Chronic oral infection with Porphyromonas gingivalis accelerates atheroma formation by shifting the lipid profile. by Tomoki Maekawa, Naoki Takahashi, Koichi Tabeta, Yukari Aoki, Hirotaka Miyashita, Sayuri Miyauchi, Haruna Miyazawa, Takako Nakajima, Kazuhisa Yamazaki

“…Stimulation with P. gingivalis LPS induced the change of cholesterol transport via targeting the expression of LDL receptor-related genes and resulted in the disturbance of regulatory mechanisms of the cholesterol level in macrophages. …”
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Novel Therapeutical Approaches to Managing Atherosclerotic Risk by Rosaria Vincenza Giglio, Anca Pantea Stoian, Khalid Al-Rasadi, Maciej Banach, Angelo Maria Patti, Marcello Ciaccio, Ali A. Rizvi, Manfredi Rizzo

“…There are several therapeutic strategies including Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) inhibitors, inclisiran, bempedoic acid, Glucagon-Like Peptide-1 Receptor agonists (GLP-1 RAs), and nutraceuticals that promise improvement in the atheromatous plaque from a molecular point of view, because have actions on the exposure of the LDL-Receptor (LDL-R), on endothelial dysfunction, activation of macrophages, on lipid oxidation, formations on foam cells, and deposition extracellular lipids. …”
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<i>Daeshiho-tang</i> Attenuates Atherosclerosis by Regulating Cholesterol Metabolism and Inducing M2 Macrophage Polarization by Min-Young Song, Haneul Cho, Sora Lee, Kyung Hye Lee, Weon Kim

“…Moreover, DSHT effectively regulated cholesterol metabolism by increasing the levels of PPARγ, ABCA1 and ABCG1, and the LDL receptor genes. We further found that DSHT promoted polarization to the M2 phenotype by increasing the levels of M2 macrophage (ARG1, CD163, and PPARγ) markers. …”
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Platycodin D inhibits autophagy and increases glioblastoma cell death via LDLR upregulation by Sol Ji Lee, Yu‐Jeong Choi, Hyo In Kim, Hyo Eun Moon, Sun Ha Paek, Tai Young Kim, Seong‐Gyu Ko

“…Moreover, PD promoted the uptake of exogenous LDL cholesterol via upregulation of LDL receptor (LDLR), leading to further accumulation of cholesterol within lysosomes and GBM cell death. …”
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Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression. by Marek M Nagiec, Adam P Skepner, Joseph Negri, Michelle Eichhorn, Nicolas Kuperwasser, Eamon Comer, Giovanni Muncipinto, Aravind Subramanian, Clary Clish, Kiran Musunuru, Jeremy R Duvall, Michael Foley, Jose R Perez, Michelle A J Palmer

“…Remarkably, active benzofurans, as well as natural products capable of TRIB1 upregulation, also modulate hepatic cell cholesterol metabolism by elevating the expression of LDLR transcript and LDL receptor protein, while reducing the levels of PCSK9 transcript and secreted PCSK9 protein and stimulating LDL uptake. …”
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Amelioration of Hyperglycemia with a Sodium-Glucose Cotransporter 2 Inhibitor Prevents Macrophage-Driven Atherosclerosis through Macrophage Foam Cell Formation Suppression in Type... by Michishige Terasaki, Munenori Hiromura, Yusaku Mori, Kyoko Kohashi, Masaharu Nagashima, Hideki Kushima, Takuya Watanabe, Tsutomu Hirano

“…Gene expression of lectin-like ox-LDL receptor-1 and acyl-coenzyme A:cholesterol acyltransferase 1 was upregulated, whereas that of ATP-binding cassette transporter A1 was downregulated in the peritoneal macrophages of both types of diabetic mice. …”
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Krill Oil Inhibits Cholesterol Synthesis and Stimulated Cholesterol Excretion in Hypercholesterolemic Rats by Ok-Kyung Kim, Jeong Moon Yun, Dakyung Kim, Soo-Jeung Park, Chungil Lee, Eun Byeol Go, Jae Sil Kim, Sang Yong Park, Jeongmin Lee

“…It stimulated AMPK phosphorylation, LDL receptor and ACAT2 expression in the liver, and the fecal output of cholesterol. …”
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Finasteride delays atherosclerosis progression in mice and is associated with a reduction in plasma cholesterol in men by Patrick McQueen, Donald Molina, Ivan Pinos, Samuel Krug, Anna J. Taylor, Michael R. LaFrano, Maureen A. Kane, Jaume Amengual

“…We evaluated the role of finasteride on atherosclerosis using low-density lipoprotein (LDL) receptor-deficient (Ldlr−/−) mice. Next, we examined the relevance to humans by analyzing the data deposited between 2009 and 2016 in the National Health and Nutrition Examination Survey. …”
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Large impact of low concentration oxidized LDL on angiogenic potential of human endothelial cells: a microarray study. by Magomed Khaidakov, Sona Mitra, Xianwei Wang, Zufeng Ding, Nalini Bora, Valery Lyzogubov, Francesco Romeo, Steven A Schichman, Jawahar L Mehta

“…It is taken up by endothelial cells primarily by ox-LDL receptor-1 (LOX-1). To elucidate transcriptional responses, we performed microarray analysis on human coronary artery endothelial cells (HCAECs) exposed to small physiologic concentration of ox-LDL- 5 µg/ml for 2 and 12 hours. …”
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Delineation of molecular changes in intrahepatic cholesterol metabolism resulting from diminished cholesterol absorption by Joyce J. Repa, Stephen D. Turley, Gang Quan, John M. Dietschy

“…These studies used ezetimibe, a potent inhibitor of cholesterol absorption, to delineate the biochemical and molecular changes in intrahepatic metabolism and biliary lipid secretion when there is a major reduction in chylomicron cholesterol delivery to the liver. In female LDL receptor (LDLR)-deficient (LDLR−/−) mice fed a basal diet containing ezetimibe (0–10 mg/day/kg body weight), cholesterol absorption was reduced up to 91%, fecal neutral sterol excretion was increased up to 4.7-fold, and plasma total cholesterol concentrations decreased by up to 18%. …”
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MicroRNA-217 attenuates intima–media complex thickness of ascending aorta measured by ultrasound bio-microscopy and inhibits inflammation and lipid metabolism in atherosclerotic mo... by Haina Liu, Xia Li, Yanpeng Song, Zhibin Wang

“…Inflammation relevant genes, such as F4/80, tumor necrosis factor (TNF)-α, interleukin (IL)-1, IL-6, and monocyte chemoattractant protein (MCP)-1, and lipid metabolism associated gene, such as LDL receptor, class A scavenger receptors (SR-A), scavenger receptor class B type I (SR-BI), CD36, ATP binding cassette subfamily A member 1 (ABCA1), and ATP binding cassette subfamily G member 1 (ABCG1) in the aorta were significantly down-regulated in miR-217 group when compared with atherosclerosis group. …”
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Elevated soluble LOX-1 predicts risk of first-time myocardial infarction by Alexandru Schiopu, Harry Björkbacka, Gayathri Narasimhan, Bi Juin Loong, Gunnar Engström, Olle Melander, Marju Orho-Melander, Jan Nilsson

“…Experimental studies have identified a pro-atherogenic role of the oxidized LDL receptor LOX-1. We investigated the association between circulating soluble LOX-1 (sLOX-1) and the risk for development of myocardial infarction.Methods The study subjects (n = 4658) were part of the Malmö Diet and Cancer study. …”
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Increased Circulating Levels of PCSK9 and Pro-Atherogenic Lipoprotein Profile in Pregnant Women with Maternal Supraphysiological Hypercholesterolemia by Claudette Cantin, María Jesús Garchitorena, Rodrigo Escalona, Jorge A. Carvajal, Sebastián E. Illanes, Jaime Gutierrez, Andrea Leiva

“…We aim to determine if proprotein convertase subtilisin/kexin type 9 (PCSK9) levels (a protein that regulate the availability of LDL receptor in the cells surface), as well as the composition and function of LDL, are modulated in MSPH women. …”
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Disruption of ldlr causes increased LDL-c and vascular lipid accumulation in a zebrafish model of hypercholesterolemia[S] by Elizabeth A. O'Hare, Xiaochun Wang, May E. Montasser, Yen-Pei C. Chang, Braxton D. Mitchell, Norann A. Zaghloul

“…We sought to develop a genetic model for lipid metabolism in zebrafish, capitalizing on one well-understood player in LDL cholesterol (LDL-c) transport, the LDL receptor (ldlr), and an established in vivo model of hypercholesterolemia. …”
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Case conference concerning 9-year-old boy having 20 mmol/lcholesterol: from diagnosis to effective treatment by AV Susekov, ZG Luginova, AN Meshkov, EY Solovyova, TV Balakhonova, MA Saidova, TI Kotkina, MY Scherbakova, VV Davydkin, MA Dubovenko, AY Postnov, ZB Khasanova, GA Konovalov, VV Kukharchuk

“…For the first time the molecular defect - absence or dysfunction of the LDL receptor (LDL-R), the main route for cholesterol catabolism in humans [2, 3, 12, 13] - was described with regard to this genetic disease. …”
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The relative atherogenicity of VLDL and LDL is dependent on the topographic site[S] by Eline Van Craeyveld, Frank Jacobs, Yingmei Feng, Leen C.J. Thomassen, Johan A. Martens, Joke Lievens, Jan Snoeys, Bart De Geest

“…To evaluate whether the relative atherogenicity of VLDL and LDL is dependent on the topographic site, atherosclerosis was compared at four topographic sites in homozygous LDL receptor (LDLr)-deficient rabbits fed normal chow and in heterozygous LDLr-deficient rabbits with the same genetic background fed a 0.15% cholesterol diet to match cholesterol levels. …”
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The molecular mechanisms underlying the reduction of LDL apoB-100 by ezetimibe plus simvastatins⃞ by Dawn E. Telford, Brian G. Sutherland, Jane Y. Edwards, Joseph D. Andrews, P. Hugh R. Barrett, Murray W. Huff

“…Combination treatment decreased hepatic microsomal cholesterol (−29%) and cholesteryl ester (−65%) and increased LDL receptor (LDLR) expression by 240%. The combination increased NPC1L1 expression in liver and intestine, consistent with increased SREBP2 expression. …”
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The glycosylation-dependent interaction of perlecan core protein with LDL: implications for atherosclerosis[S] by Yu-Xin Xu, David Ashline, Li Liu, Carlos Tassa, Stanley Y. Shaw, Katya Ravid, Matthew D. Layne, Vernon Reinhold, Phillips W. Robbins

“…Its core protein has five domains (DI–DV) with disparate structures and DII is highly homologous to the ligand-binding portion of LDL receptor (LDLR). The functional significance of this domain has been unknown. …”
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Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice by Shunxing Rong, Víctor A Cortés, Shirya Rashid, Norma N Anderson, Jeffrey G McDonald, Guosheng Liang, Young-Ah Moon, Robert E Hammer, Jay D Horton

“…Here, we genetically deleted Srebf-2 from hepatocytes and confirmed that SREBP-2 regulates all genes involved in cholesterol biosynthesis, the LDL receptor, and PCSK9; a secreted protein that degrades LDL receptors in the liver. …”
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Effects of statins on the inducible degrader of low-density lipoprotein receptor in familial hypercholesterolemia by Melody Lok-Yi Chan, Sammy Wing-Ming Shiu, Ching-Lung Cheung, Anskar Yu-Hung Leung, Kathryn Choon-Beng Tan

“…The inducible degrader of low-density lipoprotein receptor (IDOL) is an E3 ubiquitin ligase involved in the post-transcriptional regulation of LDL receptor (LDLR). Statins lower plasma LDL by activating transcription of hepatic LDLR expression, and we have determined whether statins modulate IDOL expression and influence LDLR protein abundance. …”
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