Impact of congenital uterine anomalies on reproductive outcomes of IVF/ICSI-embryo transfer: a retrospective study by Jia Kang, Jie Qiao

“…Abstract Objective To study the impact of congenital uterine anomalies on reproductive outcomes after in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI)-embryo transfer (ET). Methods A retrospective study including a total of 865women with congenital uterine anomalies and 865 age and admission time matched controls who underwent the first IVF/ICSI-ET cycle between January 2010 and December 2019 was conducted. …”
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Anti-Müllerian hormone independently affect mtDNA copy number in human granulosa cells by Anom Bowolaksono, Ayu Mulia Sundari, Muhammad Fauzi, Mila Maidarti, Budi Wiweko, Kresna Mutia, Pritta Ameilia Iffanolida, Ririn Rahmala Febri, Astari Dwiranti, Hiroaki Funahashi

“…Methods: In the present study, we utilized a real-time quantitative PCR (RT-qPCR) to quantify the mtDNA copy number of granulosa cells obtained from 43 women undergoing an in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) program. Results: According to our analysis, a significant correlation was observed between age and mtDNA copy number (r = −0.54, P < 0.001) and between age and AMH level (r = −0.48, P < 0.001) of the same individual. …”
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MicroRNAs secreted by human preimplantation embryos and IVF outcome by Shintaro Kamijo, Toshio Hamatani, Hiroyuki Sasaki, Hiroki Suzuki, Akane Abe, Osamu Inoue, Maki Iwai, Seiji Ogawa, Kei Odawara, Kanako Tanaka, Mutsumi Mikashima, Masami Suzuki, Kenji Miyado, Ryo Matoba, Yasushi Odawara, Mamoru Tanaka

“…Patients Sixty patients who underwent thawed embryo transfer of blastocysts after intracytoplasmic sperm injection. Intervention(s) None. Main outcome measure(s) The association of miRNA abundance levels secreted by blastocysts in culture medium and implantation success. …”
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Degenerated oocyte in the cohort adversely affects IVF outcome by Yuval Atzmon, Mediea Michaeli, Diana Poltov, Nechami Rotfarb, Oshrit Lebovitz, Nardin Aslih, Einat Shalom-Paz

“…Abstract The presence of Degenerated Oocyte (DEG) was mostly described after intracytoplasmic sperm injection (ICSI), with fewer reports on DEG at the time of ovum pick-up (OPU). …”
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Effect of Paternal Body Mass Index on In Vitro Fertilization and Neonatal Outcomes among Oligozoospermia and Asthenospermia Patients by Xudong Zhang, Shanshan Wu, Xiaohan Qi, Shan Gao, Jiarui Qi, Siwen Zhang, Jichun Tan

“…This study aims to assess the impact of paternal BMI on ART and neonatal outcomes among oligozoospermia and/or asthenospermia patients undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI). Materials and Methods: In this study, 2,075 couples undergoing their first fresh embryo transfer between January 2015 and June 2022 were recruited. …”

Impact of dehydroepiandrosterone sulfate and free androgen index on pregnancy and neonatal outcomes in PCOS patients by Wen Zhao, Zeting Li, Bing Cai, Canquan Zhou, Qingyun Mai

“…Methods A retrospective cohort study was conducted at the Reproductive Medicine Center of the First Affiliated Hospital of Sun Yat-sen University from January 2015 to November 2022, involving 636 cycles of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). Subgroup analyses were performed using cut-off values of 6.4 for free androgen index (FAI), 9.5 µmol/L for DHEAS. …”
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Effect of Coenzyme Q10 and transcutaneous electrical acupoint stimulation in assisted reproductive technology: a retrospective controlled study by Shanqin Qi, Qi Liang, Lixia Yang, Xueyuan Zhou, Kun Chen, Ji Wen

“…Methods A total of 330 POR patients who were pretreated with CoQ10 or CoQ10 combined with TEAS before their in vitro fertilization/intracytoplasmic sperm injection and embryo transfer (IVF/ICSI-ET) cycles and who were not pretreated were selected and divided into CoQ10 group (group A, n = 110), CoQ10 + TEAS group (group B, n = 110) and control group (group C, n = 110). …”
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A novel mutation in CFAP47 causes male infertility due to multiple morphological abnormalities of the sperm flagella by Mohan Liu, Siyu Dai, Siyu Dai, Jiying Zhang, Yihong Yang, Ying Shen, Hongqian Liu, Hongqian Liu, Yanting Yang, Yanting Yang, Chuan Jiang, Erpo Tian

“…The functional effect of the identified mutations was investigated by immunofluorescence staining and western blotting. Intracytoplasmic sperm injection (ICSI) was used to assist fertilization for the patient with MMAF.ResultsIn this study, we identified a novel missense mutation (c.1414G&gt;A; p.V472M) in CFAP47 in two unrelated patients with oligoasthenoteratozoospermia. …”
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Predictive Factors for Recovery Time in Conceived Women Suffering From Moderate to Severe Ovarian Hyperstimulation Syndrome by Kai Huang, Ying Shi, Gezi Chen, Hao Shi, Jun Zhai

“…ObjectiveThis study aimed to evaluate potential predictors for recovery time in pregnant patients with moderate to severe ovarian hyperstimulation syndrome (OHSS).MethodsA total of 424 pregnant patients with moderate to severe OHSS who underwent in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) were retrospectively identified. …”
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Advantages of cumulative pregnancy outcomes in freeze-all strategy in high responders – A case-control matching analysis of a large cohort by Ming-Yih Wu, Chi-Hsien Chung, Song-Po Pan, Gaii-Chen Jou, Mei-Jou Chen, Chin-Hao Chang, Shee-Uan Chen, Chu-Chun Huang, Yu-Shih Yang

“…Background/Purpose: The freeze-all strategy in high responders is considered to be a safe and effective strategy for in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment; however, the cumulative pregnancy outcomes have not been established. …”
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Gut Microbiota-Derived Short Chain Fatty Acids Are Associated with Clinical Pregnancy Outcome in Women Undergoing IVF/ICSI-ET: A Retrospective Study by Xinrui Yao, Sitong Dong, Wenzheng Guan, Lingjie Fu, Gaoyu Li, Zhen Wang, Jiao Jiao, Xiuxia Wang

“…This retrospective cross-sectional study recruited 147 patients undergoing in vitro fertilization or intracytoplasmic sperm injection and embryo transfer (IVF/ICSI-ET) (70 with no pregnancies and 77 with clinical pregnancies). …”
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The follicular-phase depot GnRH agonist protocol results in a higher live birth rate without discernible differences in luteal function and child health versus the daily mid-luteal... by Ying Zhang, Wenxian Zhao, Yifan Han, Xin Chen, Shaoyuan Xu, Yueyue Hu, Honglu Diao, Changjun Zhang

“…Abstract Background The gonadotropin-releasing hormone agonist (GnRH-a) has been used in in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles for a long time. …”
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Sperm DNA integrity does play a crucial role for embryo development after ICSI, notably when good-quality oocytes from young donors are used by Jordi Ribas-Maynou, Sergi Novo, Marc Torres, Albert Salas-Huetos, Sergi Rovira, Marta Antich, Marc Yeste

“…Abstract Based on the inconsistent literature published thus far involving infertile patients, whether intracytoplasmic sperm injection (ICSI) allows overcoming total fertilization failure due to sperm DNA fragmentation is still unclear. …”
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Living birth following preimplantation genetic testing for monogenic disorders to prevent low-level germline mosaicism related Nicolaides–Baraitser syndrome by Jiexue Pan, Jiexue Pan, Jiexue Pan, Jiexue Pan, Jie Li, Jie Li, Songchang Chen, Songchang Chen, Chenming Xu, Chenming Xu, Hefeng Huang, Hefeng Huang, Hefeng Huang, Li Jin, Li Jin

“…Here, we present a live birth of a female infant from a father with low-level sperm DNA mosaicism achieved via preimplantation genetic testing for monogenic disorders (PGT-M).Methods: A couple with the father carrying sperm DNA mosaicism received standard in vitro fertilization treatment, with intracytoplasmic sperm injection, embryo biopsy, polymerase chain reaction, and DNA analysis. …”
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Effects of body mass index on IVF outcomes in different age groups by Dan Liu, Li Li, Ningyu Sun, Xiaole Zhang, Ping Yin, Wuwen Zhang, Panwei Hu, Hua Yan, Qinhua Zhang

“…Methods A total of 2311 cycles from 986 women undergoing their first IVF/intracytoplasmic sperm injection cycle with fresh/frozen embryo transfer between January 2018 and December 2021 at the Center of Reproductive Medicine, Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine, were considered in this retrospective cohort study. …”
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Supporting Women Undergoing IVF Treatment With Timely Patient Information Through an App: Randomized Controlled Trial by Thomas Timmers, Manouk Keijsers, Jan A M Kremer, Loes Janssen, Jesper Smeenk

“…Patients who were scheduled for IVF or intracytoplasmic sperm injection treatments between April 2018 and August 2019 were invited to participate in a physician-blinded, randomized controlled trial. …”
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Mitochondrial complex I deficiency leads to the retardation of early embryonic development in Ndufs4 knockout mice by Mei Wang, Ya-Ping Huang, Han Wu, Ke Song, Cong Wan, A-Ni Chi, Ya-Mei Xiao, Xiao-Yang Zhao

“…Then, we described the phenotypes of our mouse model by forced swimming and the open-field test as well as by assessing other behavioral characteristics. Intracytoplasmic sperm injection (ICSI) was performed to obtain KO embryos to test the influence of NDUFS4 deletion on early embryonic development. …”
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The influence of leukocytospermia on the outcomes of assisted reproductive technology by Cavagna Mario, Oliveira Joao Batista A, Petersen Claudia G, Mauri Ana L, Silva Liliane F I, Massaro Fabiana C, Baruffi Ricardo L R, Franco José G

“…This investigation analysed the outcomes of the intracytoplasmic sperm injection (ICSI) and intracytoplasmic morphologically selected sperm injection (IMSI) cycles in couples in which the male partner exhibited leukocytospermia.…”
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Temporary Increased LDL-C in Offspring with Extreme Elevation of Maternal Preconception Estradiol: A Retrospective Cohort Study by Feng W, Zhang D, Fu L, Hu J, Gao S, Song X, Cui L

“…Overall, 3690 children conceived by in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) between July 2014 and December 2017 were recruited and divided into four groups categorized by maternal E2 quartiles (Q1, < 2420; Q2, 2420– 3839; Q3, 3839– 5599; and Q4, ≥ 5599 pg/mL). …”
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Low LH level does not indicate poor IVF cycle outcomes with GnRh-a single trigger: a retrospective analysis by Xue-Fei Li, Qiao-Feng Wang, Qi-Qi He, Xue-Jiao Wang, Xing-Yu LV, Xiao-Jun Tang, Zhao-Hui Zhong, Yu-Bin Ding, Qi Wan

“…Abstract Objective To compare the in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycle outcomes between patients with low and normal serum luteinizing hormone (LH) levels on the day after a gonadotropin-releasing hormone agonist (GnRH-a) single trigger. …”
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