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Regeneration of invariant natural killer T (iNKT) cells: application of iPSC technology for iNKT cell-targeted tumor immunotherapy
Published 2023-05-01Subjects: “…iNKT cells…”
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The iNKT Cell–Macrophage Axis in Homeostasis and Disease
Published 2022-01-01“…Invariant natural killer T (iNKT) cells are CD1d-restricted, lipid-reactive T cells that exhibit preponderant immunomodulatory properties. …”
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New insights into iNKT cells and their roles in liver diseases
Published 2022-10-01“…Type I NKT cells are also named iNKT cells as they express a semi-invariant T cell-receptor (TCR) α chain. …”
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Modulation of Tregs and iNKT by Fingolimod in Multiple Sclerosis Patients
Published 2021-11-01Subjects: Get full text
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Human iNKT Cells Modulate Macrophage Survival and Phenotype
Published 2022-07-01Subjects: “…iNKT cells…”
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CD8+ T-cell immunity orchestrated by iNKT cells
Published 2023-01-01Subjects: “…invariant NKT (iNKT) cell…”
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iNKT cell production of GM-CSF controls Mycobacterium tuberculosis.
Published 2014-01-01“…Invariant natural killer T (iNKT) cells are activated during infection, but how they limit microbial growth is unknown in most cases. …”
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Exploring the Therapeutic Potentials of iNKT Cells for Anti-HBV Treatment
Published 2014-07-01“…CD1d-restricted invariant NKT (iNKT) cells are a group of innate-like regulatory T cells that recognize lipid antigens. …”
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Synthetic iNKT cell-agonists as vaccine adjuvants--finding the balance.
Published 2010“…Several synthetic iNKT-cell agonists that have potential as vaccine adjuvants have been identified, but these are not without their limitations-strong agonists can lead to the undesirable effects associated with overstimulation of the immune system, whereas too weak agonists may provide insufficient iNKT cell help to stimulate maturation of dendritic cells and differentiation of B cells. …”
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Characterization and Functional Analysis of Mouse Invariant Natural T (iNKT) Cells
Published 2006“…Invariant natural T (iNKT) cells are innate lymphocytes that recognize CD1d‐restricted lipid antigens and have immunoregulatory properties. …”
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The complement system and invariant natural killer T (iNKT) cell responses
Published 2021“…Modulation of DC effector function may in turn influence iNKT activation at the iNKT-APC interface.…”
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22511 Glycolipid-loaded nanoparticles harness iNKT cells for tumor immunotherapy
Published 2021-03-01“…ABSTRACT IMPACT: My work is on the development of a novel tumor immunotherapy to treat various types of cancer OBJECTIVES/GOALS: As iNKT cells can have direct and indirect killing effects on tumor cells, we propose a novel strategy for activating iNKT cells, via a PLGA nanoparticle delivery platform, to promote anti-tumor immune responses. …”
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Role of CD1d and iNKT cells in regulating intestinal inflammation
Published 2024-01-01“…Invariant natural killer T (iNKT) cells, a subset of unconventional T cells that recognize glycolipid antigens in a CD1d-dependent manner, are crucial in regulating diverse immune responses such as autoimmunity. …”
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License to Kill: When iNKT Cells Are Granted the Use of Lethal Cytotoxicity
Published 2020-05-01Subjects: “…iNKT…”
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Bystander activation of iNKT cells occurs during conventional T-cell alloresponses.
Published 2012“…It is well established that iNKT cells can be activated by both exogenous and a limited number of endogenous glycolipids. …”
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Bystander activation of iNKT cells occurs during conventional T-cell alloresponses
Published 2012“…It is well established that iNKT cells can be activated by both exogenous and a limited number of endogenous glycolipids. …”
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Perturbation of mucosal-associated invariant T cells and iNKT cells in HIV infection
Published 2018“…<strong>Purpose of review</strong> To analyze the possible role that the ‘unconventional’ T-cell populations mucosal-associated invariant T cell (MAIT) and iNKT cells play during HIV infection and following antiretroviral therapy (ART) treatment. …”
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3502 Stimulating iNKT Cell-Mediated Neuroblastoma Cytotoxicity in a Mouse Model
Published 2019-03-01“…OBJECTIVES/SPECIFIC AIMS: Overall Research Aim: To develop an iNKT-cell engaging reagent (“CAb”)to induce neuroblastoma-directed cytotoxicity in vitro and in a mouse model of neuroblastoma. …”
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Correction: Tissue-specific shaping of the TCR repertoire and antigen specificity of iNKT cells
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Expansion of highly activated iNKT cells with altered phenotype in acute dengue infection.
Published 2016“…<p>Invariant natural killer T cells (iNKTs) are capable of rapid activation and production of cytokines upon recognition of antigenic lipids presented by CD1d molecules. …”
Journal article