Upregulation of hepatic LDL transport by n-3 fatty acids in LDL receptor knockout mice by Chandna Vasandani, Abdallah I. Kafrouni, Antonella Caronna, Yuriy Bashmakov, Michael Gotthardt, Jay D. Horton, David K. Spady

“…Upregulation of hepatic LDL Transport by n-3 fatty acids in LDL receptor knockout mice. J. Lipid Res. 2002. 43: 772–784.…”
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Protection against atherosclerosis by estrogen is independent of plasma cholesterol levels in LDL receptor-deficient mice by Marion M. Marsh, V. Robert Walker, Linda K. Curtiss, Carole L. Banka

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Changes in soluble LDL receptor and lipoprotein fractions in response to diet in the DIETFITS weight loss study by Ronald M. Krauss, Lois M. Fisher, Sarah M. King, Christopher D. Gardner

“…Circulating levels of the soluble ligand-binding ectodomain of the LDL receptor (sLDLR) that is proteolytically cleaved from the cell surface have been shown to correlate with plasma triglycerides, but the lipid and lipoprotein effects of longitudinal changes in sLDLR have not been examined. …”
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Both K63 and K48 ubiquitin linkages signal lysosomal degradation of the LDL receptor by Li Zhang, Ming Xu, Elena Scotti, Zhijian J. Chen, Peter Tontonoz

“…The E3 ubiquitin ligase inducible degrader of the LDL receptor (IDOL) targets the low density lipoprotein receptor (LDLR) for degradation. …”
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LDL receptor deficiency or apoE mutations prevent remnant clearance and induce hypertriglyceridemia in mices⃞ by Kyriakos E. Kypreos, Vassilis I. Zannis

“…These findings suggest that a) the LDL receptor alone can account for the clearance of apoE-containing lipoproteins in mice, and the contribution of other receptors is minimal, and b) defects in either the LDL receptor or in apoE that affect its interactions with the LDL receptor, increase the sensitivity to apoE-induced hypertriglyceridemia in mice.…”
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Genetically determined hypercholesterolemia in a rhesus monkey family due to a deficiency of the LDL receptor. by A M Scanu, A Khalil, L Neven, M Tidore, G Dawson, D Pfaffinger, E Jackson, K D Carey, H C McGill, G M Fless

“…The hyperresponsiveness noted in the sire that had no evidence for LDL-receptor deficiency illustrates that factors other than the LDL receptor were responsible for the hypercholesterolemia attending the fat challenge.…”
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Activation of LDL receptor gene expression in HepG2 cells by hepatocyte growth factor by Y K Pak, M P Kanuck, D Berrios, M R Briggs, A D Cooper, J L Ellsworth

“…The effect of recombinant human hepatocyte growth factor (HGF) on low density lipoprotein (LDL) receptor gene expression was studied in the human hepatoma cell line HepG2. …”
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Effects of cyclosporin on cholesterol 27-hydroxylation and LDL receptor activity in HepG2 cells. by D A Winegar, J A Salisbury, S S Sundseth, R L Hawke

“…The hypothesis that mitochondrial sterol 27-hydroxylase plays a role in the sterol-mediated down-regulation of LDL receptor activity was evaluated in HepG2 cells. 27-Hydroxycholesterol was found to be more potent at suppressing LDL receptor activity than cholesterol (IC50 values of 8 mu M and 142 mu M for 27-hydroxycholesterol and cholesterol, respectively) when the sterols were delivered to cells from 2-hydroxypropyl-beta-cyclodextrin (beta-CD)-solubilized solutions. …”
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Statins and New-Onset Diabetes Mellitus: LDL Receptor May Provide a Key Link by Qi Yu, Qi Yu, Qi Yu, Ying Chen, Ying Chen, Cang-Bao Xu, Cang-Bao Xu

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The small GTPase RAB10 regulates endosomal recycling of the LDL receptor and transferrin receptor in hepatocytes by Taslima Gani Khan, David Ginsburg, Brian T. Emmer

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Inhibitors of AKT kinase increase LDL receptor mRNA expression by two different mechanisms. by Katrine Bjune, Lene Wierød, Soheil Naderi

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Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis by Adekunle Alabi, Xiao-Dan Xia, Hong-Mei Gu, Faqi Wang, Shi-Jun Deng, Nana Yang, Ayinuer Adijiang, Donna N. Douglas, Norman M. Kneteman, Yazhuo Xue, Li Chen, Shucun Qin, Guiqing Wang, Da-Wei Zhang

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Myeloid-specific deficiency of pregnane X receptor decreases atherosclerosis in LDL receptor-deficient mice[S] by Yipeng Sui, Zhaojie Meng, Se-Hyung Park, Weiwei Lu, Christopher Livelo, Qi Chen, Tong Zhou, Changcheng Zhou

“…In this study, we generated an LDL receptor-deficient mouse model with myeloid-specific PXR deficiency (PXRΔMyeLDLR−/−) to elucidate the role of macrophage PXR signaling in atherogenesis. …”
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The role of cyclooxygenase-2 on endurance exercise training in female LDL-receptor knockout ovariectomized mice by FLAVIA DE OLIVEIRA, LAURA B.M. MAIFRINO, GUSTAVO P.P. DE JESUS, JULIANA G. CARVALHO, CLAUDIA MARCHON, DANIEL A. RIBEIRO

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Effects of secreted macrophage scavenger receptor on atherogenesis and lipoprotein metabolism in LDL receptor knockout mice by Laukkanen, J, Leppanen, P, Gough, P, Greaves, D, Gordon, S, Yla-Herttuala, S

Annexin A2 is a natural extrahepatic inhibitor of the PCSK9-induced LDL receptor degradation. by Nabil G Seidah, Steve Poirier, Maxime Denis, Rex Parker, Bowman Miao, Claudio Mapelli, Annik Prat, Hanny Wassef, Jean Davignon, Katherine A Hajjar, Gaétan Mayer

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Oxidized LDL receptor 1 (OLR1) as a possible link between obesity, dyslipidemia and cancer. by Magomed Khaidakov, Sona Mitra, Bum-Yong Kang, Xianwei Wang, Susan Kadlubar, Giuseppe Novelli, Vinay Raj, Maria Winters, Weleetka C Carter, Jawahar L Mehta

“…Recent studies have linked expression of lectin-like ox-LDL receptor 1 (OLR1) to tumorigenesis. We analyzed microarray data from Olr1 knockout (KO) and wild type (WT) mice for genes involved in cellular transformation and evaluated effects of OLR1 over-expression in normal mammary epithelial cells (MCF10A) and breast cancer cells (HCC1143) in terms of gene expression, migration, adhesion and transendothelial migration. …”
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Lectin-like oxidized LDL receptor-1 is an enhancer of tumor angiogenesis in human prostate cancer cells. by Iván González-Chavarría, Rita P Cerro, Natalie P Parra, Felipe A Sandoval, Felipe A Zuñiga, Valeska A Omazábal, Liliana I Lamperti, Silvana P Jiménez, Edelmira A Fernandez, Nicolas A Gutiérrez, Federico S Rodriguez, Sergio A Onate, Oliberto Sánchez, Juan C Vera, Jorge R Toledo

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Identification of amino acid residues in the ligand binding repeats of LDL receptor important for PCSK9 binding[S] by Shi-jun Deng, Adekunle Alabi, Hong-mei Gu, Ayinuer Adijiang, Shucun Qin, Da-wei Zhang

“…Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes LDL receptor (LDLR) degradation, increasing plasma levels of LDL cholesterol and the risk of cardiovascular disease. …”
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Modulation of LDL receptor mRNA stability by phorbol esters in human liver cell culture models by G M Wilson, E A Roberts, R G Deeley

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