The use of carbon monoxide breath test to detect the effect of iron overload on erythrocyte lifespan in MDS by Yao Zhang, Yan Qian, Lu-xi Song, Chao Xiao, Chun-kang Chang

“…ObjectiveTo investigate the effect of iron overload (IO) on red blood cell (RBC) lifespan in MDS patients with the use of carbon monoxide breath testMethodsThe red blood cell lifespan of 93 patients with myelodysplastic syndrome (MDS) and 22 healthy volunteers in the control group were measured by alveolar gas carbon monoxide (CO) assay, with the detection of liver iron concentration, iron metabolism index, erythropoietin (EPO) concentration, peripheral blood inflammatory cytokines, etc. …”
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Dysmetabolic Iron Overload Syndrome: Going beyond the Traditional Risk Factors Associated with Metabolic Syndrome by Sandra Maria Barbalho, Lucas Fornari Laurindo, Ricardo José Tofano, Uri Adrian Prync Flato, Claudemir G. Mendes, Ricardo de Alvares Goulart, Ana Maria Gonçalves Milla Briguezi, Marcelo Dib Bechara

Subjects: “…dysmetabolic iron overload syndrome…”
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Effect of deferoxamine therapy on insulin resistance in end-stage renal disease patients with iron overload by Alsayed Ahmed Alnahal, Magdy Tahan, Aymen Fathy, Tamer Fathy

“…No statistically significant difference was seen with regard to lipid profile, blood pressure and CAIMT. Iron overload increases insulin resistance and cardiovascular risk in hemodialysis subjects. …”
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Chronic red cell exchange in sickle cell patients with iron overload may not affect mortality by Yi Yuan Zhou, Yi Yuan Zhou, Hollie M. Reeves, Hollie M. Reeves, LaRhonda Webb, Zamira Santiago, Robert W. Maitta, Robert W. Maitta

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Iron Overload, Oxidative Stress and Calcium Mishandling in Cardiomyocytes: Role of the Mitochondrial Permeability Transition Pore by Richard Gordan, Nadezhda Fefelova, Judith K. Gwathmey, Lai-Hua Xie

Subjects: “…iron overload…”
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Transfusion burden in early childhood plays an important role in iron overload in Diamond‐Blackfan anaemia by Jonathan R. A. deWilde, Birgit vanDooijeweert, Annelies J. vanVuren, Elise J. Huisman, Frans J. Smiers, Arian vander Veer, Richard vanWijk, Wouter W. vanSolinge, Edward E. S. Nieuwenhuis, Eduard J. vanBeers, Marije Bartels

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P1502: CHARACTERIZATION OF THE MUTATION PATTERN OF GENES ASSOCIATED WITH IRON OVERLOAD IN A BRAZILIAN POPULATION by Ana Carolina Toreli, Paula De Melo Campos, Isabella Toni, Daniela Pinheiro Leonardo, Carolina Lanaro, Dulcineia Martins de Albuquerque, Kleber Yotsumoto Fertrin, Fernando F Costa

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Non-heme iron overload impairs monocyte to macrophage differentiation via mitochondrial oxidative stress by Yue Cui, Saray Gutierrez, Sheller Ariai, Lisa Öberg, Kristofer Thörn, Ulf Gehrmann, Suzanne M. Cloonan, Suzanne M. Cloonan, Thomas Naessens, Henric Olsson

“…Macrophages are key cells in regulating iron levels in tissues as they sequester excess iron. How iron overload affects macrophage differentiation and function remains a subject of debate. …”
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Management of Iron Overload in Beta-Thalassemia Patients: Clinical Practice Update Based on Case Series by Valeria Maria Pinto, Gian Luca Forni

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Iron overload and impaired iron handling contribute to the dystrophic pathology in models of Duchenne muscular dystrophy by Francesca M. Alves, Kai Kysenius, Marissa K. Caldow, Justin P. Hardee, Jin D. Chung, Jennifer Trieu, Dominic J. Hare, Peter J. Crouch, Scott Ayton, Ashley I. Bush, Gordon S. Lynch, René Koopman

“…Despite having features of iron overload, dystrophic muscles had lower protein expression of ALAS‐1, the rate‐limiting enzyme for haem synthesis (dko −44%, P < 0.05), and the haem‐containing protein myoglobin (dko −54%, P < 0.05). …”
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Iron overload in endometriosis peritoneal fluid induces early embryo ferroptosis mediated by HMOX1 by Shishi Li, Yier Zhou, Qiongxiao Huang, Xiaohua Fu, Ling Zhang, Fang Gao, Zhen Jin, Limei Wu, Chongyi Shu, Xirong Zhang, Weihai Xu, Jing Shu

“…Iron overload in endometriosis PF disrupted blastocyst formation, decreased GPX4 expression and induced lipid peroxidation, suggesting that iron overload causes embryotoxicity and induces ferroptosis. …”
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Is iron overload associated with worse outcomes in patients with chronic liver disease undergoing liver transplantation? by Sergio Rodriguez-Rodriguez, Antonio Olivas-Martínez, Jesus Delgado-de la Mora, Braulio Martinez-Benitez, Ignacio García-Juarez, Roberta Demichelis-Gómez

Subjects: “…Ferritin. Iron overload. Liver transplantation. Post-transplant complications. …”
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Choroid plexus and pituitary gland hemochromatosis induced by transfusional iron overload: Two case reports by Hiroyuki Fujii, MD, PhD, Mitsuru Matsuki, MD, PhD, Takefumi Hamakawa, MD, Yumiko Toda, MD, Nana Fujii, MD, Sota Masuoka, MD, Akihiro Nakamata, MD, Emiko Chiba, MD, PhD, Kazunari Ishii, MD, PhD, Harushi Mori, MD, PhD

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Development of an iron overload HepG2 cell model using ferrous ammonium citrate by Usama Abbasi, Srinivas Abbina, Arshdeep Gill, Jayachandran N. Kizhakkedathu

“…Abstract Cell-based iron overload models provide tremendous utility for the investigations into the pathogenesis of different diseases as well as assessing efficacy of various therapeutic strategies. …”
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Effect of deferiprone or deferoxamine on right ventricular function in thalassemia major patients with myocardial iron overload by Gotsis Efstathios D, Aessopos Athanassios, Piga Antonio, Ladis Vasili, Karagiorga Markissia, Berdoukas Vasili, Alam Mohammed H, Carpenter John, Alpendurada Francisco, Smith Gillian C, Tanner Mark A, Westwood Mark A, Galanello Renzo, Roughton Michael, Pennell Dudley J

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Oleanolic acid inhibits mercury chloride induced-liver ferroptosis by regulating ROS/iron overload by Chuan Ouyang, Xuan Ma, Jiali Zhao, Siqi Li, Chen Liu, Yunfeng Tang, Jian Zhou, Junhao Chen, Xiaohong Li, Wanwei Li

“…We found that mercury chloride-induced oxidative stress in liver tissues and cells, leading to lipid peroxidation and iron overload, thereby reducing the expression levels of GPX4 and SLC7A11, and increasing the expression level of TRF1, OA pretreatment improved the changes of GPX4, SLC7A11 and TRF1 induced by mercury chloride, which were related to its inhibition of oxidative stress. …”
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Iron-Storage Protein Ferritin Is Upregulated in Endometriosis and Iron Overload Contributes to a Migratory Phenotype by Jeong-Hwa Woo, Youn Seok Choi, Jung-Hye Choi

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Role of HFE in iron metabolism, hereditary haemochromatosis, anaemia of chronic disease, and secondary iron overload. by Townsend, A, Drakesmith, H

“…Hereditary haemochromatosis is an iron overloading disorder caused by common mutations in the HFE gene. …”

Role of HFE in iron metabolism, hereditary haemochromatosis, anaemia of chronic disease, and secondary iron overload by Townsend, A, Drakesmith, H

The safety, tolerability, and efficacy of a liquid formulation of deferiprone in young children with transfusional iron overload by El Alfy, M., Sari, T.T., Lee, C.L., Tricta, F., El-Beshlawy, A.

“…The results of this study show a favorable benefit/risk ratio of deferiprone oral solution for the treatment of young children with transfusional iron overload.…”