Metabolic profiles by 1H-magnetic resonance spectroscopy in natalizumab-associated post-PML lesions of multiple sclerosis patients who survived progressive multifocal leukoencephal... by Ruth Schneider, Barbara Bellenberg, Robert Hoepner, Eva-Maria Kolb, Gisa Ellrichmann, Aiden Haghikia, Ralf Gold, Carsten Lukas

“…We aimed at the examination of metabolic differences using 1H-magnetic resonance spectroscopy (1H-MRS) in multiple sclerosis patients at various post-PML stages and at the exploration of differences according to their disease and JC virus (JCV) status. METHODS:1H-MRS of PML lesions was carried out on 15 relapsing-remitting multiple sclerosis patients with natalizumab-associated PML. …”
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Real-world study of efficacy, risk management and reasons for discontinuation of natalizumab for treatment of multiple sclerosis in Russia. by Evgeniy Evdoshenko, Alexandra Stepanova, Maria Shumilina, Maria Davydovskaya, Natalia Khachanova, Nikolay Neofidov, Ivan Kalinin, Ekaterina Popova, Ekaterina Dubchenko, Natalia Pozhidaeva, Andrey Volkov, Stella Sivertseva, Anna Prilenskaya, Nadezhda Malkova, Denis Korobko, Ilona Vergunova, Sergey Shchur, Gleb Makshakov

“…Relapse rate, MRI activity, NEDA-3 status after 2 years were assessed. Anti-JC virus antibodies status and RMP implementation were evaluated. …”
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Stability and predictive value of anti-JCV antibody index in multiple sclerosis: A 6-year longitudinal study. by Harald Hegen, Michael Auer, Gabriel Bsteh, Franziska Di Pauli, Tatiana Plavina, Janette Walde, Florian Deisenhammer, Thomas Berger

“…BACKGROUND:Risk of natalizumab-related progressive multifocal leukoencephalopathy is associated with the presence of anti-JC-virus (JCV) antibodies. OBJECTIVE:To investigate the longitudinal evolution of anti-JCV antibody index and to determine the predictive value of baseline anti-JCV antibody index for long-term stability of anti-JCV antibody status. …”
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Risk acceptance in multiple sclerosis patients on natalizumab treatment. by Carmen Tur, Mar Tintoré, Ángela Vidal-Jordana, Denis Bichuetti, Pablo Nieto González, María Jesús Arévalo, Georgina Arrambide, Elisenda Anglada, Ingrid Galán, Joaquín Castilló, Carlos Nos, Jordi Río, María Isabel Martín, Manuel Comabella, Jaume Sastre-Garriga, Xavier Montalban

“…We obtained disease severity perception scores, personality traits' scores, and risk-acceptance scores (RAS) so that higher RAS indicated higher risk acceptance. We recorded JC virus status (JCV+/-), prior immunosuppression, NTZ treatment duration, and clinical characteristics. …”
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Mapping the history and current situation of research on John Cunningham virus – a bibliometric analysis by Guan Yi-fu, Cui Lei, Yan Lei, Zheng Hua-chuan, Takano Yasuo

“…These top highly-cited articles were divided into 5 aspects: (1) The correlation between JC virus and tumors; (2) Causal correlation of JCV with PML; (3) Polyoma virus infection and its related diseases in renal-allograft recipients; (4) Detection of JCV antibody, oncogene and its encoding protein; (5) Genetics and molecular biology of JCV. …”
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Polyomaviruses BK and JC DNA infection in peripheral blood cells from blood donors by Malihe Fathi Haghighi, Noorossadat Seyyedi, Ali Farhadi, Farahnaz Zare, Leila Kasraian, Gholam Reza Refiei Dehbidi, Reza Ranjbaran, Abbas Behzad-Behbahani

“…Objectives: To investigate the prevalence of human polyomavirus (BK and JC viruses) infection in peripheral blood mononuclear cells of healthy blood donors. …”
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Examining the role of EGR1 during viral infections by Caitlin M. Woodson, Caitlin M. Woodson, Kylene Kehn-Hall, Kylene Kehn-Hall

“…EGR1 is also associated with multiple viral infections such as Venezuelan equine encephalitis virus (VEEV), Kaposi’s sarcoma-associated herpesvirus (KSHV), herpes simplex virus 1 (HSV-1), human polyomavirus JC virus (JCV), human immunodeficiency virus (HIV), and Epstein–Barr virus (EBV). …”
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Leukoencephalopathy During Daratumumab-Based Therapy: A Case Series of Two Patients with Multiple Myeloma by Kareem SS, Viswanathan N, Sahebjam S, Tran ND, Gatewood T, Tobon K, Baz R, Piña Y, Shain KH, Mokhtari S

“…In the absence of central nervous system (CNS) disease, many medication-induced leukoencephalopathy cases reported with MM, including daratumumab-induced, are associated with progressive multifocal leukoencephalopathy (PML) and John Cunningham (JC) virus. Currently, there are no reported cases of daratumumab-induced leukoencephalopathy among patients without CNS involvement or PML. …”
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A case of progressive multifocal leukoencephalopathy in a post-kidney transplant patient with improvement after discontinuation of immunosuppressive drugs and combination therapy w... by Neri Sone, Hiroki Nishiwaki, Mayu Shimokawa, Keishu Kawanishi, Tsuyoshi Oshiro, Reiji Takami, Natsuki Taira, Masahito Amagasa, Shinya Omiya, Tadahide Maezumi, Yoko Nabeshima, Kazuo Nakamichi, Yoshiharu Miura, Fumihiko Koiwa

“…Magnetic resonance imaging of the brain revealed a subcortical demyelinating lesion. JC virus DNA was identified in cerebrospinal fluid, and he was diagnosed with progressive multifocal leukoencephalopathy. …”
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A human T-lymphotropic virus-1 carrier who developed progressive multifocal leukoencephalopathy following immunotherapy for sarcoidosis: a case report by Takashi Nagahori, Wataru Shiraishi, Masafumi Nishikawa, Ayano Matsuyoshi, Takenori Ogura, Yui Yamada, Kenta Takahashi, Tadaki Suzuki, Kazuo Nakamichi, Tetsuya Hashimoto, Taketo Hatano

“…Abstract Background Progressive multifocal leukoencephalopathy (PML) is a devastating demyelinating disorder of the central nervous system caused by opportunistic infection of the JC virus (JCV). Case presentation A 58-year-old Japanese woman was admitted to our hospital for aphasia. …”
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Prospective investigation of polyomavirus infection and the risk of adult glioma by Kathleen M. Egan, Youngchul Kim, Noemi Bender, James M. Hodge, Anna E. Coghill, Stephanie A. Smith-Warner, Dana E. Rollison, Lauren R. Teras, Tom K. Grimsrud, Tim Waterboer

“…We studied the association of 4 human polyomaviruses (HPyV)—JC virus (JCV), BK virus (BKV), human polyomavirus 6 (HPyV6), and Merkel cell polyomavirus (MCPyV) with glioma risk within the Cancer Prevention Study II in the US (CPS-II) and the Janus Serum Bank in Norway. …”
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Genetic and Functional Dissection of the Role of Individual 5-HT2 Receptors as Entry Receptors for JC Polyomavirus by Benedetta Assetta, Jenna Morris-Love, Gretchen V. Gee, Abigail L. Atkinson, Bethany A. O’Hara, Melissa S. Maginnis, Sheila A. Haley, Walter J. Atwood

“…. : 5-HT2 receptors are important for infection of cells by JC virus (JCPyV). Assetta et al. show that JCPyV interacts transiently with each of three 5-HT2 receptors during entry and pinpoint a critical role for a proline in the second intracellular loop of each receptor in facilitating virus infection. …”
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Hepatitis B virus-induced CD4 lymphocytopenia: A rare cause of progressive multifocal leukoencephalopathy by Amar Kumar Mishra, Sanjay Kumar, Niraja Agasti, Gautam Guha, Saikat Ghosh, Bijendra Mohanty, Pideno S Ngullie, Joydeep Mukherjee

“…Progressive multifocal leukoencephalopathy (PML) is a rare subacute-onset fatal demyelinating disease of the central nervous system caused by the John Cunningham (JC) virus. It usually occurs in impaired cell-mediated immunity settings such as lymphoproliferative disorders, chronic infective or granulomatous conditions on immunosuppressive medications, and human immunodeficiency virus infection. …”
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Spanish consensus on the use of natalizumab (Tysabri®)-2013 by O. Fernández, J.A. García-Merino, R. Arroyo, J.C. Álvarez-Cermeño, G. Izquierdo, A. Saiz, J. Olascoaga, A. Rodríguez-Antigüedad, J.M. Prieto, C. Oreja-Guevara, M.A. Hernández, E. Moral, J. Meca, X. Montalbán

“…Although the presence of anti-JC virus antibodies is a significant finding, it should not be considered an absolute contraindication for natalizumab. …”
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Risk Assessment of Progressive Multifocal Leukoencephalopathy in Multiple Sclerosis Patients during 1 Year of Ocrelizumab Treatment by Carla Prezioso, Alfonso Grimaldi, Doriana Landi, Carolina Gabri Nicoletti, Gabriele Brazzini, Francesca Piacentini, Sara Passerini, Dolores Limongi, Marco Ciotti, Anna Teresa Palamara, Girolama Alessandra Marfia, Valeria Pietropaolo

“…Background: Progressive multifocal leukoencephalopathy (PML) caused by the JC virus is the main limitation to the use of disease modifying therapies for treatment of multiple sclerosis (MS). …”
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Effectiveness of Natalizumab in Achieving No Evidence of Disease Activity (NEDA-3)—Data From a Local Norwegian Cohort by Andreas K. Jaklin, Espen Benjaminsen, Karl B. Alstadhaug, Karl B. Alstadhaug

“…Prior to NTZ treatment, 83% had used other disease modulating drugs and 65% were anti-JC virus (JCV) seronegative. During the study period, seven patients converted to seropositive. …”
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DISTÚRBIOS NEUROCOGNITIVOS ASSOCIADOS A QUANTIFICAÇÃO DA CARGA VIRAL DO HIV-1 NO LÍQUOR: RELATO DE DOIS CASOS by Jaysa Pizzi, Pedro Moreno Fonseca, Frederico da Cunha Abbott, Andressa Noal, Julia Somenzi de Villa

“…Em análise liquórica, apresentava 17 células, predominantemente linfócitos, além de hiperproteinorraquia (106), glicorraquia normal. Realizado PCR para JC vírus, toxoplasmose, HHV e CMV, MTB e EBV, todos com resultados negativos. …”
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Outcomes of natalizumab treatment within 3 years of relapsing-remitting multiple sclerosis diagnosis: a prespecified 2-year interim analysis of STRIVE by Jai Perumal, Robert J. Fox, Roumen Balabanov, Laura J. Balcer, Steven Galetta, Shavy Makh, Sourav Santra, Christophe Hotermans, Lily Lee

“…Abstract Background STRIVE is a multicenter, observational, open-label, single-arm study of natalizumab in anti–JC virus (JCV) seronegative patients with early relapsing-remitting multiple sclerosis (RRMS). …”
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Progressive multifocal leukoencephalopathy lesion and brain parenchymal segmentation from MRI using serial deep convolutional neural networks by Omar Al-Louzi, Snehashis Roy, Ikesinachi Osuorah, Prasanna Parvathaneni, Bryan R. Smith, Joan Ohayon, Pascal Sati, Dzung L. Pham, Steven Jacobson, Avindra Nath, Daniel S. Reich, Irene Cortese

“…Progressive multifocal leukoencephalopathy (PML) is a rare opportunistic brain infection caused by the JC virus and associated with substantial morbidity and mortality. …”
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Effects of RANKL Knockdown by Virus-like Particle-Mediated RNAi in a Rat Model of Osteoporosis by Daniel B. Hoffmann, Jens Gruber, Kai O. Böker, Delia Deppe, Stephan Sehmisch, Arndt F. Schilling, Nicolas Lemus-Diaz, Marina Komrakova, Stefan Schneider

“…Virus-like-particles (VLPs) derived from polyoma JC virus were used for delivering RANKL siRNA in ovariectomized (OVX) rats. 48 rats were ovariectomized and treated with either 17β-estradiol (E2), VLPs containing RANKL siRNA (siRANKL), or VLPs containing non-cognate siRNA (siCtrl). …”
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