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    Petromurin C Induces Protective Autophagy and Apoptosis in FLT3-ITD-Positive AML: Synergy with Gilteritinib by You Na Ha, Sungmi Song, Barbora Orlikova-Boyer, Claudia Cerella, Christo Christov, Anake Kijjoa, Marc Diederich

    Published 2020-01-01
    “…We show in this study that petromurin C, which was isolated from the culture extract of the marine-derived fungus <i>Aspergillus candidus</i> KUFA0062, isolated from the marine sponge <i>Epipolasis</i> sp., induces early autophagy followed by apoptotic cell death via activation of the intrinsic cell death pathway concomitant with mitochondrial stress and downregulation of Mcl-1 in FLT3-ITD mutated MV4-11 cells. …”
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