The low density lipoprotein receptor modulates the effects of hypogonadism on diet-induced obesity and related metabolic perturbations by Caterina Constantinou, Diogenis Mpatsoulis, Anastasios Natsos, Peristera-Ioanna Petropoulou, Evangelia Zvintzou, Abdulmaged M. Traish, Peter J. Voshol, Iordanes Karagiannides, Kyriakos E. Kypreos

“…Here, we investigated how LDL receptor deficiency (Ldlr−/−) modulates the effects of testosterone on obesity and related metabolic dysfunctions. …”
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Dietary cholesterol opposes PUFA-mediated repression of the stearoyl-CoA desaturase-1 gene by SREBP-1 independent mechanism by Hyoun-Ju Kim, Makoto Miyazaki, James M. Ntambi

“…The mRNA for SREBP-1 was increased by the PUFA/CH diet but the mRNA levels of SREBP-1 target genes such as fatty acid synthase and LDL receptor were decreased, indicating that the main control of PUFA-mediated suppression of SREBP-1 target genes is the maturation of SREBP-1.This study demonstrates that cholesterol overrides the PUFA-mediated repression of the SCD1 gene and regulates SCD1 gene expression through a mechanism independent of SREBP-1 maturation.…”
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An ABCA1-independent pathway for recycling a poorly lipidated 8.1 nm apolipoprotein E particle from glia by Jianjia Fan, Sophie Stukas, Charmaine Wong, Jennifer Chan, Sharon May, Nicole DeValle, Veronica Hirsch-Reinshagen, Anna Wilkinson, Michael N. Oda, Cheryl L. Wellington

“…Selective deletion of the LDL receptor (LDLR) reduced the level of 8.1 nm particle production by approximately 90%, suggesting that apoE is preferentially recycled through the LDLR. …”
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The genetic basis of familial hypercholesterolemia: inheritance, linkage, and mutations by Isabel De Castro-Orós, Miguel Pocoví, Fernando Civeira

“…The most common FH cause is mutations along the entire gene that encode for LDL receptor (LDLR) protein, but it has been also described that mutations in apolipoprotein B (APOB) and proprotein convertase subtilisin/kexin type 9 genes produce this phenotype. …”
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Structural features in lipoprotein lipase necessary for the mediation of lipoprotein uptake into cells by A Krapp, H Zhang, D Ginzinger, M S Liu, A Lindberg, G Olivecrona, M R Hayden, U Beisiegel

“…The uptake is initiated by binding of LpL to cell surface proteoglycans and to the low density lipoprotein (LDL) receptor-related protein. This ability of LpL is independent of catalytic activity and depends on the intact dimeric structure of the lipase and functional residues in the C-terminal domain. …”
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Contribution of LRP1 in Human Congenital Heart Disease Correlates with Its Roles in the Outflow Tract and Atrioventricular Cushion Development by Angelo B. Arrigo, Wenjuan Zhu, Kylia A. Williams, Carla Guzman-Moreno, Cecilia Lo, Jiuann-Huey I. Lin

“…A homozygous missense mutation in the LDL receptor-related protein 1 (<i>Lrp1</i>) in mice was shown to cause congenital heart defects, including atrioventricular septal defect (AVSD) and double outlet right ventricle (DORV). …”
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In vivo efficacy of HDL-like nanolipid particles containing multivalent peptide mimetics of apolipoprotein A-I[S] by Yannan Zhao, Audrey S. Black, David J. Bonnet, Bruce E. Maryanoff, Linda K. Curtiss, Luke J. Leman, M. Reza Ghadiri

“…Building on these promising results, we now describe chronic in vivo studies to assess anti-atherosclerotic efficacy of HDL-like nanoparticles assembled from a trimeric construct, administered over 10 weeks either ip or orally to LDL receptor-null mice. When dosed ip, the trimer-based nanolipids markedly reduced plasma LDL-cholesterol levels by 40%, unlike many other apoA-I mimetic peptides, and were substantially atheroprotective. …”
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Chromosomally Unstable Gastric Cancers Overexpressing Claudin-6 Disclose Cross-Talk between HNF1A and HNF4A, and Upregulated Cholesterol Metabolism by Sanyog Dwivedi, Georgina Hernández-Montes, Luis Felipe Montaño, Erika Patricia Rendón-Huerta

“…Cholesterol metabolism was the most affected pathway as APOA1, APOA2, APOH, APOC2, APOC3, APOB-100, LDL receptor-related protein 1/2, Sterol O-acyltransferase, STARD3, MAGEA-2, -3, -4, -6, -9B, and -12 genes were overexpressed in Cldn6^high gastric cancers; interestingly, APOA2 and MAGEA9b were identified as top hub genes. …”
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Evaluation of hypolipidemic peptide (Val-Phe-Val-Arg-Asn) virtual screened from chickpea peptides by pharmacophore model in high-fat diet-induced obese rat by Wen Shi, Tao Hou, Danjun Guo, Hui He

“…Additionally, peroxisome proliferator-activated receptors (PPAR)α and LDL receptor (LDLR) expressions were up-regulated, and sterol regulatory element-binding protein (SREBP)-2 expression was down-regulated by ChPs significantly (P < 0.05). …”
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Inhibition of apoB secretion from HepG2 cells by insulin is amplified by naringenin, independent of the insulin receptor* by Emma M. Allister, Erin E. Mulvihill, P. Hugh R. Barrett, Jane Y. Edwards, Lindsey P. Carter, Murray W. Huff

“…The combination of naringenin and submaximal concentrations of insulin potentiated extracellular-regulated kinase 1/2 activation and enhanced upregulation of the LDL receptor, downregulation of microsomal triglyceride transfer protein expression, and inhibition of apoB-100 secretion. …”
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A Clinical Case of Probable Sitosterolemia by Michishige Terasaki, Mikiko Izumi, Sho-ichi Yamagishi

“…Therefore, targeted gene sequencing analysis was performed using custom panels focusing on the exome regions of 21 lipid-associated genes, including <i>ABCG5</i>, <i>ABCG8</i>, and familial hypercholesterolemia-causing genes (<i>LDL receptor</i>, <i>LDLRAP1</i>, <i>PCSK9</i>, and <i>apolipoprotein B</i>). …”
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Fluid-phase pinocytosis of native low density lipoprotein promotes murine M-CSF differentiated macrophage foam cell formation. by Manoj K Barthwal, Joshua J Anzinger, Qing Xu, Thomas Bohnacker, Matthias P Wymann, Howard S Kruth

“…The present study investigates the mechanism of LDL uptake for macrophage colony-stimulating factor (M-CSF)-differentiated murine bone marrow-derived macrophages. LDL receptor-null (LDLR-/-) macrophages incubated with LDL showed non-saturable accumulation of cholesterol that did not down-regulate for the 24 h examined. …”
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In Vivo Pravastatin Treatment Reverses Hypercholesterolemia Induced Mitochondria-Associated Membranes Contact Sites, Foam Cell Formation, and Phagocytosis in Macrophages by Leandro Henrique de Paula Assis, Gabriel de Gabriel Dorighello, Thiago Rentz, Jane Cristina de Souza, Aníbal Eugênio Vercesi, Helena Coutinho Franco de Oliveira

“…By comparing bone marrow-derived macrophages (BMDM) of wild-type (WT) and LDL receptor knockout (LDLr−/−) mice, we observed hypercholesterolemia increased the number of contact sites at mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs), enhanced mitochondrial hydrogen peroxide release, altered the gene expression of inflammatory markers, and increased oxidized LDL (ox-LDL) uptake and phagocytic activity. …”
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Characterization of Two Variants at Met 1 of the Human <i>LDLR</i> Gene Encoding the Same Amino Acid but Causing Different Functional Phenotypes by Rafael Graça, Rafael Fernandes, Ana Catarina Alves, Juliane Menezes, Luísa Romão, Mafalda Bourbon

“…FH phenotype has considerable genetic heterogeneity and phenotypic variability, depending on LDL receptor activity and lifestyle. To improve diagnosis and patient management, here, we characterized two single nucleotide missense substitutions at Methionine 1 of the human <i>LDLR</i> gene (c.1A>T/p.…”
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Dissociation of LPL and LDL: effects of lipoproteins and anti-apoB antibodies. by S Y Choi, L Pang, P A Kern, H J Kayden, L K Curtiss, T M Vanni-Reyes, I J Goldberg

“…LPL association with LDL was diminished by antibodies to the amino-terminal region of apoB; antibodies to the carboxyl-terminal LDL receptor binding region of apoB were less effective. …”
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Targeting HIV-1 Env gp140 to LOX-1 Elicits Immune Responses in Rhesus Macaques. by Gerard Zurawski, Sandra Zurawski, Anne-Laure Flamar, Laura Richert, Ralf Wagner, Georgia D Tomaras, David C Montefiori, Mario Roederer, Guido Ferrari, Christine Lacabaratz, Henri Bonnabau, Peter Klucar, Zhiqing Wang, Kathryn E Foulds, Shing-Fen Kao, Nicole L Yates, Celia LaBranche, Bertram L Jacobs, Karen Kibler, Benedikt Asbach, Alexander Kliche, Andres Salazar, Steve Reed, Steve Self, Raphael Gottardo, Lindsey Galmin, Deborah Weiss, Anthony Cristillo, Rodolphe Thiebaut, Giuseppe Pantaleo, Yves Levy

“…LOX-1, or 1ectin-like oxidized low-density lipoprotein (LDL) receptor-1, is expressed on various antigen presenting cells and endothelial cells, and is involved in promoting humoral immune responses. …”
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Squalene synthase inhibitors suppress triglyceride biosynthesis through the farnesol pathway in rat hepatocytes by Hironobu Hiyoshi, Mamoru Yanagimachi, Masashi Ito, Nobuyuki Yasuda, Toshimi Okada, Hironori Ikuta, Daisuke Shinmyo, Keigo Tanaka, Nobuyuki Kurusu, Ichiro Yoshida, Shinya Abe, Takao Saeki, Hiroshi Tanaka

“…We recently demonstrated that squalene synthase (S111111148) inhibitors reduce plasma triglyceride through an LDL receptor-independent mechanism in Watanabe heritable hyperlipidemic rabbits (Hiyoshi et al. 2001. …”
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Low levels of PCSK9 are associated with remission in patients with rheumatoid arthritis treated with anti-TNF-α: potential underlying mechanisms by Johan Frostegård, Sabbir Ahmed, Ingiäld Hafström, Sofia Ajeganova, Mizanur Rahman

“…Abstract Background Proprotein convertase subtilisin kexin 9 (PCSK9) targets the LDL-receptor (LDLR) which raises LDL-levels. In addition, PCSK9 has proinflammatory immunological effects. …”
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Control of LDL Uptake in Human Cells by Targeting the LDLR Regulatory Long Non-coding RNA BM450697 by Roslyn M. Ray, Anders Højgaard Hansen, Sofie Slott, Maria Taskova, Kira Astakhova, Kevin V. Morris

“…Cholesterol is removed from the blood by the LDL receptor (LDLR) in the liver. Others and we have discovered that a long non-coding RNA (lncRNA; BM450697) functions as an endogenous epigenetic regulator of LDLR and that the repression of this lncRNA by the action of small interfering RNAs (siRNAs) results in the activation of LDLR. …”
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The apolipoprotein-AI mimetic peptide L4F at a modest dose does not attenuate weight gain, inflammation, or atherosclerosis in LDLR-null mice. by Michelle M Averill, Eung Ju Kim, Leela Goodspeed, Shari Wang, Savitha Subramanian, Laura J Den Hartigh, Chongren Tang, Yilei Ding, Catherine A Reardon, Godfrey S Getz, Alan Chait

“…This study investigated the effect of L4F mimetic peptide and apoA-I overexpression on weight gain, insulin resistance, and atherosclerosis in an LDL receptor deficient (Ldlr-/-) model fed a high fat high sucrose with cholesterol (HFHSC) diet.Studies in differentiated 3T3-L1 adipocytes tested whether L4F could inhibit palmitate-induced adipocyte inflammation. …”
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