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Pluripotent stem cells - Methods and protocols
Published 2013-09-01“…The 2012 Nobel prize for Physiology or Medicine has been awarded conjunctely to Sir John Gurdon and Shinya Yamanaka <em>for</em><em> the discovery that mature cells can be reprogrammed to become pluripotent</em> as during the syxties John Gurdon challenged the dogma that the specialised cell is irreversibly committed to its fate and just few years ago Shinya Yamanaka was the first to induce mature cells to reverse their development and turn back into induced pluripotent stem cells....…”
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Epigenetic memory and parliamentary privilege combine to evoke discussions on inheritance.
Published 2012“…At a recent Company of Biologists Workshop held at Steyning's historic Wiston House, thirty researchers led by John Gurdon interrogated three central questions: how are cell type-specific programs generated, what mechanisms duplicate this programmatic information as cells divide, and how does epigenetics contribute to trans-generational inheritance? …”
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Genome editing of human pluripotent stem cells to generate human cellular disease models
Published 2013-07-01“…Disease modeling with human pluripotent stem cells has come into the public spotlight with the awarding of the Nobel Prize in Physiology or Medicine for 2012 to Drs John Gurdon and Shinya Yamanaka for the discovery that mature cells can be reprogrammed to become pluripotent. …”
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Human embryonic stem cells handbook
Published 2013-03-01“…After the Nobel prize in physiology or medicine was awarded jointly to Sir John Gurdon and Shinya Yamanaka <em>for the discovery that mature cells can be reprogrammed to become pluripotent</em> it became imperative to write down the review for a book entirely devoted to human embryonic stem cells (hES), those cells that are a urgent need for researchers, those cells that rekindle the ethical debates and finally, last but not least, those cells whose study paved the way to obtain induced pluripotent stem cells by the OSKC’s Yamanaka method (the OSKC acronim refers, for those not familiar with the topic, to the four stemness genes used to transfect somatic fibroblasts: Oct4, Sox2, Klf4 and c-Myc)....…”
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Nuclear Cloning and Direct Reprogramming: The Long and the Short Path to Stockholm
Published 2014“…This year’s Nobel Prize in Physiology or Medicine was awarded to John Gurdon and Shinya Yamanaka for solving key problems of biology. …”
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Generation of American mink induced pluripotent stem cells: a protocol
Published 2017-11-01“…Mammalian genome reprogramming has been studied for more than half a century. First, Sir John Gurdon showed the possibility of differentiated cell genome reprogramming by enucleated oocyte factors in 1962. …”
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