Expression of auxin transporter genes in flax (<i>Linum usitatissimum</i>) fibers during gravity response by N. N. Ibragimova, N. E. Mokshina

“…The difference was observed due to the expression of genes, the products of which are responsible for auxin intracellular transport (LusPILS3, LusPILS7-A) and its efflux (LusABCB15-B, LusABCB19-B). …”
Get full text

Silver Nanoparticles Surface-Modified with Carbosilane Dendrons as Carriers of Anticancer siRNA by Elżbieta Pędziwiatr-Werbicka, Michał Gorzkiewicz, Katarzyna Horodecka, Viktar Abashkin, Barbara Klajnert-Maculewicz, Cornelia E. Peña-González, Javier Sánchez-Nieves, Rafael Gómez, F. Javier de la Mata, Maria Bryszewska

“…The application of non-viral carriers based on nanomaterials aims at protecting genetic material from degradation and enabling its effective intracellular transport. We proposed the use of silver nanoparticles (AgNPs) surface-modified with carbosilane dendrons as carriers of anticancer siRNA (siBcl-xl). …”
Get full text

Begomovirus–Host Interactions: Viral Proteins Orchestrating Intra and Intercellular Transport of Viral DNA While Suppressing Host Defense Mechanisms by Sâmera S. Breves, Fredy A. Silva, Nívea C. Euclydes, Thainá F. F. Saia, James Jean-Baptiste, Eugenio R. Andrade Neto, Elizabeth P. B. Fontes

“…Pioneering studies on species of the <i>Begomovirus</i> genus have identified specific viral transport proteins involved in intracellular transport, cell-to-cell movement, and systemic spread. …”
Get full text

In-Depth Bioinformatic Study of the CLDN16 Gene and Protein: Prediction of Subcellular Localization to Mitochondria by Erasmia Rouka, Vassilios Liakopoulos, Konstantinos I. Gourgoulianis, Chrissi Hatzoglou, Sotirios G. Zarogiannis

“…<i>Conclusions:</i> This is the first study to identify mitochondria as a probable cytoplasmic compartment for CLDN16 localization, thus providing new insights into the protein&#8217;s intracellular transport. The results relative to the <i>CLDN16</i> interactome underline its role in renal pathophysiology and highlight the functional dependence of CLDNs-10, 14, 16, 19. …”
Get full text

Splicing variation of BMP2K balances abundance of COPII assemblies and autophagic degradation in erythroid cells by Jaroslaw Cendrowski, Marta Kaczmarek, Michał Mazur, Katarzyna Kuzmicz-Kowalska, Kamil Jastrzebski, Marta Brewinska-Olchowik, Agata Kominek, Katarzyna Piwocka, Marta Miaczynska

“…Intracellular transport undergoes remodeling upon cell differentiation, which involves cell type-specific regulators. …”
Get full text

Using a comprehensive approach to investigate the interaction between Kinesin-5/Eg5 and the microtubule by Wenhan Guo, Shengjie Sun, Jason E. Sanchez, Alan E. Lopez-Hernandez, Tolulope A. Ale, Jiawei Chen, Tanjina Afrin, Weihong Qiu, Yixin Xie, Lin Li

“…Kinesins are microtubule-based motor proteins that play important roles ranging from intracellular transport to cell division. Human Kinesin-5 (Eg5) is essential for mitotic spindle assembly during cell division. …”
Get full text

Long QT Syndrome Type 2: Emerging Strategies for Correcting Class 2 <i>KCNH2</i> (<i>hERG</i>) Mutations and Identifying New Patients by Makoto Ono, Don E. Burgess, Elizabeth A. Schroder, Claude S. Elayi, Corey L. Anderson, Craig T. January, Bin Sun, Kalyan Immadisetty, Peter M. Kekenes-Huskey, Brian P. Delisle

“…Almost half of suspected LQT2-causing mutations are missense mutations, and functional studies suggest that about 90% of these mutations disrupt the intracellular transport, or trafficking, of the <i>KCNH2</i>-encoded Kv11.1 channel protein to the cell surface membrane. …”
Get full text

Integration of metabolomics and proteomics reveals the underlying hepatotoxic mechanism of perfluorooctane sulfonate (PFOS) and 6:2 chlorinated polyfluoroalkyl ether sulfonic acid... by Chuanhai Li, Lidan Jiang, Yuan Qi, Donghui Zhang, Xinya Liu, Wenchao Han, Wanli Ma, Lin Xu, Yuan Jin, Jiao Luo, Kunming Zhao, Dianke Yu

“…Interestingly, 6:2 Cl-PFESA-induced cellular metabolic process disorder was associated with the cellular membrane-bounded signaling pathway, while PFOS was associated with the intracellular transport process. Moreover, the disruption effects of 6:2 Cl-PFESA were also involved in inositol phosphate metabolism and phosphatidylinositol signaling system. …”
Get full text

A C. albicans TRAPP Complex-Associated Gene Contributes to Cell Wall Integrity, Hyphal and Biofilm Formation, and Tissue Invasion by Dakota Ma, Miranda Yu, Susan Eszterhas, Christiane Rollenhagen, Samuel A. Lee

“…In this study, we focus on identifying and characterizing a gene potentially involved in the C. albicans secretory pathway, as intracellular transport is critical for C. albicans virulence. …”
Get full text

Kidney diseases and long non-coding RNAs in the limelight by Chenxin Liu, Kuai Ma, Yunchao Zhang, Xing He, Linjiang Song, Mingxuan Chi, Mingxuan Chi, Zhongyu Han, Guanhua Li, Qinxiu Zhang, Chi Liu, Chi Liu

“…LncRNAs are involved in various levels of gene regulatory processes, including but not limited to promoter activity, epigenetics, translation and transcription efficiency, and intracellular transport. They are also dysregulated in various pathophysiological processes, especially in diseases and cancers involving genomic imprinting. …”
Get full text

Influence of engineered nanoparticles (ENPs) on cytoskeletal remodeling of human dermal fibroblasts (HDF) in geometrical constraints by Ng, Alina Wenhui

“…The cellular cytoskeleton comprises a dynamic meshwork of protein filaments essential for maintaining cellular architecture, facilitating intracellular transport, and enabling cell movement. It participates in fundamental cellular processes, encompassing not only basic functions like cell division and migration but also complex activities such as embryonic development and wound healing. …”
Get full text

Three-dimensional single-particle tracking in live cells: news from the third dimension by A Dupont, M Gorelashvili, V Schüller, F Wehnekamp, D Arcizet, Y Katayama, D C Lamb, D Heinrich

“…Here we investigate the differences between the 2D and 3D analyses of intracellular transport with the 3D development of a time-resolved mean square displacement (MSD) analysis introduced previously. …”
Get full text

FcRn regulates antigen presentation in dendritic cells downstream of DEC205-targeted vaccines by Christophe Macri, Matthew Paxman, Devi Jenika, Xiao Peng Lin, Zahra Elahi, Paul A. Gleeson, Irina Caminschi, Mireille H. Lahoud, Jose A. Villadangos, Justine D. Mintern

“…The neonatal Fc receptor (FcRn) is a non-classical Fc receptor that binds to immunoglobulin G (IgG) in acidified endosomes and controls its intracellular transport and recycling. FcRn is known to participate in the antigen presentation of immune complexes, however its contribution to DC-targeted vaccination has not previously been examined. …”
Get full text

Selection and Validation of Reference Genes for RT-qPCR Analysis in <i>Aegilops tauschii</i> (Coss.) under Different Abiotic Stresses by Adeel Abbas, Haiyan Yu, Xiangju Li, Hailan Cui, Jingchao Chen, Ping Huang

“…Phosphate2A serine/threonine-protein phosphatase 2A (<i>PP2A</i>) and eukaryotic translation initiation factor 3 (<i>ETIF3</i>) are the most stable genes at seedling and developmental stages. Intracellular transport protein (<i>CAC</i>) is recommended as the most stable gene under different abiotic stresses and at developmental stages. …”
Get full text

Analysis of networks in the dorsolateral prefrontal cortex in chronic schizophrenia: Relevance of altered immune response by América Vera-Montecinos, Ricard Rodríguez-Mias, Èlia Vila, Judit Villén, Belén Ramos, Belén Ramos, Belén Ramos, Belén Ramos

“…Analysis of this panel showed an enrichment of biological processes implicated in vesicle-mediated transport, processing and antigen presentation via MHC class II, intracellular transport and selenium metabolism. The enriched identified pathways were MHC class II antigen presentation, vesicle-mediated transport, Golgi ER retrograde transport, Nef mediated CD8 downregulation and the immune system. …”
Get full text

Design of New Polyaspartamide Copolymers for siRNA Delivery in Antiasthmatic Therapy by Emanuela Fabiola Craparo, Salvatore Emanuele Drago, Nicolò Mauro, Gaetano Giammona, Gennara Cavallaro

“…Gene silencing experiments on 16-HBE showed that these copolymers have a significant role in improving the intracellular transport of naked siRNA, where the presence of PEG does not seem to hinder the cellular uptake of polyplexes. …”
Get full text

PAQR3 Regulates Endoplasmic Reticulum-to-Golgi Trafficking of COPII Vesicle via Interaction with Sec13/Sec31 Coat Proteins by Qianqian Cao, Zheng Wang, Huida Wan, Lijiao Xu, Xue You, Lujian Liao, Yan Chen

“…Proximity labeling using PAQR3 fused with APEX2 identified that many proteins involved in intracellular transport are in close proximity to PAQR3. ER-to-Golgi trafficking of N-acetylgalactosaminyltransferase-2 on removal of brefeldin A is delayed by PAQR3 deletion. …”
Get full text

Clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9-generated diallelic mutants reveal Arabidopsis actin-related protein 2 function in the traffic... by Peng Gao, Peng Gao, Li Qin, Hanh Nguyen, Huajin Sheng, Teagen D. Quilichini, Daoquan Xiang, Leon V. Kochian, Yangdou Wei, Raju Datla

“…The formation of actin patches is essential for the intracellular transport of organelles and molecules toward pathogen penetration sites and the formation of papillae for an early cellular response to powdery mildew attack in Arabidopsis thaliana. …”
Get full text

A New Derivative of Retro-2 Displays Antiviral Activity against Respiratory Syncytial Virus by Adrien Le Rouzic, Jenna Fix, Robin Vinck, Sandrine Kappler-Gratias, Romain Volmer, Franck Gallardo, Jean-François Eléouët, Mathilde Keck, Jean-Christophe Cintrat, Julien Barbier, Daniel Gillet, Marie Galloux

“…Taken together, our data show that targeting intracellular transport may be an effective strategy against hRSV infection.…”
Get full text

Host Factors Genes <i>BcCLC1</i> and <i>BcCLC2</i> Confer Turnip Mosaic Virus Resistance in Non-Heading Chinese Cabbage (<i>Brassica campestris</i> ssp. <i>chinensis</i>) by Mengguo Yuan, Shanwu Lyu, Yaolong Wang, Liu E, Tongkun Liu, Xilin Hou, Ying Li, Changwei Zhang

“…In conclusion, we speculate that <i>BcCLCs</i> confer <i>Turnip mosaic virus</i> (TuMV) resistance in NHCC by interacting with TuMV proteins to promote the intracellular transport of the virus.…”
Get full text