Simultaneous inhibition of FXR and TGR5 exacerbates atherosclerotic formation by Shinobu Miyazaki-Anzai, Masashi Masuda, Shohei Kohno, Moshe Levi, Yuji Shiozaki, Audrey L. Keenan, Makoto Miyazaki

“…To investigate the role of simultaneous inactivation of FXR and TGR5 in vivo, we generated LDL receptor knockout (LDLR) KO mice with FXR and TGR5 dual deficiency, which exhibited severe atherosclerosis and aortic inflammation through nuclear factor κΒ activation. …”
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A lipoprotein-containing particle is transferred from the serum across the mammary epithelium into the milk of lactating mice by Jenifer Monks, Patricia Uelmen Huey, Linda Hanson, Robert H. Eckel, Margaret C. Neville, Sean Gavigan

“…Quantitatively similar results were obtained with mice homozygous for disruption of the LDL receptor gene (LDLR null). Analysis of endogenous lipoproteins showed that the milk lipoprotein particles were denser than the corresponding serum lipoproteins and largely depleted of triglyceride and cholesterol. …”
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Hempseed (<i>Cannabis sativa</i>) Peptide H3 (IGFLIIWV) Exerts Cholesterol-Lowering Effects in Human Hepatic Cell Line by Jianqiang Li, Carlotta Bollati, Martina Bartolomei, Angelica Mazzolari, Anna Arnoldi, Giulio Vistoli, Carmen Lammi

“…Furthermore, the activation of the sterol regulatory element binding proteins (SREBP)-2 transcription factor, followed by the increase of low-density lipoprotein (LDL) receptor (LDLR) protein levels, was observed in human hepatic HepG2 cells treated with peptide H3 at 25 µM. …”
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Trans-9-octadecenoic acid is biologically neutral and does not regulate the low density lipoprotein receptor as the cis isomer does in the hamster. by L A Woollett, C M Daumerie, J M Dietschy

“…Therefore, these studies provide strong support for the thesis that fatty acids exert regulatory effects on hepatic LDL receptor activity by altering the distribution of cholesterol in the hepatocyte between a putative regulatory pool and the inert pool of cholesteryl esters. …”
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The elevation of plasma concentrations of apoB-48-containing lipoproteins in familial hypercholesterolemia is independent of PCSK9 levels by Jean-Philippe Drouin-Chartier, Jean-Charles Hogue, André J. Tremblay, Jean Bergeron, Benoît Lamarche, Patrick Couture

“…However, the extent to which LDL receptor deficiency and PCSK9 levels influence plasma apoB-48 concentrations in humans remains to be fully characterized. …”
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Oxidative Stress and Lipid Accumulation Augments Cell Death in LDLR-Deficient RPE Cells and <i>Ldlr</i>^−/− Mice by Parameswaran Gangadharan Sreekumar, Feng Su, Christine Spee, Eduardo Araujo, Steven Nusinowitz, Srinivasa T Reddy, Ram Kannan

“…The retina is abundant with circulating low-density lipoproteins (LDL), which are taken up by LDL receptor (LDLR) in the RPE and Müller cells. The purpose of this study is to investigate the role of LDLR in the NaIO₃-induced model of dry AMD. …”
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The panorama of familial hypercholesterolemia in Latin America: a systematic review[S] by Roopa Mehta, Rafael Zubirán, Alexandro J. Martagón, Alejandra Vazquez-Cárdenas, Yayoi Segura-Kato, María Teresa Tusié-Luna, Carlos A. Aguilar-Salinas

“…Few countries have registries and there was little commonality in FH mutations between LA countries. LDL receptor mutations predominate; APOB and PCSK9 mutations are rare. …”
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Lectin-like, oxidized low-density lipoprotein receptor-1-deficient mice show resistance to age-related knee osteoarthritis by Kazuhiko Hashimoto, Yutaka Oda, Fumihisa Nakamura, Ryosuke Kakinoki, Masao Akagi

“…<p>The lectin-like, oxidized low-density lipoprotein (ox-LDL) receptor-1 (LOX-1)/ox-LDL system contributes to atherosclerosis and may be involved in cartilage degeneration. …”
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Amlodipine reduces AngII-induced aortic aneurysms and atherosclerosis in hypercholesterolemic mice. by Xiaofeng Chen, Debra L Rateri, Deborah A Howatt, Anju Balakrishnan, Jessica J Moorleghen, Andrew J Morris, Richard Charnigo, Lisa A Cassis, Alan Daugherty

“…The purpose of this study was to determine effects of amlodipine, a dihydropyridine calcium channel blocker, on development of angiotensin II (AngII)-induced vascular pathologies.Male LDL receptor -/- mice were infused with vehicle, amlodipine (5 mg/kg/d), AngII (1,000 ng/kg/min), or AngII + amlodipine for 4 weeks through osmotic pumps (n=10/group). …”
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LPA receptor 4 deficiency attenuates experimental atherosclerosis by Liping Yang, Maria Kraemer, Xianjun Frank Fang, Peggi M. Angel, Richard R. Drake, Andrew J. Morris, Susan S. Smyth

“…We investigated the role of LPAR4 in experimental atherosclerosis elicited by adeno-associated virus expressing PCSK9 to lower LDL receptor levels. After 20 weeks on a Western diet, cholesterol levels and lipoprotein distribution were similar in WT male and Lpar4Y/− mice (P = 0.94). …”
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Hepatic SR-BI, not endothelial lipase, expression determines biliary cholesterol secretion in mice1[S] by Harmen Wiersma, Alberto Gatti, Niels Nijstad, Folkert Kuipers, Uwe J.F. Tietge

“…In each model, injection of an EL expressing adenovirus decreased plasma HDL cholesterol (P < 0.001) whereas hepatic cholesterol content increased (P < 0.05), translating into decreased expression of sterol-regulatory element binding protein 2 (SREBP2) and its target genes HMG-CoA reductase and LDL receptor (each P < 0.01). Biliary cholesterol secretion was dependent on hepatic SR-BI expression, being decreased in SR-BI knockouts (P < 0.001) and increased following hepatic SR-BI overexpression (P < 0.001). …”
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Accumulation of cholesterol, triglycerides and ceramides in hepatocellular carcinomas of diethylnitrosamine injected mice by Elisabeth M. Haberl, Rebekka Pohl, Lisa Rein-Fischboeck, Marcus Höring, Sabrina Krautbauer, Gerhard Liebisch, Christa Buechler

“…Higher rates of de novo lipogenesis cause a shift towards saturated acyl chains, which did not occur in the murine HCC model. Besides, LDL-receptor protein and cholesteryl ester levels were higher in the murine HCC tissues. …”
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Role of Endocytosis Proteins in Gefitinib-Mediated EGFR Internalisation in Glioma Cells by Elisabete Cruz Da Silva, Laurence Choulier, Jessica Thevenard-Devy, Christophe Schneider, Philippe Carl, Philippe Rondé, Stéphane Dedieu, Maxime Lehmann

“…Here, using pharmacological inhibitors, siRNA-mediated silencing, or expression of mutant proteins, we showed that dynamin 2 (DNM2), the small GTPase Rab5 and the endocytosis receptor LDL receptor-related protein 1 (LRP-1), contribute significantly to gefitinib-mediated EGFR endocytosis in glioma cells. …”
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CTP:phosphocholine cytidylyltransferase, a new sterol- and SREBP-responsive gene by Heidi Rachelle Kast, Catherine M. Nguyen, Andrew M. Anisfeld, Johan Ericsson, Peter A. Edwards

“…CTα mRNA levels, like farnesyl diphosphate synthase and the LDL receptor, are repressed when human or rodent cells are incubated with exogenous sterols and induced when cells are incubated in lipid-depleted medium. …”
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Transgenic rabbits as models for atherosclerosis research by Margaret E. Brousseau, Jeffrey M. Hoeg

“…In both NZW and WHHL rabbits, human apoA-I expression was associated with a significant reduction in the extent of aortic atherosclerosis, which was similarly the case for LCAT in rabbits having at least one functional LDL receptor allele. Conversely, expression of apoE2 in NZW rabbits caused increased susceptibility to atherosclerosis. …”
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LOX-1 deficient mice show resistance to zymosan-induced arthritis by Kazuhiko Hashimoto, Yutaka Oda, Koichi Nakagawa, Terumasa Ikeda, Kazuhiro Ohtani, Masao Akagi

“…Recent data suggest that the lectin-like oxidized low-density lipoprotein (ox-LDL) receptor-1 (LOX-1)/ox-LDL system may be involved in the pathogenesis of arthritis. …”
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Levels of apolipoprotein M are not associated with the risk of coronary heart disease in two independent case-control studies by Josefin Ahnström, Olof Axler, Matti Jauhiainen, Veikko Salomaa, Aki S. Havulinna, Christian Ehnholm, Ruth Frikke-Schmidt, Anne Tybjærg-Hansen, Björn Dahlbäck

“…Overexpression of human apoM in LDL receptor-deficient mice reduced the atherogenic effect of a cholesterol-rich diet. …”
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Grape juice attenuates left ventricular hypertrophy in dyslipidemic mice. by Ângela Maria Martins, Danielle Aparecida Quintino Silva Sarto, Karine de Paula Caproni, Janaína Silva, Jaqueline Silva, Paulo Sérgio Souza, Leandro Dos Santos, Marcos Javier Espino Ureña, Maria das Graças de Souza Carvalho, Brígida Monteiro Vilas Boas, Lidiane Paula Ardisson Miranda, José Antonio Dias Garcia

“…<h4>Objective</h4>We evaluated the effects of grape juice (Vitis labrusca L.) on dyslipidemia, resistance to insulin, and left ventricular hypertrophy (LVH) in mice homozygous for the absence of the LDL receptor gene (LDLr -/-) under a hyperlipidemic diet.…”
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Diabetic atherosclerosis in APOE*4 mice: synergy between lipoprotein metabolism and vascular inflammation by Lance A. Johnson, Hyung-Suk Kim, Melissa J. Knudson, C. Taylor Nipp, Xianwen Yi, Nobuyo Maeda

“…To examine how diabetes interacts with a mildly compromised lipid metabolism, we introduced the diabetogenic Ins2C96Y/+ (Akita) mutation into mice expressing human apoE4 (E4) combined with either an overexpressing human LDL receptor gene (hLDLR) or the wild-type mouse gene. …”
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Pharmacological Inhibition of Lipid Import and Transport Proteins in Ovarian Cancer by Lisa Lemberger, Renate Wagner, Gerwin Heller, Dietmar Pils, Thomas W. Grunt

“…Therefore, we treated A2780 and SKOV3 OC cells with inhibitors of the lipid uptake proteins fatty acid translocase/cluster of differentiation 36 (FAT/CD36) and low-density lipoprotein (LDL) receptor (LDLR), as well as intracellular lipid transporters of the fatty acid-binding protein (FABP) family, fatty acid transport protein-2 (FATP2/SLC27A2), and ADP-ribosylation factor 6 (ARF6), which are overexpressed in OC. …”
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