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Electroanalytical Overview: The Determination of Levodopa (L-DOPA)
Published 2023-02-01Get full text
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L-DOPA BIOSYNTHESIS WITH Agaricus bisporus TYROSINASES ASSISTANCE
Published 2023-06-01Subjects: “…l-dopa synthesis…”
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L-dopa metabolism and the regulation of brain polysome aggregation
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Plasma concentrations of L-dopa and 3-methoxydopa and improvement in clinical ratings and motor performance in patients with Parkinsonism treated with L-dopa alone or in combination with amantadine.
Published 1975“…Six patients with idiopathic Parkinsonism were treated with a combination of amantadine and L-dopa and after 12 to 24 weeks amantadine was replaced by placebo for a six week period in a double-blind trial. …”
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Effects of hydrogen gas inhalation on L-DOPA-induced dyskinesia
Published 2023-07-01“…L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia is a side effect of Parkinson's disease treatment and it is characterized by atypical involuntary movements. …”
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Propranolol Relieves L-Dopa-Induced Dyskinesia in Parkinsonian Mice
Published 2020-11-01“…Background: Parkinsonism is caused by dopamine (DA) insufficiency and results in a hypokinetic movement disorder. Treatment with L-Dopa can restore DA availability and improve motor function, but patients can develop L-Dopa-induced dyskinesia (LID), a secondary hyperkinetic movement disorder. …”
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Kinetic evaluation of L-Dopa loaded WGA-grafted nanoparticles
Published 2020-06-01“…In this study wheat germ agglutinin (WGA) conjugated, L-Dopa loaded, poly lactic-co-glycolic acid (PLGA) nanoparticles were analyzed for determining the release pattern of L-Dopa. …”
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Targeting Striatal Glutamate and Phosphodiesterases to Control L-DOPA-Induced Dyskinesia
Published 2023-11-01Subjects: “…L-DOPA-induced dyskinesia…”
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Receptor Ligands as Helping Hands to L-DOPA in the Treatment of Parkinson’s Disease
Published 2019-04-01Get full text
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L-DOPA enhances neural direction signals in younger and older adults
Published 2022-12-01“…We studied the effect of L-DOPA, a dopamine precursor, on fMRI activation patterns that encode spatial walking directions that have previously been shown to lose specificity with age. …”
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An Overview of Methods for L-Dopa Extraction and Analytical Determination in Plant Matrices
Published 2022-08-01“…L-dopa is a precursor of dopamine used as the most effective symptomatic drug treatment for Parkinson’s disease. …”
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Nigrostriatal damage is required for induction of dyskinesias by L-DOPA in squirrel monkeys.
Published 1990“…These findings provide further evidence that nigrostriatal damage is essential for the genesis of L-DOPA-induced dyskinesias.…”
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Characterisation of dyskinesias induced by L-dopa in MPTP-treated squirrel monkeys.
Published 1990“…Intermittent treatment with L-dopa over a 2-year period induced abnormal involuntary movements in MPTP-treated squirrel monkeys. …”
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Expression of Human L-Dopa Decarboxylase (DDC) under Conditions of Oxidative Stress
Published 2023-12-01Subjects: “…L-Dopa decarboxylase…”
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Structural, Conformational and Spectroscopic Investigations of a Biologically Active Compound: L-Dopa
Published 2023-12-01“…Structural, conformational and spectroscopic investigations of the L-dopa molecule were made at the b3lyp/6-311++g** level using the Gaussian 09 software. …”
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Pyrylium based derivatization imaging mass spectrometer revealed the localization of L-DOPA.
Published 2022-01-01“…Simultaneous imaging of l-dihydroxyphenylalanine (l-DOPA), dopamine (DA) and norepinephrine (NE) in the catecholamine metabolic pathway is particularly useful because l-DOPA is a neurophysiologically important metabolic intermediate. …”
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Involvement of the L-DOPA receptor GPR143 in acute and chronic actions of methylphenidate
Published 2023-07-01Subjects: “…L-DOPA…”
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Fear extinction rescuing effects of dopamine and L-DOPA in the ventromedial prefrontal cortex
Published 2024-01-01“…Systemic L-DOPA enabled extinction learning and promoted extinction retention at one but not ten days after training. …”
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l‐Dopa responsiveness is associated with distinctive connectivity patterns in advanced Parkinson's disease
Published 2017“…CONCLUSIONS:Our findings show characteristic basal ganglia resting-state functional connectivity patterns associated with different degrees of l-dopa responsiveness in patients with advanced Parkinson's disease. l-Dopa exerts a graduated influence on remapping connectivity in distinct motor control networks, potentially explaining some of the variance in treatment response. © 2017 International Parkinson and Movement Disorder Society.…”
Journal article