Importance of Mevalonate Pathway Lipids on the Growth and Survival of Primary and Metastatic Gastric Carcinoma Cells by Ortiz N, Delgado-Carazo JC, Diaz C

“…Cell viability and growth were measured as well as cholesterol levels and the expression of the hydroxy methyl-glutaryl CoA reductase (HMGCR) and the LDL receptor (LDLR).Results: Primary and metastatic gastric carcinoma cells show different sensitivity to drugs that affect isoprenoid synthesis and the metabolism and uptake of cholesterol. …”
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Imperatorin alleviates the abnormal proliferation, migration, and foaming of ox-LDL-induced VSMCs through regulating PI3K/Akt/mTOR signaling pathway by Wenqi Li, Xinyi Niu, Jinjin Yu, Xin Xiao, Lulu Zang, Jinmeng Zhao, Qiuxia Huang, Weifeng Li

“…This was consistent with the determination of Lectin-like oxidation of lectin-like ox-LDL receptor-1 (LOX-1) and total cholesterol (TC). IMP also reduced the expression of p-PI3K, p-Akt and p-mTOR in ox-LDL-treated VSMCs. …”
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LOX-1 plays an important role in ischemia-induced angiogenesis of limbs. by Takeru Shiraki, Takuma Aoyama, Chiharu Yokoyama, Yuka Hayakawa, Toshiki Tanaka, Kazuhiko Nishigaki, Tatsuya Sawamura, Shinya Minatoguchi

“…LOX-1, lectin-like oxidized low-density lipoprotein (LDL) receptor-1, is a single transmembrane receptor mainly expressed on endothelial cells. …”
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Activation of Wnt signaling by chemically induced dimerization of LRP5 disrupts cellular homeostasis. by Payam Shahi, Dongsu Park, Adam C Pond, Mamatha Seethammagari, Shin-Heng Chiou, Kyucheol Cho, Julienne L Carstens, William K Decker, Pierre D McCrea, Michael M Ittmann, Jeffrey M Rosen, David M Spencer

“…By applying chemical inducer of dimerization (CID) technology, we were able to modify the Wnt co-receptor, low-density lipoprotein (LDL)-receptor-related protein 5 (LRP5), to generate the synthetic ligand inducible Wnt switch, iLRP5. …”
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Changes in cholesterol homeostasis modify the response of F1B hamsters to dietary very long chain n-3 and n-6 polyunsaturated fatty acids by Rader Daniel J, Billheimer Jeffrey T, Matthan Nirupa R, Lecker Jaime L, Lichtenstein Alice H

“…</p> <p>Results</p> <p>Cholesterol-supplemented hamsters fed fish oil, relative to safflower oil, had higher non-high density lipoprotein (HDL) cholesterol and triglyceride concentrations (P < 0.001) which were associated with lower hepatic low density lipoprotein (LDL) receptor, sterol regulatory element binding protein (SREBP)-1c and acyl-CoA: cholesterol acyl transferase-2 (ACAT) mRNA and protein (p < 0.05), and higher hepatic apolipoprotein (apo) B-100 and apo E protein levels. …”
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Localization of apolipoprotein E receptor 2 to caveolae in the plasma membrane by David R. Riddell, Xi-Ming Sun, Anita K. Stannard, Anne K. Soutar, James S. Owen

“…The LDL receptor (LDL-R) promotes the specific endocytosis and lysosomal delivery of extracellular lipoprotein ligands via clathrin-coated pits. …”
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Identification of liver CYP51 as a gene responsive to circulating cholesterol in a hamster model by Haiqiu Huang, Zhuohong Xie, Wallace Yokoyama, Liangli Yu, Thomas T. Y. Wang

“…The high-fat diet and CA diet altered the expression level of cholesterol, bile acids and lipid metabolism-associated genes (LDL receptor, cholesterol 7α-hydroxylase (CYP7A1), liver X receptor (LXR) α, and ATP-binding cassette subfamily G member 5/8 (ABCG5/8)) in the liver, which were significantly correlated with circulating cholesterol levels. …”
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Effect of lipid transfer activity and triglyceride hydrolysis on apolipoprotein B immunoreactivity in modified low density lipoproteins by L Viens, L Lagrost

“…Consequences of alterations in the size and the lipid composition of low density lipoproteins (LDL) on apolipoprotein (apo) B immunoreactivity were analyzed using two distinct anti-apoB monoclonal antibodies (Mabs), i.e., 4G3, which recognizes an epitope closed to the binding site to the LDL receptor, and 2D8, which is directed against a distal region. …”
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Endocytosis and physiology: insights from Disabled-2 deficient mice by Wensi Tao, Robert Moore, Elizabeth R. Smith, Xiang-Xi Mike Xu

“…The membrane receptors reported to bind directly to Dab2 include LDL receptor and its family members LRP1 and LRP2 (megalin), growth factor receptors EGFR and FGFR, and the cell adhesion receptor beta1 integrin. …”
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Familial hypercholesterolemia class II low-density lipoprotein receptor response to statin treatment by Linda Omer, Lubna Hindi, Giuseppe Militello, Katlin B. Stivers, Kenneth C. Tien, Nolan L. Boyd

“…Low-density lipoprotein (LDL) receptor (LDLR) mutations are the primary cause of familial hypercholesterolemia (FH). …”
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Novel Therapeutic Approaches for the Management of Elevated Lipoprotein(a): From Traditional Agents to Future Treatment Options by György Paragh, Péter Zilahi, László Róbert Kolozsvári, Hajnalka Lőrincz, Péter Fülöp, Mariann Harangi

“…Agents that increase LDL receptor expression, including statins, proprotein convertase subtilisin kexin type 9 inhibitors, and LDL production inhibitors, are also discussed. …”
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A virus-like particle-based bivalent PCSK9 vaccine lowers LDL-cholesterol levels in non-human primates by Alexandra Fowler, Koen K. A. Van Rompay, Maureen Sampson, Javier Leo, Jennifer K. Watanabe, Jodie L. Usachenko, Ramya Immareddy, Debbie M. Lovato, John T. Schiller, Alan T. Remaley, Bryce Chackerian

“…Here, we evaluated the cholesterol-lowering efficacy of virus-like particle (VLP) based vaccines that target epitopes found within the LDL receptor (LDL-R) binding domain of PCSK9. In both mice and non-human primates, a bivalent VLP vaccine targeting two distinct epitopes on PCSK9 elicited strong and durable antibody responses and lowered cholesterol levels. …”
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Development of a high-resolution melting method for mutation detection in familial hypercholesterolaemia patients. by Whittall, R, Scartezini, M, Li, K, Hubbart, C, Reiner, Z, Abraha, A, Neil, H, Dedoussis, G, Humphries, SE

“…Methods and subjects Polymerase chain reaction and melt conditions (HRM) for 23 fragments of the LDL-receptor gene, a region of exon 26 in the APOB gene (including p.R3527Q) and exon 7 of the PCSK9 gene (including p.D374Y) were optimized. …”

Maternal betaine suppresses adrenal expression of cholesterol trafficking genes and decreases plasma corticosterone concentration in offspring pullets by Halima Abobaker, Yun Hu, Nagmeldin A. Omer, Zhen Hou, Abdulrahman A. Idriss, Ruqian Zhao

“…Furthermore, expression of transcription factors, such as steroidogenic factor-1, sterol regulatory element-binding protein 1 and cAMP response element-binding protein, was significantly (P < 0.05) enhanced, together with their downstream target genes, such as 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, LDL receptor and sterol regulatory element-binding protein cleavage-activating protein. …”
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Evidence from a randomized trial that simvastatin, but not ezetimibe, upregulates circulating PCSK9 levels. by Heiner K Berthold, Nabil G Seidah, Suzanne Benjannet, Ioanna Gouni-Berthold

“…Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted inhibitor of the low-density lipoprotein (LDL) receptor and an important regulator of LDL metabolism. …”
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FACI is a novel clathrin adaptor protein 2-binding protein that facilitates low-density lipoprotein endocytosis by Yun Cheng, Xiao-Zhuo Kang, Pearl Chan, Pak-Hin Hinson Cheung, Tao Cheng, Zi-wei Ye, Chi-Ping Chan, Cheng-Han Yu, Dong-Yan Jin

“…Cellular uptake of cholesterol is mediated primarily through endocytosis of low-density lipoprotein (LDL) receptor. New modifiers of this process remain to be characterized. …”
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Effects of apple polyphenols on oxidative stress and cerebral vasospasm after subarachnoid hemorrhage in a rabbit double hemorrhage model by Masato Naraoka, Yuchen Li, Takeshi Katagai, Hiroki Ohkuma

“…Apple polyphenols have already been demonstrated to strongly suppress oxidized low-density lipoprotein (ox-LDL) and lectin-like oxidized LDL receptor-1 (LOX-1) derived from reactive oxygen species (ROS), and to improve cerebral vasospasm. …”
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Tofacitinib inhibits ox-LDL-induced adhesion of THP-1 monocytes to endothelial cells by Xiaoyang Yang, Mengjie Wan, Zhiyong Cheng, Zhiming Wang, Qingxia Wu

“…Moreover, tofacitinib inhibits elevation of endothelial lectin-like ox-LDL receptor-1 (LOX-1) and production of reactive oxygen species (ROS) triggered by ox-LDL. …”
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Definition of a nonlinear conformational epitope for the apolipoprotein B-100-specific monoclonal antibody, MB47. by S.G. Young, R.K. Koduri, R.K. Austin, D.J. Bonnet, R.S. Smith, L.K. Curtiss

“…When bound to apoB-100 on low density lipoproteins (LDL), antibody MB47 completely blocks the binding of LDL to the LDL receptor. The epitope for antibody MB47 has previously been mapped to the vicinity of apoB-100 amino acid (aa) residue 3500. …”
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Both apolipoproteins B-48 and B-100 are synthesized and secreted by the human intestine by JM Hoeg, DD Sviridov, GE Tennyson, SJ Demosky, Jr, MS Meng, D Bojanovski, IG Safonova, VS Repin, MB Kuberger, VN Smirnov

“…Apolipoprotein B (apoB), an apolipoprotein associated with very low density lipoproteins and the atherogenic low density lipoproteins (LDL), directs the metabolism of lipoprotein particles in plasma by interacting with the LDL receptor. Utilizing human intestinal biopsy organ cultures, we have studied the synthesis of intestinal apoB in man. …”
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