Neurological complications of hematopoietic cell transplantation in children and adults by Adriana Octaviana Dulamea, Ioana Gabriela Lupescu

“…In this review, neurological complications are presented according to time of onset after HCT: (1) early complications (in the first month) - related to harvesting of stem cells, during conditioning (drug toxicity, posterior reversible encephalopathy syndrome), related to pancytopenia, (2) intermediate phase complications (second to sixth month) - central nervous system infections caused by prolonged neutropenia and progressive multifocal leukoencephalopathy due to JC virus, (3) late phase complications (after sixth month) - neurological complications of GvHD, second neoplasms and relapses of the original disease.…”
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The glial growth factors deficiency and synaptic destabilization hypothesis of schizophrenia by Zoega Tomas, Moises Hans W, Gottesman Irving I

“…A genetically and epigenetically determined low baseline of glial growth factor signaling and synaptic strength is expected to increase the vulnerability for additional reductions (e.g., by viruses such as HHV-6 and JC virus infecting glial cells). This should lead to a weakening of the positive feedback loop between the presynaptic neuron and its targets, and below a certain threshold to synaptic destabilization and schizophrenia.…”
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Treatment of Resıstant Cyclophosphamide Induced Haemorrhagic Cystıtıs: Revıew of Literature and Three Case Reports by Turgay Ebiloglu, Engin Kaya, Sercan Yilmaz, Gökhan Özgür, Yusuf Kibar

“…Infectious causes of HC in immunocomprimesed patients are adenovirus, BK polyoma-virus (BK), JC virus, and Cytomegalovirus (CMV). The present article attempts to make a review of literature for the treatment of intractable HC and report three cases with HC.…”
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Progressive multifocal leukoencephalopathy in an HIV patient: A case report and literature review by Ting Lei, Ai Deng, Lianchi Li, Ming Wang, Dongbo Wu, Taoyou Zhou

“…Key Clinical Message Progressive multifocal leukoencephalopathy (PML) is a rare opportunistic infection of the brain caused by reactivation of the JC virus, which can lead to a lytic infection of oligodendrocytes. …”
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Remission of progressive multifocal leukoencephalopathy following highly active antiretroviral therapy in a man with AIDS by Yoganathan K, Brown D, Yoganathan K

“…A magnetic resonance imaging scan on admission showed multiple white matter lesions involving both subcortical cerebral hemispheres and cerebellar regions, with no mass effect or surrounding edema. JC virus was detected by nested polymerase chain reaction in the cerebrospinal fluid. …”
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Patient monitoring during treatment with natalizumab (ORP-24) by Zohreh Abna

“…Baseline and routine evaluation of patients who receive natalizumab is essential because of the association of natalizumab with progressive multifocal leukoencephalopathy (PML), an opportunistic infection caused by the JC virus. Three major factors have been associated with increased risk of the development of PML in MS patients treated with natalizumab. (1) The presence of JCV antibodies (2) prior immunosuppression and (3) duration of therapy especially beyond 2 years. …”
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Molecular biomarkers in multiple sclerosis by Michaličková Danica, Kübra Öztürk Hatice, Das Debanjan, Osama Bukhari Syed, Slanař Ondřej

“…Molecular biomarkers (e.g., immunoglobulin G (IgG) oligoclonal bands, IgG index, anti-aquaporin-4 antibodies, neutralizing antibodies against interferon-beta and natalizumab, anti-varicella zoster virus and anti-John Cunningham (JC) virus antibodies) complement these markers excellently. …”
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BKV agnoprotein interacts with α-soluble N-ethylmaleimide-sensitive fusion attachment protein, and negatively influences transport of VSVG-EGFP. by Mona Johannessen, Mari Walquist, Nancy Gerits, Marte Dragset, Anne Spang, Ugo Moens

“…Agnoprotein is conserved among BKV, JC virus (JCV) and SV40, and agnoprotein-deficient mutants reveal reduced viral propagation. …”
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Addition of m6A to SV40 late mRNAs enhances viral structural gene expression and replication. by Kevin Tsai, David G Courtney, Bryan R Cullen

“…Polyomaviruses are a family of small DNA tumor viruses that includes several pathogenic human members, including Merkel cell polyomavirus, BK virus and JC virus. As is characteristic of DNA tumor viruses, gene expression in polyomaviruses is temporally regulated into an early phase, consisting of the viral regulatory proteins, and a late phase, consisting of the viral structural proteins. …”
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Do polyomavirus hominis strains BK and JC play a role in oral squamous cell carcinoma? by Dorota Polz, Kamal Morshed, Agnieszka Stec, Łukasz Podsiadło, Małgorzata Polz-Dacewicz

“…The aim of this study was to analyze the prevalence of BK and JC virus infections among patients with oral squamous cell carcinoma (OSCC). …”
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Progressive multifocal leukoencephalopathy in a 27-year-old lady with systemic lupus erythematosus – rheumatoid arthritis overlap syndrome by Chiao-Feng Cheng, Jen-Jen Su, Ya-Fang Chen, Yen-Chun Lin, Yi-Min Huang, Ko-Jen Li

“…PML was suspected for her immunosuppressive status and suggestive radiological findings, and the diagnosis was confirmed by a polymerase chain reaction of JC virus from cerebrospinal fluid. After restoring the immune status by decreasing the dose of immunosuppressants, the condition of the patient improved significantly. …”
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Progressive multifocal leukoencephalopathy or immune reconstitution inflammatory syndrome after fingolimod cessation? A case report by D. Mickeviciene, A. Baltusiene, B. Afanasjeva, D. Afanasjevas, R. Gleizniene, D. Rastenyte, JR. Berger

“…The diagnostic possibilities included IRIS due to fingolimod withdrawal versus PML-IRIS. The JC virus (JCV) antibody index was positive (2.56); however, cerebrospinal fluid (CSF) JCV real-time polymerase chain reaction (JCV-PCR) was negative and brain biopsy was not performed. …”
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A "candidate-interactome" aggregate analysis of genome-wide association data in multiple sclerosis. by Rosella Mechelli, Renato Umeton, Claudia Policano, Viviana Annibali, Giulia Coarelli, Vito A G Ricigliano, Danila Vittori, Arianna Fornasiero, Maria Chiara Buscarinu, International Multiple Sclerosis Genetics Consortium, Wellcome Trust Case Control Consortium,2, Silvia Romano, Marco Salvetti, Giovanni Ristori

“…We looked for statistical enrichment of associations among interactomes that, at the current state of knowledge, may be representative of gene-environment interactions of potential, uncertain or unlikely relevance for multiple sclerosis pathogenesis: Epstein-Barr virus, human immunodeficiency virus, hepatitis B virus, hepatitis C virus, cytomegalovirus, HHV8-Kaposi sarcoma, H1N1-influenza, JC virus, human innate immunity interactome for type I interferon, autoimmune regulator, vitamin D receptor, aryl hydrocarbon receptor and a panel of proteins targeted by 70 innate immune-modulating viral open reading frames from 30 viral species. …”
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Do polyomavirus hominis strains BK and JC play a role in oral squamous cell carcinoma? by Dorota Polz, Kamal Morshed, Agnieszka Stec, Łukasz Podsiadło, Małgorzata Polz-Dacewicz

“…Objective The aim of this study was to analyze the prevalence of BK and JC virus infections among patients with oral squamous cell carcinoma (OSCC). …”
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Bag3-induced autophagy is associated with degradation of JCV oncoprotein, T-Ag. by Ilker Kudret Sariyer, Nana Merabova, Prem Kumer Patel, Tijana Knezevic, Alessandra Rosati, Maria C Turco, Kamel Khalili

“…JC virus, JCV, is a human neurotropic polyomavirus whose replication in glial cells causes the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML). …”
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A "candidate-interactome" aggregate analysis of genome-wide association data in multiple sclerosis by Mechelli, R, Umeton, R, Policano, C, Annibali, V, Coarelli, G, Ricigliano, V, Vittori, D, Fornasiero, A, Buscarinu, M, Romano, S, Salvetti, M, Ristori, G

“…We looked for statistical enrichment of associations among interactomes that, at the current state of knowledge, may be representative of gene-environment interactions of potential, uncertain or unlikely relevance for multiple sclerosis pathogenesis: Epstein-Barr virus, human immunodeficiency virus, hepatitis B virus, hepatitis C virus, cytomegalovirus, HHV8-Kaposi sarcoma, H1N1-influenza, JC virus, human innate immunity interactome for type I interferon, autoimmune regulator, vitamin D receptor, aryl hydrocarbon receptor and a panel of proteins targeted by 70 innate immune-modulating viral open reading frames from 30 viral species. …”

In situ hybridisation: principles and applications by Looi, Lai Meng, Cheah, Phaik Leng

“…It has been applied for the detection of various infective agents particularly CMV, HPV, HIV, JC virus, B19 parvovirus, HSV-1, EBV, HBV, hepatitis delta virus, Chlamydia trachomatis, salmonella and mycoplasma in tissue sections.…”

Neural Crest Cells Isolated from the Bone Marrow of Transgenic Mice Express JCV T-Antigen. by Jennifer Gordon, Ilker K Sariyer, Marisol De La Fuente-Granada, Brian J Augelli, Jessica Otte, S Ausim Azizi, Shohreh Amini, Kamel Khalili, Barbara Krynska

“…JC virus (JCV), a common human polyomavirus, is the etiological agent of the demyelinating disease, progressive multifocal leukoencephalopathy (PML). …”
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Pur-Alpha Induces JCV Gene Expression and Viral Replication by Suppressing SRSF1 in Glial Cells. by Ilker Kudret Sariyer, Rahsan Sariyer, Jessica Otte, Jennifer Gordon

“…OBJECTIVE:PML is a rare and fatal demyelinating disease of the CNS caused by the human polyomavirus, JC virus (JCV), which occurs in AIDS patients and those on immunosuppressive monoclonal antibody therapies (mAbs). …”
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Development of a Nucleic Acid Lateral Flow Immunoassay for the Detection of Human Polyomavirus BK by Yi-Huei Huang, Kuan-Yi Yu, Shou-Ping Huang, Hui-Wen Chuang, Wen-Zhi Lin, Juin-Hong Cherng, Yao-Wen Hung, Ming-Kung Yeh, Po-Da Hong, Cheng-Che Liu

“…The specificity study showed no cross-reactivity with other polyomaviruses, such as JC virus and simian virus 40. For the <i>Escherichia coli</i> containing BKV plasmid cultured samples, the sensitivity was determined to be 10⁷ copies/mL. …”
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