Building Microbial Machines<source>The International Genetically Engineered Machines</source> website: <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="http://www.2009.igem.org" ext-link-type="uri">http://www.2009.igem.org</ext-link> by Lisa Z. Scheifele

“…Review of: The International Genetically Engineered Machines website.…”
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Forecasting SARS-CoV-2 spike protein evolution from small data by deep learning and regression by Samuel King, Samuel King, Samuel King, Xinyi E. Chen, Xinyi E. Chen, Xinyi E. Chen, Sarah W. S. Ng, Sarah W. S. Ng, Sarah W. S. Ng, Kimia Rostin, Kimia Rostin, Kimia Rostin, Samuel V. Hahn, Samuel V. Hahn, Tylo Roberts, Tylo Roberts, Janella C. Schwab, Janella C. Schwab, Parneet Sekhon, Parneet Sekhon, Madina Kagieva, Madina Kagieva, Madina Kagieva, Taylor Reilly, Taylor Reilly, Taylor Reilly, Ruo Chen Qi, Ruo Chen Qi, Paarsa Salman, Paarsa Salman, Paarsa Salman, Ryan J. Hong, Ryan J. Hong, Eric J. Ma, Steven J. Hallam, Steven J. Hallam, Steven J. Hallam, Steven J. Hallam, Steven J. Hallam, Steven J. Hallam

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CAR‐T‐cell products in solid tumors: Progress, challenges, and strategies by Kewen Qian, Guangyao Li, Shuyi Zhang, Wenyan Fu, Tian Li, Jian Zhao, Changhai Lei, Yuqing Wang, Shi Hu

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CAR exosomes derived from effector CAR-T cells have potent antitumour effects and low toxicity by Wenyan Fu, Changhai Lei, Shuowu Liu, Yingshu Cui, Chuqi Wang, Kewen Qian, Tian Li, Yafeng Shen, Xiaoyan Fan, Fangxing Lin, Min Ding, Mingzhu Pan, Xuting Ye, Yongji Yang, Shi Hu

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TIGIT-Fc as a Potential Therapeutic Agent for Fetomaternal Tolerance by Wenyan Fu, Renfei Cai, Zetong Ma, Zetong Ma, Tian Li, Changhai Lei, Changhai Lei, Jian Zhao, Shi Hu, Shi Hu

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Bridging gaps in synthetic biology oversight : iGEM as a testbed for proactive, adaptive risk management by McNamara, Julie H. (Julie Hutton)

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iGEM 2021: A Year in Review by Hannah Moon

“…The international Genetically Engineered Machine (iGEM) Foundation has continued to promote synthetic biology education throughout its 2021 competition. …”
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Reproducibility of Fluorescent Expression from Engineered Biological Constructs in E. coli. by Jacob Beal, Traci Haddock-Angelli, Markus Gershater, Kim de Mora, Meagan Lizarazo, Jim Hollenhorst, Randy Rettberg, iGEM Interlab Study Contributors

“…We present results of the first large-scale interlaboratory study carried out in synthetic biology, as part of the 2014 and 2015 International Genetically Engineered Machine (iGEM) competitions. Participants at 88 institutions around the world measured fluorescence from three engineered constitutive constructs in E. coli. …”
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Implementing adaptive risk management for synthetic biology: Lessons from iGEM's safety and security programme by Piers Millett, Tessa Alexanian

“…This study details efforts by the International Genetically Engineered Machine (iGEM) competition in creating and implementing an adaptive risk management approach. …”
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Living machines go wild by Kirksey, E

“…Every year thousands of young people exhibit designs for genetically modified organisms at the International Genetically Engineered Machine (iGEM) competition in Boston. …”

Microfluidic Organ Chip for In Vitro Model of Blood Glucose Monitoring and Regulation by Wu Yingqiang, Wu Guo, Fu Pengcheng, Hu Meng

“…This study is based on our iGEM (international genetically engineered machine) 2019 competition project in which an in vitro model was established to simulate the human monitoring and regulation of blood glucose level using the “liver-on-a-chip” and a genetically engineered bacterium capable of producing proinsulin efficiently. …”
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A multi-platform flow device for microbial (co-) cultivation and microscopic analysis. by Matthijn C Hesselman, Dorett I Odoni, Brendan M Ryback, Suzette de Groot, Ruben G A van Heck, Jaap Keijsers, Pim Kolkman, David Nieuwenhuijse, Youri M van Nuland, Erik Sebus, Rob Spee, Hugo de Vries, Marten T Wapenaar, Colin J Ingham, Karin Schroën, Vítor A P Martins dos Santos, Sebastiaan K Spaans, Floor Hugenholtz, Mark W J van Passel

“…Within the context of the international Genetically Engineered Machine (iGEM) competition, we set out to design, manufacture, and implement a flow device that can accommodate multiple growth platforms, that is, a silicon nitride based microsieve and a porous aluminium oxide based microdish. …”
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The role of women in STEM disciplines. A multimodal analysis of crowdfunding project videos for the iGEM science competition. by Ana Cristina Vivas- Peraza

“…By applying a multimodal analysis from a social semiotic perspective, I examine how gender identities are represented in eight crowdfunding project videos of science created by undergraduate students for an international science competition, the International Genetically Engineered Machine (iGEM). Relying on the Swalesian move-step analysis genre approach for the verbal content (Swales, 1990, 2004), and Kress and van Leeuwen’s Visual Grammar (VG) model for the visual content (Kress & van Leeuwen, 2006), the analysis intends to uncover ideological purposes and meanings about gender roles within a context of scientific research. …”
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Protein engineering in the computational age: An open source framework for exploring mutational landscapes in silico by Shirin Bamezai, Giovanni Maresca di Serracapriola, Freya Morris, Rasmus Hildebrandt, Marc Augustine Sojerido Amil, Sporadicate iGEM Team, Rodrigo Ledesma‐Amaro

“…The international Genetically Engineered Machine (iGEM) competition represents a platform for undergraduate students to innovate in synthetic biology. …”
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iGEM and Gene Drives: A Case Study for Governance by Millett, Piers, Alexanian, Tessa, Palmer, Megan J, Evans, Sam Weiss, Kuiken, Todd, Oye, Kenneth

“…In this case study, we explore the International Genetically Engineered Machine (iGEM) competition's experiences in gene drive-related research and lessons in developing, revising, and implementing a governance system. iGEM's experiences and lessons are distilled into 6 key insights for future gene drive policy development in the United States: (1) gene drives deserve special attention because of their potential for widescale impact and remaining uncertainty about how to evaluate intergenerational and transboundary risks; (2) an adaptive risk management approach is logical for gene drives because of the rapidly changing technical environment; (3) review by individual technical experts is limited and may fail to incorporate other forms of expertise and, therefore, must be complemented with a range of alternative governance methods; (4) current laboratory biosafety and biosecurity review processes may not capture gene drive research or its components in practice even if they are covered theoretically; (5) risk management for research and development must incorporate discussions of values and broader implications of the work; and (6) a regular technology horizon scanning capacity is needed for the early identification of advances that could pose governance system challenges.…”
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BioMaster: An Integrated Database and Analytic Platform to Provide Comprehensive Information About BioBrick Parts by Beibei Wang, Beibei Wang, Huayi Yang, Jianan Sun, Chuhao Dou, Jian Huang, Jian Huang, Feng-Biao Guo, Feng-Biao Guo

“…Here, a database termed BioMaster http://www.biomaster-uestc.cn was developed to extensively complement information about BioBrick parts, which includes 47,934 items of BioBrick parts from the international Genetically Engineered Machine (iGEM) Registry with more comprehensive information integrated from 10 databases, providing corresponding information about functions, activities, interactions, and related literature. …”
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Sintezna biologija za proizvodnjo biobutanola by Marina Klemenčič, Ilja Gasan Osojnik Črnivec, Albin Pintar, Marko Dolinar

“…In 2015, the first-ever Slovenian high school team competed at the iGEM (international Genetically Engineered Machine) competition in synthetic biology. …”
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Auxotrophy to Xeno-DNA: an exploration of combinatorial mechanisms for a high-fidelity biosafety system for synthetic biology applications by Christopher M. Whitford, Saskia Dymek, Denise Kerkhoff, Camilla März, Olga Schmidt, Maximilian Edich, Julian Droste, Boas Pucker, Christian Rückert, Jörn Kalinowski

“…Abstract Background Biosafety is a key aspect in the international Genetically Engineered Machine (iGEM) competition, which offers student teams an amazing opportunity to pursue their own research projects in the field of Synthetic Biology. iGEM projects often involve the creation of genetically engineered bacterial strains. …”
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The BioExperience Research and Entrepreneurship Challenge: An iGEM-inspired applied research program for BIOSTEM talent and skills development by Hertek Gill, Hertek Gill, Hertek Gill, Mahdi Ahsan, Mahdi Ahsan, Mahdi Ahsan, Yara Khalil, Yara Khalil, Yara Khalil, Victoria Feng, Victoria Feng, Victoria Feng, Jessie Pearce, Jessie Pearce, Jessie Pearce, Tarasha Sharma, Tarasha Sharma, Tarasha Sharma, Mohamad Radwan, Mohamad Radwan, Mohamad Radwan, Mohamad Radwan, Austin Boucinha, Austin Boucinha, Mads Kærn, Mads Kærn, Mads Kærn

“…The program provided undergraduates with meaningful talent and skills development opportunities by implementing a student-centred, project-based learning approach inspired by the International Genetically Engineered Machine (iGEM) competition. We present evidence from participant exit surveys suggesting that the program delivers a high-quality learning environment and improves learning outcomes compared to traditional work-integrated learning. …”
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Synthesizing a novel genetic sequential logic circuit: a push‐on push‐off switch by Chunbo Lou, Xili Liu, Ming Ni, Yiqi Huang, Qiushi Huang, Longwen Huang, Lingli Jiang, Dan Lu, Mingcong Wang, Chang Liu, Daizhuo Chen, Chongyi Chen, Xiaoyue Chen, Le Yang, Haisu Ma, Jianguo Chen, Qi Ouyang

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