Recent Progress in the Theranostics Application of Nanomedicine in Lung Cancer by Anubhab Mukherjee, Manash Paul, Sudip Mukherjee

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381 Intratumoral oncolytic virus V937 plus ipilimumab in patients with advanced melanoma: the phase 1b MITCI study by Kim Margolin, Robert HI Andtbacka, Carlo Bifulco, Gregory Daniels, Sigrun Hallmeyer, Mark Grose, Jon Richards, Mark Faries, Yiwei Zhang, John Hyngstrom, Lynn Feun, Anlong Li

479 AGEN1181, an Fc-enhanced anti-CTLA-4 antibody, alone and in combination with balstilimab (anti-PD-1) in patients with advanced solid tumors: Initial phase I results by Andrea Bullock, Justin Moser, Daruka Mahadevan, Michael Gordon, Przemyslaw Twardowski, Apostolia Tsimberidou, Breelyn Wilky, Waldo Ortuzar Feliu, Anthony El-Khoueiry, Steven O’Day, Bruno Bockorny, Katherine Rosenthal

Unleashing endogenous TNF-alpha as a cancer immunotherapeutic by Steven F. Josephs, Thomas E. Ichim, Stephen M. Prince, Santosh Kesari, Francesco M. Marincola, Anton Rolando Escobedo, Amir Jafri

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Clinical Course of Two Patients with COVID-19 Respiratory Failure After Administration of the Anticancer Small Molecule, RRx-001 by Hammond TC, Lee RC, Oronsky B, Reid TR, Caroen S, Juarez TM, Gill J, Heng A, Kesari S

“…Johns Health Center, Santa Monica, CA, USA; 2John Wayne Cancer Institute, Santa Monica, CA, USA; 3Cardiovascular Thoracic Institute, Keck School of Medicine of USC, Los Angeles, CA, USA; 4EpicentRx, Inc., La Jolla, CA, USA; 5Pacific Neuroscience Institute, Santa Monica, CA, USACorrespondence: Bryan Oronsky, EpicentRx, Inc, 11099 North Torrey Pines Road, La Jolla, CA, 92037, USA, Tel +1 858 947-6635, Fax +1 858 724-3080, Email boronsky@epicentrx.comAbstract: Two critically ill COVID-19 infected patients, who had exhausted all available treatment options, were treated with the small-molecule RRx-001 with subsequent improvement. …”
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Dysregulated Expression of Glycolipids in Tumor Cells: From Negative Modulator of Anti-Tumor Immunity to Promising Targets for Developing Therapeutic Agents by Jose Luis Daniotti, Ricardo Dante Lardone, Aldo Alejandro Vilcaes

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Effect of Infla-Kine supplementation on the gene expression of inflammatory markers in peripheral mononuclear cells and on C-reactive protein in blood by Nina A. Mikirova, Santosh Kesari, Thomas E. Ichim, Neil H. Riordan

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Lipid–polymer hybrid nanoparticles as a next-generation drug delivery platform: state of the art, emerging technologies, and perspectives by Mukherjee A, Waters AK, Kalyan P, Achrol AS, Kesari S, Yenugonda VM

“…Anubhab Mukherjee,1,2 Ariana K Waters,1,2 Pranav Kalyan,3 Achal Singh Achrol,2 Santosh Kesari,2 Venkata Mahidhar Yenugonda1,2 1Drug Discovery and Nanomedicine Research Program, 2Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Pacific Neuroscience Institute, Providence Saint John’s Health Center, Santa Monica, CA, USA; 3Agoura High School, Agoura Hills, CA, USA Abstract: Lipid–polymer hybrid nanoparticles (LPHNPs) are next-generation core–shell nanostructures, conceptually derived from both liposome and polymeric nanoparticles (NPs), where a polymer core remains enveloped by a lipid layer. …”
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Demethylation by low-dose 5-aza-2′-deoxycytidine impairs 3D melanoma invasion partially through miR-199a-3p expression revealing the role of this miR in melanoma by Cécile Desjobert, Arnaud Carrier, Audrey Delmas, Diego M. Marzese, Antoine Daunay, Florence Busato, Arnaud Pillon, Jörg Tost, Joëlle Riond, Gilles Favre, Chantal Etievant, Paola B. Arimondo

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Xenon in the treatment of panic disorder: an open label study by Alexander Dobrovolsky, Thomas E. Ichim, Daqing Ma, Santosh Kesari, Vladimir Bogin

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542 Randomized trial of tumor lysate particle only vaccine vs. tumor lysate particle-loaded, dendritic cell vaccine to prevent recurrence of resected stage III/IV melanoma: 36-mont... by Thomas Wagner, Timothy Vreeland, Guy Clifton, George Peoples, Diane Hale, Mark Faries, Xianzhong Yu, Montaser Shaheen, Lexy Adams, Robert Chick, Patrick McCarthy, Anne O’Shea, Annelies Hickeron, John Myers, Jessica Cindass, John Hyngstrom, Adam Berger, James Jakub, Jeffrey Sussman, Phillip Kemp Bohan, Elizabth Carpenter, Franklin Valdera

Molecular Mechanisms of AMPA Receptor Trafficking in the Nervous System by Yi-Yang Cao, Ling-Ling Wu, Xiao-Nan Li, Yu-Lian Yuan, Wan-Wei Zhao, Jing-Xuan Qi, Xu-Yu Zhao, Natalie Ward, Jiao Wang

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Inter-Tumor Heterogeneity—Melanomas Respond Differently to GM-CSF-Mediated Activation by Adi Moshe, Sivan Izraely, Orit Sagi-Assif, Sapir Malka, Shlomit Ben-Menachem, Tsipi Meshel, Metsada Pasmanik-Chor, Dave S.B. Hoon, Isaac P. Witz

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Demographics of Skin Cancer Knowledge Among Middle and High Schoolers in Texas by Dina Zamil, Shangyi Fu, Zahra Majd, Emily Powell, Jenna Zamil, Zeena Nawas, Ida Orengo

“…Objectives: This study sought to evaluate melanoma knowledge among students in Texas viewing John Wayne Cancer Foundation Block the Blaze (JWCFBTB) presentations and identify group differences with regard to sociodemographic factors. …”
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Clinical Outcomes of Stereotactic Radiosurgery-Related Radiation Necrosis in Patients with Intracranial Metastasis from Melanoma by Holly M Thomson, Shannon P Fortin Ensign, Victoria S Edmonds, Akanksha Sharma, Richard J Butterfield, Steven E Schild, Jonathan B Ashman, Richard S Zimmerman, Naresh P Patel, Alan H Bryce, Sujay A Vora, Terence T Sio, Alyx B Porter

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Gliosarcoma vs. glioblastoma: a retrospective case series using molecular profiling by Christopher Dardis, David Donner, Nader Sanai, Joanne Xiu, Sandeep Mittal, Sharon K. Michelhaugh, Manjari Pandey, Santosh Kesari, Amy B. Heimberger, Zoran Gatalica, Michael W. Korn, Ashley L. Sumrall, Surasak Phuphanich

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First-in-human study of TK-positive oncolytic vaccinia virus delivered by adipose stromal vascular fraction cells by Boris R. Minev, Elliot Lander, John F. Feller, Mark Berman, Bernadette M. Greenwood, Ivelina Minev, Antonio F. Santidrian, Duong Nguyen, Dobrin Draganov, Mehmet O. Killinc, Anna Vyalkova, Santosh Kesari, Edward McClay, Gabriel Carabulea, Francesco M. Marincola, Lisa H. Butterfield, Aladar A. Szalay

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Phase 2 study of AV-GBM-1 (a tumor-initiating cell targeted dendritic cell vaccine) in newly diagnosed Glioblastoma patients: safety and efficacy assessment by Daniela A. Bota, Thomas H. Taylor, David E. Piccioni, Christopher M. Duma, Renato V. LaRocca, Santosh Kesari, Jose A. Carrillo, Mehrdad Abedi, Robert D. Aiken, Frank P. K. Hsu, Xiao-Tang Kong, Candace Hsieh, Peter G. Bota, Gabriel I. Nistor, Hans S. Keirstead, Robert O. Dillman

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CDCA2 Inhibits Apoptosis and Promotes Cell Proliferation in Prostate Cancer and Is Directly Regulated by HIF-1α Pathway by Yixiang Zhang, Yingduan Cheng, Zhaoxia Zhang, Zhongyuan Bai, Hongtao Jin, Xiaojing Guo, Xiaoyan Huang, Meiqi Li, Maolin Wang, Xing-sheng Shu, Yeqing Yuan, Ying Ying

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miR-29c plays a suppressive role in breast cancer by targeting the TIMP3/STAT1/FOXO1 pathway by Wan Li, Jie Yi, Xiangjin Zheng, Shiwei Liu, Weiqi Fu, Liwen Ren, Li Li, Dave S. B. Hoon, Jinhua Wang, Guanhua Du

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