemia: an observational study by Chao Zhou, Wei Rao, Xinhua Zhou, Dan He, Zhen Li, Nyambayar Dashtsoodol, Yue Ren

“…Our results demonstrate for the first time the reduction of peripheral blood NKTL, iNKT and γδ T cells in patients with the cerebral ischemia, and particularly reduced iNKT and γδ T cells in the acute phase. …”
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The influence of invariant natural killer T cells on myeloid-derived suppressor cell generation and function by Arscott, R

“…Moreover, iNKT cell adoptive transfer into flu-infected mice has been shown to abolish the expansion and flu-induced suppressive activity of the MDSCs in a CD1d- and CD40-dependent manner. …”

Mechanisms of induction and modulation of the pro-inflammatory cytokine interleukin-1beta by Yip, RHN

“…</p> <p>We hypothesise that this effect of iNKT cells is important in controlling inflammatory responses in vivo, and demonstrate exacerbated IL-1beta production and inflammation during influenza virus infection of iNKT cell-deficient animals. …”

Natural Killer T Cells Are Involved in Atherosclerotic Plaque Instability in Apolipoprotein-E Knockout Mice by Yoshinori Ohmura, Naoki Ishimori, Akimichi Saito, Takashi Yokota, Shunpei Horii, Satoshi Tokuhara, Kazuya Iwabuchi, Hiroyuki Tsutsui

“…However, it remained unclear whether iNKT cells are also involved in plaque instability. …”
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Invariant natural killer T cells in lung diseases by Dongjin Jeong, Yeon Duk Woo, Doo Hyun Chung

“…Here, we provide insights into the biology of iNKT cells in health and disease, with a particular focus on the role of pulmonary iNKT cells in airway inflammation and other lung diseases.…”
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Activation of invariant NKT cells in early phase of experimental autoimmune encephalomyelitis results in differentiation of Ly6Chi inflammatory monocyte to M2 macrophages and impro... by Denney, L, Kok, W, Cole, S, Sanderson, S, Mcmichael, A, Ho, L

“…Adoptive transfer of M2-enriched cells to iNKT-deficient mice markedly improved neurologic impairment. …”

Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans. by De Santo, C, Salio, M, Masri, S, Lee, L, Dong, T, Speak, A, Porubsky, S, Booth, S, Veerapen, N, Besra, G, Gröne, H, Platt, F, Zambon, M, Cerundolo, V

“…Adoptive transfer of iNKT cells abolished the suppressive activity of MDSCs, restored IAV-specific immune responses, reduced IAV titer, and increased survival rate. …”

Invariant Natural Killer T Cells Shape the Gut Microbiota and Regulate Neutrophil Recruitment and Function During Intestinal Inflammation by Sj Shen, Kathryn Prame Kumar, Dragana Stanley, Robert J. Moore, Robert J. Moore, Thi Thu Hao Van, Shu Wen Wen, Michael J. Hickey, Connie H. Y. Wong

“…Invariant natural killer T (iNKT) cells and neutrophils play an increasingly important part in the pathogenesis of inflammatory diseases, but their precise roles in modulating colitis remain unclear. …”
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Utilizing the adjuvant properties of CD1d-dependent NK T cells in T cell-mediated immunotherapy. by Silk, J, Hermans, I, Gileadi, U, Chong, T, Shepherd, D, Salio, M, Mathew, B, Schmidt, R, Lunt, S, Williams, K, Stratford, I, Harris, A, Cerundolo, V

“…Together these data highlight the therapeutic potential of iNKT cell ligands in vaccination strategies, particularly "heterologous prime-boost" strategies against tumors, and provide evidence that iNKT cell stimulation may be exploited in the development of oral vaccines.…”

Utilizing the adjuvant properties of CD1d-dependent NK T cells in T cell-mediated immunotherapy by Silk, J, Hermans, I, Gileadi, U, Chong, T, Shepherd, D, Salio, M, Mathew, B, Schmidt, R, Lunt, S, Williams, K, Stratford, I, Harris, A, Cerundolo, V

“…Together these data highlight the therapeutic potential of iNKT cell ligands in vaccination strategies, particularly "heterologous prime-boost" strategies against tumors, and provide evidence that iNKT cell stimulation may be exploited in the development of oral vaccines.…”

Preparation, characterisation and entrapment of a non-glycosidic threitol ceramide into liposomes for presentation to invariant natural killer T cells by Kaur, R, Chen, J, Dawoodji, A, Cerundolo, V, Garcia-Diaz, Y, Wojno, J, Cox, L, Besra, G, Moghaddam, B, Perrie, Y

“…Dendritic cells (DCs) are able to present glycolipids to invariant natural killer T (iNKT) cells in vivo. Very few compounds have been found to stimulate iNKT cells, and of these, the best characterised is the glycolipid α-galactosylceramide, which stimulates the production of large quantities of interferon-gamma (IFN-γ) and interleukin-4 (IL-4). …”

Preparation, characterisation and entrapment of a non-glycosidic threitol ceramide into liposomes for presentation to invariant natural killer T cells. by Kaur, R, Chen, J, Dawoodji, A, Cerundolo, V, Garcia-Diaz, Y, Wojno, J, Cox, L, Besra, G, Moghaddam, B, Perrie, Y

“…Dendritic cells (DCs) are able to present glycolipids to invariant natural killer T (iNKT) cells in vivo. Very few compounds have been found to stimulate iNKT cells, and of these, the best characterised is the glycolipid α-galactosylceramide, which stimulates the production of large quantities of interferon-gamma (IFN-γ) and interleukin-4 (IL-4). …”

Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans. by De Santo, C, Salio, M, Masri, S, Lee, L, Dong, T, Speak, A, Porubsky, S, Booth, S, Veerapen, N, Besra, G, Gröne, H, Platt, F, Zambon, M, Cerundolo, V

“…Adoptive transfer of iNKT cells abolished the suppressive activity of MDSCs, restored IAV-specific immune responses, reduced IAV titer, and increased survival rate. …”

Peripheral blood invariant natural killer T cells throughout pregnancy and in preeclamptic women. by Southcombe, J, Redman, C, Sargent, I

“…Invariant natural killer T (iNKT) cells are implicated in the pathogenesis of several diseases. …”

Activated invariant NKT cells regulate osteoclast development and function. by Hu, M, Bassett, J, Danks, L, Howell, P, Xu, K, Spanoudakis, E, Kotsianidis, I, Boyde, A, Williams, G, Horwood, N, Roberts, I, Karadimitris, A

“…Invariant NKT (iNKT) cells modulate innate and adaptive immune responses through activation of myeloid dendritic cells and macrophages and via enhanced clonogenicity, differentiation, and egress of their shared myeloid progenitors. …”

Motility and tumor infiltration are key aspects of invariant natural killer T cell anti-tumor function by Chenxi Tian, Yu Wang, Miya Su, Yuanyuan Huang, Yuwei Zhang, Jiaxiang Dou, Changfeng Zhao, Yuting Cai, Jun Pan, Shiyu Bai, Qielan Wu, Sanwei Chen, Shuhang Li, Di Xie, Rong Lv, Yusheng Chen, Yucai Wang, Sicheng Fu, Huimin Zhang, Li Bai

“…Abstract Dysfunction of invariant natural killer T (iNKT) cells contributes to immune resistance of tumors. …”
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Pivotal Advance: Invariant NKT cells reduce accumulation of inflammatory monocytes in the lungs and decrease immune-pathology during severe influenza A virus infection. by Kok, W, Denney, L, Benam, K, Cole, S, Clelland, C, Mcmichael, A, Ho, L

“…Activation of iNKT cells correlated with reduction of MCP-1 levels and improved outcome. iNKT cells were able to selectively lyse infected, MCP-1-producing monocytes in vitro, in a CD1d-dependent process. …”

Interaction between invariant NKT cells and myeloid-derived suppressor cells in cancer patients: evidence and therapeutic opportunities. by Mussai, F, De Santo, C, Cerundolo, V

“…Recently, we presented evidence that iNKT cells are able to interact with and decrease the numbers of circulating MDSCs in melanoma patients. …”