Multiple mechanisms, independent of sterol regulatory element binding proteins, regulate low density lipoprotein gene transcription by Robert S.J. Makar, Peter E. Lipsky, Jennifer A. Cuthbert

“…Transcription of the LDL receptor gene is markedly enhanced in the Jurkat T cell line by stimulation with the combination of the phorbol ester phorbol 12-myristate 13-acetate (PMA) and the protein synthesis inhibitor cycloheximide (CHX). …”
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Saturated fat-induced changes in Sf 60–400 particle composition reduces uptake of LDL by HepG2 cells by Kim G. Jackson, Vatsala Maitin, David S. Leake, Parveen Yaqoob, Christine M. Williams

“…In conclusion, these findings suggest an alternative or additional mechanism whereby acute fat ingestion can influence LDL clearance via competitive apoE-dependent effects of TRL on the LDL receptor.…”
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Turnover and tissue sites of degradation of glucosylated low density lipoprotein in normal and immunized rabbits by O Wiklund, J L Witztum, T E Carew, R C Pittman, R L Elam, D Steinberg

“…Cholesterol feeding inhibited LDL clearance from plasma and decreased LDL uptake of LDL receptor-rich tissues. In a similar manner, glucosylation of LDL inhibited its ability to bind to the LDL receptor and redirected sites of LDL degradation away from LDL receptor-rich tissues. …”
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Mutation in the PCSK9 Gene in Omani Arab Subjects with Autosomal Dominant Hypercholesterolemia and its Effect on PCSK9 Protein Structure by Khalid Al-Waili, Ward Al-Muna Al-Zidi, Abdul Rahim Al-Abri, Khalid Al-Rasadi, Hilal Ali Al-Sabti, Karna Shah, Abdullah Al-Futaisi, Ibrahim Al-Zakwani, Yajnavalka Banerjee

“…Proprotein convertase subtilisin/kexin type (PCSK9) is a crucial protein in LDL cholesterol (LDL-C) metabolism by virtue of its pivotal role in the degradation of the LDL receptor. Mutations in the PCSK9 gene have previously been found to segregate with autosomal dominant familial hypercholesterolemia (ADFH). …”
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Advances on the treatment of Dyslipidaemias by Eleni Bilianou

“…Therefore, PCSK9 inhibitors prevent the LDL receptor from its continous recycling to the hepatic membrane. …”
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VARIABILITY IN LEVELS OF LOW-DENSITY LIPOPROTEINS CHOLESTEROL IN PATIENTS WITH FAMILIAL HYPERCHOLESTEROLEMIA DEPENDING ON AGE AND SEX AND ITS IMPORTANCE IN THE DIAGNOSIS OF THIS DI... by V. А. Korneva, T. Yu. Kuznetsova, G. P. Tihova

“…Characteristic values of LDLC levels for the Russian population of patients with FHС were shown; relationship between LDLC levels and detection of mutations of the LDL receptor was analyzed.…”
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Accelerated lipoprotein uptake by transplantable hepatomas that express hepatic lipase by Charles Donner, Sungshin Choi, Michael Komaromy, Allen D. Cooper

“…Both types of tumors had about twice as much LDL receptor related protein as the liver. Wild-type tumors had the highest level of LDL receptor, twice hepatic lipase-secreting tumors, and six times that of the liver. …”
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Extensive diet-induced atherosclerosis in scavenger receptor class B type 1-deficient mice is associated with substantial leukocytosis and elevated vascular cell adhesion molecule-... by Mark T. Fuller, Mark T. Fuller, Omid Dadoo, Omid Dadoo, Ting Xiong, Ting Xiong, Pardh Chivukula, Pardh Chivukula, Melissa E. MacDonald, Samuel K. Lee, Samuel K. Lee, Richard C. Austin, Richard C. Austin, Suleiman A. Igdoura, Bernardo L. Trigatti, Bernardo L. Trigatti

“…Mice that lack genes involved in the clearance of LDL from the bloodstream, such as the LDL receptor and apolipoprotein E, are widely used models of experimental atherosclerosis. …”
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Immuno-electron cryo-microscopy imaging reveals a looped topology of apoB at the surface of human LDL[S] by Yuhang Liu, David Atkinson

“…ApoB is crucial for LDL particle stabilization and is the ligand for LDL receptor, through which cholesterol is delivered to cells. …”
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Endothelial dysfunction in nonalcoholic fatty liver disease by Angela PELTEC, Murad ALNABGHALIE

“…Markers, such as lectin-like oxidized LDL receptor-1 and pentraxin-3, have been considered as potential targets in the assessment of endothelial dysfunctions in NAFLD.…”
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Proprotein convertase subtilisin/kexin type 9 (PCSK9) levels are not associated with severity of liver disease and are inversely related to cholesterol in a cohort of thirty eight... by Susanne Feder, Reiner Wiest, Thomas S. Weiss, Charalampos Aslanidis, Doris Schacherer, Sabrina Krautbauer, Gerhard Liebisch, Christa Buechler

“…Positive correlations of PCSK9 and LDL-receptor protein in the liver of patients with chronic liver injury are consistent with these findings.…”
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Heparan sulfate proteoglycans mediate internalization and degradation of beta-VLDL and promote cholesterol accumulation by pigeon macrophages by T Seo, R W St Clair

“…The high affinity site had the characteristics of the LDL receptor. Most rabbit beta-VLDL and some pigeon beta-VLDL bound to the low affinity site that was not down-regulated by cholesterol loading. beta-VLDL binding to the low affinity site and subsequent internalization and degradation were mediated by cell surface heparan sulfate proteoglycans (HSPG). …”
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Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E by Robert W. Mahley, Zhong-Sheng Ji

“…The final step, endocytosis by hepatocytes, appears to be mediated, at least in part, by the low density lipoprotein (LDL) receptor and by the LDL receptor-related protein (LRP). …”
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Familial defect of apolipoprotein В-100: molecular disease basis and clinico-biochemical characteristics of the patients by P. P. Malyshev, A. N. Meshkov, L. A. Kotova, V. V. Kukharchuk

“…Compared to patients with low-density lipoprotein (LDL) receptor mutation, subjects with apo B-100 defect had less manifested HCH. …”
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Human apolipoprotein B: analysis of internal repeats and homology with other apolipoproteins. by H De Loof, M Rosseneu, C Y Yang, W H Li, A M Gotto, Jr, L Chan

“…Apolipoprotein B (apoB) is the major protein component of plasma low density lipoproteins (LDL) and, through its binding to the LDL receptor, it plays a prominent role in lipoprotein metabolism and in the development of atherosclerosis. …”
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Severe Atherosclerosis and Hypercholesterolemia in Mice Lacking Both the Melanocortin Type 4 Receptor and Low Density Lipoprotein Receptor. by Vera Lede, Christin Franke, Andrej Meusel, Daniel Teupser, Albert Ricken, Joachim Thiery, Jürgen Schiller, Daniel Huster, Torsten Schöneberg, Angela Schulz

“…To study the impact of obesity and dyslipidemia on the cardiovascular system, we generated mice double-deficient for the melanocortin type 4 receptor (Mc4rmut mice) and the LDL receptor (Ldlr-/- mice). Mc4rmut mice develop obesity due to hyperphagia. …”
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Astaxanthin suppresses End MT by LOX-1 pathway in ox-LDL-induced HUVECs by Zhongsheng Zhu, Jinyu Li, Rui Tong, Xiaorong Zhang, Bo Yu

“…The mRNA and protein expressions of lectin-like ox-LDL receptor (LOX-1) and other related genes were determined. …”
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New Drugs for Treating Dyslipidemia: Beyond Statins by Chang Ho Ahn, Sung Hee Choi

“…The pro-protein convertase subtilisin/kexintype 9 (PCSK9) inhibitor increases the expression of low density lipoprotein (LDL) receptor in hepatocytes by enhancing LDL receptor recycling. …”
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Receptor-mediated and bulk-phase endocytosis cause macrophage and cholesterol accumulation in Niemann-Pick C disease by Benny Liu, Chonglun Xie, James A. Richardson, Stephen D. Turley, John M. Dietschy

“…In animals lacking LDL receptors, liver uptake remained about the same (411 μg/day), but more cholesterol was taken up in extrahepatic organs. …”
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Butyrate Lowers Cellular Cholesterol through HDAC Inhibition and Impaired SREBP-2 Signalling by Stephanie Bridgeman, Hon Chiu Woo, Philip Newsholme, Cyril Mamotte

“…In contrast to statins, which increase SREBP-2 regulated processes, HDAC inhibition downregulated SREBP-2 targets such as HMGCR and the LDL receptor. Moreover, in contrast to statin treatment, butyrate did not increase cholesterol uptake by HepG2 cells, consistent with its failure to increase LDL receptor expression. …”
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