Role of the C-terminal domain of PCSK9 in degradation of the LDL receptors by Øystein L. Holla, Jamie Cameron, Kristian Tveten, Thea Bismo Str⊘m, Knut Erik Berge, Jon K. Laerdahl, Trond P. Leren

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Detection of large deletions in the LDL receptor gene with quantitative PCR methods by Larsen Mogens L, Stenderup Anette, Nielsen Gitte G, Jensen Lillian G, Nissen Peter H, Damgaard Dorte, Faergeman Ole

“…<p>Abstract</p> <p>Background</p> <p>Familial Hypercholesterolemia (FH) is a common genetic disease and at the molecular level most often due to mutations in the LDL receptor gene. In genetically heterogeneous populations, major structural rearrangements account for about 5% of patients with LDL receptor gene mutations.…”
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Intradomain Confinement of Disulfides in the Folding of Two Consecutive Modules of the LDL Receptor. by Juan Martínez-Oliván, Hugo Fraga, Xabier Arias-Moreno, Salvador Ventura, Javier Sancho

“…The LDL receptor internalizes circulating LDL and VLDL particles for degradation. …”
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Mutation Analysis of the LDL Receptor Gene in Indian Families with Familial Hypercholesterolemia by Suyamindra S Kulkarni

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Rapid fluorometric assay of LDL receptor activity by DiI-labeled LDL. by ZF Stephan, EC Yurachek

“…Therefore, detection by 125I-labeled LDL has remained the method of choice for assaying LDL receptor activity rapidly and reliably. In this paper, we describe a rapid, simple, and nonradioactive assay of LDL receptor activity using DiI-LDL. …”
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A cross-species comparison of the apolipoprotein B domain that binds to the LDL receptor. by A Law, J Scott

“…Apolipoprotein (apo)-B-100 is the ligand that mediates the clearance of low density lipoprotein (LDL) from the circulation by the apoB,E (LDL) receptor pathway. Clearance is mediated by the interaction of a domain enriched in basic amino acid residues on apoB-100 with clusters of acidic residues on the apoB,E (LDL) receptor. …”
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Mitogenic stimulation alters the regulation of LDL receptor gene expression in human lymphocytes. by JA Cuthbert, PE Lipsky

“…To address the possibility that influences other than ambient cholesterol concentrations regulate low density lipoprotein (LDL) receptor expression, the effect of mitogenic activation on the levels of LDL receptor mRNA in human lymphocytes was examined. …”
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Phenotypic consequences of a deletion of exons 2 and 3 of the LDL receptor gene by Olaug K. Rødningen, Serena Tonstad, Jheem D. Medh, David A. Chappell, Leiv Ose, Trond P. Leren

“…Screening for structural alterations of the low density lipoprotein (LDL) receptor gene by Southern blot analysis revealed an abnormal band pattern in one subject with a clinical diagnosis of homozygous familial hypercholesterolemia (FH). …”
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Effects of polymorphism on the microenvironment of the LDL receptor-binding region of human apoE by Sissel Lund-Katz, Suzanne Wehrli, Mohamed Zaiou, Yvonne Newhouse, Karl H. Weisgraber, Michael C. Phillips

“…To understand the molecular basis for the differences in receptor-binding activity of the three common human apolipoprotein E (apoE) isoforms, we characterized the microenvironments of their LDL receptor (LDLR)-binding regions (residues 136–150). …”
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Dissociated regulation of macrophage LDL receptor and apolipoprotein E gene expression by sterol by T Mazzone, K Basheeruddin

“…The control of apoE gene expression by sterols and the relationship between regulation of the apoE and low density lipoprotein (LDL) receptor genes were investigated in a human macrophage line. …”
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Carbon Nanodots Attenuate Lipid Peroxidation in the LDL Receptor Knockout Mouse Brain by Keith M. Erikson, Kristina El-Khouri, Radmila Petric, Chenhao Tang, Jinlan Chen, Delicia Esther Cardenas Vasquez, Steve C. Fordahl, Zhenquan Jia

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VLDL best predicts aortic root atherosclerosis in LDL receptor deficient mice*[S] by Paul A. VanderLaan, Catherine A. Reardon, Ronald A. Thisted, Godfrey S. Getz

“…To address this issue, we analyzed over 300 LDL receptor (LDLR) deficient mice that have been fed a high-fat diet and for which a full lipoprotein profile and aortic root atherosclerosis values were assessed. …”
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Relationship between Brain Metabolic Disorders and Cognitive Impairment: LDL Receptor Defect by Dong-Yong Hong, Dong-Hun Lee, Ji-Young Lee, Eun-Chae Lee, Sang-Won Park, Man-Ryul Lee, Jae-Sang Oh

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Leukocyte ABCA1 remains atheroprotective in splenectomized LDL receptor knockout mice. by Bart Lammers, Ying Zhao, Amanda C Foks, Reeni B Hildebrand, Johan Kuiper, Theo J C Van Berkel, Miranda Van Eck

“…It mediates the efflux of cellular cholesterol to lipid-poor apolipoprotein A-I. LDL receptor (LDLr) knockout (KO) mice deficient for leukocyte ABCA1 (ABCA1 KO→LDLr KO) show increased atherosclerosis and splenic lipid accumulation despite largely attenuated serum cholesterol levels. …”
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Posttranscriptional regulation of the LDL Receptor in humans by the U2-spliceosome and its interactors by M. Futema, S.E. Humphries, P. Zanoni, G. Panteloglou, A. Othman, A. von Eckardstein

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Genetics of Hypercholesterolemia: Comparison Between Familial Hypercholesterolemia and Hypercholesterolemia Nonrelated to LDL Receptor by Estíbaliz Jarauta, Estíbaliz Jarauta, Estíbaliz Jarauta, Ana Ma Bea-Sanz, Ana Ma Bea-Sanz, Victoria Marco-Benedi, Victoria Marco-Benedi, Itziar Lamiquiz-Moneo, Itziar Lamiquiz-Moneo, Itziar Lamiquiz-Moneo

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BLOS1 mediates kinesin switch during endosomal recycling of LDL receptor by Chang Zhang, Chanjuan Hao, Guanghou Shui, Wei Li

Subjects: “…LDL receptor…”
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Degradation of the LDL receptor class 2 mutants is mediated by a proteasome-dependent pathway by Yonghe Li, Wenyan Lu, Alan L. Schwartz, Guojun Bu

“…Familial hypercholesterolemia is a genetic disorder that results from various gene mutations, primarily within the LDL receptor (LDLR). Approximately 50% of the LDLR mutations are defined as class 2 mutations, with the mutant proteins partially or entirely retained in the endoplasmic reticulum. …”
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LDL Receptor-Related Protein-1 (LRP1) Regulates Cholesterol Accumulation in Macrophages. by Anna P Lillis, Selen Catania Muratoglu, Dianaly T Au, Mary Migliorini, Mi-Jeong Lee, Susan K Fried, Irina Mikhailenko, Dudley K Strickland

“…To investigate the role of LRP1 in cholesterol accumulation in macrophages, we generated mice with a selective deletion of LRP1 in macrophages on an LDL receptor (LDLR)-deficient background (macLRP1-/-). …”
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Failure to replicate an association of SNPs in the oxidized LDL receptor gene (<it>OLR1</it>) with CAD by Risch Neil, Myers Richard, Li Jun, Iribarren Carlos, Hlatky Mark, Go Alan, Grove Megan L, Fortmann Stephen P, Boerwinkle Eric, Assimes Themistocles L, Knowles Joshua W, Sidney Stephen, Southwick Audrey, Volcik Kelly A, Quertermous Thomas

“…<p>Abstract</p> <p>Background</p> <p>The lectin-like oxidized LDL receptor LOX-1 (encoded by <it>OLR1</it>) is believed to play a key role in atherogenesis and some reports suggest an association of <it>OLR1 </it>polymorphisms with myocardial infarction (MI). …”
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