Risk factors associated with preterm birth after IVF/ICSI by Jian Li, Jinhua Shen, Xiaoli Zhang, Yangqin Peng, Qin Zhang, Liang Hu, Christoph Reichetzeder, Suimin Zeng, Jing Li, Mei Tian, Fei Gong, Ge Lin, Berthold Hocher

“…Abstract In vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) is associated with an increased risk of preterm (33rd–37th gestational week) and early preterm birth (20th–32nd gestational week). …”
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Role of N-acetylcysteine treatment in women with advanced age undergoing IVF/ICSI cycles: A prospective study by Xiufang Li, Xiufang Li, Zhongqing Wang, Zhongqing Wang, Huidan Wang, Haiyan Xu, Yan Sheng, Fang Lian

“…ObjectiveThe main objective of this study was to explore the efficacy of a new antioxidant N-acetylcysteine (NAC) supplementation in reproductive outcomes of advanced age women undergoing in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET), and the effect on the expression of L-glutathione (GSH) in follicular fluid (FF) and mitochondrial DNA (mtDNA) copy number of granulosa cells.MethodsThe present prospective randomized controlled study was conducted in 200 patients with advanced age women undergoing GnRH antagonist protocol. …”
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CFAP70 is a solid and valuable target for the genetic diagnosis of oligo-astheno-teratozoospermia in infertile menResearch in context by Hui-Juan Jin, Jun-Li Wang, Xin-Yan Geng, Chun-Yan Wang, Bin-Bin Wang, Su-Ren Chen

“…Moreover, we suggest that CFAP70-associated male infertility could be overcome by intracytoplasmic sperm injection (ICSI) treatment. Interpretation: Overall, we demonstrate that CFAP70 is necessary to assemble spermatid flagella and that CFAP70 gene could be used as a diagnostic target for male infertility with OAT in the clinic. …”
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Factors affecting male-to-female ratio at birth in frozen-thawed embryo transfer cycles: a large retrospective cohort study by Tong Du, Qin Xie, Jing Ye, Xindi Wang, Jiaxin Qiu, Zheng Yan, Suqun Zhang, Dong Zhao, Jiaying Lin, Bin Li

“…BackgroundICSI (intracytoplasmic sperm injection) leads to a reduced male-to-female ratio at birth, whereas blastocyst transfer results in an increased male-to-female ratio. …”
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The serum oestradiol/progesterone ratio on the day of OPU + 7, but not the day of OPU + 5, affects the rates of live birth in fresh blastocyst embryo transfer cycles by Wenxian Zhao, Honglu Diao, Xin Chen, Shaoyuan Xu, Shengfang Jiang, Hong Cao, Changjun Zhang, Ying Zhang

“…Methods This is a retrospective cohort study of 2,257 women undergoing a follicular-phase depot gonadotropin-releasing hormone agonist (GnRH-a) protocol for in vitro fertilization /intracytoplasmic sperm injection (IVF/ICSI) treatment and fresh blastocyst embryo transfer cycles at a university-affiliated fertility center between January 2016 and April 2021. …”
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Elevated follicular cortisone level is a negative predictor of clinical pregnancy in women undergoing fresh embryo transfer by Zuwei Yang, Jiexue Pan, Chengliang Zhou, Jianzhong Sheng, Li Jin, Hefeng Huang

“…Background: Although numerous studies have investigated the potential correlation between follicular fluid (FF) steroid concentrations and in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) outcomes, few have accounted for the effect of controlled ovarian hyperstimulation regimes on FF steroid concentrations. …”
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Comparison of the Clinical Outcomes in Women with A or D PCOS Phenotypes versus Single Polycystic Ovary undergoing IVF-ET by Fangfang Dai, Yasong Geng, Meiyang Du, Shusong Wang, Guozhen Li, Linlin Tao, Bo Zheng

“…Methods: Overall, a total of 767 PCOS patients with first in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) treatment classified into phenotype A (n = 167 patients) and phenotype D (n = 600 patients) were eligible for analysis. …”
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Risk of Higher Blood Pressure in 3 to 6 Years Old Singleton Born From OHSS Patients Undergone With Fresh IVF/ICSI by Yimin Zhu, Yanling Fu, Minyue Tang, Huanmiao Yan, Fanghong Zhang, Xiaoling Hu, Guofang Feng, Yu Sun, Lanfeng Xing

“…Few studies have investigated any association between OHSS and cardiovascular or metabolic function in subsequent children.ObjectiveTo evaluate the effect of ovarian hyperstimulation syndrome (OHSS) on blood pressure of singletons after in vitro fertilization (IVF) with or without intracytoplasmic sperm injection (ICSI).Study DesignThe singlet-center corhort study included 1780 singletons born with IVF/ICSI and 83 spontaneously conceived children from 2003 to 2014. …”
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A Machine Learning Approach for the Prediction of Testicular Sperm Extraction in Nonobstructive Azoospermia: Algorithm Development and Validation Study by Guillaume Bachelot, Ferdinand Dhombres, Nathalie Sermondade, Rahaf Haj Hamid, Isabelle Berthaut, Valentine Frydman, Marie Prades, Kamila Kolanska, Lise Selleret, Emmanuelle Mathieu-D’Argent, Diane Rivet-Danon, Rachel Levy, Antonin Lamazière, Charlotte Dupont

“…A TESE was considered positive if we obtained sufficient spermatozoa for intracytoplasmic sperm injection. After preprocessing the raw data, 8 machine learning (ML) models were trained and optimized on the retrospective training cohort data set: The hyperparameter tuning was performed by random search. …”
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The Effects of Endometrial Thickness on Pregnancy Outcomes of Fresh IVF/ICSI Embryo Transfer Cycles: An Analysis of Over 40,000 Cycles Among Five Reproductive Centers in China by Jianing Xu, Shaodi Zhang, Lei Jin, Yundong Mao, Juanzi Shi, Rui Huang, Xiao Han, Xiaoyan Liang, Cuilian Zhang

“…ObjectiveTo investigate the effects of endometrial thickness (EMT) on pregnancy outcomes on hCG trigger day in fresh in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles.MethodsA total of 42,132 fresh cycles between 1 January 2013 and 31 December 2019 were included in this retrospective cohort study. …”
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Should ICSI be implemented on patients with poor-quality embryos in the previous IVF cycle? by Jiang Wang, Shun Xiong, Yang Gao, Fei Xia, Biao Wei, Jiayi Zou, Guoning Huang, Wei Han

“…This study was to evaluate whether Intracytoplasmic sperm injection (ICSI) can improve the quality of embryo in patients with poor-quality embryos in the previous In-vitro fertilization (IVF) cycle, which was cancelled before transfer. …”
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The Impact of Assisted Reproductive Technology on Umbilical Cord Insertion: Increased Risk of Velamentous Cord Insertion in Singleton Pregnancies Conceived through ICSI by Eriko Fukuda, Akihiro Hamuro, Kohei Kitada, Yasushi Kurihara, Mie Tahara, Takuya Misugi, Akemi Nakano, Mami Tamaue, Sae Shinomiya, Hisako Yoshida, Masayasu Koyama, Daisuke Tachibana

“…They were divided into three groups: spontaneous pregnancy, conventional in vitro fertilization (cIVF), and in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). We recorded patient background information, perinatal complications, perinatal outcomes, and a numerical “displacement score”, indicating the degree of separation between umbilical CI and the placental center. …”
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Infertility Treatment and Hypertension in Pregnancy: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study by Mami Ishikuro, Taku Obara, Keiko Murakami, Fumihiko Ueno, Aoi Noda, Tomomi Onuma, Fumiko Matsuzaki, Masahiro Kikuya, Zen Watanabe, Naomi Shiga, Masahito Tachibana, Noriyuki Iwama, Hirotaka Hamada, Masatoshi Saito, Junichi Sugawara, Hirohito Metoki, Nobuo Yaegashi, Shinichi Kuriyama

“…In vitro fertilization/intracytoplasmic sperm injection were also associated with HDP. …”
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The Normal Body Mass Index (BMI) of Women with Polycystic Ovary Syndrome (PCOS) was Associated with IVF/ICSI Assisted Conception Outcomes by Ning Ma, Jing Zhou, Weiying Lu

“…Methods: From January 1, 2021 to April 30, 2022, 133 in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cases with normal body mass index were enrolled in the Reproductive Medical Center of Hainan Women and Children’s Medical Centre, including 77 PCOS patients with normal BMI and 46 non-PCOS patients with normal BMI, the ovulation induction regimen was used as an antagonist regimen, and the waist circumference, body mass index, follicle-stimulating hormone (FSH), luteinizing hormone (LH), LH/FSH, anti-Mullerian hormone (AMH), blood lipids, homeostasis model assessment of insulin resistance (HOMA-IR), gonadotropin (Gn) dosage between the two groups were compared, Gn days of use, number of eggs obtained, normal fertilization rate, normal cleavage rate, number of available embryos, number of high-quality embryos, embryo implantation rate, clinical pregnancy rate and other indicators. …”
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Impact of Advanced Paternal Age on Fertility and Risks of Genetic Disorders in Offspring by Aris Kaltsas, Efthalia Moustakli, Athanasios Zikopoulos, Ioannis Georgiou, Fotios Dimitriadis, Evangelos N. Symeonidis, Eleftheria Markou, Theologos M. Michaelidis, Dung Mai Ba Tien, Ioannis Giannakis, Eleni Maria Ioannidou, Athanasios Papatsoris, Panagiota Tsounapi, Atsushi Takenaka, Nikolaos Sofikitis, Athanasios Zachariou

“…Paternal age has been shown to affect reproductive and fertility outcomes, such as the success rate of in vitro fertilisation (IVF), intracytoplasmic sperm injection (ICSI), and premature birth rate. …”
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Onco-TESE (Testicular Sperm Extraction): Insights from a Tertiary Center and Comprehensive Literature Analysis by Lorenzo Cirigliano, Marco Falcone, Murat Gül, Mirko Preto, Carlo Ceruti, Natalia Plamadeala, Federica Peretti, Ilaria Ferro, Martina Scavone, Paolo Gontero

“…Among the three patients with successful sperm retrieval, an intracytoplasmic sperm injection (ICSI) was performed in two patients, resulting in two pregnancies, leading to one healthy live birth and one miscarriage. …”
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Effect of accurate assessment for uterine cavity environment on outcome of repeated transplantation failures by HAN Shujie, HAN Shujie, SHU Mingming, SONG Chunlan, CHEN Fu, WANG Lu

“…Methods A total of 223 patients with repeated transplantation failure who underwent in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) in the Assisted Reproductive Center of the Sixth Medical Center of Chinese PLA General Hospital from September 2019 to January 2021 were recruited as the research subjects. …”
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Assisted reproductive technology induces different secondary sex ratio: parental and embryonic impacts by Jiansen Zhao, Haoran Shen, Qijiong Zhu, Jiong Liu, Jianhua Han, Ruiting Yi, Junxing Li, Yanshan Lin, Tao Liu, Xinqi Zhong

“…Women aged > 35 years and intracytoplasmic sperm injection (ICSI) were associated with lower SSR (OR = 0.539, 95% CI: 0.293–0.990 and OR = 0.331, 95% CI: 0.158–0.690, respectively). …”
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Associations of personal care products use with reproductive outcomes of IVF/ICSI treatment by Qing-Chun Guo, Wen Yao, Chong Liu, Tao-Ran Deng, Juan Li, Hong-Mei Liao, Wen-Qu Tian, Yi Wang, Yao-Yao Du, Yu-Feng Li

“…The current study aimed to explore the relationships between PCPs use patterns and reproductive outcomes in women undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatment.MethodsA total of 1500 women from the Tongji Reproductive and Environmental (TREE) study between December 2018 and January 2020 were included in this study. …”
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Preimplantation Genetic Testing for Aneuploidy Could Not Improve Cumulative Live Birth Rate Among 705 Couples with Unexplained Recurrent Implantation Failure by Liu Y, Lan X, Lu J, Zhang Q, Zhou T, Ni T, Yan J

“…Yang Liu,1– 6,* Xiangxin Lan,1– 6,* Juanjuan Lu,1– 6,* Qian Zhang,1– 6 Tingting Zhou,1– 6 Tianxiang Ni,1– 6 Junhao Yan1– 6 1Center for Reproductive Medicine, Shandong University, Jinan, Shandong, 250012, People’s Republic of China; 2Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, Shandong, 250012, People’s Republic of China; 3Shandong Key Laboratory of Reproductive Medicine, Jinan, Shandong, 250012, People’s Republic of China; 4Shandong Provincial Clinical Research Center for Reproductive Health, Jinan, Shandong, 250012, People’s Republic of China; 5Shandong Technology Innovation Center for Reproductive Health, Jinan, Shandong, 250012, People’s Republic of China; 6National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, 250012, People’s Republic of China*These authors contributed equally to this workCorrespondence: Tianxiang Ni; Junhao Yan, Center for Reproductive Medicine, Shandong University, Jinan, People’s Republic of China, Tel +0531-85651172, Email tianxiangni907@163.com; yyy306@126.comObjective: We evaluate whether next-generation sequencing (NGS)-based preimplantation genetic testing for aneuploidy (PGT-A) improves the cumulative pregnancy outcomes of patients with unexplained recurrent implantation failure (uRIF) as compared to conventional in vitro fertilization or intracytoplasmic sperm injection (IVF/ICSI).Patients and Methods: This was a retrospective cohort study (2015– 2022). …”
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